Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT06384456RecruitingPhase 4
TXA vs Placebo for Pain After Wrist Surgery
This study tests if tranexamic acid (TXA), a medicine used to reduce bleeding, can help lessen pain right after wrist fracture surgery. You may be able to join if you had breast cancer and radiation at least a year ago, are not currently on active cancer treatment, and don't take blood thinners or daily strong pain pills.
Toronto, OntarioAges 18 years+ - NCT06384664Recruiting
Freezing Nerves to Reduce Pain After Chest Surgery
This study tests whether freezing a nerve (cryoablation) during chest surgery can reduce pain after the operation. It might help patients who are having their first chest surgery and have never used strong painkillers.
Ann Arbor, MichiganAges 18 years+ - NCT06384846Recruiting
AI predicts heart attacks using white blood cells
This study tests whether an artificial intelligence tool can accurately predict a heart attack (acute coronary syndrome) by looking at the properties of your white blood cells. If successful, it could help doctors diagnose heart attacks faster from a simple blood sample.
Graz, Styria / SteiermarkAges 18 years+ - NCT06387290RecruitingPhase 3
Mindfulness and pain management for chronic pain on opioids
This study tests whether adding mindfulness training to standard pain management visits can help people with chronic pain who are taking long-term opioids. It aims to improve pain relief and reduce opioid-related risks.
La Jolla, CaliforniaAges 18 years+ - NCT06387303RecruitingEarly Phase 1
Comparing IV Methadone vs Spinal Morphine for Pain After Abdominal Surgery
This study compares two strong painkillers—methadone given through an IV versus morphine injected into the spine—to see which provides better pain relief and recovery after major abdominal surgery. It may help you if you're having open surgery and want less pain afterward.
Charlottesville, VirginiaAges 18–75 - NCT06387693Recruiting
AI for chest pain without blocked arteries
This study uses artificial intelligence to better understand chest pain in people without blocked heart arteries. It may help find the cause of your symptoms and guide your treatment.
UtrechtAges 18 years+ - NCT06387914Recruiting
Deep brain stimulation for chronic stroke pain
This trial tests whether deep brain stimulation (using a device implanted in the brain) can help relieve severe, long-lasting pain caused by a stroke. It is for people who have tried other treatments without success.
Oxford, OxfordshireAges 21 years+ - NCT06388590Recruiting
Acupuncture for chronic pelvic pain
This trial tests whether acupuncture can help relieve long-term pelvic pain. It is for women who are part of the military community and have not had endometriosis found during a laparoscopy.
Nellis Air Force Base, NevadaAges 21–65 - NCT06393101RecruitingPhase 1
High-CBD cannabis extract for complex regional pain syndrome treatment
This study tests a high-CBD cannabis extract (BRC-002) to see if it can help reduce pain and improve health in people with Complex Regional Pain Syndrome (CRPS). Participants will not use opioids or other cannabis during the study.
La Jolla, CaliforniaAges 21–75 - NCT06393608RecruitingPhase 2
Epsom salt compresses for postpartum perineal relief
This study tests whether warm compresses with Epsom salt can soothe pain and swelling in the vaginal area after childbirth. It's for mothers who had a vaginal delivery and are staying in one of the three participating hospitals.
Chicoutimi, QuebecAges 18 years+ - NCT06393959Recruiting
Injection treatment for lumbar spinal stenosis pain
This study tests whether an injection treatment can help relieve back and leg pain caused by a narrowed spinal canal in the lower back. It is for people whose pain has lasted at least 3 months and who have not had back surgery.
Ankara, TürkiyeAges 18–90 - NCT06395428RecruitingPhase 4
Haloperidol for severe back pain in the ER
This study tests whether the medication haloperidol, given in the emergency room, can help relieve severe back pain that started on its own (not from an injury). It compares haloperidol to a common pain reliever called ketorolac.
Kalamazoo, MichiganAges 18–65 - NCT06397196Recruiting
Laser-guided neck exercises for cervical radiculopathy
This study tests if combining laser guidance with neck exercises helps people with cervical radiculopathy (nerve pain in the neck that travels to the arm) improve their neck control and reduce pain. It may be a good fit if you have moderate neck-related arm pain.
Sialkot, Punjab ProvinceAges 35–55 - NCT06397157Recruiting
Virtual reality and motor imagery for neck pain
This study tests whether combining virtual reality with mental practice of movements can help reduce long-term neck pain. If you have had non-specific neck pain for at least three months, this treatment may help retrain how your brain controls your neck muscles.
Rawalpindi, Punjab ProvinceAges 18–50 - NCT06398353Recruiting
Acupuncture for frequent primary headaches
This study tests whether acupuncture can improve quality of life for people with frequent primary headaches (like migraines or tension headaches). If you have headaches more than twice a week, this trial may help you find relief.
Taoyuan, Select A StateAges 18 years+ - NCT06398574Recruiting
Dry needling for shoulder muscle function
This study tests if dry needling (using thin needles on trigger points) can change how the shoulder muscles work. It aims to help people with long-term shoulder pain or healthy people understand muscle responses.
Alcalá de Henares, MadridAges 18–70 - NCT06400290Recruiting
Balloon test to find which artery causes chest pain
This study tests a new way to find which blocked heart arteries are causing your chest pain. During a stent procedure, doctors will briefly block each artery to see which one triggers your symptoms. This might help them decide which blockages to treat.
BasildonAges 18 years+ - NCT06402409Recruiting
Studying multiple health conditions in spinal pain patients
This study looks at people who have neck or back pain along with other health conditions. It aims to understand how these conditions together affect your health and well-being.
AalborgAges 18 years+ - NCT06404983Recruiting
Opioid-free anesthesia for breast cancer surgery
This study tests whether breast cancer surgery can be done safely without using opioid pain medicines during anesthesia. The goal is to see if avoiding opioids leads to fewer side effects and a smoother recovery.
Ioannina, EpirusAges 18–99 - NCT06407518Recruiting
Preoperative medicine for pain relief in colorectal cancer patients with sleep or anxiety issues
This trial tests whether taking a medicine called midazolam before surgery can help with pain after surgery in people with colorectal cancer who have trouble sleeping or feel anxious. You would receive the medicine as a drink before your operation.
Guangzhou, GuangdongAges 18–60 - NCT06409442Recruiting
Support and vibration for shoulder impingement
This study tests two non-invasive treatments—corrective external support (like special tape) and regional vibration—for people with subacromial impingement syndrome, a common cause of shoulder pain. It aims to see if these treatments can reduce pain and improve shoulder function.
Izmir, BalçovaAges 18 years+ - NCT06409832Recruiting
Study of rimegepant for migraine prevention
This study tests a medicine called rimegepant to see if it helps prevent migraines. If you have migraine at least 4 days per month, this might be for you.
Florence, FlorenceAges 18 years+ - NCT06411054Recruiting
Acupuncture with electrical stimulation for pain during miscarriage procedure
This study tests whether adding a type of acupuncture (Acu-TENS) to standard care can reduce pain during a procedure to remove pregnancy tissue after a first-trimester miscarriage. If you are eligible, you may receive either acupuncture with a mild electrical current or a placebo device during the procedure.
Hong KongAges 18 years+ - NCT06411197Recruiting
Walking and muscle pain in healthy adults
This study looks at how people walk and how muscles in the legs may feel sore. It is for healthy adults to understand normal movement patterns.
Aalborg, North DenmarkAges 18–45
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.