Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07477860RecruitingPhase 1
Achilles tendon pain treatment trial
This trial tests a minimally invasive treatment for chronic Achilles tendon pain that hasn't improved with at least 3 months of rest, therapy, or other non-surgical care. It aims to help people who want to avoid surgery.
Libertyville, IllinoisAges 25–80 - NCT06780904Recruiting
Dry needling plus stretching for neck pain relief
This study tests if combining dry needling with gentle stretching or muscle energy techniques works better for treating neck pain caused by muscle knots (trigger points). It aims to find a simple, effective way to reduce pain and improve movement.
Kandy, Central ProvinceAges 18–60 - NCT06779578Recruiting
Comparing two types of radiofrequency for trigeminal neuralgia
This study compares two treatments (bipolar vs monopolar pulsed radiofrequency) for people with trigeminal neuralgia that hasn't improved with medication. It aims to see which method provides better pain relief.
AlexandriaAges Any age - NCT07478289RecruitingPhase 2
Radiation boost for painful spinal metastases
This trial tests a higher dose of radiation (a boost) to painful spots in the spine where cancer has spread. The goal is to see if it can better relieve pain and improve function.
Toronto, OntarioAges 18 years+ - NCT07473609Recruiting
Studying epidurals that don't work well during labor
This study looks at epidurals that don't work well during labor. It aims to understand why some epidurals fail, which could help improve pain relief for mothers.
MadridAges 18 years+ - NCT07474662Recruiting
Online vs. in-person physiotherapy for jaw muscle pain
This trial compares online physiotherapy sessions with face-to-face visits to see which works better for treating jaw muscle pain (myalgia). It aims to find a more convenient way to get care for this common condition.
Budapest, Pest CountyAges 18 years+ - NCT07474896Recruiting
Nerve-block techniques for shoulder surgery in older adults
This study tests whether certain nerve-block techniques for shoulder surgery can reduce side effects while still controlling pain. It is for people 65 and older having planned shoulder surgery with regional anesthesia.
PoznanAges 65–100 - NCT07472842Recruiting
Study on outcomes for endometriosis in emergency care
This study follows women who come to a specific hospital's emergency department with known endometriosis or symptoms that might be endometriosis, to learn more about their health outcomes over time.
CréteilAges 18 years+ - NCT07473206Recruiting
Laughing gas for pain during office hysteroscopy
This study tests whether using laughing gas (nitrous oxide) plus a calming video on a screen can reduce pain and anxiety during a quick procedure to look inside the uterus (hysteroscopy). If you are having this procedure, the trial may help you feel more comfortable.
BiellaAges 25–60 - NCT07472959RecruitingPhase 4
Morphine for pain after heart bypass surgery
This study tests whether giving morphine during coronary artery bypass surgery can help control pain after the operation. It is for people having planned heart bypass surgery who are moderately sick and not already on strong pain medicines.
Istanbul, Outside of the USAges 18–80 - NCT07479199Recruiting
Radiofrequency ablation and radiation for painful spine tumors
This trial tests a treatment that uses heat (radiofrequency ablation) and radiation to relieve pain from tumors in the spine. It may help if you have cancer that has spread to your upper or lower back and you have moderate to severe pain.
Chapel Hill, North CarolinaAges 18 years+ - NCT07480304Enrolling by invitation
Dexmedetomidine mist for stable breathing tube placement
This trial tests if a medication called dexmedetomidine (given as a mist through a nebulizer) can help keep your heart rate and blood pressure steady when a breathing tube is placed for surgery. It may be an option for people having planned surgery who want a smoother experience.
Karachi, SindhAges 18–65 - NCT07479082Recruiting
Ear nerve stimulation for headache after aneurysm coiling
This trial tests whether a gentle electrical device placed on your ear (called transcutaneous auricular vagus nerve stimulation) can help prevent or reduce headaches that sometimes happen after a procedure to treat an unruptured brain aneurysm. If you're scheduled for stent-assisted coiling or flow diverter treatment, this study may offer a non-drug option to manage post-surgery pain.
Beijing, Beijing MunicipalityAges 18–80 - NCT07472296Recruiting
Comparing nerve blocks for heart surgery pain relief
This trial compares different types of nerve blocks to see which works best for managing pain after heart surgery through the breastbone. It may help reduce the need for strong pain medications.
Bursa, NilüferAges 18–80 - NCT07477847Enrolling by invitation
Custom exercise for back pain, posture, and quality of life
This study tests a personalized exercise program to see if it reduces back pain, improves posture (kyphosis angle), and boosts quality of life. It may help if you have nonspecific back pain and haven't been exercising regularly.
IstanbulAges 18–45 - NCT07478614Recruiting
Study of treatments for adenomyosis pain and heavy bleeding
This study follows people with adenomyosis to see which treatments work best for pain and heavy bleeding. It may help doctors find better ways to manage symptoms.
PotenzaAges 20–50 - NCT07474610Recruiting
Belly muscle and arm function in chronic low back pain
This study looks at how a deep belly muscle (transversus abdominis) relates to arm and shoulder function in people with long-term low back pain. It may help understand why some people have trouble with upper body movements.
AnkaraAges 18–45 - NCT07479602RecruitingPhase 4
Medicine via nose for less pain after tonsil surgery in kids
This trial tests whether giving two medicines (dexmedetomidine and esketamine) through the nose can help children ages 3-7 have less pain after their tonsil or adenoid surgery. The goal is to find a better way to manage pain without using strong drugs.
Beijing, Beijing MunicipalityAges 3–7 - NCT06781554Recruiting
Collagen device for thumb arthritis
This trial tests a new collagen-based medical device injected into the thumb joint to treat thumb base arthritis (rhizarthrosis). It aims to see if it safely reduces pain and improves hand function without surgery.
Milan, MIAges 18–75 - NCT05736744RecruitingPhase 2/Phase 3
Magnesium before surgery in children to reduce complications
This study tests whether giving magnesium before planned (elective) keyhole abdominal surgery can improve outcomes in children. It may help reduce problems related to anesthesia and muscle function during and after surgery.
Asyut, Assiut GovernorateAges 2–12 - NCT06044584Recruiting
AI tool for tracking pain after injury or nerve pain
This study tests a smartphone-based tool that uses artificial intelligence to track your pain and how it affects your daily life. It may help you and your doctor better understand your pain over time.
Pietra Ligure, SavonaAges 18–80 - NCT04729686RecruitingPhase 4
Nerve block during hip replacement for less postoperative pain
This trial tests whether a specific nerve block given during planned hip replacement surgery can reduce pain afterward. It may help you use less opioid pain medicine, but you must meet certain safety and medication criteria.
Baltimore, MarylandAges 18–80 - NCT05819476Recruiting
Testing how open-label placebos affect induced pain
This study tests whether people can feel less pain when they know they are receiving a “placebo” (a treatment with no active pain-relieving medicine). It’s done in healthy adults by triggering short-lasting pain in a controlled way to see how the placebo effect changes pain feelings.
BaselAges 18–65 - NCT06763653Recruiting
Low-frequency device for chronic low back pain
This trial tests a new device that uses very low-frequency electrical pulses to treat chronic low back pain. It is for people whose pain hasn't improved with other treatments and who are not candidates for stronger therapies.
Norwood, South AustraliaAges 22 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.