Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,764 recruiting studies in this area right now.
By phase
- Not applicable3,111
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University97
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,763 total
- NCT02025023RecruitingPhase 3
5-FU injection for eyelid bumps called chalazia
This trial compares a specific medicine injection (5-fluorouracil) to treat chalazia, which are non-cancerous eyelid bumps. It may help reduce the bump when other approaches haven’t worked yet.
Seattle, WashingtonAges 18 years+ - NCT00804154RecruitingPhase 1
Capsaicin-like drug for severe cancer pain
This Phase 1 trial tests a new drug related to capsaicin (resiniferatoxin) to reduce severe nerve pain from advanced cancer. It is given through a small catheter near the spinal fluid space and is meant for people whose pain medicines and other options have not worked well enough.
Bethesda, MarylandAges 18–99 - NCT01550575Recruiting
Study of outcomes in people treated with Boston Scientific devices
This study looks back at what happened to patients after treatment (or if they could have used) Boston Scientific medical devices. It may help improve how these devices are used and understand real-world results.
Lake Havasu City, ArizonaAges 18 years+ - NCT01218776Recruiting
Survey study for people with acute heart symptoms
This study is an international survey about acute coronary syndromes, which are sudden signs of heart-related problems. Your answers can help researchers better understand symptoms and care needs after these events.
Bologna, Emilia-RomagnaAges 18 years+ - NCT01301885Recruiting
Tests new diagnosis and treatments for endometriosis
This trial studies people who definitely have endometriosis (confirmed by surgery and tissue testing) and compares them with people whose endometriosis was ruled out during laparoscopy. It aims to improve how endometriosis is diagnosed and to explore new treatment approaches.
HelsinkiAges 19–48 - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Phoenix, ArizonaAges 18 years+ - NCT01765777Recruiting
Osteopathic hands-on therapy and light treatment for long-term low back pain
This trial studies whether hands-on osteopathic treatment and a type of light (phototherapy) can reduce chronic low back pain. It may help people who have had non-specific low back pain for at least 3 months.
Old Westbury, New YorkAges 18–65 - NCT01840930Recruiting
Study of severe cerebral palsy in children
This study looks at children ages 2 to 10 who have severe, long-term cerebral palsy to better understand this condition. It may help clinicians learn what to expect and how to support children with the most significant mobility needs.
BronAges 2–10 - NCT02083835Recruiting
Study to improve pain after surgery using patient questionnaires
This trial studies how to better understand and improve pain after surgery by asking patients to complete short questionnaires. It may help hospitals find ways to reduce postoperative pain and better track recovery.
JenaAges 4 years+ - NCT02362685Recruiting
Metabolic exercise testing study
This study is about doing a breathing-and-heart performance test while you exercise to better understand how your body uses energy. You may join if you’re referred for this type of test and can safely complete it.
BrestAges 5 years+ - NCT02124499Recruiting
Study links genes to complications after scheduled surgery
This study looks at how certain genetic differences may affect the risk of complications and recovery outcomes after surgery. It may help doctors understand who is more likely to have problems around the time of an operation.
BernAges 18 years+ - NCT02321423Recruiting
Research registry for pachyonychia congenita patients
This study builds an international database of people with pachyonychia congenita (or a closely related condition). Sharing your information may help researchers understand the condition better and improve future treatments.
Salt Lake City, UtahAges Any age - NCT02533804Recruiting
Life Project study for adults in Lake Nona
This study is collecting information from adults living or working in the Lake Nona area. It may help researchers understand community needs and improve programs for residents.
Orlando, FloridaAges 18–110 - NCT02448485Recruiting
Measuring Troponin T blood levels in aortic valve narrowing
This study looks at a blood test called high-sensitivity troponin T in people with aortic stenosis (a narrowed heart valve). The results may help doctors understand heart strain or risk in this condition.
Innsbruck, TyrolAges Any age - NCT02707029Recruiting
Study of how people report pain and painful conditions
This study looks at how accurately people can describe their pain and related symptoms. It may help researchers improve how pain is measured in future studies.
Bethesda, MarylandAges 12–120 - NCT02355457Recruiting
Blood marker study in new heart attack symptoms
This study looks at blood “biomarkers” (signals in blood tests) in people who arrive with symptoms that could be a heart attack. It may help doctors spot and manage acute heart problems sooner and more accurately.
HamburgAges 18 years+ - NCT02346396Recruiting
At-home brain stimulation trial for long-lasting nerve pain
This study tests a device that delivers mild electrical stimulation to the brain from home to help reduce chronic nerve pain. It focuses on people whose pain has not improved enough despite stable pain medicines.
BronAges 18–80 - NCT02463266Recruiting
PACE/PACENET program outcomes study for people 65+
This study looks at how well the PACE/PACENET care program works for older adults over time. If you join, you’ll provide consent for a check-in about your outcomes about 3 months after the acute (most intense) phase of care ends, with follow-up around 6 months.
Philadelphia, PennsylvaniaAges 65 years+ - NCT02257723Recruiting
Testing combined Korean herbal and therapy for hospitalized spine or joint pain
This trial studies whether a combined complementary treatment approach helps people who are hospitalized for spine or joint problems. It may help reduce the types of pain that come from those areas.
Seoul, Gangnam-GuAges Any age - NCT02845531RecruitingPhase 4
Defibrillator device vs medicines for a rare heart spasm after arrest
This trial compares an implantable defibrillator device plus best care versus best medicines alone in people who survived a cardiac arrest caused by a specific abnormal heart rhythm. It focuses on variant angina, where a heart-spasm problem can trigger dangerous rhythm events, to see which approach prevents future events.
Bucheon-siAges 18 years+ - NCT02446262Recruiting
Study of how the brain and mind shape pain in healthy adults
This study tests how people sense heat and pain, and how the brain and emotions may influence that experience. It is designed for healthy adults and may involve training sessions and (for some parts) MRI scanning.
Bethesda, MarylandAges 18–50 - NCT02521311RecruitingPhase 2
Clemastine to help restore nerve covering in optic neuritis
This Phase 2 trial tests whether clemastine can help regrow the protective covering around the optic nerve after acute optic neuritis (an inflammation-related vision problem). It may help improve vision recovery and signal how well “remyelination” happens.
San Francisco, CaliforniaAges 18–55 - NCT03382938Recruiting
Dexmedetomidine injected into C-section wounds
This trial studies whether a specific numbing/comfort medicine (dexmedetomidine) injected into the wound area during a C-section can improve recovery or reduce symptoms after surgery. You may be able to take part if you are a low-risk pregnancy and meet safety requirements.
Athens, OtherAges 18–40 - NCT07676422Recruiting
Stress ball use during mouth care
This study tests if squeezing a stress ball during mouth care can help reduce discomfort or stress. You may be able to join if you can follow instructions and don't have any hand or movement issues.
VanAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,764 recruiting pain medicine studies from the U.S. registry right now, out of 6,842 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.