Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT06320041RecruitingPhase 4
Oliceridine for pain after orthopedic surgery
This trial tests a new painkiller called oliceridine for moderate to severe pain after orthopedic surgery. It may help you recover more comfortably with fewer side effects.
Yiwu, ZhejiangAges 18–100 - NCT06324942Recruiting
Nerve block for C-section pain relief
This study tests whether an extra nerve block (called a TAP block) given by your surgeon during a planned C-section can provide better pain relief than standard care alone. Researchers want to see if it reduces the need for stronger pain medicines after delivery.
Calgary, AlbertaAges 18 years+ - NCT07655388Recruiting
Wound healing and dressing changes after hip replacement
This study compares different types of dressings and how often they should be changed after total hip replacement surgery. It aims to find the best way to help the surgical wound heal.
Novi SadAges 65–95 - NCT07695935Recruiting
Pain relief after hernia repair: nerve block vs low-dose morphine
This study compares two ways to manage pain after open inguinal hernia repair: a nerve block (injection near the abdominal muscles) versus a low-dose painkiller (morphine) given through the spinal needle. The goal is to find which method provides better relief with fewer side effects.
ÇorumAges 18–80 - NCT07696286Recruiting
Alexithymia in chronic pain patients with a spinal cord stimulator
This study looks at a condition called alexithymia (difficulty identifying and describing emotions) in people who have chronic pain and a spinal cord stimulator. It aims to help doctors better understand how emotions affect pain treatment.
IstanbulAges 18 years+ - NCT06828185Recruiting
Comparing two surgery methods for testicular cancer
This trial compares two ways of doing surgery (radical orchiectomy) for testicular cancer. One method is the standard approach and the other spares a layer of muscle tissue. The study looks at patient experiences and recovery.
Loma Linda, CaliforniaAges 18 years+ - NCT06438471RecruitingPhase 1
Study of a new drug for nerve pain after spinal cord injury
This trial tests an experimental pill for people with spinal cord injury who have long-term nerve pain. It aims to see if the drug can reduce pain and be safe.
Augusta, GeorgiaAges 18 years+ - NCT06955221Recruiting
Alcohol injection for ovarian endometriosis pain
This study tests if injecting alcohol into ovarian endometriosis cysts can reduce pelvic pain and improve quality of life. It may offer a less invasive option for women with persistent cysts.
Palma de Mallorca, Balearic IslandsAges 18–45 - NCT06692400Recruiting
Suctioning, pain, and blood markers in intubated patients
This study looks at how routine suctioning of the breathing tube affects pain levels and certain substances in the blood in adults who are on a breathing machine for serious infections like flu, pneumonia, COVID, or sepsis. It may help doctors better understand and manage your comfort during this procedure.
Loma Linda, CaliforniaAges 18 years+ - NCT06327542Recruiting
Group pain management in primary care clinics
This trial tests a group-based program to help people with chronic pain manage their symptoms. It is offered in primary care clinics that serve underinsured communities, and sessions are available in English or Spanish.
San Francisco, CaliforniaAges 18 years+ - NCT06328751Recruiting
Virtual reality meditation for cancer pain relief
This study tests whether using meditation with virtual reality can help reduce pain in people with cancer. If you have chronic pain from cancer and can use a simple VR headset, this might be a gentle way to find relief.
Manaus, AmazonasAges 18–75 - NCT06330207Recruiting
Emergency provider training for dental care
This trial teaches emergency department doctors and advanced providers how to better manage dental emergencies. It aims to improve care for patients with non-traumatic dental problems.
Gainesville, FloridaAges 18 years+ - NCT06330181Recruiting
Virtual walking therapy for spinal cord injury nerve pain
This study tests a new virtual reality walking therapy program designed to help people with incomplete spinal cord injury reduce nerve pain. If you use a wheelchair and have lasting nerve pain, this could be a way to try a non-drug treatment from home.
College Station, TexasAges 18 years+ - NCT06330779Recruiting
Trauma-adapted yoga for teens with PTSD or ADHD
This trial tests if a special yoga program helps teenagers with PTSD or ADHD feel better. It is designed to be safe and supportive for their mental health.
GothenburgAges 12–18 - NCT06332495Recruiting
Bedpan comfort study for bedridden patients
This study looks at how comfortable and safe bedpans are for patients and caregivers. It aims to find ways to reduce pain and skin irritation for people who are bedridden.
Nantes, Loire AtlantiqueAges 18 years+ - NCT06332560Recruiting
Endometriosis pain and lifestyle
This study looks at how diet and lifestyle changes, including cognitive behavioral therapy (a type of talk therapy), might help reduce pain from endometriosis. You would follow a special diet and attend therapy sessions while researchers track your symptoms.
's-HertogenboschAges 17 years+ - NCT06333353Recruiting
Can brain stimulation reduce endometriosis pain?
This study tests whether a gentle, non-invasive brain stimulation technique (repetitive transcranial magnetic stimulation, or rTMS) can reduce ongoing endometriosis-related pain. If you have persistent pelvic pain that hasn't improved with other treatments, this trial may offer a new option to explore.
Ottawa, OntarioAges 18–60 - NCT06336447Recruiting
Virtual reality and nerve block for chronic knee pain
This study tests whether using virtual reality (VR) before a standard heat-based nerve block (radiofrequency ablation) can improve relief of long-term knee pain caused by arthritis. If you qualify, you'll receive the RFA procedure and may be randomly assigned to also use VR.
Chicago, IllinoisAges 18 years+ - NCT06338865Recruiting
Lower pressure vs. standard pressure for laparoscopic gynecologic surgery
This trial compares using lower gas pressure during minimally invasive gynecologic surgery to the standard pressure. The goal is to see if lower pressure reduces pain and speeds recovery after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT06344169RecruitingPhase 2/Phase 3
Pain relief after C-section with Naldebain
This trial tests a long-acting painkiller, Naldebain, for women having a planned C-section. It aims to see if it provides better pain control after the surgery.
Dalin, Chai-YiAges 20 years+ - NCT06345716RecruitingPhase 2
Pain relief for kidney stones at home after ER
This study tests whether combining paracetamol with either tramadol or caffeine works better than a placebo for pain from kidney stones when you leave the emergency room. It aims to find a simple, effective pain reliever to take home.
MonastirAges 18–99 - NCT06345872Recruiting
Better sleep to help reduce opioid use for chronic pain
This study tests a sleep improvement program to help people with chronic widespread pain reduce or stop their opioid pain medication. If you want to cut back on opioids and have trouble sleeping, this treatment might be a good fit.
Tampa, FloridaAges 18 years+ - NCT06346132Recruiting
Does virtual reality help during heart device surgery?
This study tests if wearing a virtual reality headset during a heart device implant or battery change helps you feel more comfortable and relaxed. The surgery is done under local anesthesia (numbing medicine) while you stay awake, and you go home the same day.
Lugano, Canton TicinoAges 18 years+ - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Aurora, ColoradoAges 12–17
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.