Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06398847Recruiting
Virtual reality self-hypnosis for HIV-related pain
This study tests if using a virtual reality (VR) headset for self-hypnosis can help people with HIV manage chronic pain. You would practice at home with a smartphone app, and researchers will track your pain levels over time.
New York, New YorkAges 18 years+ - NCT07426796Recruiting
Comparing two pain blocks for pediatric testicle surgery
This trial compares two types of numbing injections for pain after surgery to fix an undescended testicle in young boys. It aims to find which injection works better for comfort during recovery.
IstanbulAges 1–7 - NCT06723158Recruiting
Virtual reality glasses for oral surgery with sedation
This trial tests if wearing virtual reality (VR) glasses during oral surgery helps patients relax while under IV sedation. It may be a good option if you need sedation for a tooth extraction or other mouth procedure.
Boston, MassachusettsAges 16–65 - NCT05508360Recruiting
Testing an artificial spacer implant for one-level low back pain
This study tests whether inserting a small artificial implant into a single painful disc can reduce long-term low back pain and disability. It’s for people who tried non-surgical treatments for at least 6 months but still have significant symptoms from degenerative disc disease.
Medellín, AntioquiaAges 22 years+ - NCT07724704Recruiting
Exercise comparison for long-term low back pain
This study compares two sets of exercises (called McGill and Sahrmann) to see which is better at reducing chronic low back pain. If you have had non-specific low back pain for more than 12 weeks, this trial may help you strengthen your core and feel better without surgery or medication.
Lahore, Punjab ProvinceAges 20–50 - NCT07724691Recruiting
Comparing two shoulder therapies for frozen shoulder
This study compares two types of gentle shoulder movements (mobilizations) to treat frozen shoulder. The goal is to reduce pain and help you move your arm more easily.
Lahore, Punjab ProvinceAges 30–50 - NCT07726030Recruiting
Exercises for chronic rotator cuff pain in overhead athletes
This trial compares two types of exercises to see which better reduces chronic shoulder pain in male athletes who play overhead sports. If you have ongoing rotator cuff tendinopathy and are an active overhead athlete, this study may help find the best exercise approach for you.
Faisalābad, Punjab ProvinceAges 17–35 - NCT05561595Recruiting
Reducing health-related stigma through group support
This trial tests a virtual group program to help people cope with health-related stigma from conditions like obesity, cancer, HIV, diabetes, skin disease, or chronic pain. It aims to reduce internalized stigma and improve well-being.
Gainesville, FloridaAges 18 years+ - NCT07725861Recruiting
Gentle Therapies for Non-Specific Neck Pain
This study compares two gentle manual therapy techniques for neck pain that is not caused by a specific injury or nerve problem. The goal is to see which approach works better for reducing pain and improving movement.
Multan, Punjab ProvinceAges 18–60 - NCT07725198Recruiting
Neck muscle responses after upper neck therapy
This trial looks at how a specific neck therapy affects a small muscle at the top of your neck. It may help researchers understand how hands-on treatment works for neck pain or stiffness.
Fort Myers, FloridaAges 18–65 - NCT05684692RecruitingPhase 2
Pain-relief study for adults with schwannomatosis
This Phase 2 study tests whether an antibody medicine (either siltuximab or erenumab) can reduce moderate-to-severe pain in adults with schwannomatosis. It compares the medicine to a placebo and looks for improved pain control and tolerability.
Boston, MassachusettsAges 18 years+ - NCT06661850Recruiting
Using Nociscan to guide discogenic low back pain surgery
This trial tests whether using a tool called Nociscan helps improve outcomes in people having surgery for low back pain caused by damaged discs. It may help doctors decide which discs need treatment.
Beverly Hills, CaliforniaAges 18–70 - NCT07711626Recruiting
Foot massage and ear stimulation for head and neck cancer symptoms
This study tests whether foot massage (reflexology) and a mild nerve-stimulation device on the ear can help reduce side effects during chemotherapy and radiation for head and neck cancer.
Hualien CityAges 30–75 - NCT07486232Enrolling by invitation
Neck pain relief with posture exercises and taping
This study tests whether combining postural exercises with taping can help people with long-term neck pain who work at a desk. It aims to find a simple way to reduce pain and improve comfort.
IstanbulAges 25–55 - NCT07494734Enrolling by invitation
Manual therapy for neck pain, disability, and quality of life
This study tests whether manual therapy (hands-on techniques) can reduce neck pain, improve daily function, and enhance quality of life for people with long-term neck pain.
Kocaeli, GebzeAges 18–65 - NCT06013878Recruiting
Testing a tool for caregivers who help with transfers
This study tests a special instrument to measure how caregivers help people with physical disabilities move from one place to another (transfers). It may help improve safety and technique for both caregivers and care recipients.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07721571Recruiting
Pain control after kidney stone surgery via tube site injection
This trial tests whether injecting a numbing medicine into the tube site after kidney stone removal can reduce pain. If you are having this surgery, this approach might help you feel more comfortable afterward.
Çorum, ÇorumAges 18–75 - NCT07721389Recruiting
Breathing exercises vs. manual therapy for forward head posture
This study compares two non-drug treatments—special breathing exercises and hands-on manual therapy—to see which works better for fixing forward head posture and reducing neck pain in university students.
Istanbul, ZeytinburnuAges 18–28 - NCT07723352Enrolling by invitation
Testing Journavx for Thumb Arthritis Surgery Pain
This trial tests a new pain medicine called Journavx (suzetrigine) for people having thumb arthritis surgery. It aims to see how well the medicine controls pain after the operation.
Philadelphia, PennsylvaniaAges 40–80 - NCT07297901Enrolling by invitation
Breathing app study for migraine relief
This trial tests a smartphone-based breathing program to help reduce migraines. It uses heart rate data to guide breathing exercises tailored to you.
Phoenix, ArizonaAges 18 years+ - NCT06889389Recruiting
Education and exercise for neck pain relief
This study tests if combining education with exercise can reduce pain and improve function for people with non-specific neck pain (pain not caused by a specific injury or disease). Participants will learn about their condition and do guided exercises.
Elche, AlicanteAges 18–65 - NCT06188793Recruiting
Virtual reality for IBD pain during hospital stay
This study tests if using virtual reality can help manage pain for people with inflammatory bowel disease (IBD) while they are in the hospital. It may offer a drug-free way to feel better.
Ann Arbor, MichiganAges 18 years+ - NCT06897007Recruiting
Ciprofol dosage in patients with insomnia under anesthesia
This study looks at how the sedative drug ciprofol works differently in people with insomnia compared to those who sleep well. It aims to help doctors give the right dose for your type of surgery.
Beijing, Beijing MunicipalityAges 18–64 - NCT07720336Recruiting
Essential oils and a wearable device for long-term nausea
This study tests whether a wearable device (like a wristband) and essential oils can help calm chronic nausea. It focuses on people who have had nausea for more than 6 months, feel it at least 3 times a week, and also have anxiety.
Columbus, OhioAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.