Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+ - NCT06948162Recruiting
Dental MRI for routine dental care
This study tests whether a special MRI machine can take detailed images of teeth and jaws for routine dental care. It may help find problems without using X-rays.
Minneapolis, MinnesotaAges 18 years+ - NCT06946290Recruiting
Nerve block for pain relief after heart surgery
This study tests a nerve block, called an intertransverse process block, to see if it helps people feel better and recover faster after heart surgery. The block is given during surgery to reduce pain.
Hong KongAges 18 years+ - NCT06944314Enrolling by invitation
Doctors' views on pain during flexible cystoscopy with local anesthetic
This trial asks doctors to rate how much pain they think male patients feel during a minimally invasive bladder exam. It aims to see if doctors' estimates of pain are accurate.
Istanbul, IstanbulAges 18 years+ - NCT06240299Recruiting
Neurofeedback for chronic pain in rheumatoid arthritis
This trial tests a brain-training technique called neurofeedback to see if it can help people with rheumatoid arthritis who also have chronic widespread pain. It uses a computer to show you your brain activity and teach you to control it, which may reduce pain.
Glasgow, ScotlandAges 18–75 - NCT06343714RecruitingPhase 1
Testing a new drug for knee osteoarthritis pain
This study tests a new antibody drug (FB1003) for people with knee osteoarthritis pain. It will check if the drug is safe and helps reduce pain. You may be eligible if you have moderate to severe knee pain and are willing to temporarily stop your usual pain medications.
Brisbane, QueenslandAges 18–75 - NCT06812832RecruitingPhase 4
Simethicone in bariatric surgery recovery
This trial tests if giving simethicone (a gas-relief medication) as part of a standard recovery plan helps patients feel better after weight-loss surgery. It may reduce bloating and discomfort after surgery.
Tacoma, WashingtonAges 18–89 - NCT06845215Recruiting
Pain block comparison for abdominoplasty recovery
This trial compares two types of nerve blocks (TAP and ESP) to see which provides better pain relief after tummy tuck surgery. Both are injections near the abdominal muscles that numb the area, and you'll also have a patient-controlled pain pump.
Ankara, KeçiörenAges Any age - NCT06940986Recruiting
Holistic pain self-management for military health system patients
This trial tests a holistic pain self-management program for people with long-term muscle or bone pain. It aims to help you take control of your pain through education and support, without relying only on medications.
Fairbanks, AlaskaAges 18 years+ - NCT06933498Recruiting
Nerve block for less pain meds in back surgery
This trial tests whether a nerve block (called an erector spinae plane block) given before surgery can reduce the amount of pain medicine and anesthesia needed during lumbar disc surgery. It may help people have less pain and fewer side effects.
AnkaraAges 18–75 - NCT06939491Enrolling by invitation
Ultrasound-guided electrolysis vs. sham for patellar tendon pain
This trial tests whether a treatment called ultrasound-guided electrolysis therapy can reduce pain and improve tendon health in people with patellar tendinopathy (knee tendon pain). It compares the real treatment to a sham (fake) treatment to see if it works better.
Bremen, Free Hanseatic City of BremenAges 18–59 - NCT06937853Recruiting
Genes and painkiller response for tooth pain
This trial tests whether your genes affect how well a common painkiller (NSAID) works for tooth pain after a root canal procedure. It may help find the best pain relief for you.
Erzurum, ErzurumAges 18–65 - NCT06932406Recruiting
Personality and self-help for jaw pain
This study tests whether a self-management program for jaw and face pain works differently in people with different personalities. You will learn techniques to manage your pain at home.
Valencia, ValenciaAges 18–65 - NCT06935331Enrolling by invitationPhase 4
Opioid-free spinal fusion for teens with scoliosis
This trial tests a way to manage pain after scoliosis surgery without using opioid medications. It aims to see if patients can recover comfortably using only non-opioid pain relievers, which may help avoid opioid side effects and addiction risks.
Charlotte, North CarolinaAges 10–20 - NCT06933381Recruiting
Cold spray for pain during Nexplanon insertion
This study tests whether a numbing cold spray (vapocoolant) can reduce pain during Nexplanon implant insertion. If you are getting a Nexplanon placed in your arm, you may be able to join.
Honolulu, HawaiiAges 14 years+ - NCT06931951Recruiting
Acupuncture with medicine for knee pain after a car accident
This trial tests a type of acupuncture that injects medicine into specific points (pharmacopuncture) to treat severe knee pain from a recent traffic accident. It looks at whether this treatment is safe and effective for people who are already in the hospital for their injury.
DaejeonAges 19–69 - NCT06935201Recruiting
Digital rehab program for spinal stenosis surgery recovery
This study tests a digital, person-centered rehab program to help people recovering from surgery for lumbar spinal stenosis become more physically active. It aims to see if an online program can improve recovery and quality of life after surgery.
StockholmAges 18 years+ - NCT06932887RecruitingPhase 3
Walking to reduce arthritis pain
This study tests a walking program to help reduce pain from osteoarthritis. It is designed for people with arthritis in their hips, knees, feet, or spine.
Salt Lake City, UtahAges 45 years+ - NCT06940063Recruiting
Music therapy for chronic low back pain
This trial tests whether an active music-based program can help reduce chronic low back pain. It is for adults aged 18 to 65 whose pain has lasted at least 3 months and has been present on most days.
Denton, TexasAges 18–65 - NCT06941298Recruiting
Cannabis and depression study for teens and young adults
This study looks at how cannabis affects the brain and mood in teens and young adults. It compares people who use cannabis, people with depression who don't use cannabis, and healthy volunteers to understand links between cannabis use and mental health.
Miami, FloridaAges 14–20 - NCT06939257Recruiting
Hormone therapy and pain in gender diverse adults
This study looks at how gender-affirming hormone therapy affects pain in gender diverse (GM) adults. It may help understand whether these hormones change how you feel pain.
Kansas City, KansasAges 18–50 - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT06724679Recruiting
Virtual reality for chronic back pain treatment
This trial tests if using a virtual reality (VR) headset can help people with long-term lower back pain during a spine rehabilitation program. It will see if VR is a practical and helpful addition to the program.
AngersAges 18–65 - NCT06893822Recruiting
Griffonia simplicifolia for pain in healthy volunteers
This trial tests if a natural supplement called Griffonia simplicifolia can change how your body processes pain. It is looking for healthy people to take part.
GrazAges 18–99
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.