Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06207617Recruiting
Immediate implant after molar removal: with or without bone graft
This study tests whether placing a dental implant right after removing a lower molar works better with or without adding a bone graft. It looks at how the bone and gum change over time.
CairoAges 18–50 - NCT05821972RecruitingPhase 4
Breathing-mist medicines for cleft palate surgery pain control
This trial tests whether a breathing mist of two medicines (dexmedetomidine plus ketamine) works better than dexmedetomidine alone during cleft palate repair surgery. It may help improve comfort and safety around anesthesia for eligible patients.
AsyutAges 1–4 - NCT06197776Recruiting
Predicting treatment success for advanced nasopharyngeal cancer
This study uses advanced testing (multi-omics) to predict if combining chemoradiation with immunotherapy works better for nasopharyngeal cancer that has returned or spread. It aims to find the right treatment for each person.
Guangzhou, GuangdongAges 18–70 - NCT06185075Enrolling by invitation
Dental implant crown design study
This trial tests how the shape of a dental implant crown affects your gum and bone health. It might help you if you have a dental implant that is ready to receive a crown.
Ann Arbor, MichiganAges 20–80 - NCT06195241RecruitingPhase 4
DaxibotulinumtoxinA for eyelid and facial spasms
This trial tests a new type of botulinum toxin (DaxibotulinumtoxinA) for people with eyelid or facial muscle spasms. It aims to see if it works better or lasts longer than current treatments.
The Bronx, New YorkAges 18 years+ - NCT06168695Recruiting
Treating front teeth crossbite to help children's speech
This study looks at how fixing a crossbite (where upper front teeth sit behind lower teeth) can improve speech in children. It may help kids who have trouble saying certain sounds because of their teeth alignment.
Tanta, Gharbia GovernorateAges 8–10 - NCT06153212Enrolling by invitation
Regenerative treatment for gum infection around dental implants
This study tests a new regenerative treatment for gum infections around dental implants (peri-implantitis). It may help people whose implants are otherwise healthy and positioned correctly, and who have good overall health.
Ann Arbor, MichiganAges 18 years+ - NCT06145308RecruitingPhase 2
Precision treatment for salivary gland cancer
This trial tests a personalized treatment approach for recurrent or metastatic salivary gland cancer. It uses special tests on your tumor to find the best targeted therapy for your specific cancer type.
Beijing, Beijing MunicipalityAges 18–100 - NCT06149585Recruiting
Bacteria changes in gum disease patients getting all dental implants
This study looks at how bacteria in your mouth change when all your teeth are removed and replaced with dental implants. If you have severe gum disease and need all your teeth extracted, joining this trial could help researchers understand your healing process.
Cleveland, OhioAges 21 years+ - NCT05852145RecruitingPhase 1/Phase 2
Testing sweet drinks effect on children’s mouth health
This early-stage study looks at how drinking soft drinks with and without sweeteners affects children’s mouths and teeth. It may help researchers understand which types of sweet drinks contribute to more tooth damage.
Mexico City, CuahutemocAges 12–18 - NCT06114706Recruiting
Better assessment of sore throat and antibiotic use
This study tests a new way to assess sore throats in primary care and pharmacies to help decide when antibiotics are needed. It aims to improve treatment and reduce unnecessary antibiotic use.
StenungsundAges 6 years+ - NCT06110611Enrolling by invitation
Zirconia crowns on titanium abutments: 5-year study
This study checks how well a type of ceramic crown (zirconia) attached to a titanium base works for replacing a single missing back tooth. It looks at results 5 years after treatment.
GroningenAges 18 years+ - NCT03047369Recruiting
Myelin brain disorder research biobank for samples and data
This study collects brain-related medical information and biological samples to help researchers better understand leukodystrophies and other white-matter brain disorders. It may help future diagnosis and treatments by building a valuable “biobank” of patient data and samples.
Los Angeles, CaliforniaAges Any age - NCT06091228Recruiting
Tongue scraping for bad breath with gum disease treatment
This trial checks if adding tongue scraping to regular gum disease treatment can help reduce bad breath more than gum treatment alone.
LeuvenAges 18 years+ - NCT06088381RecruitingPhase 2
HPV-related throat cancer treatment based on tumor DNA levels
This trial tests if monitoring cancer DNA left in your blood after surgery can help decide if you need additional treatment. It is for people with HPV-positive oropharynx (throat) cancer who have a certain amount of cancer DNA detected before surgery.
Baltimore, MarylandAges 18 years+ - NCT06099717Recruiting
Testing a two-tooth dental bridge on one implant
This study tests if a special bridge supported by a single implant can replace three missing back teeth. It may help people who have a large enough jawbone and good overall health.
Goiânia, GoiásAges 18 years+ - NCT06099431Enrolling by invitation
Bone plate for jaw reconstruction after benign tumor removal
This trial is testing a bone plate used to rebuild the lower jaw after removing a non-cancerous growth. It may help patients who need surgery to remove a benign lesion from the center of their jawbone.
Tanta, Gharbia GovernorateAges 12–50 - NCT06093061RecruitingPhase 2
Maintenance therapy for high-risk nasopharyngeal cancer
This trial tests a combination of two drugs—tislelizumab (an immunotherapy that helps your immune system fight cancer) and capecitabine (a chemo pill taken daily)—as maintenance therapy after initial chemotherapy for high-risk nasopharyngeal cancer. The goal is to see if this approach can lower the chance of cancer coming back.
SingaporeAges 21–99 - NCT06086873Recruiting
Comparing two dental implant surfaces for healing
This study compares two types of dental implant surfaces to see which helps the implant bond better with the jawbone after a tooth is pulled. It may help you if you need a single front tooth or first premolar replaced.
LondonAges 18 years+ - NCT06096220Enrolling by invitationPhase 4
Study of two treatments for jaw cysts
This trial tests if applying 5-fluorouracil or Carnoy's solution during surgery helps treat odontogenic keratocysts (a type of jaw cyst) and reduce the chance they come back.
BelgradeAges 18–70 - NCT00898638Recruiting
Tissue sample study for head and neck cancer patients and healthy people
This study collects tissue samples from people with head and neck cancer and from healthy volunteers. The samples help researchers better understand the disease and may support future tests or treatments.
Nashville, TennesseeAges 18 years+ - NCT06064097RecruitingPhase 2
Nivolumab plus chemo for young people with nasopharyngeal cancer
This trial tests combining the immunotherapy drug nivolumab with standard chemotherapy to treat newly diagnosed nasopharyngeal cancer in children and young adults. The goal is to see if adding this immune-boosting medicine can help shrink tumors and prevent the cancer from coming back.
Birmingham, AlabamaAges Up to 21 years - NCT06075134Recruiting
EMG-guided vs. standard Botox for gummy smile treatment
This trial compares two ways of giving Botox for a gummy smile: one using a machine that measures muscle activity (EMG‑guided) and the usual method. The goal is to see which approach works better.
CairoAges 18–50 - NCT06075017Recruiting
Zirconia vs. titanium implants and biofilm buildup
This trial compares how much biofilm (a sticky layer of bacteria) builds up on two types of dental implants – one made of zirconia (a white ceramic) and one made of titanium (a metal). It's for people getting a single implant to replace a missing tooth.
Madrid, MadridAges 18–99
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.