Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT05089994Recruiting
Pain-control injections after bladder surgery
This trial compares two different injection techniques to reduce pain after radical cystectomy (bladder removal surgery). It may help find which approach gives better pain relief with fewer side effects.
AsyutAges 40–70 - NCT05109208Recruiting
Ultrasound check for erection recovery after prostate surgery
This study looks at whether ultrasound imaging can help understand and improve erectile function after prostate removal surgery that aims to protect the nerves. If you’re interested in keeping or improving erections, your ultrasound results may be used to guide follow-up care.
Rochester, MinnesotaAges 40 years+ - NCT05495399Recruiting
Radiation after limited spine surgery for spine metastases
This study tests whether radiation given after limited surgery helps control cancer that has spread to a small area of the spine. It may help reduce tumor growth in the treated spine area and improve local control after operation.
TaipeiAges 20 years+ - NCT04730700Recruiting
Radiofrequency treatment test for facet back pain
This study compares a nerve procedure (radiofrequency “neurotomy” using an expandable electrode) to non-procedure medical care for long-lasting low back pain from facet joints. It aims to see whether the procedure helps more safely than conservative treatment.
Kansas City, KansasAges 18 years+ - NCT05229224Recruiting
Study of a new device for frequent tension headaches
This pilot study tests a device approach (“Osteo-Fluidic-Sensitive”) for people who get frequent episodic tension-type headaches. It aims to see whether the device is safe and can reduce headache burden for the right kind of headache pattern.
PoitiersAges 18–75 - NCT04720846Recruiting
Physical therapy for hip and groin pain without arthritis
This trial studies a categorized physical therapy approach for people with hip impingement and hip/groin pain that is not caused by arthritis. It may help by testing whether a structured PT plan improves pain and function for the right type of hip problem.
New York, New YorkAges 18–60 - NCT04786977Recruiting
Measuring a nerve-related eye signal in children on vincristine
This study checks how children’s pupil responses look while they are receiving vincristine (a cancer medicine). The goal is to learn whether a simple eye measurement can reflect how the body is responding to treatment.
Washington D.C., District of ColumbiaAges 6–18 - NCT04933149Enrolling by invitationPhase 4
Ketamine infusion for nerve pain after shoulder nerve injuries
This trial tests whether a ketamine infusion can reduce nerve-related pain after traumatic brachial plexus (shoulder/arm nerve) injuries. It specifically targets people with pain caused by nerve damage who are scheduled for surgery to repair the nerve.
Rochester, MinnesotaAges 18 years+ - NCT04949087Recruiting
Shoulder arthritis injection study for ongoing pain relief
This trial looks at how well medicine given directly into the shoulder joint reduces pain from primary shoulder osteoarthritis. If you have ongoing shoulder pain confirmed by X-ray, you may be eligible to receive an in-joint injection and be followed for response.
Chicago, IllinoisAges 18 years+ - NCT05024344Recruiting
Nerve block to reduce pain after kidney stone surgery
This trial tests whether an “ESP block” (a targeted local anesthetic injection near nerves) works better than standard care to control pain after percutaneous kidney stone removal. If it helps with pain, it could reduce the need for stronger pain medicines after surgery.
Knoxville, TennesseeAges 18 years+ - NCT04730609RecruitingPhase 4
Dexmedetomidine to reduce shaking during scheduled C-section
This trial tests whether dexmedetomidine, a calming medicine, can reduce unwanted shaking (shivering) during a planned C-section done with spinal anesthesia. It may help make the surgery and recovery more comfortable.
Rochester, MinnesotaAges 18 years+ - NCT05070078Recruiting
Assessing recovery after lumbar disc surgery using SANE
This study uses a simple recovery questionnaire called SANE to understand how people do after lumbar discectomy (surgery to relieve a slipped or herniated disc). It may help the care team measure recovery in a clearer, more consistent way.
Windsor, OntarioAges 18 years+ - NCT04802603Recruiting
Focused spine radiation for limited spread to the spine
This trial tests a stronger, carefully measured form of radiation aimed at a small number of spots where cancer has spread to the spine. It may help control pain and tumor growth while protecting the spinal cord.
Miami, FloridaAges 18 years+ - NCT04752761Recruiting
Digital tracking after knee replacement for people with severe knee arthritis
This study checks whether using digital tools (like a phone app or tablet) can better track patient-reported outcomes after knee replacement, compared with usual outpatient follow-up. It may help improve how symptoms and recovery are monitored, which can guide care.
Bologna, ItaliaAges 18–78 - NCT04095637Recruiting
Compare two types of partial knee replacement surgeries
This study compares two implant types used for a partial knee replacement (only the inside/medial part) for people with “wear-and-tear” arthritis in that compartment. It looks to see which option leads to better outcomes after surgery and follow-up.
LondonAges 40–80 - NCT05862246Recruiting
Kids with foot or leg pain and normal leg function
This trial looks at children who have tightness, foot pain, and/or leg pain, as seen in a pediatric orthopedic clinic. The goal is to study this problem in children who otherwise seem healthy and do not have signs of a different underlying foot or medical condition.
TrondheimAges 4–16 - NCT04454203RecruitingPhase 4
Local anesthetic catheter to reduce tourniquet-related blood pressure spikes
This Phase 4 trial tests whether a local anesthetic catheter placed near a nerve and artery can prevent high blood pressure caused by a tourniquet during total ankle replacement surgery. If it works, it may make recovery safer and more comfortable for some patients.
Durham, North CarolinaAges 18–75 - NCT05421416RecruitingPhase 2
Loratadine to prevent bone pain after stem cell transplant treatment
This trial tests loratadine (an allergy medicine) to see if it can prevent bone pain caused by a growth-factor injection used during lymphoma or multiple myeloma treatment. It may help reduce pain around the time you get that injection and your upcoming stem cell transplant.
Edmonton, AlbertaAges 18 years+ - NCT05589701Recruiting
Compare two radiation plans for painful spinal cancer spread
This study compares two different radiation approaches—SBRT and CRT—for people with painful cancer that has spread to the spine. It may help determine which plan controls pain and tumor growth while limiting side effects to nearby organs.
Toronto, OntarioAges 18–100 - NCT04575688Enrolling by invitationPhase 4
Nerve-block injection options for ankle or heel surgery
This trial compares two methods of numbing pain—an injection near the joint versus a nerve block—during ankle or hindfoot surgery. It aims to see which approach helps with comfort and recovery after surgery.
Germantown, TennesseeAges 18–80 - NCT04270617Recruiting
Yoga practice for long-term back pain
This study looks at whether regular yoga helps people with chronic (long-lasting) back pain. If you can safely take part in yoga sessions and your pain has lasted at least 3 months, you may be able to enroll.
New York, New YorkAges 18 years+ - NCT03968614Recruiting
Needling plus exercises for Achilles tendon pain
This trial studies whether electrical “deep needling” (a clinician inserts very thin needles and uses electricity) added to stretching and exercises can reduce Achilles tendon pain. It’s mainly for people with Achilles tendinopathy that started at least 3 months ago.
Columbia, South CarolinaAges 18 years+ - NCT04312880Enrolling by invitationPhase 4
Tranexamic acid during elective back surgery to reduce bleeding
This trial studies whether giving tranexamic acid (a medicine that helps reduce bleeding) during planned lower-back decompression surgery can lower blood loss or related complications. It compares patients who receive the infusion during surgery to those who meet study procedures and safety requirements.
Albany, New YorkAges 18–80 - NCT04104412RecruitingPhase 1
Stem cell injection study for long-lasting disc back pain
This Phase 1 study tests the safety and early effectiveness of an umbilical cord stem cell injection for people with persistent lumbar (lower back) disc-related pain that has not improved with standard care. If you qualify, it may offer a new treatment option, while researchers closely monitor side effects and pain changes.
Beijing, Beijing MunicipalityAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.