Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT05722782RecruitingPhase 2
Kidney stone pain treatment after ER discharge
This study compares an anti-inflammatory pain medicine (NSAID) given by mouth versus acetaminophen (paracetamol) or placebo after you leave the emergency room for a “renal colic” (kidney stone pain). It looks at whether the NSAID helps control pain better and whether it’s safe for people with uncomplicated kidney stone pain.
MonastirAges 18 years+ - NCT05723081Recruiting
Study of stress, coping, and pain risk in Native Americans
This study looks at how stress and coping (“resilience”) may affect risk for pain. It may help researchers understand why some people develop ongoing, bothersome pain and how stress might play a role.
Tulsa, OklahomaAges 18 years+ - NCT05724446RecruitingPhase 3
Steroid eye drops for inflammation after cataract surgery in young children
This study tests whether a clobetasol steroid eye drop (a nanoemulsion) reduces eye inflammation after cataract surgery in babies and toddlers. It may help protect comfort and eye healing after surgery.
BarcelonaAges birth–3 years - NCT05726331Recruiting
Tai chi and chiropractic for long-term neck pain
This trial looks at whether a program of tai chi and chiropractic care can improve chronic, non-specific neck pain and daily function. It may help people who have had neck pain for months and want a structured exercise-and-care approach.
Chestnut Hill, MassachusettsAges 18–65 - NCT05730491Recruiting
Online parenting program for kids with IBS-related belly pain
This trial tests an online social learning program to help parents support their child when the parent has irritable bowel syndrome (IBS) or related belly pain. It may help families build coping skills and resilience through guided parent sessions.
Seattle, WashingtonAges 18 years+ - NCT05738278Recruiting
Care changes guided by heart rate in non-speaking autistic people
This study tests whether using a person’s heart rate to guide care can improve day-to-day support for autistic people who do not communicate verbally. It’s aimed at people who live in a care home or attend a staffed day program most days of the week.
OsloAges 5–70 - NCT05741788Recruiting
Telefitting spinal cord stimulation for chronic pain
This study checks a “remote fitting” process to set up spinal cord stimulation for people with high levels of pain. You may be a fit if you are planning a stimulation trial and have severe pain right now.
Minneapolis, MinnesotaAges 22 years+ - NCT05746143RecruitingPhase 4
Zolpidem during recovery after lower-back fusion surgery
This trial studies whether taking zolpidem around the time of recovery from lower-back (lumbar) fusion surgery affects outcomes. It may help doctors understand how sleep medicine can (or can’t) support recovery in certain people.
Los Angeles, CaliforniaAges 18–75 - NCT05748028Recruiting
Testing treatment for pain and nerve symptoms in Parkinson’s
This study looks at pain and “autonomic” (automatic body) symptoms in people with Parkinson’s disease or a related condition called multiple system atrophy. It aims to understand what helps and to learn more about these symptoms in different types of Parkinson-like illnesses.
Telese Terme, BeneventoAges 18 years+ - NCT05750992Recruiting
Ultrasound vs surgery guidance for numbing during C-section
This trial compares two ways of placing numbing medicine (with bupivacaine) during a planned C-section: an ultrasound-guided approach versus a surgical approach. It aims to find which method provides better pain control and comfort with fewer problems.
CairoAges 21–35 - NCT05752396Recruiting
Study of Pain Patterns Over Time in Kids
This study follows kids who have a specific type of chronic pain (headaches, stomach pain, or muscle/joint pain) to better understand how pain changes over time. It also checks whether certain factors are linked to those pain patterns.
Cincinnati, OhioAges 10–19 - NCT05751811Recruiting
Virtual reality and music to reduce pain during hysteroscopy
This study tests whether virtual reality plus music therapy can help reduce pain during an outpatient hysteroscopy. If you have your procedure at Prince of Wales Hospital, it may be an option to try non-drug comfort methods.
Hong KongAges 18–80 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT05761392Recruiting
App-guided care plan for long-lasting hard-to-treat pain
This trial tests an app-based system to help manage chronic pain using precise treatment planning, including an implanted pain device. It may help by improving follow-up, adjusting care over time, and aiming to reduce pain when usual treatments didn’t work.
BeijingAges 18 years+ - NCT05761275Recruiting
Sexual quality of life after minimally invasive benign surgery
This study looks at how minimally invasive “vNOTES” surgery affects women’s sexual quality of life after a non-cancer (benign) gynecologic procedure. You might be eligible if you recently had this type of surgery and meet specific health, infection, and language requirements.
GenevaAges 18–70 - NCT05761860RecruitingEarly Phase 1
Oxytocin to lower opioid misuse risk and pain in older adults
This early-phase study tests whether oxytocin (a hormone-like medication) can reduce how “appealing” opioids feel and also reduce pain. It’s aimed at older adults who have used opioids before but are not currently dealing with chronic pain most days.
Gainesville, FloridaAges 45–85 - NCT05762250Recruiting
Ear acupuncture for symptom relief in advanced cancer
This study tests whether auricular (ear) acupuncture can reduce ongoing symptoms and daily limitations in people with advanced cancer. It may help with discomfort and other side effects related to the disease or its treatment.
StuttgartAges 18–70 - NCT05764681Recruiting
Study for long-term pain after surgery
This study is for people who have chronic post-surgical pain and have a planned surgery on a leg or the spine. The goal is to better understand this long-term pain and what may help manage it after surgery.
Wilmington, DelawareAges 5–17 - NCT05765162Recruiting
Research study on safer, more tailored anesthesia
This study looks at safer anesthesia—meaning medicines used during procedures—using a more personalized approach. It may help make anesthesia safer for adults having medical procedures.
Nykøbing FalsterAges 18–100 - NCT05766059Recruiting
Noninvasive brain stimulation to aid stroke or phantom limb pain rehab
This trial tests new, noninvasive brain stimulation techniques to help recovery after stroke weakness or after arm amputation with phantom limb pain. If you fit the type and timing of your condition, the study may help improve pain or hand/arm function without surgery.
Milan, LombardyAges 18–85 - NCT05767619Recruiting
Digital tool to guide care for chest pain calls
This trial tests a digital decision-support tool that helps emergency teams manage people who call for help because of chest pain. It may improve how safely and consistently chest pain is assessed and treated in the ambulance setting.
Kungsbacka, Region HallandAges 18 years+ - NCT05768477Recruiting
Testing different treatments for chronic pain patients
This study looks at different ways to treat long-term (chronic) pain. You may be invited to participate if you’re an adult with chronic pain and can understand the study information.
GhentAges 18 years+ - NCT05776771Recruiting
Spine movement study for people with back or neck pain
This study measures how your spine and back/neck move using motion testing and equipment. It may help researchers better understand differences between people with spine pain and people without.
Columbus, OhioAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.