Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT06443281Recruiting
Understanding pain after spinal cord injury or nerve damage
This study is looking at how people with spinal cord injuries or peripheral neuropathy (nerve damage outside the spine) experience pain. The goal is to better understand the different types of pain, which could help doctors create more personalized treatments in the future.
Zurich, Canton of ZurichAges 18–80 - NCT06444919RecruitingPhase 4
Capsaicin patch for finger osteoarthritis with nerve pain
This study tests if a capsaicin patch (a hot pepper extract) can reduce finger pain in people with osteoarthritis who also have nerve-like pain. It's for those who haven't gotten enough relief from standard painkillers.
Clermont-FerrandAges 18 years+ - NCT06446596Recruiting
Phone-based exercise coach vs. standard home exercises for low back pain
This study compares doing exercises at home with a video coach on your phone versus doing standard exercises you get from a doctor. The goal is to see if the video program helps people with low back pain more than regular home exercises.
Valencia, Select OneAges 18–65 - NCT06446830Recruiting
Vitamin B complex for pain relief after cesarean in ICU
This trial tests whether adding vitamin B complex to standard pain medicine can improve pain control after a cesarean section in critically ill women. It aims to find a safer, effective way to manage pain without relying too much on strong opioids.
Cairo, EgyptAges Any age - NCT06447545Recruiting
Comparing air pressure levels for gallbladder surgery pain
This trial compares two different air pressure levels used during laparoscopic gallbladder removal to see which one causes less pain after surgery, including shoulder pain and bile duct injuries.
Lahore, PUNAges Any age - NCT06448923RecruitingPhase 2
CBD for Pain and Opioid Reduction After Fracture
This trial tests if cannabidiol (CBD) can help reduce pain and the need for opioids after a broken arm or leg. If you recently broke a bone and are between 18 and 70, you might be able to join.
Montreal, QuebecAges 18–70 - NCT06449547Recruiting
Risk factors for anxiety and depression in shingles nerve pain
This study looks at what makes people with shingles nerve pain more likely to feel anxious or depressed. By joining, you'll help doctors understand how to better support patients like you.
Wuhan, HubeiAges 18 years+ - NCT06450483Recruiting
Acupuncture for neck pain in college athletes
This study tests whether a type of acupuncture (called auricular vagus nerve stimulation, or AVNS) can help college athletes with neck pain. It looks at how the treatment affects pain, balance, and heart rate. If you’re a healthy college athlete with mild to moderate neck pain and no recent injuries, you may be a good fit.
Sharjah cityAges 18–26 - NCT06452030Recruiting
Testing a new exercise for trunk muscles in low back pain
This study is testing a special training program for the muscles that support your spine. It is for people who have had frequent but mild episodes of low back pain that have recently calmed down. The goal is to see if changing how these muscles work can prevent future pain.
GhentAges 18–65 - NCT06452407Recruiting
App for managing endometriosis symptoms and treatment
This trial tests a new app called elleFA to help track endometriosis symptoms and treatment. If you are being treated for endometriosis at the McGill University Health Centre, the app may make it easier to manage your care from home.
Montreal, QuebecAges 18 years+ - NCT06452615Recruiting
Shock wave therapy for nerve pain after mastectomy
This study tests if a treatment called extracorporeal shock wave therapy (using sound waves from outside the body) can help relieve nerve pain that some women have after a mastectomy. It may be an option if you have burning, tingling, or numbness in your chest, armpit, or upper arm that started after your surgery.
CairoAges 40–65 - NCT06453005Recruiting
Comparison of two tooth cap methods for baby molars
This trial compares two ways to fix cavities in baby molars: the SMART Hall technique (a newer, less invasive method) and the traditional stainless steel crown. The goal is to see which works better for children aged 3 to 9.
Tirupati, AndhrapradeshAges 3–9 - NCT06453109Recruiting
Focused ultrasound for chronic back pain with opioid use
This study tests whether focused ultrasound (a non-invasive treatment using sound waves) can help people with chronic back pain who also have opioid use disorder and anxiety. It aims to find a better way to manage pain without relying on opioids.
Washington D.C., District of ColumbiaAges 18–75 - NCT06453447Recruiting
Prednisone to prevent CRPS after wrist fracture surgery
This trial tests whether a short course of the steroid prednisone can prevent or reduce complex regional pain syndrome (CRPS) after wrist surgery. It is for people who had a broken wrist fixed with a plate and screws and have a higher chance of developing CRPS.
Vancouver, British ColumbiaAges 19 years+ - NCT06454669RecruitingPhase 2
Dronabinol added to opioids for chronic low back pain
This trial tests whether adding dronabinol (a prescription medication derived from cannabis) to your current opioid pain treatment can help reduce chronic low back pain more effectively. It is for people who have had persistent low back pain for at least 3 months and are already on a stable opioid regimen.
Houston, TexasAges 18–64 - NCT06456268Recruiting
VibraCool to reduce pain and opioid use after ACL surgery
This trial tests a device called VibraCool to see if it can reduce pain and the need for opioid painkillers after ACL reconstruction surgery.
New York, New YorkAges Any age - NCT06456502Recruiting
Non-invasive brain stimulation for long COVID symptoms
This trial tests whether a gentle, non-invasive brain stimulation device can help relieve long COVID symptoms. It involves wearing special gloves and socks that deliver mild electrical pulses to improve how you feel.
Alcorcón, MadridAges 18 years+ - NCT06457828Recruiting
Root canal methods for painful molars: open tip vs steroid
This trial is testing two methods during a root canal on a painful molar: one that keeps the tip of the root open and one that uses a steroid medicine inside the tooth. The goal is to see which approach causes less pain afterward.
IsmailiaAges 21–60 - NCT06458478Recruiting
Gel to help healing after wisdom tooth removal
This trial tests a special gel applied after removing lower wisdom teeth to see if it helps healing. It is for healthy people who need both bottom wisdom teeth taken out.
PerugiaAges 18–35 - NCT06460675Recruiting
Comparing two muscle-relaxing techniques for piriformis syndrome
This study compares two gentle muscle-relaxing techniques (called muscle energy techniques) to treat piriformis syndrome—a condition where a muscle in the buttock presses on a nerve and causes pain. If you have hip or buttock pain that’s been bothersome for at least 3 months and worsens with sitting, this trial may help find a better way to manage your pain.
Rawalpindi, Punjab ProvinceAges 25–45 - NCT06461312Recruiting
Two nerve blocks for pudendal neuralgia pain relief
This study tests if combining two nerve blocks—one near the pudendal nerve and one at the ganglion impar—can better relieve chronic pelvic pain from pudendal neuralgia. The goal is to find a more effective treatment for people who haven't gotten enough relief from standard treatments.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06464042Recruiting
Air Quality and Early Heart Disease Study
This trial studies how air quality affects early heart disease in young adults aged 18 to 40. It looks at people in Galicia, Spain, who already have coronary artery disease and compares them to healthy individuals.
Vigo, PontevedraAges 18–40 - NCT06464146RecruitingPhase 3
Comparing nose and mouth pain medicines for broken bones in kids
This study compares three different fast-acting pain medicines given through the nose or by mouth to children with a suspected broken arm or leg in the emergency room. The goal is to find which medicine works best for pain relief within the first hour.
Boulogne-BillancourtAges 2–17
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.