Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT06350786Recruiting
Using a placebo to help reduce opioid pain medication
This trial tests whether a special placebo pill, given with your knowledge, can help you reduce your opioid pain medication. You'll work with your own doctor to safely lower your dose while taking the placebo.
Zurich, Canton of ZurichAges 18 years+ - NCT06351839Recruiting
Sleep better despite long-term pain
This trial tests a program to help people with chronic pain and insomnia sleep better. It focuses on combining pain management with sleep improvement strategies.
Tromsø, Troms CountyAges 18–75 - NCT06353529RecruitingPhase 4
Pain management after pituitary tumor surgery
This study tests a nerve block (called sphenopalatine ganglion block) for pain relief after pituitary tumor surgery through the nose. It aims to see if this block helps manage pain and reduces the need for other pain medicines.
Hamilton, OntarioAges 18–100 - NCT06353789Recruiting
Teen Period Pain and Future Health
This study at the University of Oxford is looking at whether painful periods in teenagers can lead to long-term pain. You will be asked about your period pain and may have an MRI scan of your brain (safe, no radiation). The goal is to find ways to prevent chronic pain later in life.
Oxford, OxfordshireAges 11–20 - NCT06354699Recruiting
Pain after surgery in children: a long-term study
This study looks at children who have certain types of surgery to understand who might have ongoing pain, what causes it, and how it affects them over time.
San Francisco, CaliforniaAges Up to 16 years - NCT06355271Recruiting
Pain relief and recovery after planned C-section
This trial studies how well pain is controlled and how quickly women recover after a planned C-section under spinal anesthesia. It compares different pain relief methods to find the best approach.
BellinzonaAges 18 years+ - NCT06357702Recruiting
Physical Self-Regulation vs Placebo for Chronic Jaw Pain
This study tests whether a physical self-regulation treatment (like relaxation or biofeedback) can help reduce chronic jaw muscle pain. It compares the treatment to a placebo (inactive) version to see if it works better.
Lexington, KentuckyAges 18 years+ - NCT06358040Recruiting
Opioid dispenser after back surgery trial
This trial tests a special device that gives you pain medication (opioids) after back surgery, instead of a prescription. It may help you use just the right amount of pain medicine, and you'll use your smartphone for follow-up visits.
New York, New YorkAges 18 years+ - NCT06361485RecruitingPhase 1
Umbilical cord injection for chronic low back pain
This study tests whether a special injection made from umbilical cord tissue is safe and can help with long-term low back pain. It is for adults who have not had recent back procedures or certain health problems.
Scottsdale, ArizonaAges 20 years+ - NCT06364540RecruitingPhase 4
Ketamine vs fentanyl for severe pain in the ER
This trial compares two inhaled pain relievers, ketamine and fentanyl, to see which works better for sudden, severe pain in the emergency room. You would receive one of these medicines through a breathing mask to help your pain quickly.
Brooklyn, New YorkAges 18–120 - NCT06364592Recruiting
Electroacupuncture for pain from adenomyosis
This trial tests whether electroacupuncture (a type of acupuncture that uses a mild electric current) can reduce severe period pain caused by adenomyosis. If you have painful periods from adenomyosis and have not used hormonal treatments recently, this study may offer a non-drug treatment option.
BeijingAges 18–50 - NCT06365151Recruiting
Jaw pain treatment in fibromyalgia
This study tests a gentle hands-on treatment (osteopathic manual therapy) for jaw pain or problems in people with fibromyalgia. The goal is to see if this approach can help ease jaw discomfort and improve function.
Cornellà de Llobregat, BarcelonaAges 18–75 - NCT06367777Recruiting
Neck and back nerve stimulation for pain processing
This trial studies how electrical stimulation of nerves in the neck and upper back affects the way your body processes pain. It aims to help understand pain better, which could lead to new treatments.
BrusselsAges 18–40 - NCT06368492Recruiting
Psilocybin for fibromyalgia pain
This trial tests whether psilocybin, a substance found in certain mushrooms, can help reduce pain in people with fibromyalgia. You would receive the drug and be monitored closely to see if it improves your pain levels.
Maastricht, LimburgAges 18–65 - NCT06369922Recruiting
TENS for pain during urethral bulking for incontinence
This trial tests whether using a TENS device (a mild electrical stimulation machine) during an in-office urethral bulking procedure helps reduce pain. If you are a woman with stress urinary incontinence scheduled for this treatment, you may be able to join.
Rochester, New YorkAges 18 years+ - NCT06374238Recruiting
Peer Support for Young People with Sickle Cell Pain
This study is testing a peer support program for teens and young adults (ages 16–30) with sickle cell disease who have chronic pain. You'll connect with a trained peer supporter through your smartphone to learn pain coping skills and get support.
Mobile, AlabamaAges 16–30 - NCT06374537Recruiting
Exercise program for weak kidney patients
This study tests whether a targeted exercise program can help people who are very weak due to kidney disease. If you are on dialysis, have advanced kidney disease, or have had a kidney transplant, this program may improve your strength and daily function.
Chicago, IllinoisAges 18 years+ - NCT06379425RecruitingPhase 4
Can pain meds without opioids help you pee sooner after surgery?
This study looks at whether giving a mix of pain medicines (without opioids) before surgery can help you recover faster and avoid needing a catheter after a vaginal repair or sling procedure. It enrolls women having minor gynecologic surgery at the South Shore Surgery Center in New York.
Bay Shore, New YorkAges Any age - NCT06379997Recruiting
Oral supplement vs. shoulder injection for rotator cuff pain
This trial compares taking an oral supplement versus getting hyaluronic acid injections for ongoing shoulder pain due to a partial rotator cuff tear. It aims to see which treatment works better for improving movement and reducing pain without surgery.
Roma, RMAges 30–80 - NCT06381011Recruiting
Local vibration for neck pain from pinched nerve
This study tests whether gentle vibration applied to the neck can help relieve pain, numbness, or tingling caused by a pinched nerve in the neck. It's for people with moderate to severe neck pain or arm pain who haven't had neck surgery.
Bitlis, TatvanAges 18–70 - NCT06381063RecruitingPhase 3
Anti-inflammatory for heart surgery
This trial is testing whether a non-steroidal anti-inflammatory drug (NSAID) given during heart surgery can reduce complications. It's for people having planned open-heart surgery with a heart-lung machine.
AmiensAges 18 years+ - NCT06381921Recruiting
IBS pain measurement study
This study tests a new way to measure belly pain in people with IBS using special sensors. It may help doctors better understand and treat your pain.
Storrs, ConnecticutAges 18–50 - NCT06382272Recruiting
Bionic breast project to reduce chronic pain after mastectomy
This study tests a new device (a neuroprosthesis) placed during breast reconstruction to see if it can reduce long-term pain after a mastectomy. If you are having both breasts removed and plan to get tissue expander reconstruction, you may be able to join.
Chicago, IllinoisAges 18 years+ - NCT06384430Recruiting
Shoulder impingement tests and ultrasound in diagnosis
This study looks at how certain shoulder tests and ultrasound images relate to each other in people with shoulder impingement (a common cause of shoulder pain). It aims to improve diagnosis and understand which tests work best.
MuğlaAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.