Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06153277Recruiting
Does swelling affect TENS treatment after knee replacement?
This trial studies how swelling (edema) in the knee after replacement surgery might change the way a TENS machine works. TENS is a device that uses mild electrical pulses to help with pain. The results could help doctors set the right TENS level for each patient.
KaramanAges 40 years+ - NCT06848023Enrolling by invitation
Shoulder replacement vs tendon repair in older adults
This study compares how well two different shoulder surgeries—reverse total shoulder replacement and rotator cuff repair—work for people 60 and older, at least one year after the operation. If you meet the age and surgery requirements, your results could help doctors decide which procedure is better for older adults.
Germantown, TennesseeAges 60–95 - NCT07388745Recruiting
Comparing two pain blocks for heart bypass surgery
This study compares two different nerve-block injections (one near the spine, one under the shoulder blade) to see which provides better pain relief after heart bypass surgery. If you are scheduled for a planned bypass and are in reasonably good health, you might be able to join.
KütahyaAges 45–85 - NCT07746973Enrolling by invitation
Magic show to reduce pain and fear during needle procedures
This study tests whether watching a magic show called 'Kuco' during a needle procedure (like getting blood drawn or an IV) helps children aged 5 to 8 feel less pain and fear. If your child needs a needle and can watch the show, they might be eligible to join.
Bingoel, BingölAges 5–8 - NCT07518953Recruiting
Can Music Help With Pain During a Nail Biopsy?
This study tests whether listening to music during a nail biopsy—a small procedure to remove a sample of nail tissue—can reduce pain and anxiety. You would listen to music during the procedure and answer a few questions about how you felt.
New York, New YorkAges 18 years+ - NCT07016581Enrolling by invitation
Best length for a spinal cord stimulation test
This study is testing how long a spinal cord stimulation trial should last to best diagnose whether it will help your chronic pain. It compares different trial lengths to see which one gives the most accurate result.
Baltimore, MarylandAges 18 years+ - NCT07743606Enrolling by invitationPhase 3
Pain medicine after lower back fusion surgery
This study tests whether taking a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen after lumbar spine fusion surgery is safe and helps with pain without affecting bone healing. It may offer an alternative to stronger pain medicines.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06578767Recruiting
Nerve release surgery for pelvic pain
This trial tests if robot-assisted surgery can relieve pain caused by trapped nerves in the pelvic area. It may help people who have not improved with medication.
Bordeaux, GirondeAges 18 years+ - NCT07740967Recruiting
Collagen and omega supplements for middle-aged women
This study tests whether daily collagen and omega-3 supplements can improve health in healthy middle-aged women. You would take the supplements for a period and have your health measured.
LoughboroughAges 35–65 - NCT07743073Recruiting
Ceylon cinnamon for diabetic nerve pain
This study tests whether taking Ceylon cinnamon daily can help lower blood sugar, improve cholesterol, and reduce nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. If you qualify, you might get a natural supplement that could ease your symptoms.
AmmanAges 18 years+ - NCT07742111Recruiting
Virtual reality for long-term low back pain
This study tests whether virtual reality exercises can help people with chronic low back pain feel better and move more comfortably. You might join if you have had low back pain for a while, your pain is moderate, and you have some fear of movement.
AmaranteAges 18 years+ - NCT07742826Recruiting
Platelet-rich fibrin vs. steroids after wisdom tooth removal
This study compares two treatments to reduce pain and swelling after removing an impacted wisdom tooth: one uses a special blood clot (platelet-rich fibrin) placed in the socket, and the other uses steroid medication. The goal is to find which works better for healing and comfort.
NicosiaAges 18 years+ - NCT07742228Recruiting
SCENAR therapy for long-term neck pain
This study tests a device called SCENAR that uses gentle electrical signals to help reduce chronic neck pain. It may be an option for people whose neck pain has lasted at least 3 months and who have not found relief with other treatments.
Suresnes, Île-de-France RegionAges 18–80 - NCT07502157Recruiting
Massage for pain and anxiety during first cancer infusion
This study tests whether massage therapy can help reduce pain and anxiety in people with gynecologic cancer who are getting their first infusion treatment. You may be eligible if you are about to receive your first infusion and haven't had any in the past 2 years.
Lexington, KentuckyAges 18–85 - NCT05864053RecruitingPhase 1/Phase 2
Ketamine medicine trial for chronic nerve pain in adults
This Phase 1/2 study tests hydroxynorketamine (a related ketamine-type medicine) to see if it can reduce chronic nerve pain in the arms or legs. You may be able to join if you have nerve pain for more than 3 months and meet safety and health check requirements.
Chicago, IllinoisAges 18–75 - NCT07740759Enrolling by invitation
Educational videos for pre-surgery anxiety
This trial tests whether watching educational videos before your laparoscopic surgery helps reduce anxiety. It may help you feel more prepared and calm before your procedure.
Farmington, ConnecticutAges 18 years+ - NCT07118332RecruitingEarly Phase 1
Psilocybin for chronic pain in veterans who smoke
This trial tests if psilocybin can help veterans with chronic pain who also smoke cigarettes. You will take psilocybin in a controlled setting to see if it reduces pain and helps with smoking.
West Haven, ConnecticutAges 21–65 - NCT06916403Enrolling by invitation
Ketamine infusions for fibromyalgia pain
This study looks at whether ketamine given through an IV can help reduce fibromyalgia pain. It reviews past treatments and also plans new treatments to see how well they work and how safe they are.
Thornhill, OntarioAges 18 years+ - NCT07738770Recruiting
Comparing two numbing techniques for pain relief after mastectomy
This trial tests two different numbing injections to see which one works better for pain after breast cancer surgery. If you are having a mastectomy, you may be able to join and help find a better way to manage pain.
Jakarta, DKI JakartaAges 18–60 - NCT06596681RecruitingEarly Phase 1
Study of GA for hard-to-treat nerve pain
This early-phase trial tests a new treatment called GA for people with hard-to-treat neuropathic pain that hasn't improved with standard therapies. The goal is to see if it is safe and tolerable.
Beijing, Beijing MunicipalityAges 18–65 - NCT07403929Recruiting
Fermented grape juice for fibromyalgia symptoms
This trial tests whether drinking fermented grape juice can help relieve fibromyalgia symptoms like pain and cramping. If you are a woman between 20 and 40 with mild excess weight and fibromyalgia, you may be eligible.
Istanbul, IstanbulAges 20–40 - NCT06791044Recruiting
Vitamin D and bone health in neurological patients
This trial looks at how vitamin D levels relate to bone strength and daily function in people with neurological disorders. If you have a neurological condition or are healthy, you may join to help understand how vitamin D affects bone health.
Nea Liosia, AthensAges 20–85 - NCT05833048Recruiting
Pain-relief nerve block during cardiac surgery
This study tests whether a numbing “nerve block” placed in the rectus sheath area can reduce pain for people having certain heart surgeries with chest tubes. If you qualify, it may help your comfort during recovery, but it also depends on how suitable you are for local anesthesia.
New York, New YorkAges 18–85 - NCT07736144Recruiting
Herbal formula study for fibromyalgia pain relief
This study tests a Chinese herbal formula called Yangyin Roujin (which nourishes yin and softens the muscles) to see if it helps reduce pain and other symptoms of fibromyalgia. If you have fibromyalgia and a pain level of 4 or more, you may be able to join.
Beijing, Beijing MunicipalityAges 18–75
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.