Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80 - NCT05662371Recruiting
Testing pain-monitor guided pain medicine during robot bowel surgery
This study checks whether using a pain-activity monitor during robot-assisted colorectal surgery can help the surgical team choose the right pain medicine. It may improve comfort and reduce the chance of giving too much or too little pain medicine.
AabenraaAges 18–80 - NCT05662722Recruiting
Needle electrolysis for “cold nose/patch” headache pattern
This trial tests a small procedure that uses a needle on the ear (near the concha) to treat headaches. It focuses on people whose headaches match a specific pattern called the “cold nose” and/or “cold patch” pattern.
Alcalá de Henares, MadridAges 18–70 - NCT05666726Recruiting
Study how stress and body feelings affect choices
This study tests how changes in your internal body feelings (like heart rate and awareness of bodily sensations) and stress can affect decision-making and self-reflection. It may help researchers understand how thoughts, feelings, and body signals connect—especially in people vulnerable to anxiety or depression.
Bethesda, MarylandAges 18–55 - NCT05666921Recruiting
Study thoughts and relationships in teens with body-pain symptoms
This trial studies how emotions and attachment (how people relate to others) may affect teens who have long-lasting body symptoms without an organic cause. It may help explain why symptoms happen and how support strategies could improve quality of life.
Florence, FirenzeAges 11–17 - NCT05667090Recruiting
High-dose vitamin D3 to ease chronic pain in dialysis patients
This study tests whether taking a very high dose of vitamin D3 can reduce moderate to severe chronic pain in people on hemodialysis. It may help by improving vitamin D-related pathways that could affect pain, but you must also meet specific health and testing requirements.
TaipeiAges 20 years+ - NCT05669027Recruiting
Mobile brain training to help low back pain
This study tests whether mobile “neurofeedback” training can reduce low back pain and improve how much it affects your daily life. You would likely use sensors that measure brain and body signals to guide the training.
Durham, North CarolinaAges 18–90 - NCT05672784Recruiting
Knee numbing injections during knee replacement surgery
This trial compares two ways of numbing a knee area during planned knee replacement surgery: a nerve block alone versus a nerve block plus additional numbing medicine near the back of the knee. It may help doctors find which approach improves pain control and recovery while keeping side effects low.
ZagazigAges 21–60 - NCT05674357Recruiting
Training therapists to help people with cancer distress
This trial trains therapists in evidence-based treatments to reduce distress related to cancer and cancer care. You may be able to join if you’re being treated or followed at MGH Cancer Center and your distress level is high.
Boston, MassachusettsAges 18 years+ - NCT05674604Recruiting
Cryoneurolysis to reduce knee and shoulder pain in hospital
This trial tests whether a procedure called cryoneurolysis can reduce pain in people recovering from certain recent brain or nerve injuries (like stroke or traumatic brain injury). It may be helpful if you have either hemiplegic shoulder pain or knee pain from osteoarthritis while you’re in inpatient rehab.
Victoria, British ColumbiaAges 18–80 - NCT05677412Recruiting
Studying sleep, stress, and pain in teens with ongoing pain
This study looks at how sleep and stress relate to pain that keeps coming back in teens. It may help researchers understand what could improve comfort and daily functioning when pain lasts more than three months.
HelsinkiAges 15–17 - NCT05679167Recruiting
Digital training program for long-lasting low back pain
This trial tests an online (phone/tablet/computer) training program for people with low back pain lasting more than 3 months. It may help you learn exercises and self-management steps through digital instructions.
VänersborgAges 18–50 - NCT05689788Recruiting
High-intensity laser treatment for chronic neck pain
This trial tests whether high-intensity laser therapy can reduce long-lasting neck pain and improve daily function. It may help people whose neck pain has lasted at least 3 months and who meet specific pain and disability scores.
Santiago, Las CondesAges 18 years+ - NCT05689944Recruiting
Dance therapy for teens with chronic pain
This trial studies whether dance therapy can help reduce chronic pain in teens when usual pain treatments haven’t worked well. It may be helpful if you’re followed in a pain clinic and are able to participate in movement-based sessions.
BronAges 12–20 - NCT05697159Recruiting
7-tesla brain MRI to study how filgotinib eases RA pain
This trial uses a very high-strength brain MRI to understand how the RA medicine filgotinib may reduce pain. If you have active rheumatoid arthritis and can safely complete the scan, the study may help researchers better target pain relief in RA.
GlasgowAges 18–74 - NCT05700279Recruiting
PTSD treatment to help prevent future chronic pain
This study tests whether treating post-traumatic stress disorder (PTSD) right when you come to the emergency room for new, acute pain can lower the chance you develop long-term (chronic) pain. It may help people whose pain and trauma symptoms start around the same time.
Chicago, IllinoisAges 18–70 - NCT05700318Recruiting
Test of a device therapy for frequent migraine
This trial studies a migraine device (the ShiraTronics Migraine Therapy System) to help people with frequent migraine headaches. It may be a good option if you’ve tried common migraine preventions but they didn’t work for you, weren’t safe, or you couldn’t take them.
Broadmeadow, New South WalesAges 22 years+ - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT05701852Recruiting
Study brain scans during tasks in chronic nerve pain
This study looks at how brain activity changes in people with long-lasting nerve pain using an MRI scan while you do simple behavioral tasks. It may help researchers understand brain function in chronic neuropathic pain and how it affects day-to-day abilities.
ParisAges 18 years+ - NCT05706103Recruiting
Exercise therapy for recurrent low back pain with brain changes
This trial studies whether a specific exercise program can improve recurrent low back pain by changing activity in muscles and the brain. If you have non-specific low back pain that comes and goes over time, you may be asked to do exercises and undergo brain and muscle testing (including MRI).
Ghent, Oost-VlaanderenAges 18–45 - NCT05711849RecruitingPhase 2
Stem cell treatment for long-lasting chest pain not helped by meds
This Phase 2 trial tests whether stem cells placed into the heart artery can safely reduce symptoms in people with “refractory” angina (chest pain) despite maximum heart-healthy medication. You may qualify if your chest pain is limiting your activity and other heart procedures (stents/bypass) aren’t possible or are too risky.
London, EnglandAges 18 years+ - NCT05716321Recruiting
Study of pain and function after limb amputation surgery
This study looks at pain and day-to-day functioning after someone has a limb removed due to surgery. The results may help doctors better understand what to expect and how to improve comfort and mobility after amputation.
Hershey, PennsylvaniaAges 18–89 - NCT05719545Recruiting
Study of people getting a heart procedure through the skin
This study follows people who have an acute heart problem and need a heart procedure done through the skin. It may help researchers better understand care for people in this urgent situation.
Jinan, ShandongAges 18–85 - NCT05721027RecruitingPhase 4
Ibuprofen alone or with a steroid for new sciatica pain
This trial compares ibuprofen alone versus ibuprofen plus dexamethasone (a steroid) for short-term relief of acute nerve-related low back pain that shoots into the buttock or leg. It aims to see which approach reduces pain and improves function after an emergency visit.
The Bronx, New YorkAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.