Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT05563792Recruiting
Non-drug options for managing chronic pain
This study tests non-drug treatments for chronic pain in the back, neck, or joints. It aims to help people manage pain and improve daily function without relying on medications.
Indianapolis, IndianaAges 18 years+ - NCT06518720RecruitingPhase 2
Psilocybin for Chronic Nerve Pain and Depression
This trial tests whether psilocybin (a psychedelic medication) can help people who have both chronic nerve pain and depression that hasn't responded to standard treatments. The goal is to see if it can reduce pain and improve mood.
Toronto, OntarioAges 18–65 - NCT07716566Recruiting
Nerve block for pain after kidney transplant
This trial tests a nerve block called a quadroiliac plane block to see if it helps control pain after kidney transplant surgery. If you are having a kidney transplant, this study might help reduce your pain and need for pain medication.
Istanbul, IstanbulAges 18–80 - NCT07733583Recruiting
Pelvic floor therapy and exercise for endometriosis pain
This study tests whether a special type of physical therapy (pelvic floor therapy) combined with exercise can help reduce chronic pelvic pain in women with endometriosis. It aims to see if these treatments improve pain, daily function, and quality of life.
Porto Alegre, Rio Grande do SulAges 18–45 - NCT07732764Recruiting
TENS for Pain After Chest Surgery
This trial tests if a mild electrical therapy (TENS) can reduce pain after chest surgery. It may help you need less pain medicine and feel better during recovery.
Kaohsiung City, Kaohsiung CityAges 15–85 - NCT07732556Recruiting
Nerve block comparison for shingles pain relief
This trial compares two different nerve blocks (MTP and ESP) to see which works better for treating shingles pain in the chest or back. It could help you if you have moderate to severe shingles pain that started within the last 30 days.
Tanta, El-GharbiaAges 21–60 - NCT03581318Recruiting
Heart MRI study for people with and without heart disease
This study uses magnetic resonance imaging (MRI) to take detailed pictures of the heart. It aims to improve how doctors use heart MRI to diagnose and manage heart conditions.
Bethesda, MarylandAges 7–100 - NCT07733128Recruiting
Pain relief with buprenorphine patch after lung surgery
This study tests a skin patch that releases buprenorphine, a pain medicine, to control pain after lung surgery. It may help reduce pain and the need for other pain medicines.
Santiago, Santiago MetropolitanAges 18 years+ - NCT07733752Recruiting
AI symptom-checking for spine pain in physical therapy
This trial tests if a computer tool that checks your symptoms before a visit can help you and your physical therapist make better decisions about your spine care. It is for adults with neck, mid-back, or low back pain (with or without leg pain) who are starting physical therapy.
AsyutAges 18 years+ - NCT04371445RecruitingPhase 4
Dextenza drops after eye surgery to reduce post-op pain
This trial studies whether Dextenza (a steroid pain-relief eye insert) can improve comfort after a specific type of retina surgery (pars plana vitrectomy). It looks at people getting surgery for conditions like macular hole, epiretinal membrane, or vitreomacular traction.
Cleveland, OhioAges 18 years+ - NCT07388368Recruiting
Root canal pain study: comparing two tooth fillings
This study compares two types of fillings used after a root canal to see which one causes less pain afterward. If you have a tooth with severe, constant pain that needs a root canal, this trial may help find the best option for you.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT07386548Recruiting
Biologic injection for low back disc problems
This study tests if an injection can help people with a herniated disc in the lower back who have not gotten better with other treatments and are already planning surgery. It aims to see if the injection can reduce symptoms and possibly avoid or improve surgery outcomes.
Manhattan, New YorkAges 18 years+ - NCT06984796Enrolling by invitation
Light therapy for pain during IUD insertion
This study tests if light therapy (photobiomodulation) can reduce pain when an IUD is inserted. It might help women who are anxious about pain during the procedure.
São PauloAges 18–50 - NCT07104825Recruiting
Nerve block for pain after weight loss surgery
This trial tests if a nerve block can help control pain after gastric bypass or sleeve gastrectomy. The goal is to reduce the need for strong pain medicines and improve recovery.
Evanston, IllinoisAges 18–90 - NCT07731295Recruiting
Pain management study for teens getting wisdom teeth removed
This study looks at how to improve pain management after wisdom tooth extraction. It focuses on teens and young adults who use cannabis regularly, to see how it affects pain and recovery.
Providence, Rhode IslandAges 15–20 - NCT07729774Recruiting
Spray-and-stretch vs. gentle pressure for back pain
This study compares two hands-on techniques—spray-and-stretch and strain-counterstrain—to see which better relieves nonspecific low back pain. It may help if you have muscle-related back pain without nerve problems or other serious conditions.
Multan, Punjab ProvinceAges 35–50 - NCT07731243Recruiting
Vibration, massage and myofascial release for period pain
This study tests whether combining vibration, massage, and myofascial release (a gentle stretching technique) can help relieve pain from primary dysmenorrhea (period pain without an underlying condition). If you are a woman with regular periods and moderate to severe menstrual pain, this trial may offer a non-drug treatment option.
Istanbul, IstanbulAges 18–30 - NCT07729930Recruiting
Creatine supplement study for healthy middle-aged women
This study is testing a creatine supplement (a substance that may help with energy and muscle function) in healthy middle-aged women. You may join if you are between 35 and 65, a non-smoker, and have a certain activity level.
LoughboroughAges 35–65 - NCT07525063Enrolling by invitation
Brain Stimulation for Fibromyalgia Pain Relief
This study tests whether a non-invasive brain stimulation technique (called TMS) can help reduce pain and improve mood in women with fibromyalgia. Researchers will use MRI scans and brain stimulation to understand how pain and reward circuits in the brain work.
Durham, North CarolinaAges 18 years+ - NCT07275710Recruiting
Alprazolam for tooth pain after root canal
This trial tests if adding alprazolam (a mild anti-anxiety medicine) to standard painkillers can better manage pain after a root canal. It aims to find a more effective way to control post-procedure discomfort.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT07729735Enrolling by invitation
Physiotherapy after breast reduction surgery
This study tests whether adding physical therapy after breast reduction surgery helps you recover faster and feel better. You must be between 18 and 50, have had cosmetic breast reduction, and be free of certain health conditions like arm swelling or nerve problems.
IstanbulAges 18–50 - NCT07729722Enrolling by invitation
Chiropractic vs physiotherapy for chronic neck pain
This study compares two different treatments for people with long-term neck pain: chiropractic care and physical therapy. The goal is to see which approach works better to reduce pain and improve function.
IstanbulAges 18–65 - NCT06851533Recruiting
Pain relief methods for lumbar microsurgery recovery
This trial compares two different types of nerve blocks to see which one reduces the need for strong pain medicine after lumbar microsurgery. It may help patients have better pain control and fewer side effects from opioids.
IstanbulAges 18–80 - NCT06183281Recruiting
Comparing two non-drug approaches for chronic pain
This study compares two different ways to help people manage chronic pain without using medications. Over 12 months, you'll use a smartphone app and learn strategies to feel better and have more control over your pain.
San Francisco, CaliforniaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.