Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06785753RecruitingPhase 2
Cold therapy for tooth pain after root canal
This study tests whether applying cold (cryotherapy) to the tooth and gum can reduce pain after root canal treatment in people with severe tooth pain. It aims to find a safe, drug-free way to manage pain during the procedure.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT06785909Recruiting
Understanding why pregnancy back and pelvic pain persists
This study looks at why some women develop ongoing pain in the lower back or pelvis during pregnancy. It tests how your body's sense of movement, fear of pain, and inflammation might be related. You may join if you are early in a single pregnancy and do not have that pain yet.
HasseltAges 18–40 - NCT06788275Recruiting
Can exercise improve blood vessel health after a heart attack?
This study looks at whether aerobic exercise can improve blood vessel health in people who have had a heart attack or chest pain (angina). If you qualify, you'll join a monitored exercise program.
Alicante, AlicanteAges 45–75 - NCT06788314RecruitingPhase 2
Enalapril for painful venous malformations
This trial tests if the blood pressure drug enalapril can reduce pain from venous malformations (abnormal veins). It may help people whose pain limits daily activities or interrupts sleep.
Oslo, NorwayAges 18–70 - NCT06788977Recruiting
Migraine treatment in pregnancy with a nerve stimulation device
This trial tests if a device that gently stimulates a nerve on your forehead can safely treat migraines during pregnancy. You'll use the device at home and track your headaches via text or email.
Darien, ConnecticutAges 18–44 - NCT06789861RecruitingPhase 1
First test of TT5 in healthy volunteers and surgical patients
This is a first-in-human study testing a new medicine (TT5) in healthy people and patients recovering from surgery. It checks how the body handles the drug and whether it is safe to use for pain.
Adelaide, South AustraliaAges 18–55 - NCT06794528Recruiting
Neck pain exercise program using mobile exergames
This trial tests if doing therapeutic exercises through fun mobile games (exergames) can help people with neck pain. You'll use your own smartphone or tablet to follow the program.
Palma de Mallorca, Balearic IslandsAges 18–70 - NCT06795243Recruiting
Physical therapy for endometriosis and exercise adherence
This study tests whether physical therapy (exercise for your muscles) can help with endometriosis symptoms and how well people stick with the program. If you have endometriosis and can do light strength exercises, you may be able to join.
SevilleAges 18 years+ - NCT06795386Recruiting
Widespread pain after rapid weight loss in Black and Hispanic adults
This study looks at whether rapid weight loss from bariatric surgery leads to long-term widespread pain in Black and Hispanic adults. The goal is to understand how weight loss affects pain and find better ways to help people manage it.
New York, New YorkAges 18–75 - NCT06796309Recruiting
Testing a rural health app for seniors and shoulder pain
This study tests a digital tool (called TRAK) to improve healthcare quality and access in rural areas. It is for healthcare workers or patients who are seniors or have long-term shoulder pain.
MadridAges 18 years+ - NCT06796595Recruiting
Nerve recovery program for chronic pelvic nerve pain
This study tests a medical program designed to help nerves heal better after surgery for long-term pelvic or buttock nerve pain. It looks at results one year after a minimally invasive operation to free compressed nerves.
BordeauxAges 18 years+ - NCT06797973RecruitingPhase 4
Morphine for pain after planned cesarean section
This trial studies whether giving a small dose of morphine into the spinal fluid during a planned cesarean section helps with pain after surgery. It aims to find a safe and effective way to manage pain for new mothers.
AarhusAges 18 years+ - NCT06798181Recruiting
Neuropathic pain and type 2 diabetes study
This study looks at nerve pain (called neuropathic pain) in people with type 2 diabetes. It aims to understand this type of pain better so doctors can help improve comfort and quality of life.
BilecikAges 18–100 - NCT06800703Recruiting
Opioid use, pain, and the brain
This study uses brain scans (MRI) to understand how pain affects people with opioid use disorder or regular opioid use, compared to healthy volunteers. It aims to find better ways to treat both pain and opioid addiction.
New Haven, ConnecticutAges 21–60 - NCT06803732Recruiting
Pain after robotic, endoscopic or open neck surgery for thyroid cancer
This trial compares pain levels after three different surgical methods for removing cancerous lymph nodes in the neck. It may help patients with thyroid cancer that has spread to neck lymph nodes understand which approach causes less discomfort.
Shanghai, Shanghai MunicipalityAges Any age - NCT06804434Recruiting
Pain monitor during stomach or liver cancer surgery
This trial tests a device that monitors your pain level during surgery using a special index called the Nociception Level Index. It may help doctors manage your pain better without using too much medicine.
Cluj-Napoca, ClujAges 18 years+ - NCT06804564Recruiting
Cold vs warm water for muscle pain recovery
This trial compares cold water and warm water immersion to see which helps recover from muscle soreness after exercise. If you are a healthy young man with moderate muscle pain from working out, this study may help you recover faster.
Biała Podlaska, Lublin VoivodeshipAges 18–25 - NCT06806111Recruiting
Healing after gum graft from the roof of the mouth
This study looks at how well a small gum graft taken from the roof of your mouth heals and how it feels for you. It aims to understand recovery after this common dental procedure.
Barcelona, Sant Cugat Del VallesAges 18 years+ - NCT06808269Recruiting
Shoulder surgery recovery study
This study looks at recovery after different types of shoulder surgery. It may help doctors understand the best way to care for people after their operation.
ParisAges 18 years+ - NCT06810336RecruitingEarly Phase 1
Pain control after brain surgery: methadone vs remifentanil
This trial compares two medicines, methadone and remifentanil, to see which one works better for pain after brain surgery. It may help improve your recovery and comfort.
Charlottesville, VirginiaAges 18–65 - NCT06811077Recruiting
Health coaching by a patient expert for chronic pain
This trial tests whether one-on-one coaching sessions led by a trained patient expert can help people better manage chronic pain. If you already attend a chronic pain clinic and are open to learning new coping skills, this program may support you.
Paris, FranceAges 18 years+ - NCT06811103Recruiting
How chronic pain patients make decisions about treatment
This study looks at what helps people with chronic pain make choices about their treatment. You will be asked some questions during your first pain clinic visit to see how your decision-making relates to how well treatments work.
Paris, ParisAges 18 years+ - NCT06812247Recruiting
Therapy dog visits for hospitalized trauma patients
This study looks at whether visits from therapy dogs can help people who are in the hospital after a traumatic injury feel better. You must be able to talk to the research team and not be afraid of dogs.
Boston, MassachusettsAges 18 years+ - NCT06812832RecruitingPhase 4
Simethicone in bariatric surgery recovery
This trial tests if giving simethicone (a gas-relief medication) as part of a standard recovery plan helps patients feel better after weight-loss surgery. It may reduce bloating and discomfort after surgery.
Tacoma, WashingtonAges 18–89
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.