Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07213661Recruiting
Long-term results of two cavity treatments
This study looks at how well two cavity treatments work over time. It's for people who already took part in an earlier study at one of 33 housing sites.
Cleveland, OhioAges 62 years+ - NCT07220850Recruiting
Oral health help for caregivers of kids having dental surgery
This trial tests a program to help caregivers improve their child's oral health after dental surgery. It may be a good fit if you care for a child under 8 years old who is getting dental surgery at the University of Illinois at Chicago clinic.
Chicago, IllinoisAges Up to 7 years - NCT05508347RecruitingPhase 2
Testing a new antibody with chemo for locally advanced throat cancer
This study tests nituzumab (a targeted antibody) added to standard induction chemotherapy versus placebo plus chemotherapy. It aims to improve tumor control and safety for people with locally advanced nasopharyngeal (throat) cancer.
Chengdu, SichuanAges 18–70 - NCT06780293RecruitingPhase 2
Laser acupuncture for dry eye and Sjogren's dry eye
This study tests if laser acupuncture can help people with dry eye symptoms, including those with Sjogren's syndrome, which causes dryness in the eyes and mouth. It may be a good fit if you have dry eye or Sjogren's and meet the age and eye test requirements.
Taipei, TaiwanAges 20–75 - NCT06918639Recruiting
Pulpotomy for painful adult teeth with deep cavities
This study tests a treatment called pulpotomy for adults with a deep cavity in a tooth that is causing pain. If you have a tooth that hurts but is still healthy enough to save, this treatment might help relieve the pain and keep the tooth.
Alcorcón, MadridAges 18 years+ - NCT06123000Recruiting
Comparing two surgeries for gum disease
This study compares two types of gum surgery for people with advanced gum disease. It's designed to see which method works better for treating deep gum pockets and saving bone.
Florence, FIAges 18 years+ - NCT06752239RecruitingPhase 3
Optimizing radiation to protect thyroid in nasopharyngeal cancer
This trial tests a way to adjust radiation therapy to better protect the thyroid gland during treatment for nasopharyngeal carcinoma. It aims to reduce thyroid damage while still effectively treating the cancer.
Nanchang, JiangxiAges 18–70 - NCT04809324Recruiting
Testing how best to check surgical margins in oral cancer
This trial compares two ways of checking whether all oral cancer tissue was removed during surgery by looking at the tissue edges. It may help surgeons choose the safest approach to reduce the chance of cancer coming back.
Mumbai, MaharashtraAges 18–100 - NCT03513003Recruiting
Pacifier use to improve misaligned baby teeth
This study tests whether using a pacifier can help correct common misalignments in young children’s baby teeth and bite. It may help children whose upper and lower teeth don’t meet properly, with or without tongue thrust.
BaselAges 2–5 - NCT07210359Recruiting
New treatment for immature teeth
This trial tests a regenerative treatment for immature permanent teeth (front teeth with developing roots) in children and teens. The goal is to help the tooth's pulp heal and allow the root to continue growing naturally.
Kafr ash Shaykh, Kafr ElsheikhAges 9–15 - NCT07206108Recruiting
Crown vs post-core for large tooth repairs after root canal
This trial compares two ways to fix large holes in premolars after root canal treatment: a modified crown attached to the remaining tooth, or a personalized post-and-crown. It looks for people with good oral health whose tooth has enough strong structure left for a successful repair.
ChinaAges 18–65 - NCT07205172Recruiting
Gum looks and teeth crowding in children
This study looks at how the appearance of the gums relates to crowding of teeth in children. It will examine kids in different stages of tooth development to see if there is a link.
RomaAges 5–16 - NCT07203911Recruiting
Ultrasound guidance for oral cancer surgery
This trial tests whether surgeons can use ultrasound during surgery to better guide the removal of oral cancer. It may help ensure all cancer is removed while sparing healthy tissue.
Stanford, CaliforniaAges 18 years+ - NCT07211711Recruiting
Splint therapy for tinnitus linked to jaw joint issues
This trial tests if a custom mouthpiece (occlusal splint) can relieve ringing in the ears (tinnitus) that started along with jaw or face pain (TMD). It aims to see if stabilizing the jaw helps reduce both the noise in your ears and the discomfort.
São Paulo, São PauloAges 18 years+ - NCT07209189RecruitingPhase 2
Chemo and immunotherapy before surgery for head and neck cancer
This trial tests a combination of chemotherapy and an immunotherapy drug called Toripalimab before surgery for certain head and neck cancers. The goal is to see if this approach can reduce the extent of treatment needed while still being effective.
Baltimore, MarylandAges 18 years+ - NCT07208812Recruiting
3D-printed lower dentures: comparing impression methods
This study compares two ways of making dental impressions for 3D-printed overdentures (removable tooth replacements held by implants). It looks for people who need new lower-jaw implants and are otherwise healthy.
Al Mansurah, Dakahlia GovernorateAges 45 years+ - NCT07210762Recruiting
Gum cleft during canine tooth movement
This study looks at whether a small gum opening (gingival cleft) forms when a canine tooth is pulled back after premolar removal. It may help understand how gums heal during orthodontic treatment.
Karachi, SindhAges Any age - NCT07205588Recruiting
Dental health check using digital tools
This study uses digital tools to assess dental problems in adults who are new to a dental practice or haven't visited in the last six months. It aims to understand how well these tools work for finding dental issues.
ChâtillonAges 18 years+ - NCT06517030Recruiting
Rebuilding bone for a same-day dental implant
This study compares two types of bone-graft materials used to rebuild the bone after a tooth is removed, so that a dental implant can be placed right away. If successful, this could mean fewer surgeries and faster recovery for people who need a single tooth replaced.
Milan, MiAges 22–70 - NCT04927819Recruiting
Extra-short versus standard dental implants in a fixed bridge
This study compares extra-short dental implants versus standard-length implants when they are joined together in the same fixed bridge. It may help people understand which implant type works better for supporting a stable multi-tooth replacement.
Vitoria-GasteizAges 18 years+ - NCT05986669Recruiting
DSP dental implant safety study for tooth loss
This trial tests several types of DSP dental implants to see if they are safe and work well for people with missing teeth. It is for patients who have had tooth loss for at least three months and are in good overall health.
Campo Largo, ParanáAges 18–70 - NCT06934551Recruiting
Study on patient satisfaction after jaw surgery
This trial tests how happy patients are with their dental work after having part of the upper jaw removed (hemi-maxillectomy). It also checks how healthy the nearby teeth stay. This could help doctors pick the best way to replace missing teeth in these cases.
CairoAges 30–60 - NCT07195734RecruitingPhase 2
Adding chemo or immunotherapy before surgery for advanced head and neck cancer
This trial tests whether giving chemotherapy or chemotherapy plus immunotherapy before surgery can improve outcomes for people with advanced head and neck cancer that has come back or not gone away after prior treatment.
Tucson, ArizonaAges 18 years+ - NCT07200258Recruiting
Comparing Two Ways to Treat Gum Recession
This trial compares two surgical techniques (MCAT and VISTA) to fix receding gums on multiple teeth. It tests which method better restores gum thickness and reduces tooth sensitivity or cosmetic concerns.
MadridAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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- Genetic & congenital
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- Pain
- Injuries & trauma
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.