Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06068270Recruiting
MOPs cleaning aid for gum disease patients getting braces
This trial tests whether a special type of oral hygiene device (called MOPs) helps protect teeth and gums during orthodontic treatment (braces or aligners) in people with severe gum disease (stage IV periodontitis). It may help prevent further damage and improve the success of moving teeth.
Madrid, MadridAges 18–80 - NCT06070181Recruiting
Adding Emdogain to deep cleaning for gum disease
This trial tests whether adding a treatment called Emdogain to a standard deep cleaning helps heal gum pockets better than deep cleaning alone. Emdogain is a gel that helps gums and bone regrow, and it is applied during the cleaning.
Linköping, Region ÖstergötlandAges 18 years+ - NCT06070558Recruiting
Study of normal and abnormal jaw joint motion using real-time MRI
This study uses real-time MRI to take detailed images of your jaw joint (the temporomandibular joint) to better understand its normal and painful variations. It may help if you have jaw pain or clicking, but you don't need to have a problem to join.
NancyAges 18 years+ - NCT06071637RecruitingPhase 3
Preventing mouth sores with laser therapy in stem cell transplant
This trial tests if a low-power laser can prevent painful mouth sores and throat pain in people getting a stem cell transplant from a donor. The laser is applied to the mouth before sores start, aiming to reduce pain and speed healing.
Rio de Janeiro, Rio de JaneiroAges 18–100 - NCT06072495Recruiting
Understanding Why Some Cleft Palate Repair Patients Have Ongoing Speech Issues
This study uses special MRI scans to help doctors understand why some children who had cleft palate surgery still have difficulty with certain speech sounds. By looking at how the muscles in the back of the throat work, researchers hope to improve future surgical techniques and speech outcomes.
AmiensAges 7–12 - NCT06073704Recruiting
Light therapy for gum disease in people with obesity
This study tests whether adding a special light-activated cleaning (antimicrobial photodynamic therapy) to standard gum disease treatment can help people with obesity who have gum disease. It aims to see if this extra step improves gum health more than standard treatment alone.
Bauru, São PauloAges 18–70 - NCT06080633Recruiting
Facial prediction tech for people with no teeth
This study tests a new facial prediction technology that helps create better-fitting dentures for people with no natural teeth. It may improve how your dentures look and feel.
Leuven, HeverleeAges 50–100 - NCT06083649Recruiting
Dental education: AI vs. human counseling for gum disease
This trial compares two ways of teaching about dental care—AI-assisted education versus speaking with a counselor—to see which one helps people with gum disease better control plaque and improve treatment outcomes.
Kaohsiung CityAges 35–65 - NCT06088381RecruitingPhase 2
HPV-related throat cancer treatment based on tumor DNA levels
This trial tests if monitoring cancer DNA left in your blood after surgery can help decide if you need additional treatment. It is for people with HPV-positive oropharynx (throat) cancer who have a certain amount of cancer DNA detected before surgery.
Baltimore, MarylandAges 18 years+ - NCT06091228Recruiting
Tongue scraping for bad breath with gum disease treatment
This trial checks if adding tongue scraping to regular gum disease treatment can help reduce bad breath more than gum treatment alone.
LeuvenAges 18 years+ - NCT06092957RecruitingPhase 3
Reduced radiation after chemo-immunotherapy for high-risk nasopharyngeal cancer
This trial tests whether a lower dose of radiation, with or without additional chemo-immunotherapy, works as well as the standard full-dose chemoradiation for people with advanced nasopharyngeal cancer who had a complete response after initial chemo-immunotherapy.
Guangzhou, GuangdongAges 18–70 - NCT06093061RecruitingPhase 2
Maintenance therapy for high-risk nasopharyngeal cancer
This trial tests a combination of two drugs—tislelizumab (an immunotherapy that helps your immune system fight cancer) and capecitabine (a chemo pill taken daily)—as maintenance therapy after initial chemotherapy for high-risk nasopharyngeal cancer. The goal is to see if this approach can lower the chance of cancer coming back.
SingaporeAges 21–99 - NCT06105112Recruiting
Comparing hyaluronic acid to enamel matrix for gum regrowth
This trial tests whether a gel made from hyaluronic acid helps rebuild bone and gum tissue around teeth as well as a standard treatment (enamel matrix derivative). It's for people with advanced gum disease who have completed initial cleaning and still have deep pockets that need repair.
TurinAges 18 years+ - NCT06105099Recruiting
Speech therapy for children with cleft palate
This study tests a special speech therapy program for children with a cleft palate who have speech errors. The therapy focuses on improving speech sounds and seeing if the improvements last over time.
GhentAges 4–12 - NCT06110143Recruiting
Gum health and pregnancy complications study
This study looks at how gum disease (periodontitis) during pregnancy might affect pregnancy outcomes. It may help you if you have gum disease and want to learn more about its impact on your pregnancy.
Holbæk, HolbaekAges 16–48 - NCT06114706Recruiting
Better assessment of sore throat and antibiotic use
This study tests a new way to assess sore throats in primary care and pharmacies to help decide when antibiotics are needed. It aims to improve treatment and reduce unnecessary antibiotic use.
StenungsundAges 6 years+ - NCT06119490RecruitingEarly Phase 1
Methylprednisolone and JAK inhibitor for severe skin reaction
This trial tests a combination of a steroid (methylprednisolone) and a JAK inhibitor to treat toxic epidermal necrolysis, a severe skin reaction. The goal is to see if adding the JAK inhibitor helps improve outcomes and safety.
Fuzhou, FujianAges 18–70 - NCT06122805Recruiting
Electric vs. Manual Toothbrush for Kids with Cleft Lip/Palate
This study compares a special dual-light electric toothbrush to a regular manual toothbrush for kids and teens with cleft lip or palate who wear braces. The goal is to see which brush keeps teeth cleaner and gums healthier during orthodontic treatment and after oral surgery.
Los Angeles, CaliforniaAges 6–20 - NCT06123000Recruiting
Comparing two surgeries for gum disease
This study compares two types of gum surgery for people with advanced gum disease. It's designed to see which method works better for treating deep gum pockets and saving bone.
Florence, FIAges 18 years+ - NCT06130332RecruitingPhase 2
Immunotherapy Plus Chemo Before Surgery for Early Oral Cancer
This trial tests a new immunotherapy drug (tirellizumab) combined with chemotherapy before surgery for early-stage oral cancer. It aims to see if this combination can help shrink the tumor and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06143254Recruiting
Infant sign training for speech development
This trial tests whether teaching infants with cleft palate simple signs can help them communicate before they can speak. It may support their speech and language development.
Ghent, East FlandersAges 1–2 - NCT06145308RecruitingPhase 2
Precision treatment for salivary gland cancer
This trial tests a personalized treatment approach for recurrent or metastatic salivary gland cancer. It uses special tests on your tumor to find the best targeted therapy for your specific cancer type.
Beijing, Beijing MunicipalityAges 18–100 - NCT06145893RecruitingPhase 3
Hemay005 for Behçet's disease mouth sores
This study tests a new pill called Hemay005 for adults with Behçet's disease who have at least two mouth sores that need treatment beyond creams or rinses. It aims to see if the drug safely reduces mouth ulcers.
Beijing, Beijing MunicipalityAges 18–75 - NCT06148818Recruiting
Neck exercises for jaw pain relief
This study tests whether special neck exercises can help reduce jaw pain in people who have both jaw (TMJ) problems and neck pain. If you have had jaw pain for at least 3 months and also have achy neck pain, you may be able to join.
TrabzonAges 18–55
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.