Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07275762RecruitingPhase 2
Y-4 for postherpes nerve pain
This trial tests a new drug called Y-4 for people with lingering nerve pain after shingles (postherpetic neuralgia). If you have had pain for more than a month after your rash healed, this study may help find a new treatment option.
Nanjing, JiangsuAges 18 years+ - NCT06888791Recruiting
Hydro dissection for frozen shoulder: ultrasound vs X-ray guidance
This trial compares two ways to guide a fluid injection for frozen shoulder—one using ultrasound and one using X-ray. The goal is to see which technique works better to reduce pain and improve movement.
AnkaraAges 18–80 - NCT06888934Recruiting
Testing a new toe implant for arthritis and crooked toes
This study tests a new implant called Lync® to fix arthritis or crooked toes (like hammer, claw, or mallet toes). The implant helps straighten the toe bone and may reduce pain.
LyonAges 18 years+ - NCT07272551Enrolling by invitation
Polyvagal therapy for chronic neck pain
This trial tests a new approach based on the polyvagal theory to help people with long-term neck pain. It uses gentle exercises and techniques to calm the nervous system and reduce pain.
Istanbul, MaltepeAges 18–50 - NCT07273136Recruiting
Belly nerve block vs. epidural for pain after cancer surgery
This study compares two ways to manage pain after major abdominal cancer surgery: a numbing injection around the belly muscles (subcostal and lateral TAP block) versus an epidural (a thin tube placed in your back). The goal is to see which provides better pain relief.
AsyutAges 18 years+ - NCT07270406Recruiting
Healthy habits for better sleep in people with HIV and pain
This study tests a healthy behaviors program to help prevent insomnia in people with HIV who also have ongoing pain. If you have trouble sleeping and chronic pain, this program may help improve your sleep and well-being.
St Louis, MissouriAges 25–65 - NCT07271849RecruitingPhase 4
Timing of Nalbuphine for Pain and Blood Pressure in Older Knee Surgery Patients
This study tests whether giving the pain medicine nalbuphine at different times during knee replacement surgery affects blood pressure and pain control in older adults. It may help find the best timing to reduce pain and keep vital signs stable.
Jinan, ShandongAges 65–90 - NCT07271030Recruiting
Cannabidiol suppositories for sexual pain
This trial studies whether cannabidiol (CBD) suppositories can help with pain during sex. If you have sexual pain and have used CBD before without a reaction, you may be able to join.
LondonAges 18–100 - NCT07272577Recruiting
Nerve block for pain after laparoscopic abdominal surgery
This study tests a nerve block (erector spinae plane block) to see if it helps reduce pain after laparoscopic abdominal surgery. If you're having keyhole surgery, you may receive the block along with standard anesthesia.
AsyutAges 18 years+ - NCT07269925Recruiting
How different electrical frequencies affect muscle strength and pain
This study tests whether changing the electrical frequency during a type of nerve stimulation (percutaneous neuromodulation) can improve muscle strength and reduce pain sensitivity in people with a hidden muscle knot (trigger point) in the shoulder blade area.
Krakow, PolandAges 18–65 - NCT07275164Recruiting
High-intensity interval exercise for shoulder pain
This trial tests if high-intensity interval training (short bursts of intense exercise) can help people with long-term shoulder pain caused by rotator cuff problems or frozen shoulder.
WilrijkAges 18 years+ - NCT07275710Recruiting
Alprazolam for tooth pain after root canal
This trial tests if adding alprazolam (a mild anti-anxiety medicine) to standard painkillers can better manage pain after a root canal. It aims to find a more effective way to control post-procedure discomfort.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT07277517Recruiting
Pain education plus physical therapy for new back pain
This study tests whether adding Pain Neuroscience Education (learning how your brain and nerves process pain) to standard physical therapy can help people with new low back pain feel better and move more easily. It's for adults whose pain started within the past 6 weeks and who do not have a serious spine condition.
TehranAges 18 years+ - NCT07276061Recruiting
Outpatient vs. in-hospital knee replacement recovery study
This study compares recovery after total knee replacement when patients go home the same day versus staying overnight in the hospital. It aims to see if outpatient surgery leads to similar or better recovery.
StrasbourgAges 18 years+ - NCT07270588Recruiting
MobACT: Online support for chronic pain
This trial tests an internet-based program to help people manage chronic pain. You participate from home using a computer or tablet.
BolognaAges 18 years+ - NCT07275983Recruiting
Knee replacement recovery: spinal vs. general anesthesia
This study looks at recovery after total knee replacement surgery. It compares people who had spinal anesthesia (numbing the lower body) to those who had general anesthesia (being fully asleep) to see which group recovers better.
StrasbourgAges 18 years+ - NCT07269561Recruiting
Headache registry and long-term follow-up study
This trial is a registry study that tracks people with various headache disorders over time. It aims to learn more about how headaches affect patients and to improve future care.
Wuhan, HubeiAges 6–70 - NCT07278570Recruiting
Tracking muscle stiffness with MRI during hands-on therapy for low back pain
This study uses a special MRI scan to see if hands-on therapy (manual therapy) helps reduce muscle stiffness and pain in people with chronic low back pain. It aims to find a better way to measure how well this treatment works.
Rochester, MinnesotaAges 18 years+ - NCT07276542RecruitingPhase 2/Phase 3
Ketamine for phantom limb pain: a six-month outpatient study
This study tests whether ketamine, given as an outpatient treatment, can reduce phantom limb pain over six months. You would come to a clinic for multiple ketamine sessions, with at least a week between each session, and be followed for a year.
Sacramento, CaliforniaAges 18–65 - NCT07278050Recruiting
Comparing two nerve blocks for shoulder surgery
This trial compares two types of nerve blocks (interscalene and serratus posterior superior intercostal plane block) for pain relief during shoulder surgery. If you are having arthroscopic shoulder surgery under general anesthesia, you may be able to join.
Istanbul, BagcilarAges 18–75 - NCT06858917Recruiting
Block comparison for tailbone pain
This trial compares two types of nerve blocks to treat long-term tailbone pain. It tests whether a block near the tailbone or one in the lower back works better for people who haven't found relief from other treatments.
Istanbul, BaşakşehirAges 18–65 - NCT06877767Recruiting
Graston vs Active Release for low back pain in women
This study compares two non-surgical hand techniques (Graston tool and Active Release Technique) to see which works better for reducing low back pain in women. If you have had low back pain for at least 3 months, you may be able to join and get free treatment.
Sialkot, Punjab ProvinceAges 25–50 - NCT06843798Recruiting
Healthcare workers' ergonomic knowledge and muscle pain
This study looks at how healthcare workers' understanding of ergonomics relates to muscle and bone problems. It may help find ways to prevent work-related pain.
IstanbulAges 25–45 - NCT06758297Recruiting
AI motivational talk after knee replacement
This study tests whether an artificial intelligence-guided motivational conversation can help reduce fear of moving after knee replacement surgery, and improve how much you can move.
Samsun, SamsunAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.