Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07203456Recruiting
Teaching dental students about jaw pain
This trial tests different ways to teach dental students about temporomandibular disorders (jaw pain conditions). It aims to find the best teaching method so future dentists can better help patients with jaw pain.
Downers Grove, IllinoisAges 18 years+ - NCT07240961Recruiting
Nerve block for pain after hip replacement
This study tests whether a nerve block injection in the back (called an erector spinae plane block) can provide better pain relief after a first-time hip replacement. It may help reduce the need for strong painkillers.
ManoubaAges 18–85 - NCT06262893Recruiting
Comparing nerve blocks for shoulder surgery
This study compares two types of nerve blocks for pain relief during shoulder surgery. It tests whether adding a common steroid (dexamethasone) to one block improves pain control.
AsyutAges 18–75 - NCT06660680Enrolling by invitationPhase 3
Methylene blue for pain after hemorrhoid surgery
This trial tests whether injecting methylene blue (a dye) into the area around the anus during hemorrhoid surgery can reduce pain after the operation. If you are having Milligan-Morgan surgery for mixed hemorrhoids, this study may help find a way to make your recovery more comfortable.
Hefei, AnhuiAges 18–75 - NCT07301632RecruitingPhase 2
MDMA for severe chronic nerve pain
This trial tests if MDMA, combined with psychotherapy, can help people with severe chronic nerve pain that hasn't improved with standard treatments. You'll receive either MDMA or a placebo to see if it safely reduces pain and improves your quality of life.
Toronto, OntarioAges 18 years+ - NCT06198010Recruiting
Managing cancer pain better for survivors
This study tests a new way to help cancer survivors manage pain that started or got worse after their diagnosis. It's for people who rate their pain as 5 or higher on a 0-10 scale and live in rural areas or identify as Hispanic.
Scottsdale, ArizonaAges 18 years+ - NCT06999460Recruiting
Shoulder block for pain relief during shoulder surgery
This trial tests if a nerve block near the shoulder blade can reduce pain before, during, and after shoulder surgery. It may help patients need less pain medicine and feel more comfortable.
Zagazig, EgyptAges 21–65 - NCT07198919Enrolling by invitationPhase 1/Phase 2
Pain relief during root canal for infected tooth: gel vs. antibiotic paste
This trial compares two medicines placed inside a tooth after root canal cleaning to see which reduces pain better between appointments. If you have an infected single-root tooth and are between 16-45 years old, you may be able to join.
Karachi, SindhAges 16–45 - NCT06182943Recruiting
Electroacupuncture for recent mild to moderate ankle sprains
This study tests whether a type of acupuncture with mild electrical current (electroacupuncture) can help heal a fresh, mild-to-moderate ankle sprain. You may be eligible if you sprained your ankle within the last 48 hours, have no broken bones, and do not have serious health issues.
Hangzhou, ZhejiangAges 18–60 - NCT04044820Recruiting
Help after outpatient hand and forearm surgery with opioid use
This study looks at how opioid (pain medicine) use should be managed after you go home following outpatient hand and forearm surgery. It may help you avoid using more opioid than needed while still controlling pain.
Toronto, OntarioAges 18 years+ - NCT07648784Recruiting
Pain Relief Comparison for Lower Leg Surgery
This trial tests different combinations of two numbing medicines (lidocaine and bupivacaine) given through the spine to manage pain during lower limb surgery. The goal is to find which mixture works best and lasts longest.
Karachi, SindhAges 20–60 - NCT06171204Recruiting
Knee arthritis treatment with your own cells
This trial tests a treatment using your own cells (stromal vascular fraction) to repair knee joint damage and reduce pain. It may help people with knee arthritis, tendon injuries, or persistent knee pain.
Ghent, Oost-VlaanderenAges 18–90 - NCT07295054RecruitingPhase 4
Inhaled pain relief for IUD insertion
This trial tests a drug called methoxyflurane, which you inhale through a small handheld device, to see if it reduces pain during IUD insertion. It may be an option for people who want extra pain control during the procedure.
Toronto, OntarioAges 18–55 - NCT06165991RecruitingPhase 4
Comparing two types of numbing medicine for lung surgery pain
This trial compares two forms of a numbing medicine (bupivacaine) injected near the spine to reduce pain after lung surgery. It aims to find which works better for controlling pain after a lobectomy (removal of a lung lobe).
Jinan, ShandongAges 18 years+ - NCT06162403Recruiting
Nerve stimulation for chemo-related leg pain
This study tests whether a small device that sends gentle electrical pulses to nerves in your leg can relieve pain caused by chemotherapy. If you have ongoing nerve pain in your legs from past chemo, this treatment might offer a new way to manage it.
Houston, TexasAges 18–85 - NCT07219472Recruiting
Scrambler therapy for nerve pain from chemotherapy
This trial tests a non-invasive treatment called Scrambler Therapy for pain caused by nerve damage from chemotherapy. If you have had this kind of pain for at least 3 months, this therapy might help reduce it without using more drugs.
Cleveland, OhioAges 18 years+ - NCT06154694Recruiting
Shoulder joint patterns in arthritis patients
This study looks at how shoulder arthritis affects joint movement patterns. It compares patients with arthritis, healthy volunteers, and people who had a shoulder replacement that later needed a revision.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06716294Recruiting
Radiofrequency ablation and stabilization for spine tumors
This trial tests a treatment that uses heat to destroy active spine tumors from cancer that has spread, followed by stabilizing the bone. It aims to see if the treatment works by using a special scan (PET-CT) to confirm the results.
Athens, AthensAges 18–90 - NCT07061782Recruiting
Neck stretching techniques for IT workers with upper cross syndrome
This trial compares two types of stretching exercises to see which one helps reduce neck and shoulder pain in IT professionals with upper cross syndrome. It may help you move better and feel less pain from long hours at the computer.
IslamabadAges 20–40 - NCT06562933Recruiting
Comparing electrical stimulation methods for chronic neck pain
This study compares two ways of using a type of electrical stimulation (interferential current) to treat long-term neck pain. It aims to find which method works better for people with chronic neck pain.
BoluAges 20–50 - NCT06097533RecruitingPhase 2
Cannabinoids to improve quality of life in cancer patients
This trial tests if a cannabinoid (a compound from the cannabis plant) can improve quality of life and reduce pain in people receiving palliative cancer care. It is for patients who have moderate to severe symptoms like pain and nutrition problems.
Hamburg, Free and Hanseatic City of HamburgAges 25 years+ - NCT07244913Recruiting
Tools for chronic low back pain relief
This trial compares two types of handheld tools—one with metal instruments and one that uses sound waves—to see which works better for long-term low back pain. It may help if you have had pain for at least 6 months and feel tightness in your hamstrings.
Lahore, Punjab ProvinceAges 40–55 - NCT06355414RecruitingPhase 1
Psilocybin for chronic back pain and depression
This trial tests if psilocybin, a psychedelic drug, can help people with long-term low back pain who also have depression. If you qualify, you'll receive psilocybin in a controlled setting, and researchers will see how it affects your pain and mood.
Baltimore, MarylandAges 21–80 - NCT07571473Recruiting
Monitoring stress during abdominal hysterectomy surgery
This study tests a new monitoring system called CoreSys that tracks your body's stress response during abdominal hysterectomy (surgical removal of the uterus). The goal is to help doctors better manage pain and stress during your operation.
Rosario, Santa Fe ProvinceAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.