Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06968871Recruiting
Gentler Pap test for cervical cancer screening
This trial tests a new, gentler Pap test to see if it makes screening more comfortable and easier for women. If you're a woman 25 or older and not pregnant or on your period, you might be able to join.
DouliuAges 25 years+ - NCT06965452Recruiting
Embolization for back pain from worn-out facet joints
This study tests if a minimally invasive procedure, called trans-arterial embolization, can reduce low back pain caused by aging facet joints (facet arthropathy). It may help people who haven't found relief from other treatments like injections or nerve blocks.
Manhasset, New YorkAges 18–85 - NCT06965595Enrolling by invitation
Physiotherapy after gynecological abdominal surgery
This trial tests different physiotherapy methods to see which helps most with recovery after gynecological abdominal surgery. It may be a good fit if you've recently had a hysterectomy or similar surgery and want to improve your recovery.
KayseriAges 18 years+ - NCT06960018Recruiting
Ennovate minimally invasive spinal screw placement study
This study tests a new, less invasive method for placing screws in the cervical spine (upper back and neck). It is designed for patients who need spinal stabilization after injury or degeneration.
AachenAges 18 years+ - NCT06957639Enrolling by invitation
Physiotherapy for chronic neck pain
This trial tests a physiotherapy program for people with neck pain lasting 3 months or longer. The goal is to see if it helps reduce pain and improve daily function.
Yozgat, YozgatAges 18–64 - NCT06955221Recruiting
Alcohol injection for ovarian endometriosis pain
This study tests if injecting alcohol into ovarian endometriosis cysts can reduce pelvic pain and improve quality of life. It may offer a less invasive option for women with persistent cysts.
Palma de Mallorca, Balearic IslandsAges 18–45 - NCT06962306RecruitingPhase 4
Pain relief study for children having cleft palate surgery
This trial tests different ways to manage pain after cleft palate repair in young children. The goal is to find which approach works best to lower pain and improve recovery.
Durham, North CarolinaAges 6 months–4 years - NCT06958289Recruiting
Cold therapy for muscle tightness: long-term effects and brain changes
This study tests if freezing a nerve (cryoneurolysis) can reduce muscle tightness (spasticity) and improve arm movement. It also looks at how the brain may change after treatment. If you have tight muscles that improved with a numbing nerve block, you may be eligible.
London, OntarioAges 18 years+ - NCT06956508Enrolling by invitation
VR therapy to prevent phantom limb pain after amputation
This study tests whether using virtual reality (VR) daily in the hospital after a major amputation can help prevent phantom limb pain. You'll use a VR headset to do simple exercises that may keep your brain from sending pain signals to the missing limb.
Charlotte, North CarolinaAges 13 years+ - NCT06959056Recruiting
Cooling therapy for pain after double lung transplant
This test uses a special cooling treatment called cryo-analgesia to see if it helps reduce pain and speed up recovery after a double lung transplant. It is only for people with end-stage COPD getting a transplant at UZ Leuven.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06957158Recruiting
How calcium levels affect pain after abdominal surgery
This study looks at whether calcium levels in your blood can affect how much pain you feel after abdominal surgery. It may help doctors manage pain better after surgery in the future.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT06956664Recruiting
Exercise after steroid injection for herniated disc
This study tests whether adding a structured exercise program after a steroid injection for a herniated disc in the lower back helps reduce pain and improve function better than the injection alone. You may be eligible if you recently had the injection but still have significant pain.
ÇankırıAges 18–70 - NCT06957743Recruiting
Meditation and hypnosis for older adults with chronic pain
This study tests whether mindfulness meditation or self-hypnosis can help older adults manage chronic pain. You'll attend training sessions and have brain scans (EEG and MRI) to see how these techniques affect pain.
Seattle, WashingtonAges 60 years+ - NCT06960317Recruiting
Numbing injection for IUD placement pain
This study tests whether a numbing injection (lidocaine) in the cervix can reduce pain during IUD placement. It's for women who have never had a vaginal birth and are getting their first IUD.
La Jolla, CaliforniaAges 18–50 - NCT06957990Enrolling by invitation
Music therapy during hernia surgery to reduce pain medication
This study tests if listening to music therapy before and during hernia surgery can lower the need for strong painkillers (narcotics). It may help you manage pain with less medication.
Cincinnati, OhioAges 18 years+ - NCT06062446Recruiting
A new way to do lumbar puncture to prevent headaches
This study tests a modified lumbar puncture (spinal tap) procedure to reduce the chance of getting a headache afterward. It's for people who need a spinal tap as part of their regular medical care.
Houston, TexasAges 18 years+ - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT06944314Enrolling by invitation
Doctors' views on pain during flexible cystoscopy with local anesthetic
This trial asks doctors to rate how much pain they think male patients feel during a minimally invasive bladder exam. It aims to see if doctors' estimates of pain are accurate.
Istanbul, IstanbulAges 18 years+ - NCT06942611Recruiting
Electrical brain stimulation for chronic pain from nerve inflammation
This study tests a noninvasive brain stimulation technique (transcranial electrical stimulation) to see if it can reduce chronic pain in people with conditions like multiple sclerosis or neuromyelitis optica. It aims to offer a new, drug-free option for pain relief without major side effects.
BeijingAges 18–65 - NCT06943898Recruiting
Core and Breathing Exercises for Chronic Low Back Pain
This study tests if core and breathing exercises can improve balance and body awareness in people with chronic low back pain. The exercises are gentle and focus on strengthening the muscles that support your spine.
Sivas, MerkezAges 18–65 - NCT06948162Recruiting
Dental MRI for routine dental care
This study tests whether a special MRI machine can take detailed images of teeth and jaws for routine dental care. It may help find problems without using X-rays.
Minneapolis, MinnesotaAges 18 years+ - NCT06949059RecruitingPhase 1/Phase 2
Hydromorphone for acute chest pain relief
This trial tests a quick-acting pain medicine (hydromorphone) given through a vein to treat severe chest pain. It may be an option for people experiencing acute pain who haven't been helped by other medicines.
Nanjing, JiangsuAges 18–64 - NCT06948500Recruiting
Virtual reality exercise program for fibromyalgia pain
This study tests whether a virtual reality exercise program that changes how you see your own movements can help reduce pain and improve function in people with fibromyalgia. You would do the exercises at home using a headset, and researchers will check if this approach works better than standard exercise.
Valencia, Valencia-valènciaAges 18–80 - NCT06949007Recruiting
Yoga for persistent pain after torso surgery
This study tests whether yoga or a health education program can help reduce long-term pain that started after a torso surgery like a chest, breast, or abdominal operation. You must have had surgery at least 3 months ago with moderate pain, and be able to attend classes in person or virtually.
Boston, MassachusettsAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.