Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07120659Recruiting
Comparing vacuum and tactile massage for chronic neck pain
This study compares two types of massage (vacuum massage and tactile massage) to see which one works better for people with long-term neck pain. If you have had neck pain for at least 3 months, you may be able to join.
Tromsø, TromsAges 21–75 - NCT07123805Recruiting
Acupuncture for knee replacement recovery
This study tests if adding acupuncture before and after knee replacement surgery helps reduce pain and improve recovery. It may be an option for people having planned knee replacement for osteoarthritis.
Pavia, PaviaAges 18 years+ - NCT07119983Recruiting
Stress ball for pain relief during diabetic foot wound cleaning
This study tests whether squeezing a stress ball during wound cleaning (debridement) can help reduce pain and distress for people with diabetic foot ulcers. If you're having this procedure for the first time and have mild pain or more, this simple technique may offer comfort.
Mersin, TarsusAges 18 years+ - NCT07118722Recruiting
Quiet focus: mindfulness for pain and depression
This study compares two programs—mindfulness-based therapy and a general health program—to see which better helps older Black adults manage long-term pain and mild depression. It aims to find new ways to improve well-being.
Boston, MassachusettsAges 50–120 - NCT07125027Recruiting
Exercise and mindfulness for sciatica pain
This study tests a program called Move-MORE that combines exercise and mindfulness to help people with nerve-related leg pain (sciatica) that has lasted at least 3 months. You would use the program at home, attend weekly video sessions for 8 weeks, and complete questionnaires and daily surveys to see if the program improves your pain and quality of life.
Portland, OregonAges 18–75 - NCT07123532Recruiting
Shoulder blade movement study in physical therapists
This trial looks at how common a certain shoulder blade movement problem (scapular dyskinesis) is among physical therapists. It will help researchers understand why some therapists might have shoulder issues and how to prevent them.
CairoAges 27–40 - NCT07116109Recruiting
Brain Stimulation Plus Therapy for Pain and PTSD
This study tests whether a brain-stimulation headband (called tDCS) combined with a proven talk therapy for PTSD can help reduce both chronic pain and PTSD symptoms. It is for adults who have had chronic pain for at least 6 months and also have PTSD.
Charleston, South CarolinaAges 21 years+ - NCT06502951Recruiting
Treatment for headache and neck pain after whiplash
This study tests if combining spinal manipulation and dry needling can reduce headache and neck pain in people who have had whiplash from a car accident. It may help if you've had symptoms for more than 4 weeks.
Montgomery, AlabamaAges 18–65 - NCT05232604Recruiting
Exercise vs local pain exercises for jaw and neck pain
This study compares two types of treatment: aerobic exercise versus exercises aimed at the painful jaw/neck area. It may help people with long-term jaw and neck pain by testing which approach improves pain and function.
Osnabrück, Lower SaxonyAges 18–60 - NCT07109492Recruiting
Mandala painting before gallbladder surgery
This study tests if painting mandalas before surgery helps reduce anxiety. It is for people scheduled for gallbladder removal surgery who are comfortable using their hands to paint.
YalovaAges 18–70 - NCT07111286Recruiting
Imagining movements to help chronic low back pain
This trial tests whether imagining movements (motor imagery) can help improve daily function and reduce pain in people with chronic low back pain. You will participate in a rehabilitation program, and if you are in the motor imagery group, you will also practice mentally rehearsing specific movements.
DijonAges 18 years+ - NCT07112404Recruiting
Dry Needling for Low Back Pain Study
This study tests a type of dry needling (inserting thin needles into muscles) to see if it helps people with and without chronic low back pain. You may join if you have no recent low back pain or if you have had low back pain for at least 3 months, as long as you have not had major back surgery or certain treatments.
Galveston, TexasAges 18–65 - NCT07110324Recruiting
Understanding long-term pain after hip or knee replacement
This study looks at people who still have moderate to severe pain months after a hip or knee replacement. The goal is to learn more about what causes this pain and how it feels, which could help improve future treatments.
Østerbro, København ØAges 18 years+ - NCT07109843Recruiting
Boswellia for pain and sensitivity in healthy volunteers
This trial tests whether a supplement called Boswellia serrata (frankincense) can change how your body processes pain and touch. It is for healthy people who do not have chronic pain or use certain medications.
Graz, StyriaAges 18 years+ - NCT07108400Recruiting
Combination therapy for hip osteoarthritis pain and function
This trial tests if combining ultrasound-guided hyaluronic acid injections with laser therapy and rehabilitation can improve hip function and reduce pain in people with hip osteoarthritis. It may be an option if you have moderate hip pain and are not currently taking anti-inflammatory medications.
Catanzaro, CZAges 18–85 - NCT07109895Recruiting
Custom insoles with electrical stimulation for diabetic foot ulcers
This study tests whether custom-made insoles combined with a mild electrical stimulation device can help heal diabetic foot ulcers better than standard care. It may reduce pain and improve healing for people with early-stage foot ulcers.
Lahore, Punjab ProvinceAges 18 years+ - NCT07112742Enrolling by invitation
Laser and exercise for thumb arthritis
This study tests if a special laser treatment plus hand exercises can reduce pain and improve function in people with thumb arthritis. It compares the laser to a placebo laser, so you won't know which group you're in.
KayseriAges 45–75 - NCT07109882RecruitingPhase 4
Comparing two muscle relaxants for bruxism pain
This study compares two muscle relaxant medications—chlorzoxazone and orphenadrine citrate—to see which works better for relieving pain caused by teeth grinding or jaw clenching (bruxism). If you have jaw or face pain and no other major health issues, you may be able to join.
BaghdadAges 15 years+ - NCT07109557Recruiting
Baduanjin for recovery after knee replacement
This study tests whether doing Baduanjin, a gentle mind-body exercise, helps people recover better after knee replacement surgery. It focuses on patients who are in stable condition and willing to try the exercise.
YalovaAges 18–70 - NCT07114913Recruiting
Carpal tunnel symptom location and pain study
This study looks at where carpal tunnel syndrome symptoms show up and how your body processes pain. By understanding this, doctors hope to find better ways to treat it.
Istanbul, UsküdarAges 18–65 - NCT06679569Recruiting
Deep muscle relaxants for less pain after children's belly-button surgery
This study looks at whether giving a deep muscle relaxant during your child's belly-button surgery can reduce pain after the operation. It may help kids feel better and recover more comfortably.
Seoul, SeoulAges 2 months–7 years - NCT06966518Recruiting
Ketamine and magnesium for pain control after nose surgery
This study tests whether giving a combination of two medicines (ketamine and magnesium sulfate) during nose surgery can help reduce pain after the operation. It may be a good option for healthy adults having rhinoplasty and looking for better pain control.
CairoAges 18–65 - NCT06968065Recruiting
Pain control after minimally invasive heart surgery: nerve block vs wound injection
This study compares two ways to manage pain after minimally invasive heart surgery: a nerve block injection near the ribs or injecting numbing medicine into the wound. The goal is to find which method works better for reducing pain and your need for painkillers.
IstanbulAges 18–75 - NCT07096765Recruiting
Comparing two injection speeds for pain relief after gallbladder surgery
This study compares two different speeds of giving a pain-blocking injection during keyhole gallbladder surgery, to see which one works better. You might join if you are otherwise healthy or have mild health issues.
BursaAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.