Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06067945Recruiting
Comparing Fit of All-Metal Crowns on Artificial Molars
This lab study is testing how well all-metal crowns fit on artificial upper back molars when made using the traditional lost-wax technique. It compares the crown's edge fit and internal adaptation to see which method works best.
Karachi, SindhAges Any age - NCT06846619Recruiting
Testing two ways to make 3D-printed dentures
This study compares two methods for making 3D-printed dentures to see which patients like better. It aims to find which technique is more comfortable and satisfying.
CairoAges Any age - NCT06393699Recruiting
Comparing fillings for worn spots on teeth
This study tests two types of tooth-colored fillings and a special glue for repairing worn spots on the sides of teeth near the gumline. It aims to see which material works best and lasts longest.
CairoAges 18–65 - NCT07355400Recruiting
NeoPill device for reducing mouth bacteria in braces patients
This trial tests a device called NeoPill to reduce bacteria in the mouths of people with braces. It involves a single visit and may help control oral bacteria levels.
LimassolAges 18 years+ - NCT07357597RecruitingPhase 4
Preventing mouth sores during breast or lung cancer treatment
This trial tests whether a steroid mouthwash can prevent mouth sores caused by the drug Datopotamab Deruxtecan (Dato-DXd). It is for people with certain types of advanced breast cancer or lung cancer who are about to start Dato-DXd for the first time.
Tucson, ArizonaAges 18 years+ - NCT07359287Recruiting
Study on antibiotic use for respiratory infections
This study tests a program to help doctors prescribe antibiotics more carefully for common respiratory infections like colds, flu, bronchitis, and sinusitis. It may lead to better treatment for you.
CaenAges Any age - NCT07361172Recruiting
Ready-made vs custom-made braces for jaw correction
This trial compares two types of orthodontic appliances to correct a Class II bite (where the upper teeth sit too far forward). It tests whether a custom-made device works better than a ready-made one for teens.
Al Mansurah, AdakhliaAges 12–16 - NCT07359339Recruiting
Microneedling with or without platelet-rich plasma for gum dark spots
This trial tests whether a treatment called microneedling (tiny needles that stimulate the skin) combined with a special healing liquid from your own blood (platelet-rich plasma) works better than microneedling alone for removing dark spots on the gums.
Cairo, El ManialAges 18 years+ - NCT07352813Recruiting
Comparing numbing methods for kids with MIH teeth
This study tests two ways to numb teeth—in the bone or in the gum—to see which works better for children with weak enamel on their back teeth and front teeth. It may help find a pain-free way to treat these teeth.
AnkaraAges 6–12 - NCT07356869Recruiting
Mouthwash study for school children's dental health
This study compares two mouthwashes (one with probiotics and one with a natural ingredient called ethyl lauroyl arginate) to see which is better at reducing cavity-causing bacteria, plaque buildup, and keeping the mouth at a healthy pH level. It may help children between 6 and 12 years old who have mild to moderate plaque.
CairoAges 6–12 - NCT07358910Recruiting
Tracking infectious diseases in communities
This study looks at how infections spread in villages in Cambodia. If you live in a participating village, you might help us understand and prevent disease outbreaks.
Phnom Penh, Phnom PenhAges 2–75 - NCT07359937Enrolling by invitation
Reducing fluoride risk in school children
This trial tests a program to lower children's exposure to fluoride in drinking water. It includes education and urine tests to measure fluoride levels. Families with kids in kindergarten who get meals at school may benefit.
PalermoAges 2–5 - NCT05351099Recruiting
Nerve-block shot for emergency dental pain relief
This study tests whether a dental nerve-block shot can safely help reduce pain for adults who come to the emergency department with tooth pain. If the ED clinician plans to use the block, you may be asked to rate your pain during the visit.
Fresno, CaliforniaAges 18 years+ - NCT06790628Recruiting
Rebuilding jaw symmetry with leg bone flap
This study compares two ways to rebuild a large missing section of your lower jaw using a piece of your own leg bone (called a fibula flap). The goal is to see which method creates better facial symmetry and a more natural result.
Cairo, Cairo GovernorateAges Any age - NCT06850194Recruiting
Comparing two jaw surgeries for severe underbite
This trial compares two surgical techniques to fix a severe underbite caused by a small lower jaw. One method uses a special cut in the jawbone and a piece of hip bone to lengthen it, while the other uses a different jawbone cut to move the jaw forward. It will help find which approach works better for people with this condition.
Beni-seuf, EgyptAges 18 years+ - NCT06851247RecruitingPhase 2
Chemoradiation plus toripalimab for advanced nasopharyngeal cancer
This trial tests a new treatment for advanced nasopharyngeal cancer. You will get chemotherapy and radiation, followed by maintenance therapy with an immunotherapy drug called toripalimab to help your immune system fight the cancer.
Guangzhou, GuangdongAges 18–65 - NCT06453005Recruiting
Comparison of two tooth cap methods for baby molars
This trial compares two ways to fix cavities in baby molars: the SMART Hall technique (a newer, less invasive method) and the traditional stainless steel crown. The goal is to see which works better for children aged 3 to 9.
Tirupati, AndhrapradeshAges 3–9 - NCT06854744Recruiting
Olive oil and zinc oxide for baby tooth root canals
This study tests a mixture of olive oil and zinc oxide to treat infected baby molars. It aims to see if this natural treatment works as well as standard medicine for stopping infection and saving the tooth.
Tanta, Gharbia GovernorateAges 4–7 - NCT05006963Recruiting
Tele-rehab for jaw pain from TMJ problems
This trial tests a remote (telehealth) rehabilitation program to help reduce pain caused by temporomandibular joint (jaw joint) problems. It may help you if you’ve had facial/jaw-related pain for months and have a related diagnosis.
São PauloAges 18–60 - NCT06737822RecruitingPhase 3
Surgery first vs chemo then surgery for oral cancer
This trial compares two approaches for treating oral cancer: having surgery right away or having chemotherapy first followed by surgery. It aims to find which sequence leads to better outcomes for patients.
Bhubaneswar, OdishaAges 18–75 - NCT07349095Recruiting
AI-assisted color test for gum redness around dental implants
This trial uses an AI tool to check for redness (erythema) in the gum tissue around dental implants. It aims to make diagnosis faster and more accurate during regular check-ups.
ShanghaiAges 18 years+ - NCT07345351Enrolling by invitation
Pilates vs. lifestyle advice for jaw muscle pain
This study compares two non-drug treatments for jaw muscle pain: clinical Pilates vs. lifestyle counseling. It aims to see which approach better reduces pain and improves jaw function in women.
Antakya, HatayAges 18–45 - NCT07344038Recruiting
Bioceramic Putty vs MTA and Crowns for Baby Teeth
This study compares two types of putty used to treat the nerve of a deep cavity in a baby tooth, and then looks at two types of crowns (caps) placed on top. It's for healthy children ages 5–7 who need this treatment on a back baby tooth.
AlexandriaAges 5–7 - NCT07348094Recruiting
Guided sinus lift with natural blood proteins for dental implants
This trial tests a new method to lift the sinus floor using your own blood proteins, creating more bone for dental implants. It may help people who need implants in the upper back jaw but don't have enough bone height.
Kafr ash Shaykh, KafrelsheikhAges 18–40
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.