Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07397312Recruiting
Toothpaste study for gum health
This study tests a new toothpaste to see if it improves gum health. It is for people who have at least 16 natural teeth and get regular dental cleanings.
Halle, Saxony-AnhaltAges 18 years+ - NCT06830148Recruiting
Tongue movement after tongue-tie release for better breastfeeding
This study tests whether gently moving the tongue after a tongue-tie release (frenotomy) helps babies breastfeed better. It's for babies under 3 months old who are having their tongue-tie cut with scissors and are breastfeeding at least some of the time.
Washington D.C., District of ColumbiaAges Up to 3 months - NCT06829147Recruiting
AI to diagnose lymph node spread in nasopharyngeal cancer
This trial tests whether a computer model can accurately detect if cancer has spread to lymph nodes in patients with nasopharyngeal carcinoma. It uses MRI and PET/CT scans taken before treatment to see if the AI can replace or supplement current methods.
Guangzhou, GuangdongAges Any age - NCT07390188Recruiting
Oral lesions in Egyptian adults
This study will examine how common oral mucosal lesions (sores or changes inside the mouth) are among Egyptian adults. By joining, you help researchers understand which mouth conditions affect people like you.
CairoAges 18 years+ - NCT07395401Recruiting
Comparing fillings for baby molar root canals
This study compares two types of filling materials used in root canals of baby molars. It looks at which material works better when the tooth is prepared with either a manual file or a rotating dental tool. This could help children keep their baby teeth longer without pain or infection.
Giza, Giza GovernorateAges 5–8 - NCT07391202Recruiting
Crown removal for treating gum disease around dental implants
This trial tests whether removing the crown from a dental implant before cleaning helps treat infection and inflammation around the implant. It may help patients with a condition called peri-implantitis, which is like gum disease but around an implant.
Chieti, ChietiAges 18 years+ - NCT07394634Enrolling by invitation
Using Your Own Tooth as a Bone Graft After Extraction
This study tests whether using your own extracted tooth (processed into a graft) helps preserve the bone in the socket after extraction, so a dental implant can be placed later. It is for people who need a tooth pulled and are healthy enough for implant surgery.
Jenjarum, SelangorAges 18 years+ - NCT07397884Recruiting
Bone loss and stress markers in implant gum disease
This study looks at markers of bone damage and stress in people with gum disease around dental implants (peri-implantitis). It aims to understand how the body responds, which could help improve treatment.
Keçiören, AnkaraAges 18–65 - NCT07393997Recruiting
Tooth transplant with platelet-rich fibrin for young patients
This trial tests a tooth transplant method that uses a healthy tooth from elsewhere in your mouth to replace a missing tooth. A special protein-rich material (platelet-rich fibrin) is placed around the new tooth to help it heal and grow roots. It's designed for children, teens, and young adults who cannot get dental implants.
BariAges 10–80 - NCT05997186Recruiting
Reinnervated flap for mouth and throat reconstruction
This trial tests a new way to rebuild parts of the mouth or throat after surgery, using a flap from the thigh that is reconnected to nerves to help it work better. It may help people who need a reconstructive procedure for these areas.
BaselAges 18 years+ - NCT06389201Recruiting
Hydroxychloroquine before radiation and chemo for NPC
This trial tests whether taking hydroxychloroquine (HCQ) before standard radiation and chemo can help treat advanced nasopharyngeal cancer. It is for patients who have not yet started any cancer therapy.
Nantong, JiangsuAges 20–70 - NCT06831214Recruiting
Bone growth with collagen membrane graft for jaw atrophy
This trial studies a new technique to help build up bone in the upper jaw (maxilla) that has become thin. It uses a special membrane and graft material to encourage bone growth, which may help people who need dental implants.
CairoAges 18–60 - NCT05677243Recruiting
Observational study of radiosurgery for trigeminal neuralgia pain
This study follows people with trigeminal neuralgia to see how radiosurgery treatment affects their facial pain. It may help doctors better understand who benefits when medicines do not control the pain enough.
MonacoAges 18 years+ - NCT06720168Recruiting
Erythritol air polisher for dental black stain treatment
This trial tests if a special cleaning tool using erythritol can safely remove black stains from teeth caused by bacteria. It may help people with at least two stained teeth who haven't used antibiotics recently or have certain health issues.
Alfara del Patriarca, ValenciaAges Any age - NCT06654141Recruiting
Healing time and tooth socket preservation after molar extraction
This study looks at how different healing times affect the success of preserving the bone where a molar is removed due to gum disease. It aims to find the best wait time before placing a dental implant.
ShanghaiAges 18 years+ - NCT06746935Recruiting
Rebuilding thin jawbone for dental implants after failed graft or implant
This trial tests a method to rebuild thin jawbones so they can support dental implants. It is for people who have lost a tooth and have had a previous implant or bone graft that didn't work.
CairoAges 20–48 - NCT07387978Recruiting
Laser therapy to prevent mouth sores during radiation for oral cancer
This trial tests if low-level laser therapy can reduce painful mouth ulcers caused by radiation treatment for oral cancer. It may help you keep your mouth healthier during therapy.
Melbourne, VictoriaAges 18 years+ - NCT07387900RecruitingPhase 2
Metformin for preventing cancer in oral leukoplakia
This study tests if metformin — a medication commonly used for diabetes — can prevent oral leukoplakia from turning into cancer when applied as a mouth rinse and taken as a pill. It is for people with non-severe white patches in the mouth.
CairoAges 21 years+ - NCT07388901Recruiting
Comparing two root canal sealers for infection treatment
This trial compares two materials (iRoot SP and nRoot SP) used to fill root canals after infection. It aims to see which works better for healing apical periodontitis, an infection around the tooth root.
Hangzhou, ZhejiangAges 18 years+ - NCT07386457Recruiting
Measuring gum graft healing after surgery
This study measures how a gum graft surgery site heals over time. It's for people who are already scheduled for this specific procedure at Ohio State University and have mild to moderate gum recession on certain teeth. The goal is to understand normal healing after the surgery.
Columbus, OhioAges 18–50 - NCT07379632Recruiting
Comparing two appliances for fixing open bite in children
This trial tests two different dental appliances to fix an open bite in children. It compares a vertical holding appliance to a special arch bar to see which works better.
CairoAges 6–12 - NCT07383350Enrolling by invitation
Information sheets for better communication on antibiotics
This study tests if using simple information sheets helps you and your doctor talk better about infections like sore throat, sinusitis, or bronchitis, and make wise decisions about antibiotics — so you only get them when truly needed.
AalborgAges 18 years+ - NCT07384403RecruitingPhase 4
Oxygen therapy around healing collar after surgery
This trial tests whether a topical oxygen therapy applied around a customized healing collar helps improve healing after dental implant surgery. It is for adults in good health who are ready to commit to follow-up visits.
CairoAges 21 years+ - NCT07386925Recruiting
Pelargonium oil for baby tooth pulpotomy
This trial tests using Pelargonium graveolens essential oil, a natural plant oil, as a treatment for cavities in baby (primary) molars. It compares the oil to standard treatments to see if it can help preserve the tooth and avoid pain or infection.
Tanta, Cairo GovernorateAges 4–7
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.