Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06763653Recruiting
Low-frequency device for chronic low back pain
This trial tests a new device that uses very low-frequency electrical pulses to treat chronic low back pain. It is for people whose pain hasn't improved with other treatments and who are not candidates for stronger therapies.
Norwood, South AustraliaAges 22 years+ - NCT06765278Recruiting
Nerve block comparison for shoulder surgery pain relief
This trial compares three different types of nerve blocks to manage pain after shoulder arthroscopy. The goal is to find which block works best for reducing pain and improving recovery.
CairoAges 18–70 - NCT06766240Recruiting
MRI for low back pain in middle-aged women
This trial is studying how well MRI can evaluate low back pain in women between 40 and 60 years old. It may help doctors better understand the cause of your pain.
SohagAges 40–60 - NCT06766916RecruitingPhase 2
Testing Crisugabalin for nerve pain after radiation
This trial tests a drug called Crisugabalin to see if it helps people with nerve pain caused by radiation treatment for head and neck cancer. The study aims to find a better way to manage this type of pain that does not go away.
Fuzhou, FujianAges 18 years+ - NCT06770374Recruiting
Zinc oxide adhesive for IV line securement
This trial tests a special adhesive dressing made with zinc oxide to keep your IV line secure. It looks at whether this dressing helps prevent the line from moving, which could reduce complications.
Lleida, CataloniaAges 18 years+ - NCT06771492RecruitingPhase 3
Antibiotics for chronic back pain with Modic changes
This trial tests whether an antibiotic (amoxicillin) can reduce chronic low back pain in people who have a specific type of bone change (Modic type I) after a past herniated disc. If you qualify, you would receive either the antibiotic or a placebo (inactive pill) for several weeks.
Rotterdam, South HollandAges 18–65 - NCT06774274RecruitingPhase 4
Ketamine for pain after major orthopedic surgery: drip vs. pump
This study tests two ways of giving a medicine called ketamine to control pain after major bone or joint surgery. One method is a steady infusion (drip) through a vein, and the other is a patient-controlled pump (PCA) that lets you press a button for more medicine when you need it.
Medellín, AntioquiaAges 18 years+ - NCT06775535Recruiting
Spinal cord stimulation trial for chronic pain
This trial tests a closed-loop spinal cord stimulator that adjusts stimulation based on nerve signals. It may help people with chronic pain who are already scheduled to try this type of device.
RoeselareAges 18 years+ - NCT06776159Recruiting
Standardizing blood thinner shots for heart patients
This study tests whether a standard way of giving blood thinner shots (LMWH) to people with heart disease in the cardiac care unit improves care. It is for Chinese patients who are awake and can make their own decisions.
Hong KongAges 18 years+ - NCT06777771Recruiting
Reformer Pilates for first-time pregnant women
This trial tests if Reformer Pilates (a type of exercise using a special machine) helps first-time pregnant women stay healthy. If you are in your first pregnancy and between 11 and 22 weeks along, this may be a good fit for you.
Izmir, KonakAges 18–35 - NCT06777875Recruiting
How genes affect pain after surgery in children
This trial looks at how certain genes may affect how children feel pain after surgery. The goal is to understand if differences in your DNA can help doctors manage pain better for each child.
BeirutAges 8–18 - NCT06778460Recruiting
Esketamine and lidocaine for pain after liver surgery
This trial tests whether two medicines, esketamine and lidocaine, can reduce long-term pain after liver surgery and possibly improve survival. It is for people who are having a planned liver removal (hepatectomy).
Chengdu, SichuanAges 18–75 - NCT06779123Recruiting
Vagus nerve stimulation for rheumatoid arthritis
This trial tests a non-invasive device that stimulates a nerve in your ear to see if it can reduce rheumatoid arthritis symptoms. It is for people whose RA has not responded well to at least one biologic or targeted DMARD.
Lund, Skåne CountyAges 18 years+ - NCT06779396RecruitingPhase 4
Scalp injection to reduce pain after brain surgery in children
This trial tests if injecting a mix of two medicines (triamcinolone and ropivacaine) into the scalp before brain surgery can lower pain in children afterward. It compares this to standard care to see if it helps kids recover more comfortably.
Beijing, Beijing MunicipalityAges 2–12 - NCT06779578Recruiting
Comparing two types of radiofrequency for trigeminal neuralgia
This study compares two treatments (bipolar vs monopolar pulsed radiofrequency) for people with trigeminal neuralgia that hasn't improved with medication. It aims to see which method provides better pain relief.
AlexandriaAges Any age - NCT06779604Recruiting
Numbing medicine mix for arm surgery pain relief
This trial tests if adding two medicines, dexmedetomidine and dexamethasone, to the numbing shot around the arm's nerves can improve pain relief during and after upper arm or hand surgery.
Istanbul, UmraniyeAges 18–70 - NCT06780904Recruiting
Dry needling plus stretching for neck pain relief
This study tests if combining dry needling with gentle stretching or muscle energy techniques works better for treating neck pain caused by muscle knots (trigger points). It aims to find a simple, effective way to reduce pain and improve movement.
Kandy, Central ProvinceAges 18–60 - NCT06782464Recruiting
Freezing nerves for shoulder pain after stroke or brain injury
This trial tests if freezing certain nerves in the upper arm (cryoneurolysis) works as well as standard care for reducing shoulder pain and muscle tightness after a stroke or brain injury. It aims to improve function and ease caregiving tasks.
LuxembourgAges 18 years+ - NCT06784089Recruiting
Hip fracture type, nutrition and pain after surgery
This study looks at how a person's nutrition before hip surgery relates to their pain levels after surgery. It aims to help doctors improve recovery for older adults.
AnkaraAges 65 years+ - NCT06784141Recruiting
Comparing two types of cognitive behavioral therapy for chronic pain
This trial tests two different ways of doing cognitive behavioral therapy (CBT) for chronic pain — one is a standard approach, the other is tailored to your personal pain network. The goal is to see which method helps you better manage your pain and improve your quality of life.
LandauAges 18 years+ - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT06785129Recruiting
Endometriosis and migraine study
This study looks at the link between endometriosis and migraine. Researchers want to understand how these conditions affect each other, so they need people with endometriosis, migraine, or both, as well as healthy volunteers without chronic pain.
St Louis, MissouriAges 12–45 - NCT06785389Recruiting
How fear before surgery affects pain and recovery
This study looks at how feeling scared or anxious before surgery might affect your pain and recovery afterward. It aims to help improve care for future patients.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.