Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06859281RecruitingPhase 1
Safety of Grammidin throat spray in healthy adults
This trial tests the safety and how the body processes a new throat spray called Grammidin. Healthy volunteers will use the spray so researchers can see how it works and if there are any side effects.
Saint PetersburgAges 18–45 - NCT04704089Recruiting
Dental enamel defect study using tooth photos and measurements
This study compares different types of enamel problems by taking detailed pictures of your front teeth. It may help researchers better tell these enamel conditions apart and improve future diagnosis and care.
ParisAges 8–55 - NCT06863103Enrolling by invitation
Treating children with major dental needs
This study explores how dentists and dental specialists treat children who need a lot of dental work. It aims to improve care for kids with extensive dental needs.
MalmöAges Up to 65 years - NCT06868433RecruitingPhase 1
TMV vaccine alone or with pembrolizumab for advanced HNSCC
This trial tests a vaccine made from your own tumor to help your immune system fight head and neck cancer that has returned or spread. It is given alone or with an immunotherapy drug (pembrolizumab) to see if it can shrink tumors or slow progression.
Atlanta, GeorgiaAges 18 years+ - NCT06864949Enrolling by invitation
Expanding the upper jaw with a preformed brace
This study tests a preformed appliance designed to widen a narrow upper jaw. It may help people whose upper jaw is too narrow, causing their back teeth to cross or tilt inward.
Pavia, LombardyAges 7–13 - NCT06863051Recruiting
Comparing two types of fibrin for dental implant success
This trial tests whether a special blood-based bandage (albumin platelet-rich fibrin) or a different type (leukocyte-platelet-rich fibrin) helps a dental implant heal better in the lower jaw. It may be an option if you need an implant for a back tooth that can't be saved.
Kafr ash Shaykh, KafrelsheikhAges 18–45 - NCT06228079RecruitingPhase 3
Chemo-immunotherapy after surgery for early reoccurring nasopharyngeal cancer
This study looks at whether adding chemo-immunotherapy after surgery is better than surgery alone for patients whose nasopharyngeal cancer has returned but is still in early stages. It may help prevent the cancer from coming back again.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06755372Recruiting
TLR-4 in gum disease patients with kidney failure
This study looks at a specific immune marker (TLR-4) in people with gum disease, comparing those who also have end-stage kidney disease (on dialysis) to those who are otherwise healthy. The goal is to understand how gum disease might be different when kidney failure is also present.
Al Fayyum, Faiyum GovernorateAges 30–60 - NCT06849908RecruitingPhase 2
Baricitinib for treating intestinal Behçet's disease
This trial tests baricitinib, an oral medication, for people with intestinal Behçet's disease that hasn't improved with standard treatments. It aims to see if baricitinib can reduce symptoms and help heal gut ulcers.
Beijing, Beijing MunicipalityAges 18–65 - NCT06851663RecruitingPhase 2/Phase 3
New PET scan for many solid tumors
This trial tests a new type of PET scan that uses a special antibody to find a marker called Trop2 on many common solid tumors. It may help doctors see tumors more clearly without needing a biopsy.
ShanghaiAges 18–75 - NCT06851910Recruiting
Lacosamide IV for acute trigeminal neuralgia pain
This trial is testing a medication called lacosamide, given through an IV, to treat sudden, severe facial pain attacks in people with trigeminal neuralgia who come to the emergency room. The goal is to see if it helps relieve pain quickly.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT06850857Enrolling by invitation
Validating IMPACT for facial injury recovery
This trial is testing a tool (IMPACT) to better understand recovery after facial injuries. If you recently had a broken facial bone or soft tissue injury to your face, this study could help improve care for others like you.
Sacramento, CaliforniaAges 18 years+ - NCT06852638RecruitingPhase 2
PET imaging for kidney cancer, lymphoma, and NPC
This study tests a new way to detect tumors by using a special injection that makes cancer cells visible on a PET scan. It may help people with renal cancer (especially clear cell type), lymphoma, or nasopharyngeal cancer.
ShanghaiAges 18–80 - NCT06856330Recruiting
Trial on a new surgery for speech in children with cleft lip and palate
This trial tests a surgical technique (Furlow palatoplasty with a cheek muscle flap) to see if it improves speech development in young children who had a complete cleft lip and palate repaired previously. It may help children between 3 and 5 years old with non-syndromic conditions.
Al FayyumAges 3–5 - NCT06843018RecruitingPhase 2
Spray vs lozenge for sore throat from infection
This trial tests a new spray with anesthetic for sore throat caused by infections like pharyngitis. It compares the spray to a lozenge (Septolete Total) to see which works better and is safer.
Engel'sAges 18–75 - NCT06839066RecruitingPhase 2
HLX43 for advanced nasopharyngeal cancer after prior treatments
This trial tests an investigational drug called HLX43 for people with nasopharyngeal cancer that has come back or spread, and who have already tried two or more prior treatments without success. The goal is to see if HLX43 can shrink tumors or slow the cancer's growth.
Fuzhou, FujianAges 18 years+ - NCT06837779Enrolling by invitation
Study for treating sensitive teeth with fluoride and mineral boosters
This trial tests if applying fluoride using a mild electric current (iontophoresis) with other minerals can reduce pain in sensitive tooth roots. It may be an option if you have at least four sensitive back teeth.
Cairo, Cairo GovernorateAges 35–60 - NCT06845449Enrolling by invitation
Screws vs bone grafts for horizontal jaw ridge repair
This trial compares using small screws or a ring-shaped bone graft to rebuild a narrow upper jaw ridge so dental implants can be placed. It is for people who need a simple horizontal bone build-up in the front of the upper jaw.
Beni-seufAges 18 years+ - NCT06843525Recruiting
Bite force measurements for molar dental work
This trial measures how your bite force changes after getting a filling or root canal on a lower back tooth. It helps doctors understand if different dental treatments affect your ability to chew.
Newark, New JerseyAges 18–89 - NCT06842316Recruiting
Study on cannabis-like compounds for inflammatory arthritis
This trial tests whether plant-based compounds similar to cannabis (called phytocannabinoids) can help calm inflammation and improve immune function in people with certain types of arthritis or autoimmune diseases like lupus or Sjögren's disease. It aims to offer a new way to treat these conditions without the 'high' of marijuana.
OrléansAges 18 years+ - NCT05200715Recruiting
Registry study for inherited and inflammatory eye and joint diseases
This study is a registry, meaning it collects your medical information to better understand several inflammatory (auto-inflammatory) conditions. It may help doctors and researchers improve diagnosis and future treatments for people with these disorders.
AlgiersAges Any age - NCT06757218Recruiting
Preserving jawbone after tooth extraction with dentin and platelet gels
This study tests two types of platelet-rich fibrin gels (one with albumin) mixed with your own tooth dentin to help preserve the jawbone after a tooth is pulled. It may reduce bone loss and improve healing for those needing a future dental implant.
Kafr ash Shaykh, KafrelsheikhAges 18–60 - NCT06826391Enrolling by invitation
Can a filler injection treat gum recession and tooth sensitivity?
This study tests a special injectable filler (calcium hydroxylapatite) to see if it can help grow back gums that have receded and reduce tooth sensitivity. It is for people with mild to moderate gum recession who are in good health.
South Euclid, OhioAges 20–70 - NCT06834139Enrolling by invitation
Testing a new cleaning device for people with braces
This trial tests a device called the Neo Pill to see if it helps keep teeth clean for people with braces. It compares the device to regular brushing and may help reduce plaque and gum problems during orthodontic treatment.
Kragujevac, SerbiaAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.