Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06152081Recruiting
Detecting cavities with two new devices
This study tests two different devices for finding cavities in adults at high risk for tooth decay, comparing how well they work against each other and standard methods.
Boston, MassachusettsAges 21 years+ - NCT06168695Recruiting
Treating front teeth crossbite to help children's speech
This study looks at how fixing a crossbite (where upper front teeth sit behind lower teeth) can improve speech in children. It may help kids who have trouble saying certain sounds because of their teeth alignment.
Tanta, Gharbia GovernorateAges 8–10 - NCT06170021Recruiting
Radiation ear problems in throat cancer patients
This study looks at how often radiation therapy for throat cancer causes middle ear infections or fluid buildup. It aims to understand and track these ear problems in patients getting a precise type of radiation called IMRT.
Guangzhou, GuangdongAges 18–70 - NCT06173167Recruiting
Same-day zirconia crowns for back teeth
This study tests a new type of same-day zirconia crown made in the dentist's office. It compares two different zirconia materials for strength and durability, and aims to see which one works best for back teeth.
Ann Arbor, MichiganAges 18 years+ - NCT06172764RecruitingPhase 4
Vitamin D for early cavities: a saliva study
This study tests whether vitamin D supplements can help improve the health of your mouth by looking at changes in saliva and the bacteria that cause cavities. If you have early cavities and low vitamin D, you may be able to join.
Karachi, SindhAges 12–50 - NCT06174428Recruiting
Study of a new oral and throat cancer test
This study is testing a new, simple test that looks for signs of oral or throat cancer. If you have a suspicious spot or symptom, this test might help find out if it's cancer.
St Louis, MissouriAges 18 years+ - NCT06177301RecruitingPhase 3
Comparing two drug combos for recurrent nasopharyngeal cancer
This study compares two combinations of drugs (tislelizumab plus either GX or GP) to see which works better for people with nasopharyngeal cancer that has returned or spread and has not been treated with systemic therapy before.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06182462Recruiting
Virtual reality for dental anxiety in children
This study tests whether wearing a virtual reality headset during dental treatment can help reduce fear and anxiety in children. If you feel nervous about dental visits, this may be a way to stay calm and comfortable.
Montreal, QuebecAges 6–17 - NCT06182657Recruiting
Nasopharyngeal cancer response to induction chemotherapy
This study looks at how well nasopharyngeal cancer (NPC) responds to the first round of chemotherapy before other treatments. It aims to see if the amount of tumor shrinkage can help predict outcomes and guide future care for people with advanced NPC.
Nanchang, JiangxiAges 18 years+ - NCT06186908Recruiting
Saliva test for gum disease diagnosis
This trial studies certain proteins in your saliva to see if they can help identify different types of gum disease. It may help improve how we diagnose and treat periodontal problems.
Izmir, ÇiğliAges 20–60 - NCT06186830Recruiting
Questionnaire for jaw and face pain
This study tests a special questionnaire (BETY-BQ) to see how well it measures the impact of jaw and face pain in people with temporomandibular disorders. It helps doctors better understand your symptoms and guide treatment.
Karabük, Karabük ProvinceAges 18–64 - NCT06191107Recruiting
Partial dentures made of PEEK
This trial tests partial dentures made of a special plastic (PEEK). It may be an option if you need a removable partial denture held by clasps.
HeidelbergAges 18–75 - NCT06195241RecruitingPhase 4
DaxibotulinumtoxinA for eyelid and facial spasms
This trial tests a new type of botulinum toxin (DaxibotulinumtoxinA) for people with eyelid or facial muscle spasms. It aims to see if it works better or lasts longer than current treatments.
The Bronx, New YorkAges 18 years+ - NCT06196515RecruitingPhase 2/Phase 3
Study of a new nano-medication for infected tooth root canals
This trial tests whether a nano-scale calcium hydroxide paste works better than standard treatments for tooth infections. If you have a permanent molar with signs of infection around the root tip, this study may be an option.
CairoAges 21–49 - NCT06197776Recruiting
Predicting treatment success for advanced nasopharyngeal cancer
This study uses advanced testing (multi-omics) to predict if combining chemoradiation with immunotherapy works better for nasopharyngeal cancer that has returned or spread. It aims to find the right treatment for each person.
Guangzhou, GuangdongAges 18–70 - NCT06207253RecruitingPhase 2/Phase 3
Testing diclofenac gel for tooth root infections
This trial tests whether a special anti-inflammatory gel (diclofenac sodium) placed inside the tooth can help treat an infection at the root tip. It is for adults with a restorable tooth and no allergies to the medication.
CairoAges 18–50 - NCT06210789Recruiting
Gum reconstruction after enlargement removal
This trial tests a procedure to repair gum tissue that may recede after removing overgrown gum areas. It may help you if you have healthy gums and a small area of enlargement.
BudapestAges 18 years+ - NCT06214923Recruiting
Virtual reality for jaw pain caused by TMD
This study tests whether immersive virtual reality can reduce chronic jaw pain from Temporomandibular Disorder (TMD). It uses EEG to see how VR affects brain activity related to pain.
Baltimore, MarylandAges 18–88 - NCT06216886RecruitingPhase 4
Botox injections for trigeminal neuralgia pain
This study tests Botox (onabotulinumtoxinA) injections to reduce pain attacks in people with trigeminal neuralgia who haven't gotten enough relief from medication or don't want surgery. You must have frequent attacks (more than 10 per week) and be on a stable medication dose.
Stanford, CaliforniaAges 18 years+ - NCT06219980RecruitingPhase 2
Radiation and immunotherapy before surgery for oral cancer
This trial tests combining radiation therapy with immunotherapy and chemotherapy before surgery for advanced oral or throat cancer. The goal is to see if this approach can shrink the tumor and improve treatment outcomes.
Guangzhou, GuangdongAges 18–70 - NCT06222736Recruiting
Cervical core exercises for jaw joint pain relief
This study tests whether exercises for the neck and upper back can reduce pain and improve function in women with jaw joint problems caused by muscle pain. It could help if you have jaw pain related to tense or sore muscles.
Istanbul, AvcılarAges 18 years+ - NCT06228079RecruitingPhase 3
Chemo-immunotherapy after surgery for early reoccurring nasopharyngeal cancer
This study looks at whether adding chemo-immunotherapy after surgery is better than surgery alone for patients whose nasopharyngeal cancer has returned but is still in early stages. It may help prevent the cancer from coming back again.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06235203RecruitingPhase 3
Comparing treatment timing in recurrent nasopharyngeal cancer
This trial compares giving chemotherapy and immunotherapy before surgery (neoadjuvant) versus after surgery (adjuvant) for patients whose nasopharyngeal cancer has returned locally. It aims to find which approach works better to control the cancer.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06239727RecruitingPhase 3
Reduced-dose radiotherapy for stage III nasopharyngeal cancer based on response
This trial tests whether a lower dose of radiation can safely treat stage III nasopharyngeal cancer if you have already responded well to initial chemotherapy plus immunotherapy (Camrelizumab). The goal is to reduce side effects while still controlling the cancer.
Fuzhou, FujianAges 18–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.