Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT05991453Recruiting
Recovery after IV vs. inhaled anesthesia for non-cardiac surgery
This trial compares recovery after two types of general anesthesia: one given through an IV (propofol) and one inhaled as a gas. It aims to see which approach leads to a smoother recovery for people having non-cardiac surgery.
Little Rock, ArkansasAges 18 years+ - NCT05992038Recruiting
Bone putty as gap filler in knee realignment surgery
This trial tests a new bone putty used to fill the small gap created during realignment surgery for knee osteoarthritis. It aims to see if the putty helps the bone heal better and reduces pain.
Utrecht, UtrechtAges 18 years+ - NCT04075539RecruitingPhase 3
At-home cycling for lumbar spinal stenosis pain
This study tests whether an at-home cycling program can reduce leg and back pain caused by lumbar spinal stenosis. It aims to see if regular, supervised cycling helps people walk and function better.
Paris, Île-de-France RegionAges 50 years+ - NCT05496296Recruiting
Compare a powder dressing vs standard care for pressure sores
This study compares a transforming powder dressing to usual recommended wound care for pressure injuries at stages 2 to 4. It may help you find out whether the powder dressing heals these sores better or faster than standard treatments.
San Diego, CaliforniaAges 18–85 - NCT04481321Recruiting
Study of endometriosis and adenomyosis in people with pelvic pain
This study looks at people who have pelvic pain and/or trouble getting pregnant, and who may have endometriosis or adenomyosis. Researchers also collect clinical and lab (molecular) information to better understand these conditions and potentially improve care.
ParisAges 18–42 - NCT05963607Recruiting
Weighted blanket trial to reduce chronic pain
This study tests whether using a 15-pound weighted blanket can lower pain and improve sleep for Veterans with long-lasting, non-cancer musculoskeletal pain. It may help by reducing discomfort during rest and sleep.
San Diego, CaliforniaAges 18 years+ - NCT05964868Enrolling by invitationPhase 3
Liposome anesthesia to reduce pain after nose surgery
This Phase 3 study tests whether a special form of local numbing medicine (liposomal bupivacaine) helps reduce pain after septorhinoplasty (nose and septum surgery). You may be considered if you’re planning this surgery and can follow study instructions before and after.
Hershey, PennsylvaniaAges 18–99 - NCT05961800Recruiting
Study ways to evaluate lumbar back pain blocks
This study looks at how well different methods can evaluate a common procedure used for chronic low back pain (lumbar medial branch blocks). If you have long-lasting, everyday back pain and are having this procedure, you may help researchers compare evaluation approaches.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05944354Enrolling by invitation
Wearable system to study spine health for military readiness
This study tests whether a wearable setup can measure spine health during training and daily movement. It may help improve how military members with or without neck or low back pain are monitored and supported.
Luke Air Force Base, ArizonaAges 18–64 - NCT05969457RecruitingPhase 3
Local pain-numbing injection before surgery for hysterectomy
This Phase 3 study tests whether a preventive numbing medicine injection before a vaginal hysterectomy (using the vNOTES approach) can reduce pain afterward. It may help with comfort and recovery after surgery for non-cancer reasons.
Le HavreAges 18–70 - NCT05961501Enrolling by invitationPhase 2/Phase 3
CBD and CBN for long-lasting facial pain and muscle headaches
This trial tests whether CBD and CBN can reduce facial pain and headaches caused by muscle-related problems that have lasted more than 3 months. It may help people who have ongoing symptoms find a new treatment option.
WroclawAges 18 years+ - NCT05953766RecruitingPhase 2
Nerve block versus sham block after hysterectomy
This trial compares a targeted pain-relief injection near the lower back (a “nerve block”) to a sham (placebo-like) procedure during recovery from a total laparoscopic hysterectomy. It aims to see whether the real block reduces post-operative pain.
Toronto, OntarioAges 18 years+ - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT05925036RecruitingPhase 1
Cell therapy trial for pain from long-term pancreatitis
This Phase 1 study tests a new cell-based treatment to reduce pain caused by chronic pancreatitis. It’s designed mainly to check safety first, and it may help people with ongoing, opioid-stable pancreatic pain.
Charleston, South CarolinaAges 18–75 - NCT05917262Recruiting
Mindfulness breathing vs heart-rate training after shoulder surgery pain
This trial compares two non-drug techniques—mindful breathing and heart-rate (HR) biofeedback—to see which helps reduce pain after shoulder surgery. You may be able to join if you have ongoing shoulder pain after surgery and haven’t been using these practices very often.
TaoyuanAges 18 years+ - NCT05917626Recruiting
Digital program for teens with long-lasting pain
This trial studies whether a digital (phone or computer) program can help teens (ages 12–17) manage chronic pain over time. It’s designed with input from patients and may also show how well the program can be used in real life with families.
Almería, AlmeríaAges 12–17 - NCT05920382Recruiting
Radiofrequency treatment for long-term knee pain after knee surgery
This trial studies whether a radiofrequency procedure can reduce chronic knee pain after knee replacement surgery. It may help people who still have bothersome pain between 6 months and 5 years after their operation, as long as their pain pattern and medications are stable.
Barcelona, CataloniaAges 18 years+ - NCT05941559Enrolling by invitation
EMDR therapy for long-term rheumatoid arthritis pain
This trial tests whether eye-movement therapy (EMDR) can reduce long-lasting pain in people with rheumatoid arthritis (RA). You may be eligible if your RA has been relatively stable, your pain is still high, and you can take part in therapy sessions safely.
Enschede, OverijsselAges 18 years+ - NCT05910567Recruiting
Ultrasound test for abdominal injuries in children after blunt trauma
This study looks at how well an abdominal ultrasound test (FAST) works for children who come to the emergency department after a serious blunt injury to the belly or torso. The goal is to help doctors find dangerous internal bleeding or organ injury quickly and safely.
Sacramento, CaliforniaAges Up to 17 years - NCT03017118Recruiting
Turmeric study for early thumb basal joint arthritis
This trial studies whether turmeric can reduce pain from “basal joint” arthritis in the thumb, especially early stages seen on X-ray. You may be a good fit if you’re having thumb base pain and meet specific exam and X-ray requirements.
Boston, MassachusettsAges 40 years+ - NCT04904575Recruiting
Erector spinae pain-block during lumbar fusion surgery
This study tests whether a numbing pain-block in a specific back muscle area (called an “erector spinae plane block”) can improve comfort during lumbar spinal fusion surgery. You might be eligible if you need this type of back surgery and can safely receive the numbing medicine.
Saint-Jean-de-VédasAges 18 years+ - NCT05906511RecruitingEarly Phase 1
Study how THC levels change in older adults
This early study measures how a THC dose (by mouth or vaporized form) moves through the body and how it affects the body’s responses. It mainly looks at safety and how THC behaves in older adults, including people who have used cannabis before.
West Haven, ConnecticutAges 65 years+ - NCT05889624Recruiting
Study of treatments for childhood migraine headaches
This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.
Birmingham, AlabamaAges 10–17 - NCT05905419Recruiting
Brain scan study of opioid effects in women with pain
This study uses brain imaging (MRI) to understand how opioid medications may affect the brain in women. People with chronic pain who take opioids (or do not) and healthy women without chronic pain may be invited to participate.
Durham, North CarolinaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.