Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06831487Enrolling by invitation
Gum disease imaging study with new microscope
This study uses a new type of imaging (like an advanced microscope) to look at gum tissue in people with healthy gums, gingivitis, or periodontitis. It aims to see if the imaging can tell the difference and help with diagnosis.
Catania, ItalyAges 18–75 - NCT06834139Enrolling by invitation
Testing a new cleaning device for people with braces
This trial tests a device called the Neo Pill to see if it helps keep teeth clean for people with braces. It compares the device to regular brushing and may help reduce plaque and gum problems during orthodontic treatment.
Kragujevac, SerbiaAges 18 years+ - NCT06828042RecruitingPhase 1/Phase 2
CAR-γδT cells for refractory autoimmune diseases
This trial tests a new type of immune cell therapy (CAR-γδT cells) that targets a protein called CD19 on your own B cells. It is for people with certain autoimmune diseases that have not gotten better with standard treatments. The goal is to see if this therapy can safely control the disease.
BeijingAges 18–80 - NCT05147844RecruitingPhase 2
Toripalimab plus radiation for limited-spread nose cancer
This Phase 2 trial studies whether adding toripalimab (an immune therapy) to radiation can control nasopharyngeal cancer that has spread only to a few places. It may help by boosting the immune system while the radiation treats the tumor sites.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT06819228RecruitingPhase 1
Lighted antibody imaging in head and neck cancer surgery
This trial tests a special fluorescent dye attached to panitumumab, a cancer-targeting antibody, to help surgeons see tumor tissue more clearly during head and neck cancer surgery. The goal is to improve removal of all cancer cells while sparing healthy tissue.
Nashville, TennesseeAges 18 years+ - NCT06821243Recruiting
Finding markers in HPV-related throat cancer to guide treatment
This study looks for certain markers in people with HPV-related throat cancer that could help doctors choose the best treatment. If you are planning to have surgery for your throat cancer, you may be able to join.
Rome, RomeAges 18 years+ - NCT06820840Recruiting
Resin vs ceramic onlays for back tooth cavities
This study compares two types of tooth-colored onlays (one made of layered resin and one of a ceramic-like material) for fixing cavities in back molars. If you need an onlay, this trial could help your dentist choose the best option for you.
CairoAges 18–50 - NCT06825273Recruiting
3D-printed space maintainer for lost baby molars
This study tests a 3D-printed space maintainer (like a small partial denture) for children who have lost a lower baby molar early. It helps keep space for the permanent tooth to come in properly.
TantaAges 7–9 - NCT06822127Recruiting
Simulating face soft tissue changes after jaw surgery
This trial uses computer simulations to predict how your facial soft tissues will change after corrective jaw surgery. It aims to make the surgical planning more accurate and help you see possible outcomes beforehand.
AnnecyAges 18 years+ - NCT06824493Recruiting
How Braces Affect Mouth Bacteria and Saliva
This study looks at how braces (orthodontic treatment) change the bacteria and proteins in your mouth. Healthy volunteers who have never had dental work or cavities are needed to provide saliva samples before and during treatment.
Xi'an, ShaanxiAges 6–18 - NCT06805617RecruitingPhase 2
Ivonescimab for advanced salivary gland cancer
This trial tests a new drug called Ivonescimab for people with advanced salivary gland cancer that has spread or cannot be removed surgically. The goal is to see if the drug can shrink tumors or slow cancer growth.
Boston, MassachusettsAges 18 years+ - NCT06803576Enrolling by invitation
Long-term study of dental implants after 10 to 22 years
This study looks at how well dental implants work and how healthy the mouth stays more than 10 years after implant placement. The goal is to learn about implant success and any gum or bone changes over time.
ThessalonikiAges 18 years+ - NCT06810752Enrolling by invitationPhase 1/Phase 2
Thyme honey for mouth lichen planus
This trial tests whether thyme honey can help manage oral lichen planus, a condition causing white patches or sores in the mouth. Participants will apply the honey to the affected areas.
CairoAges Any age - NCT05774483Recruiting
Check nodes in early mouth cancer using a biopsy or planned neck surgery
This trial studies two ways to check whether early oral cavity cancer has spread to nearby neck lymph nodes. It compares sentinel node biopsy versus limited elective neck dissection to see which approach is more useful for people with node-negative tongue or inner-cheek cancers.
Mumbai, MaharashtraAges 18–80 - NCT06798116Enrolling by invitation
Gum disease treatment with platelet-rich fibrin and albumin gel
This study tests a new treatment for severe gum disease. It combines a natural blood product (platelet-rich fibrin) with a special albumin gel to help repair bone defects around teeth. The goal is to see if this mixture helps the bone grow back better than standard treatment.
Al MansurahAges 25–55 - NCT06802835RecruitingPhase 1/Phase 2
EGFR antibody plus immunotherapy and chemo for advanced nasopharyngeal cancer
This trial tests a combination of an EGFR antibody, a PD-1 inhibitor, and chemotherapy for people with nasopharyngeal cancer that has returned or spread after initial treatment. The goal is to see if this new mix can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18–75 - NCT06797778Enrolling by invitation
Oral health program for schoolchildren
This trial is a program to teach kids in Polígono Sur schools how to take care of their teeth and gums. It's a simple, no-risk way to learn about oral health.
Seville, SevillaAges Any age - NCT06801535Recruiting
3D-printed splint for burn scars on mouth
This trial tests a custom 3D-printed mouth splint to help people who have a tight, small mouth opening after a burn. It aims to see if the splint can improve how wide you can open your mouth.
Winston-Salem, North CarolinaAges 2–99 - NCT06798922RecruitingPhase 3
Flap-sparing radiation for mouth cancer after reconstructive surgery
This trial tests a special radiation technique for people who have had reconstructive surgery for oral cavity cancer. The goal is to see if we can spare the flap (the rebuilt tissue) from high radiation doses to improve healing and quality of life.
AmiensAges 18 years+ - NCT06187337Recruiting
Expanding the upper jaw to fix crowded front teeth in children
This trial tests if expanding the upper jaw can make room for crowded front teeth in children who still have some baby teeth. It aims to help the side front teeth come in properly without needing braces later.
CoppitoAges 6–16 - NCT06783660Recruiting
Graft material for preserving tooth socket after extraction
This trial tests a new collagen-based graft material used to preserve the bone socket right after a tooth is removed. The goal is to keep the bone healthy so that a dental implant can be placed later.
Korea, SeoulAges 19–75 - NCT06785051Recruiting
AI physiotherapy for oral cancer patients
This study tests an AI-based physiotherapy program for people with newly diagnosed oral cancer. It aims to help patients maintain or improve their movement during cancer treatment, such as surgery, chemotherapy, or radiation.
TaipeiAges 20–65 - NCT06791694Enrolling by invitation
Comparing tooth color measurement methods for dental students
This trial tests different ways to measure tooth color in healthy young adults. It aims to see which method works best for dental students to learn.
Altındağ, AnkaraAges 18–40 - NCT06783595Recruiting
Gum changes after removing temporary implant crown
This study looks at how the gums around a dental implant change after the temporary crown is removed, in the front upper teeth area. It helps dentists understand healing and gum shape to improve future implant treatments.
Loma Linda, CaliforniaAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.