Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07383493Recruiting
Treatments for cold and sinus infections
This study tests treatments for the common cold, sinus pain, or sore throat caused by a virus. It compares different options to see which works best for reducing symptoms like runny nose, congestion, and cough.
Clermont-FerrandAges 18–70 - NCT07384221Recruiting
Gum health and disease severity in Pemphigus Vulgaris
This study looks at how Pemphigus Vulgaris (a rare blistering skin condition) affects gum health. Researchers will check your teeth and gums to see if the disease is linked to gum problems.
AnkaraAges 18 years+ - NCT07386457Recruiting
Measuring gum graft healing after surgery
This study measures how a gum graft surgery site heals over time. It's for people who are already scheduled for this specific procedure at Ohio State University and have mild to moderate gum recession on certain teeth. The goal is to understand normal healing after the surgery.
Columbus, OhioAges 18–50 - NCT07387978Recruiting
Laser therapy to prevent mouth sores during radiation for oral cancer
This trial tests if low-level laser therapy can reduce painful mouth ulcers caused by radiation treatment for oral cancer. It may help you keep your mouth healthier during therapy.
Melbourne, VictoriaAges 18 years+ - NCT07387900RecruitingPhase 2
Metformin for preventing cancer in oral leukoplakia
This study tests if metformin — a medication commonly used for diabetes — can prevent oral leukoplakia from turning into cancer when applied as a mouth rinse and taken as a pill. It is for people with non-severe white patches in the mouth.
CairoAges 21 years+ - NCT07391202Recruiting
Crown removal for treating gum disease around dental implants
This trial tests whether removing the crown from a dental implant before cleaning helps treat infection and inflammation around the implant. It may help patients with a condition called peri-implantitis, which is like gum disease but around an implant.
Chieti, ChietiAges 18 years+ - NCT07393997Recruiting
Tooth transplant with platelet-rich fibrin for young patients
This trial tests a tooth transplant method that uses a healthy tooth from elsewhere in your mouth to replace a missing tooth. A special protein-rich material (platelet-rich fibrin) is placed around the new tooth to help it heal and grow roots. It's designed for children, teens, and young adults who cannot get dental implants.
BariAges 10–80 - NCT01601171Recruiting
Genetic study of reproductive problems and cleft lip or palate
This study looks at genetic (inherited) causes of certain hormone and reproductive conditions, including Kallmann syndrome and cleft lip/palate. You might be asked for medical and family history and possibly a DNA sample, helping researchers find what drives these conditions.
Lausanne, Canton of VaudAges Any age - NCT01473784Recruiting
Robot-assisted mouth and throat surgery for head and neck tumors
This trial studies using a robot-assisted operation through the mouth to diagnose or treat certain non-cancer (benign) and cancer (malignant) tumors in the head and neck. It may help some people avoid more invasive surgery by using an approach that reaches the throat and voice box area through the mouth.
Columbus, OhioAges 18 years+ - NCT01630447Recruiting
Study of cherubism genes and how the condition works
This study looks at the genes in people with cherubism to understand how the condition develops. If you have cherubism—or are part of a family where cherubism is being studied—you may be invited to take part.
Farmington, ConnecticutAges Any age - NCT00900419Recruiting
Check biomarkers during bronchoscopy in breathing and throat pre-cancer
This study looks at “biomarkers” (measurable signals in samples) taken during bronchoscopy or related procedures in people with severe airway pre-cancer or certain lung/throat cancers, and in healthy volunteers. The goal is to better understand what these biomarkers mean and how they might help with diagnosis, staging, or monitoring.
Aurora, ColoradoAges 21–90 - NCT01568697Recruiting
Studying gum disease in people with immune and genetic differences
This study looks at how mouth bacteria and the immune system may work together to cause gum disease (periodontitis), especially in people with certain genetic immune problems. It may help researchers understand what drives severe gum disease and how to better monitor or treat it in the future.
Bethesda, MarylandAges 7–100 - NCT01805869Recruiting
Teeth removal study using leftover tissue for research
This study looks at people who need wisdom tooth (third molar) removal and collects the leftover tissue after extraction. The goal is to use these samples to help dental research, while making sure the procedure can be done safely.
Bethesda, MarylandAges 16–50 - NCT01425892Recruiting
Study of how Sjogren’s disease starts and changes over time
This study follows people with Sjogren’s disease to understand how it develops and how symptoms naturally change over time. The goal is to improve understanding and future care rather than provide a new immediate treatment.
Bethesda, MarylandAges 16–100 - NCT01958762Recruiting
Cigarette buyers get oral cancer screening
This trial tests whether people who recently bought cigarettes can be offered screening for oral (mouth) cancer. It may help find cancer or warning changes earlier in people at higher risk from smoking.
Amiens, PicardieAges 30–75 - NCT01885299Recruiting
Long-term registry for stereotactic radiation treatments
This study collects long-term information from people who receive stereotactic radiosurgery or stereotactic body radiotherapy for tumors or other conditions. It helps researchers understand how these precise radiation treatments work over time.
Colorado Springs, ColoradoAges Any age - NCT00898638Recruiting
Tissue sample study for head and neck cancer patients and healthy people
This study collects tissue samples from people with head and neck cancer and from healthy volunteers. The samples help researchers better understand the disease and may support future tests or treatments.
Nashville, TennesseeAges 18 years+ - NCT00932594Recruiting
New treatment approach for jaw joint problems
This trial studies a “serial” (step-by-step) treatment plan for temporomandibular disorders (TMJ), which can cause pain, clicking, and trouble opening your mouth. It may help by improving how your jaw joint moves and reducing symptoms.
Guangzhou, GuangdongAges 16–60 - NCT01269190Recruiting
Imaging mouth lesions during surgery to see them more clearly
This study uses a special dye and camera imaging while you have surgery or a biopsy to remove a mouth lesion. The goal is to better visualize the lesion during the operation, which may help doctors guide care more accurately.
Houston, TexasAges 18 years+ - NCT01365169Recruiting
How activity level and daily function relate to cancer survival
This study looks at how physical activity (movement during the day) and a clinician-rated “day-to-day function” score relate to overall survival in people with certain cancers. It may help doctors understand who benefits most from activity-focused care and better monitoring.
Houston, TexasAges 18 years+ - NCT01420562Recruiting
Posaconazole medicine study in transplant patients with mouth sores
This study looks at how posaconazole (an antifungal medicine) moves through the body in people who recently had an allogeneic stem cell transplant and have mouth sores (mucositis). It may help clinicians choose the safest and most effective dosing for preventing serious fungal infections.
Leuven, Vlaams-BrabantAges 18–75 - NCT02012699Recruiting
Cancer registry for people with or at risk of cancer
This trial collects health information and samples (a “cancer repository”) to help researchers study cancer and cancer risk. You may be able to join if you’ve had cancer before or if you’re at higher risk or have concerning findings.
Greenwood Village, ColoradoAges 19–110 - NCT02833285Recruiting
Study immune cells in people with gum disease
This study looks at how the immune system (B cells) works in gum disease and may help doctors better understand the condition. You may be asked to take part if you need gum surgery and meet other health and treatment rules.
BrestAges 18–75 - NCT02593565Recruiting
Pregnancy blood-vessel disease registry study
This is a pregnancy registry that collects information from people with certain blood-vessel inflammatory diseases during pregnancy. It helps researchers better understand these conditions in pregnancy and may guide future care.
Tampa, FloridaAges 18–50
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.