Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT05941507RecruitingPhase 1/Phase 2
TROP2 antibody drug with anti–PD-1 for advanced solid tumors
This early-phase study tests an antibody-drug (an ADC) that targets TROP2, given by itself and together with an anti–PD-1 medicine. It’s for people with advanced solid cancers that have not responded to standard treatments, aiming to shrink tumors and improve control of the disease.
Los Angeles, CaliforniaAges 18 years+ - NCT06305676Recruiting
A study for early detection of HPV throat cancer
This study looks for early signs of HPV-related throat cancer. If you've just been diagnosed and haven't started treatment, your blood or saliva samples may help improve future screening tests.
Tampa, FloridaAges 18 years+ - NCT06309225Recruiting
Adjusted Chemoradiation for HPV Throat Cancer in Older Adults
This trial tests adjusting the dose of chemotherapy and radiation for older adults (65+) with HPV-related throat cancer. The goal is to find a treatment that is effective but gentler on the body.
Jacksonville, FloridaAges 65–99 - NCT06305000Recruiting
Gum tissue addition for implant gum inflammation treatment
This study tests whether adding extra gum tissue (keratinized mucosa) around a dental implant can improve treatment results for inflamed gum tissue around the implant (peri-implant mucositis). It is for people with a single, healthy implant that has been in place for at least one year and who have not had recent periodontal treatment.
IstanbulAges 18 years+ - NCT06302296Recruiting
Speeding up braces with your own blood
This study tests whether a special injection made from your own blood (called injectable platelet-rich fibrin) can help move your teeth faster during braces treatment. It involves removing two upper premolars and then receiving the injection to see if it speeds up straightening.
HamaAges 18–26 - NCT06315855Recruiting
Oral Health Program for Cancer Survivors
This study tests a program to help cancer survivors improve their oral health using a smartphone app. It's for survivors who are at least 6 months past treatment and have not had head, neck, or mouth cancer.
Washington D.C., District of ColumbiaAges 25–75 - NCT06309719Recruiting
Hyaluronic acid and polynucleotides for gum disease treatment
This trial tests if a gel made from hyaluronic acid and polynucleotides can help repair gum damage in people with advanced gum disease. You may be eligible if you have deep pockets between your teeth and gums that haven't healed after standard cleaning.
LondonAges 18 years+ - NCT06308497Enrolling by invitation
Periodontal treatment with CoQ10 and probiotics for pregnant women
This study tests whether a combination of coenzyme Q10 and probiotics can improve gum health in pregnant women. It aims to find a safe, gentle treatment for gum problems during pregnancy.
Pavia, LombardyAges 18–40 - NCT06311253Enrolling by invitation
Gum treatment with lactoferrin toothpaste in pregnancy
This study tests whether special toothpaste and mouthwash with lactoferrin (a natural protein) can help treat gum problems in pregnant women. It may offer a safe way to care for your gums during pregnancy.
Pavia, LombardyAges 18–40 - NCT06315348Recruiting
Gum shaping during braces with a vibration tool
This trial tests a new, less invasive surgical technique (using a special tool that vibrates, not a scalpel) to help reshape the gums while straightening teeth with braces. It is for people who need braces for mild to moderate crowding and have healthy gums.
MadridAges 16–70 - NCT06277050RecruitingPhase 3
Toripalimab and capecitabine after chemo-radiation for high-risk nasopharyngeal cancer
This trial tests whether adding the immunotherapy drug toripalimab to the chemotherapy pill capecitabine after standard treatment helps prevent nasopharyngeal cancer from coming back. It is for people with high-risk features who have already had chemo and radiation.
Ganzhou, JiangxiAges 18–70 - NCT06276335Recruiting
Timing of dental implant placement and early healing
This trial compares placing a dental implant right after a tooth is pulled versus waiting for the socket to heal first. It aims to see which timing leads to better healing at the molecular level.
LondonAges 25 years+ - NCT06294587Recruiting
Testing the timing of gum grafts for dental implants
This trial studies the best time to do a gum graft (free gingival graft) for people who need dental implants but have narrow jawbone. It compares doing the graft at the same time as other implant procedures versus later, to see which leads to better outcomes.
Birmingham, AlabamaAges 18 years+ - NCT06293521RecruitingPhase 2
Nerve treatment options for deep cavities in baby teeth
This study compares two ways to treat severe cavities in baby teeth: removing only the infected part of the nerve (pulpotomy) versus removing all the nerve tissue (pulpectomy). It looks at which method helps the tooth heal better and stay healthy longer.
CairoAges 4–6 - NCT06285539RecruitingPhase 2
Testing a drug for rare inflammatory diseases
This trial is testing a new drug (a JAK inhibitor) for people with rare inflammatory diseases like Behçet's, myositis, or IgG4-related disease that hasn't improved with standard treatments. The goal is to see if it can help control symptoms and reduce inflammation.
AmsterdamAges 18–65 - NCT06275087Recruiting
Recovery speed after anesthesia for mouth surgery
This trial compares how quickly people recover from anesthesia after mouth surgery. It may help if you are having a soft-tissue procedure inside your mouth that takes 30 minutes to 2 hours.
ZagrebAges 18 years+ - NCT05956587RecruitingPhase 2
Testing two study drugs for advanced lung cancer and other tumors
This Phase 2 study tests a combination of two experimental medicines in people with advanced or metastatic solid cancers, including non-small cell lung cancer and nasopharyngeal cancer. It aims to see whether the drugs can shrink tumors and improve outcomes, while carefully checking safety and eligibility.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT06267989Recruiting
Early treatment for misplaced upper canine teeth
This trial tests whether early treatment can help guide a misplaced upper permanent canine tooth into its correct position. It may be a good option if your canine tooth is not coming in normally and is not pushed toward the cheek.
Traben-TrarbachAges 10–12 - NCT06254911RecruitingPhase 2
Immunotherapy before surgery for HPV-related throat cancer
This trial tests whether giving the drug atezolizumab before surgery can help shrink HPV-related throat cancer and improve outcomes. Atezolizumab helps your immune system fight cancer cells.
Atlanta, GeorgiaAges 18 years+ - NCT06239727RecruitingPhase 3
Reduced-dose radiotherapy for stage III nasopharyngeal cancer based on response
This trial tests whether a lower dose of radiation can safely treat stage III nasopharyngeal cancer if you have already responded well to initial chemotherapy plus immunotherapy (Camrelizumab). The goal is to reduce side effects while still controlling the cancer.
Fuzhou, FujianAges 18–65 - NCT06221306Recruiting
Comparing narrow vs standard dental implants for jaw bone loss
This trial tests whether narrow dental implants can preserve jaw bone better than standard implants with bone grafting in people missing back teeth. If you have a narrow jawbone, this study may help determine which option works best for you.
Cairo, Greater CairoAges 18 years+ - NCT06214923Recruiting
Virtual reality for jaw pain caused by TMD
This study tests whether immersive virtual reality can reduce chronic jaw pain from Temporomandibular Disorder (TMD). It uses EEG to see how VR affects brain activity related to pain.
Baltimore, MarylandAges 18–88 - NCT06219226Enrolling by invitation
Mouthwash for bad breath study
This study tests if two special mouthwashes, chlorine dioxide and chlorhexidine, can reduce bad breath. You'd be asked to use one of these rinses and have your breath checked.
Budapest, BudapestAges 18 years+ - NCT06207617Recruiting
Immediate implant after molar removal: with or without bone graft
This study tests whether placing a dental implant right after removing a lower molar works better with or without adding a bone graft. It looks at how the bone and gum change over time.
CairoAges 18–50
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.