Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT06962306RecruitingPhase 4
Pain relief study for children having cleft palate surgery
This trial tests different ways to manage pain after cleft palate repair in young children. The goal is to find which approach works best to lower pain and improve recovery.
Durham, North CarolinaAges 6 months–4 years - NCT06967402Recruiting
Mouthwash study for gum disease treatment
This study tests two types of mouthwash to see which helps treat gum disease better when used with regular dental care. It may be a good option if you have moderate to severe gum disease and are generally healthy.
Hong KongAges 18 years+ - NCT06967896Recruiting
Comparing breathing tube types for women having thyroid surgery
This trial is testing different types of breathing tubes used during thyroid surgery in women. It aims to find which tube works best to keep the airway safe and reduce side effects.
Anqing, AnhuiAges 18–65 - NCT06968780Recruiting
Comparing two gum grafts for dental implants in the upper jaw
This trial compares two surgical techniques using tissue from the cheek or the roof of the mouth to improve gum health around special implants placed in the cheekbone. It may be an option if you have severe bone loss in your upper jaw and need implants but don't have enough bone for standard ones.
Cairo, Giza GovernorateAges 18 years+ - NCT06974253Recruiting
Guided Implant Placement for Full Upper Jaw
This study tests a technology that uses a computer-guided system (dynamic navigation) to place multiple implants in the upper jaw of people who have no teeth left. It aims to improve placement accuracy and make the surgery safer.
Ho Chi Minh CityAges 18 years+ - NCT06974591Recruiting
How your teeth affect your balance
This study looks at how small disturbances to your posture affect your jaw and balance. It compares people with all their natural teeth to those who wear full dentures, to see if the type of teeth you have changes how your body responds.
Boston, MassachusettsAges 30–65 - NCT06975709Recruiting
Link between jaw pain and sleep problems
This study looks at how jaw joint disorders (TMJ) are related to sleep issues like insomnia, sleep apnea, or restless legs. If you have a sleep disorder, you may help researchers understand the connection.
Milan, ItalyAges 18 years+ - NCT06977100Recruiting
Journaling study for jaw pain with other chronic pain conditions
This study tests if a journaling program can help people with jaw pain and at least one other chronic pain condition (like fibromyalgia, IBS, or migraines). You will write about your thoughts and feelings to see if it reduces pain and improves well-being.
Gainesville, FloridaAges 18–80 - NCT06978712Recruiting
Gum inflammation and body stress link study
This study checks if gum inflammation (periodontitis) affects your body's stress system (allostatic load). It aims to find a link between severe gum disease and overall health stress.
Rohtak, HaryanaAges 30–50 - NCT06980675Recruiting
Ozonized olive oil for gum disease treatment
This trial tests if a special ozonized olive oil gel can help treat deep gum pockets caused by periodontitis (advanced gum disease). If you have gum pockets that are 4 mm or deeper, this could be an option to reduce infection and improve healing.
Bari, BAAges 18 years+ - NCT06980701Recruiting
Personalized oral hygiene advice for people with prediabetes
This trial tests whether personalized advice from a dentist or an AI can improve the oral and overall health of people with prediabetes. You may benefit if you have prediabetes and are willing to improve your daily oral care routine.
Hong Kong, Sai Ying PunAges 18 years+ - NCT06981767RecruitingPhase 2
Bromelain vs. Steroids for Oral Lichen Planus
This trial tests whether a pineapple enzyme (bromelain) works as well as a standard steroid treatment for painful mouth sores caused by oral lichen planus. If you have this condition and are not taking other medications, you may be eligible.
Cairo, Cairo GovernorateAges Any age - NCT06982300RecruitingPhase 1/Phase 2
PET scan for advanced nasopharyngeal cancer
This trial tests a special PET scan that can detect a receptor (SSTR2) on cancer cells to see if it can help guide treatment for people with nasopharyngeal cancer (a type of head and neck cancer). It may help doctors choose the best therapy for you.
GroningenAges 18 years+ - NCT06984744Recruiting
Gum health study testing a new compound
This study tests a compound in gum to see how well it prevents plaque buildup over 4 days. You may be able to join if you are a healthy adult with at least 20 natural teeth and some existing plaque.
Indianapolis, IndianaAges 18–65 - NCT06984848Recruiting
Mouth spray for dry mouth in older adults
This trial tests an enzyme-containing mouth spray (Oral7®) to see if it helps with dry mouth, improves saliva flow, and boosts quality of life for older adults. If you often have a dry mouth, this spray might offer relief.
Kubang Kerian, KelantanAges 60 years+ - NCT06984861RecruitingPhase 2
Reduced radiation with chemo for HPV-related throat cancer
This trial tests if giving less radiation along with chemotherapy is safe and effective for people with HPV-positive throat cancer. It aims to reduce side effects while still controlling the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT06988839Recruiting
Microneedling with gum flap for recession
This study tests whether using a tiny needle roller (microneedling) combined with a gum-advancement flap can help cover a receding gum on a front tooth, without needing a gum graft. It's for people with thin gums, and the goal is to reduce sensitivity and improve appearance.
Rohtak, HaryanaAges 20–50 - NCT06991114RecruitingPhase 2
AlloNK and rituximab for relapsing rheumatologic diseases
This trial tests a new natural killer (NK) cell therapy called AlloNK given with rituximab for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, inflammatory myopathies, or systemic sclerosis) that have not responded well to standard treatments. The goal is to see if this combination can better control the disease.
Tuscaloosa, AlabamaAges 18 years+ - NCT06991842Recruiting
Etching time for front tooth fillings
This study looks at how long to etch the tooth before placing a white filling on a front tooth. You may qualify if you need a standard filling on the side or corner of a front tooth.
Basel, Canton of Basel-CityAges 18 years+ - NCT06994754Recruiting
Expanding the upper jaw with clear aligners in cleft lip and palate patients
This trial tests whether clear aligners can safely widen the upper jaw in children with cleft lip and palate who still have some baby teeth. It may be an option for those needing jaw expansion without braces.
Cairo, SelectAges 6–12 - NCT06997068RecruitingPhase 2
Drug combination for returning head and neck cancer
This trial tests a combination of three drugs—methotrexate, erlotinib, and celecoxib—for people whose head and neck cancer has come back or spread. It is designed for patients in the rural Midwest who have already had or chosen not to have standard first treatment.
Rochester, MinnesotaAges 18 years+ - NCT06999005Recruiting
Dental cavity treatment study for children ages 6-12
This study tests two gentle cavity treatments for children's permanent molars. It aims to find which method works best over two years.
Santos, São PauloAges 6–12 - NCT07000643RecruitingPhase 3
Proton vs. standard radiation for nasopharyngeal cancer
This trial compares two types of radiation therapy—proton beam versus standard X-ray (photon)—for treating nasopharyngeal cancer. The goal is to see if proton therapy works as well as standard therapy while possibly causing fewer side effects.
JinanAges 18–75 - NCT07004517Recruiting
Accuracy of gum probing around dental implants
This study looks at how accurately dentists can measure the gum pocket depth around dental implants, and what factors might affect that measurement. It may help improve care for people with implants who need their crown removed for a check or repair.
Hangzhou, ZhejiangAges 18–90
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.