Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,959 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2142
- Phase 385
- Phase 181
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis102
- Nasopharyngeal Carcinoma73
- Periodontal Diseases50
- Dental Caries45
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer31
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Disorder19
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University26
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Massachusetts21
- Florida20
- Maryland20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,959 total
- NCT07874789Recruiting
Curcumin spray for faster healing after tooth extraction
This trial tests a curcumin (turmeric) spray applied to the extraction site after removing a lower molar, to see if it helps the wound heal faster and better. If you're a healthy adult having this tooth pulled, you might be able to join.
Istanbul, IstanbulAges 18–40 - NCT07869030Recruiting
Melatonin for dental implants in lower jaw
This study tests whether applying melatonin around new dental implants in the lower back teeth helps them heal and stay secure. It may improve the success of implants placed right after tooth extraction.
CairoAges 20–50 - NCT07275580RecruitingPhase 4
Antibiotics before tooth removal for people with immune disorders
This trial tests whether taking preventive antibiotics before a simple tooth extraction helps prevent infections in people with weakened immune systems due to autoimmune diseases. It might help you avoid complications after your dental procedure.
São Paulo, São PauloAges 18 years+ - NCT07667400RecruitingPhase 1/Phase 2
Docetaxel plus SX-682 for advanced head and neck or prostate cancer
This trial studies a combination of the chemotherapy drug docetaxel and an investigational drug called SX-682 for people with certain advanced head and neck cancers or prostate cancer. The goal is to see if the combination is safe and effective.
Bethesda, MarylandAges 18–120 - NCT07818031Recruiting
Comparing two types of in-office teeth whitening
This study compares two types of in-office teeth whitening treatments – one with peroxide and one without – to see which works better for brightening your smile. If you're looking to whiten your teeth, this trial may help you achieve a whiter shade safely.
Minya, Minya GovernorateAges 18–45 - NCT07483788Recruiting
Comparing two materials for infected tooth nerve treatment
This study compares two materials (MTA and Biodentine) used to treat a painful, infected nerve in a back tooth. Instead of a full root canal, the dentist will remove only the top part of the nerve and seal it. The goal is to see which material works better to save your tooth.
Karachi, SindhAges 18–40 - NCT06910579RecruitingPhase 2/Phase 3
Oxygen gel for mouth sores
This study tests a special oxygen gel to treat canker sores (small, painful mouth ulcers). If you have a single small sore and are generally healthy, this trial might help it heal faster.
Al Sherouk City, Cairo GovernorateAges Any age - NCT07796789RecruitingPhase 3
Preventing appetite loss during cancer treatment for nasopharyngeal carcinoma
This trial tests whether a medicine called nanocrystalline megestrol acetate can help prevent loss of appetite caused by chemotherapy and radiation therapy in people with nasopharyngeal carcinoma. If you are receiving chemoradiotherapy for this type of cancer, you may be able to participate.
Guangzhou, GuangdongAges 18–70 - NCT00932594Recruiting
New treatment approach for jaw joint problems
This trial studies a “serial” (step-by-step) treatment plan for temporomandibular disorders (TMJ), which can cause pain, clicking, and trouble opening your mouth. It may help by improving how your jaw joint moves and reducing symptoms.
Guangzhou, GuangdongAges 16–60 - NCT03753256Recruiting
Testing a dental eye scan during orthodontic treatment
This study checks whether an optical coherence tomography scan—a quick, non-invasive imaging test—can help in dentistry for people who need orthodontic (braces/alignment) treatment. If you join, you’ll likely be scanned as part of the study and your dentist/doctor will compare results to see how useful the scan is.
HeidelbergAges 6 years+ - NCT03625011RecruitingPhase 4
Gabapentin before tonsil surgery to reduce pain
This trial tests whether giving gabapentin before pediatric tonsil (and possibly adenoid) removal can reduce postoperative pain. It may help children feel more comfortable after surgery while still being safe to use in the right patients.
Atlanta, GeorgiaAges 3–18 - NCT03473912Recruiting
Rheumatoid disease biobank study for adults
This study asks adults with a rheumatoid condition to join a biobank, which is a safe place to store health information and biological samples for future research. It may help researchers better understand rheumatoid conditions and develop better treatments.
Kfar SabaAges 18–120 - NCT03934957Recruiting
Study of health in people living in Hamburg
This study follows adults living in Hamburg to better understand health and health-related factors over time. You may help researchers learn what influences health in this age group.
HamburgAges 45–74 - NCT03975322Recruiting
Predict which oral white patches may turn cancerous
This study looks at oral leukoplakia (persistent white patches in the mouth) to better predict which ones may develop into cancer. It uses a test based on specific immune and cancer-related markers to help estimate each person’s risk.
ErlangenAges 18–80 - NCT04136886RecruitingPhase 3
Chemo trial for return of advanced nasopharyngeal cancer
This Phase 3 study tests a chemotherapy plan for people whose nasopharyngeal cancer has come back locally (T3/T4). It aims to see if treatment given after return of cancer can help control the disease without spreading to distant organs.
Guangzhou, GuangdongAges 18–70 - NCT02814149Recruiting
Compare early vs delayed dental implant placement
This trial studies whether placing a dental implant right away or after a delay leads to better appearance and healing. It looks at cosmetic results and X-ray findings, and is for people missing one front upper tooth.
Guangzhou, GuangdongAges 18–80 - NCT04453826RecruitingPhase 3
Test PD-1 plus chemo-radiation for high-risk nasopharyngeal cancer
This Phase 3 trial tests whether adding a PD-1 immunotherapy (given with chemotherapy and radiation, and also after) can improve outcomes for people with high-risk nasopharyngeal cancer. It may help by strengthening the immune system’s attack on the cancer alongside standard treatment.
Guangzhou, GuangdongAges 18–70 - NCT04528979Recruiting
Tests a bioceramic filling material for root-canal treatment outcomes
This study looks at how well a bioceramic sealing material works for tooth root-canal treatment, including cases where previous treatment did not work. If you have certain types of tooth nerve inflammation or infection, you may be eligible to help compare outcomes and improve care.
Sant Cugat del Vallès, BarcelonaAges 18–75 - NCT04527705Recruiting
Testing endodontic retreatment in one versus two visits
This study compares doing tooth root-canal retreatment in one visit versus two visits. It’s meant to see which approach leads to better outcomes for teeth with infection at the root tip (apical periodontitis).
Sant Cugat del Vallès, BarcelonaAges 18–75 - NCT04453813RecruitingPhase 3
Immunotherapy with chemoradiation for recurring nasopharyngeal cancer
This phase 3 trial tests whether adding toripalimab (an immunotherapy medicine) to standard chemo-radiation works better for treating nasopharyngeal cancer that has come back and cannot be removed by surgery. It aims to improve control of the cancer after it returns.
Guangzhou, GuangdongAges 18–70 - NCT04448522RecruitingPhase 3
Lower-dose radiotherapy for EBV-responsive nasopharyngeal cancer
This Phase 3 study tests whether giving a reduced amount of radiotherapy can work as well as the standard dose for certain people with stage II–III nasopharyngeal cancer who respond well after initial chemotherapy. It’s designed for patients whose cancer markers improve after 3 chemotherapy cycles, to potentially reduce treatment side effects while keeping cancer control.
Guangzhou, GuangdongAges 18–70 - NCT04778956RecruitingPhase 3
Toripalimab plus surgery vs surgery alone for recurring throat cancer
This trial tests whether adding toripalimab (an immune therapy) to surgery helps people with recurrent nasopharyngeal cancer live longer or control the cancer better than surgery alone. You may qualify if your recurrence can be fully removed by surgery and it came back after a certain amount of time.
Guangzhou, GuangdongAges 18–70 - NCT03353467Recruiting
Surgery through the nose for early nasopharyngeal cancer
This trial tests whether a minimally invasive surgery done through the nose can help people newly diagnosed with early-stage nasopharyngeal cancer. It looks for patients who have not had prior cancer treatment and who are healthy enough for the procedure and follow-up.
Guangzhou, GuangdongAges 18–70 - NCT04376866RecruitingPhase 3
Immunotherapy for repeat nasopharyngeal cancer after it returns
This trial studies toripalimab (an immunotherapy that helps your immune system attack cancer) for nasopharyngeal cancer that has come back locally. It may help shrink or control the returning tumor and improve outcomes for people who meet the safety and lab requirements.
Nanning, GuangxiAges 18–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,959 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,721 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.