Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT05861609Recruiting
Tapering pain meds for nerve pain after spinal cord stimulation
This study helps people with persistent nerve pain in the low back or legs who are planned to start spinal cord stimulation (SCS). It tests a careful plan to reduce (taper) opioid pain medicines using specific replacement medicines, while monitoring safety and pain control.
JetteAges 18 years+ - NCT05484635Recruiting
Test removing mesh versus leaving it for groin pain
This study compares removing the pre-surgery mesh versus not removing it in people who have long-lasting groin pain after inguinal hernia repair. It may help doctors learn which approach best reduces ongoing pain.
Cleveland, OhioAges 18 years+ - NCT03571334RecruitingPhase 2
Botox injections for nerve pain after chemotherapy in breast cancer
This trial studies whether botulinum toxin A (Botox) injections can reduce nerve pain caused by chemotherapy in people with breast cancer. It may help if your pain started soon after chemotherapy and fits the trial’s specific nerve-pain pattern.
Milwaukee, WisconsinAges 18 years+ - NCT03513731Recruiting
Regenerative fat cell injection for facet joint arthritis pain
This trial tests whether injecting regenerative cells made from your body’s fat can reduce pain from facet joint osteoarthritis in the low back. It focuses on people whose pain has lasted months and did not improve with standard care, after a positive diagnostic injection test.
Deerfield Beach, FloridaAges 18–75 - NCT03380195Recruiting
Watermelon juice study on heart recovery and muscle soreness
This study tests whether drinking watermelon juice affects how quickly your heart rate returns to normal after exercise and how sore your muscles feel afterward. It’s for generally healthy adults and may help researchers understand how diet changes exercise recovery.
San Diego, CaliforniaAges 21–50 - NCT05354869Recruiting
Electrical stimulation therapy for pelvic floor muscle pain
This trial tests a treatment that uses gentle electrical stimulation through the vagina to reduce long-term pelvic pain caused by tight pelvic floor muscles. You might join if your pain has lasted over 6 months and exam shows specific muscle “trigger points.”
Los Angeles, CaliforniaAges 18–65 - NCT05127005Recruiting
Compare thumb arthritis surgery versus placebo surgery
This study compares a real thumb basal joint surgery (trapeziectomy) with a sham/placebo operation to see which option helps pain and daily function better. It is for people with thumb arthritis who have tried non-surgical treatments but still have significant thumb pain.
HelsinkiAges 45 years+ - NCT01344200RecruitingPhase 2
Celecoxib drug study in children on leukemia treatment
This trial studies how celecoxib moves through a child’s body and how much reaches the fluid around the brain and spinal cord. It’s for children (age 2–12) who are in the maintenance phase of certain blood cancers, to better understand dosing and safety.
Ottawa, OntarioAges 2–12 - NCT05265000Recruiting
Skin electrical stimulation for chronic low back pain
This study tests whether a gentle electrical treatment placed on the skin near the spine can reduce chronic low back pain. If you qualify, you’ll try the stimulation and complete several assessments over a day, so the team can measure any pain and function changes.
San Francisco, CaliforniaAges 21–85 - NCT05604066Enrolling by invitation
MRI scan to study muscle pain stiffness in low back or leg
This study uses a special MRI scan (magnetic resonance elastography) to measure how stiff muscles are in people with long-lasting low back or leg muscle pain. It may help researchers better understand myofascial pain—pain caused by tight, tender spots in muscle.
Rochester, MinnesotaAges 18 years+ - NCT04733599Recruiting
Spinal cord stimulation for long-term arm nerve pain
This trial tests whether a high-frequency spinal cord stimulator can reduce long-term nerve pain in the arm after a brachial plexus injury. It may help people whose pain has lasted at least 3 months despite standard treatments.
Jacksonville, FloridaAges 18 years+ - NCT04497220Recruiting
First-time epidural in pregnancy: poke versus placebo
This trial tests whether a “poke” (an added procedure or treatment) works better than a placebo to help with pain control for people getting an epidural for the first time during pregnancy. It’s mainly looking at whether the added approach is helpful and safe for first-time epidural patients.
Minneapolis, MinnesotaAges 18 years+ - NCT03808584Recruiting
Core muscle training after abdominal surgery to reduce hernia and pain
This study tests whether guided “core” muscle training after abdominal surgery can lower the chance of developing an incisional hernia and reduce pain. You may be eligible if you’re having abdominal surgery and can safely do the study exercise plan.
KoblenzAges 18 years+ - NCT04490031RecruitingPhase 4
Ketamine sedation for ERCP procedure
This trial tests whether using ketamine as a sleep/sedation medicine during ERCP (a scope procedure to check/clear bile or pancreatic ducts) is safe and effective. If you’re scheduled for ERCP and can consent, this study may help doctors improve sedation options for patients like you.
Bandar Tun Razak, Kuala LumpurAges 16 years+ - NCT04218617RecruitingPhase 2
One vs two radiation treatments for spine metastases
This trial tests whether giving radiation to a spine metastasis in one dose works as well as giving it in two smaller doses. It aims to control tumors while keeping side effects and risk to the spinal cord low.
Cleveland, OhioAges 18 years+ - NCT04548375Recruiting
Registry study of pain relief from spinal cord stimulation
This is an observational registry that follows people who have a spinal cord stimulation (SCS) implant for approved pain-related conditions. It aims to learn how well SCS works in real-world care, which may help improve treatment and outcomes over time.
Reno, NevadaAges Any age - NCT04658628Recruiting
Brain scan study to learn who responds to spinal cord stimulation
This trial uses brain imaging to understand which people with long-lasting low back pain are more likely to benefit from spinal cord stimulation (SCS). If you’re being considered for an SCS trial, the scans may help researchers predict response and improve future care.
Los Angeles, CaliforniaAges 21 years+ - NCT04628429Recruiting
Study CGRP blocker effects on migraine and body nerve function
This study tests a CGRP-blocking antibody to see how it affects migraine symptoms and the body’s automatic (involuntary) nerve functions. It may help people with migraine who have already tried several preventive medicines.
ViennaAges 18–64 - NCT04085406Recruiting
Deep brain stimulation for hard-to-treat low back pain
This trial studies deep brain stimulation (DBS) to reduce severe low back pain that hasn’t improved after many standard treatments and procedures. It may help people whose pain is long-lasting and not fixable with another surgery.
Los Angeles, CaliforniaAges 40–75 - NCT05327972RecruitingPhase 2
Botox injections for painful degenerative rotator cuff disease
This Phase 2 study tests whether botulinum toxin (Botox) injections can reduce pain from long-lasting degenerative rotator cuff problems. You may be eligible if you have shoulder pain for over a month and ultrasound evidence of specific tendon irritation.
Paris, ParisAges 41 years+ - NCT06841822Recruiting
Nerve blocks for lung surgery: a study on heart function
This trial tests if a special ultrasound-guided nerve block can help keep your heart and blood pressure stable during the start of lung surgery. It may lead to a safer and more comfortable experience.
Nanjing, JiangsuAges 18 years+ - NCT04260165Recruiting
Wrist surgery options for certain wrist arthritis
This trial compares two types of wrist surgery for osteoarthritis in the wrist bones (SLAC/SNAC stage II–III). It may help you and your surgeon choose the procedure that best improves pain and wrist function for your specific wrist arthritis pattern.
HelsinkiAges 18–75 - NCT04546230Recruiting
Epidural anesthesia for keyhole kidney removal surgery
This trial studies using a small-needle spinal/epidural type pain medicine delivered to your back during a keyhole kidney removal. It may help control pain and reduce the need for stronger pain medicines during and after surgery.
CairoAges 18–70 - NCT04458584Recruiting
Thumb surgery trial comparing treatments for basal joint arthritis
This study looks at how well different thumb (basal joint) surgery approaches restore strength and function. You would be having planned (non-replacement) thumb surgery, and your chosen surgeon would care for you while researchers compare outcomes.
Lebanon, New HampshireAges 21 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.