Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT03829033Recruiting
Photon vs proton radiation for early tonsil cancer
This trial compares two types of radiation—photon therapy and proton therapy—for early-stage tonsil cancer. The goal is to see which approach works well for cure while affecting surrounding tissues differently.
GävleAges 18 years+ - NCT03889899Recruiting
Device treatment for certain skin, mouth, or surface soft tissue cancers
This trial studies a radiation-emitting device (DaRT) to treat certain cancers on the skin, in the mouth, or in superficial soft tissues. You may qualify if you have a confirmed malignant tumor, enough body strength for treatment, and blood tests and pregnancy status that meet safety limits.
HaifaAges 18 years+ - NCT03907826RecruitingPhase 3
PD-1 therapy plus chemoradiation for recurrent nasopharyngeal cancer
This trial studies whether adding a PD-1 antibody (an immunotherapy) to standard chemoradiation can better control recurrent nasopharyngeal cancer that can’t be removed with surgery. If you qualify, you’d receive the study treatment and be closely monitored for side effects and cancer response.
Guangzhou, GuangdongAges 18–70 - NCT03916809Recruiting
Voice and swallowing therapy device during head and neck cancer treatment
This trial tests whether using a mouth-based training device (called EMST150) during planned radiation (with or without chemotherapy) can help people with head and neck cancer with swallowing and related muscle function. It may be useful if you’re starting radiation for a cancer in the mouth, throat, or voice box area.
Milwaukee, WisconsinAges 18 years+ - NCT03919552RecruitingPhase 3
Chemoradiation with two cisplatin or carboplatin plans for nasopharyngeal cancer
This Phase 3 trial compares two chemotherapy-and-radiation combinations (cisplatin-based vs carboplatin-based) for locally advanced nasopharyngeal cancer that has not spread to distant organs. It may help researchers find which plan works best while balancing safety and effectiveness.
Guangzhou, GuangdongAges 18–64 - NCT03934957Recruiting
Study of health in people living in Hamburg
This study follows adults living in Hamburg to better understand health and health-related factors over time. You may help researchers learn what influences health in this age group.
HamburgAges 45–74 - NCT03966014RecruitingPhase 3
Compare different amoxicillin schedules for Lyme rash
This trial tests which schedule of amoxicillin works best for people who have the early Lyme rash called erythema migrans. It may help you choose a treatment plan that clears infection with fewer issues.
LjubljanaAges 18 years+ - NCT03969628Recruiting
Testing two ways to check tooth-caries risk in children
This study compares two different methods of estimating how likely a child is to get tooth decay. If you visit the children’s dental clinic, the researchers will use these methods to help identify risk and plan prevention.
Pelotas, Rio Grande do SulAges 7–11 - NCT03975322Recruiting
Predict which oral white patches may turn cancerous
This study looks at oral leukoplakia (persistent white patches in the mouth) to better predict which ones may develop into cancer. It uses a test based on specific immune and cancer-related markers to help estimate each person’s risk.
ErlangenAges 18–80 - NCT03983369RecruitingPhase 3
Laser treatment to help prevent painful mouth sores from chemo
This trial tests whether low-level laser therapy (using special light on the mouth) can prevent or reduce mouth sores caused by chemotherapy in children and young adults. It may help you avoid painful inflammation that can affect eating, comfort, and treatment.
Villejuif, Val de MarneAges 4–25 - NCT03991728Recruiting
TMJ implant registry for adults with a new jaw joint replacement
This registry is for adults getting an artificial (alloplastic) full replacement of the jaw joint (TMJ). It collects real-world information about your implant and care to help improve future outcomes.
São PauloAges 18 years+ - NCT03997552Recruiting
Gum surgery options to help regenerate damaged gum bone
This trial compares two dental gum surgery approaches to see which better helps the gum and bone heal in people with periodontitis. It may help by improving the depth of gum pockets and supporting regrowth of damaged areas around teeth.
MurciaAges 18 years+ - NCT03997578Recruiting
Gum surgery for deep periodontal bone defects
This trial studies a specific gum surgery technique plus a biologic product to help fill deep gum/bone defects from periodontitis (gum disease). It may help reduce gum pocket depth and improve healing around affected teeth.
MurciaAges 18 years+ - NCT04001842Recruiting
Tested new jaw bone repair to support future dental work
This trial is studying a method to rebuild part of the lower jaw using a blood-supply bone replacement, so you can later get dental rehabilitation. It’s for adults who need a sizable, tumor-free jaw bone reconstruction and who can safely undergo surgery.
AlexandriaAges 18–65 - NCT04340024Recruiting
Testing blood markers linked to how well radiation works
This study looks for “biomarkers,” or measurable signs (often from blood or samples), that may show which cancers respond better to radiation therapy. It may help doctors choose radiation treatment more precisely, especially for people who had significant side effects before.
SingaporeAges 21–99 - NCT07702149Recruiting
Diet for Behcet's disease patients with ringing in the ears
This trial tests whether a special diet can help ringing in the ears (tinnitus) in people with Behcet's disease who also have obesity. The goal is to see if dietary changes reduce tinnitus symptoms.
Giza, DokkiAges 40–55 - NCT07702448Recruiting
Jaw surgery and its effect on mood and looks
This study looks at how jaw surgery affects your mood and how you feel about your appearance. You will answer questions one week before surgery and again 6 months after, and you need to use social media as part of the research.
KirikkaleAges 18–40 - NCT07702123Recruiting
Physical activity study for women with Behcet's and metabolic syndrome
This study tests if a physical activity program helps women who have both Behcet's disease and metabolic syndrome. It aims to improve their health and well-being.
Giza, DokkiAges 40–50 - NCT07178301RecruitingPhase 2
Lower radiation dose for HPV-related throat cancer
This trial tests whether a lower dose of radiation to the neck is safe and effective for people with HPV-related oropharyngeal cancer. It may reduce side effects while still treating the cancer.
Chicago, IllinoisAges 18 years+ - NCT07703345Recruiting
Saliva markers in people with diabetes and gum disease
This study checks whether certain substances in saliva can help detect gum disease in people with type 2 diabetes. It compares the levels of these substances in people with diabetes and gum disease, people with gum disease only, people with diabetes only, and healthy volunteers.
Konya, KonyaAges 18–80 - NCT05451004RecruitingPhase 3
SPECT-CT test to target neck radiation on one side
This study tests whether using a special scan (SPECT-CT) can guide radiation treatment to only the safer/needed side of the neck in people with a one-sided oropharyngeal cancer. It aims to keep cancer control while potentially reducing side effects from unnecessary radiation.
Corona, CaliforniaAges 18 years+ - NCT04019548RecruitingPhase 3
Test swallowing and quality of life during chemo-radiation for throat cancer
This study looks at how well people swallow and how their quality of life changes during standard chemo-radiation for newly diagnosed throat (oropharyngeal) cancer. The goal is to better understand swallowing side effects so care can improve.
BrusselsAges 18 years+ - NCT04040920Recruiting
Ozone treatment before dental sealants
This trial tests whether applying ozone to certain back teeth before placing sealants helps the sealants work better. You might qualify if you need sealants on specific molars and can safely have the area isolated during treatment.
Trieste, TriesteAges 6–16 - NCT04046237Recruiting
Treating gum disease to study heart artery inflammation after a heart attack
This study tests whether treating severe gum disease in people who recently had a heart attack can reduce inflammation in the artery plaque. It may help researchers understand if gum treatment could benefit heart health after a heart attack.
ParisAges 30–70
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.