Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,748 recruiting studies in this area right now.
By phase
- Not applicable3,094
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,747 total
- NCT06413914Recruiting
CBT for long-term pain in rheumatic disease
This trial tests if cognitive behavioral therapy (a type of talk therapy that helps change pain-related thoughts and behaviors) can reduce long-term pain in people with rheumatic diseases. It also validates a new questionnaire (AE-FS) about how pain affects daily life.
OsloAges 18 years+ - NCT06414473RecruitingPhase 1/Phase 2
CBD for knee osteoarthritis pain
This study tests whether a CBD (cannabidiol) product can help reduce pain and improve daily life for people with knee osteoarthritis. If you have moderate to severe knee pain and haven't used cannabis recently, you may be able to join.
Gainesville, FloridaAges 40–75 - NCT06414356RecruitingPhase 4
Ketamine for nerve pain and PTSD in military personnel
This study tests whether ketamine infusions can help with ongoing nerve pain and PTSD symptoms. It's for active-duty service members, veterans, and retirees who have had moderate nerve pain for at least 3 months.
San Antonio, TexasAges 18–70 - NCT06415032Recruiting
Quilting sutures after mastectomy to improve recovery
This study tests whether using special stitches (quilting sutures) during mastectomy helps reduce fluid buildup or other complications after surgery. It is for people having one breast removed without immediate reconstruction.
LeuvenAges 18 years+ - NCT06415240Recruiting
Comforting Touches for Newborn Pain in the NICU
This study tests whether gentle touch or wrapping your baby cozily (facilitated tucking) can reduce pain during a first-time arterial blood draw in the NICU. It may help find simple ways to comfort newborns during procedures.
IslamabadAges 1 day–4 weeks - NCT06415591Recruiting
Nerve stimulation for fibromyalgia in veterans
This trial tests whether a mild ear nerve stimulation device can reduce pain for veterans with fibromyalgia. It also looks at how the brain changes with treatment using MRI scans for some participants.
Decatur, GeorgiaAges 18 years+ - NCT06415890Recruiting
4-7-8 breathing for shoulder pain after gallbladder surgery
This study tests whether a simple breathing technique (called 4-7-8 breathing) can help reduce shoulder pain and improve breathing after gallbladder removal surgery. It may be a good fit if you are having planned laparoscopic gallbladder surgery and staying overnight in the hospital.
HatayAges 18 years+ - NCT06419439RecruitingPhase 2
Ketamine for Veterans with Chronic Back Pain and Depression
This study tests whether ketamine, combined with talk therapy, can help veterans with both chronic low back pain and depression. The goal is to reduce pain and improve mood.
Ann Arbor, MichiganAges 18 years+ - NCT06418958Recruiting
Heat from dental light on healthy teeth
This trial measures how much the temperature rises inside a healthy tooth when a dental curing light is used. It helps dentists understand if certain light wavelengths could be safer for teeth.
Gainesville, FloridaAges 21–35 - NCT06419842Recruiting
Hypnosis for lumbar infusion test comfort
This trial tests whether hypnosis can help make a lumbar infusion test (a procedure to check for normal pressure hydrocephalus) more comfortable. It's for adults 65 and older who are already scheduled for this test.
Amiens, PicardieAges 65 years+ - NCT06420141Recruiting
Nerve pain after ankle fracture surgery
This study looks at why some people develop nerve pain (neuropathic pain) after breaking their ankle and having surgery. If you have an ankle fracture that needs surgery, you may be able to join and help researchers understand this type of pain better.
Indianapolis, IndianaAges 18–85 - NCT06420778Recruiting
Acupuncture for head and face nerve pain after shingles
This trial tests whether a gentle form of acupuncture (superficial needling with electroacupuncture) can relieve long-lasting nerve pain after shingles on the head and face. It may help if you have had head or face shingles and the pain has continued for a month or more.
Hangzhou, ZhejiangAges 50–80 - NCT06424743Recruiting
Strength training volume for women with fibromyalgia
This study tests whether different amounts of strength training (resistance exercise) help women with fibromyalgia feel better. It compares three different workout volumes to see which one women prefer and which works best for their symptoms.
Natal, Rio Grande do NorteAges 18–65 - NCT06424834RecruitingPhase 2/Phase 3
Targeted medicines for chest pain without blocked arteries
This study tests if specific heart medicines (like beta-blockers or calcium channel blockers) can help people with chest pain that is not caused by blocked arteries. It aims to treat the tiny blood vessels or spasms that may be the real cause of your pain.
Palo Alto, CaliforniaAges 18 years+ - NCT06425016Recruiting
Robot-assisted vs. traditional sleeve gastrectomy
This study compares two types of weight-loss surgery: one done with the help of a robot and the other done by hand (laparoscopic). Both are types of sleeve gastrectomy, where the stomach is reduced in size. If you qualify for sleeve gastrectomy, this trial may help doctors learn which method works better.
Cleveland, OhioAges 18–70 - NCT06426251Recruiting
Light therapy for knee replacement recovery
This trial tests whether a special light therapy (photobiomodulation) can help reduce pain and speed healing after total knee replacement. If you're having knee replacement and don't have complications like infection or open wounds, you may be eligible.
HsinchuAges 20 years+ - NCT06426316Recruiting
Immune cells and migraines study
This study looks at how certain immune cells and inflammatory chemicals relate to migraines. If you have migraines or an autoimmune condition (like lupus, rheumatoid arthritis, or Crohn's disease), you may be able to participate. The goal is to understand what causes migraines.
Clermont-Ferrand, AURAAges 18–50 - NCT06426875Recruiting
Isometric training for shoulder pain in bowlers
This trial tests if isometric muscle training (holding still muscle contractions) can reduce shoulder pain and improve function and bowling performance in male bowlers. It may help if your pain affects your game and causes emotional distress.
Rawalpindi, Punjab ProvinceAges 18–30 - NCT06427356Recruiting
Team care for veterans with chronic pain at Salem VA
This study tests a team-based approach to help veterans with long-lasting pain. It looks at whether working with a group of specialists (like doctors, nurses, and mental health providers) can improve pain and daily life. It is for veterans already receiving care at the Salem VA who are part of the PREVAIL program.
Salem, VirginiaAges 18 years+ - NCT06434233RecruitingPhase 4
Opioid use after fallopian tube removal surgery
This study looks at how much opioid pain medicine people need after having their fallopian tubes removed through small incisions (laparoscopic or robotic salpingectomy). It aims to see if the usual pain medicine can be reduced to decrease opioid use.
Baltimore, MarylandAges 18 years+ - NCT06436092Recruiting
Stent treatment for left main coronary artery disease
This trial studies a new way to treat blockages in the left main coronary artery using a drug-coated stent. It aims to find out if a careful approach with a single stent and temporary side-branch support works well for people with heart disease.
Ichinomiya, Aichi-kenAges 18 years+ - NCT06436378Recruiting
Music Therapy for Chronic Pain Patients
This study tests whether listening to music can help people with chronic pain feel better. It is for people who are already being treated at the pain clinic at CHU de Québec-Université Laval and can attend a few sessions at the university.
Québec, QuebecAges 18 years+ - NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT06443281Recruiting
Understanding pain after spinal cord injury or nerve damage
This study is looking at how people with spinal cord injuries or peripheral neuropathy (nerve damage outside the spine) experience pain. The goal is to better understand the different types of pain, which could help doctors create more personalized treatments in the future.
Zurich, Canton of ZurichAges 18–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,748 recruiting pain medicine studies from the U.S. registry right now, out of 6,805 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.