Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06104059Recruiting
Pain management during planned laparoscopic surgery
This trial tests a new way to monitor pain during laparoscopic surgery. It may help your doctor adjust pain medicines to keep you comfortable.
Athens, AtticaAges 18–70 - NCT05598723RecruitingPhase 3
Botox versus Xeomin for chronic migraine in adults
This Phase 3 study compares two headache injections—Botox and Xeomin—for people with chronic migraine. It may help find out which option works better to reduce frequent, long-lasting migraine days.
Jacksonville, North CarolinaAges 18–89 - NCT06143306RecruitingPhase 4
Adding a second numbing shot for shoulder replacement pain
This study tests whether adding an extra numbing shot (pectoserratus block) to the standard shoulder block reduces pain after total shoulder replacement. It may help you recover more comfortably and use fewer pain medicines.
Minneapolis, MinnesotaAges 18–85 - NCT07732062Recruiting
Emotion-focused therapy for chronic pain patients using medical cannabis
This study tests a new type of talking therapy (vEAET-H) to see if it helps people with chronic pain who are already using medical cannabis. The goal is to find out if adding this therapy can improve pain and well-being.
Tel AvivAges 18 years+ - NCT04633655Recruiting
Study tests nerve side effects from certain chemotherapy drugs
This study looks at how chemotherapy that can affect nerves (“neurotoxic” chemo) changes nerve function over time. It may help researchers better measure nerve side effects and improve care for people who need these cancer treatments.
Birmingham, AlabamaAges 18 years+ - NCT07123402Enrolling by invitationPhase 2
TRD205 for chronic pain after surgery
This trial tests a new tablet called TRD205 for people who have had long-lasting nerve pain after surgery (at least 3 months). The goal is to see if it can reduce pain safely.
BeijingAges 18–80 - NCT07732036Recruiting
Inhalation aromatherapy during wound cleaning for leg ulcers
This study tests whether breathing in a special aromatherapy scent can help reduce pain and anxiety during a wound cleaning procedure (sharp debridement) for people with venous leg ulcers. It compares the aromatherapy to a placebo (a blank scent) to see if it makes the procedure more comfortable.
SingaporeAges 21–21 - NCT07731269Enrolling by invitation
Kinesiology taping for acute low back pain
This study tests if kinesiology tape (a special stretchy tape placed on the skin) can help relieve pain and improve movement in people with sudden, short-term low back pain. It may be an option if your pain just started and you haven't had long-term back issues.
IstanbulAges 18–50 - NCT05916235Recruiting
Laser light treatment for jaw pain from TMJ disorder
This trial tests whether a specific type of light therapy (called photobiomodulation/laser) can reduce pain from temporomandibular disorder (TMJ) affecting the jaw muscles. If you have jaw muscle pain for at least 3 months, the study will compare your symptoms while you follow the treatment and diary requirements.
Gainesville, FloridaAges 18–99 - NCT06784999RecruitingPhase 4
Pain relief after head and neck reconstructive surgery
This study compares two medicines, sufentanil and methadone, for pain control after head and neck surgery that uses a flap to rebuild tissue. The goal is to find which option works better and has fewer side effects.
Indianapolis, IndianaAges 18–80 - NCT07409012Recruiting
Pain assessment tool for cesarean delivery patients
This study is developing a new questionnaire to better measure pain after cesarean section. If you had a planned or unplanned cesarean with spinal or epidural anesthesia in the last 2-3 days and speak German or Swiss German, you may help improve how pain is assessed for future mothers.
Basel, Canton of Basel-CityAges 18 years+ - NCT07558226Recruiting
Pain management approaches for robotic kidney removal surgery
This study tests different combinations of pain medications during robotic surgery to remove all or part of a kidney due to cancer. The goal is to find the best way to control pain while keeping you comfortable and allowing you to go home the same day or next day.
Barcelona, BARCELONAAges 18 years+ - NCT07417462Recruiting
Pain relief after heart surgery to help you recover faster
This trial tests a combination of pain medicines given during cardiac surgery to reduce pain and speed up recovery. It may help patients who are having a first-time bypass surgery through a standard breastbone incision.
AsyutAges 40–60 - NCT07711041Recruiting
Comparing three treatments for chronic neck pain
This trial compares three therapies—integrated neuromuscular inhibition, dry cupping, and dry needling—to see which works best for long-lasting mechanical neck pain. It may help if you have had neck pain for over six months with trigger points in your upper shoulder muscle.
GizaAges 18–40 - NCT07697560RecruitingPhase 1
Safety of AH-008 in healthy volunteers
This trial tests a new medicine called AH-008 in healthy people to see if it's safe and how the body processes it. It is a first-in-human study with a single dose.
Salt Lake City, UtahAges 18–65 - NCT07671950Recruiting
Deep brain stimulation for neuropathic dental pain
This trial studies whether deep brain stimulation (DBS) can help people with a type of nerve-related tooth pain called atypical odontalgia. It is for those who have not found relief from standard treatments like medications or injections.
Vancouver, British ColumbiaAges 19–80 - NCT07638280Recruiting
How Non-Drug Factors Affect Spinal Block Numbing Duration
This study looks at how non-medication factors—like body position, temperature, or movement—might change how long spinal anesthesia (numbing medicine injected into your spine) lasts during lower abdominal surgery. Understanding these factors could help doctors predict and optimize numbing for your procedure.
IstanbulAges 18–80 - NCT07626463Recruiting
Local anesthetic injection to reduce pain after laparoscopic surgery
This trial tests whether injecting a local anesthetic (numbing medicine) and a steroid around the surgical area before surgery reduces pain after laparoscopic procedures like gallbladder, appendix, or hernia repair. The goal is to help patients recover more comfortably with potentially less pain medication needed.
Beijing, Beijing MunicipalityAges 18–64 - NCT07646899Recruiting
Unstable Loads and Shoulder Movement in Overhead Athletes
This study investigates how using unstable equipment (like a wobbly barbell) affects shoulder blade movement and muscle use during overhead pressing in athletes with shoulder impingement pain. The goal is to understand whether unstable loads might help improve shoulder mechanics and reduce pain in overhead athletes.
TaipeiAges 18–40 - NCT07641842Recruiting
Shoulder Surgery Nerve Block Pain Relief Study
This study looks at how well a single nerve-numbing injection (injected near nerves in your shoulder) works to control pain during outpatient arthroscopic shoulder surgery. Researchers want to understand your pain relief experience before, during, and after the procedure.
Toronto, OntarioAges 18 years+ - NCT07618650Enrolling by invitation
Pain Relief Blocks for Children After Appendix Surgery
This study compares two different injection techniques to reduce pain after appendix removal surgery in children ages 7–12. Both techniques use ultrasound (sound waves) to guide a numbing medication to nerves near the surgical area, and researchers want to see which works better.
TantaAges 7–12 - NCT07620002Recruiting
Monitoring Pain Levels During Arm Surgery With Nerve Block
This study tests a device that measures pain levels during upper arm surgery when patients receive a nerve block (numbing medicine injected near the nerve). The goal is to understand if this monitoring tool helps doctors give the right amount of anesthesia so patients stay comfortable.
HaifaAges 18 years+ - NCT07627308Recruiting
Ultrasound vs Fluoroscopy for Nerve Injections in Back Pain
This trial compares two imaging methods—ultrasound and fluoroscopy (X-ray)—to guide nerve injections for leg pain caused by compressed nerves in the lower back. The goal is to see which method is safer and more effective at relieving your pain.
Tanta, Gharbia GovernorateAges 18–75 - NCT07645859Recruiting
High-Intensity vs. Moderate Exercise for Chronic Lower Back Pain
This trial compares two types of exercise programs—one with short, intense bursts of activity and one with steady, moderate activity—to see which works better for people with long-lasting lower back pain that has no clear medical cause. You would participate in supervised exercise sessions over several weeks.
KarachiAges 20–48
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.