Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT07141992Enrolling by invitation
Nerve glide exercises for burning pain from diabetic neuropathy
This study compares two types of nerve gliding exercises to see which works better for reducing burning pain, improving muscle strength, and increasing movement in patients with diabetes-related nerve damage.
Karachi, SindhAges 40–65 - NCT07140640RecruitingPhase 4
Lowering anesthetic dose for C-section safety
This trial tests if using 20% less of a standard numbing medicine (bupivacaine) during a C-section can reduce the chance of the spinal block going too high. This may lower risks and improve safety for mothers.
Aswān, Aswan GovernorateAges 18–45 - NCT07144436Recruiting
Pain after stroke: brain scan and treatment study
This trial tests whether a special kind of brain scan (called tAN-fMRI) can help understand and treat pain that happens after a stroke. You may qualify if you had a stroke at least 6 months ago and are between 18 and 80 years old.
Charleston, South CarolinaAges 18–80 - NCT07139522Recruiting
Dexamethasone or magnesium for pain relief after C-section
This trial tests adding dexamethasone or magnesium sulfate to the numbing medicine given as a back injection (erector spinae plane block) to see if it provides better pain relief after a planned C-section. The goal is to reduce pain and the need for extra painkillers after surgery.
CairoAges 18–35 - NCT07135817Recruiting
Pre-surgery radiation for spinal tumors
This trial tests whether giving focused radiation before surgery can improve treatment for spinal tumors that have spread from other cancers. It may help people who need surgery for a spinal tumor and have a life expectancy of more than 6 months.
GöttingenAges 18 years+ - NCT07141459Recruiting
Laser disinfection for failed root canal treatment
This trial tests if using a special laser (810 nm diode) to disinfect the tooth after a second root canal treatment can reduce pain and inflammation. It aims to help patients whose previous root canal failed and who have a small infection around the tooth root.
CairoAges 20–40 - NCT07136441Recruiting
Sciatic nerve stiffness test for leg pain patients
This study measures how stiff the sciatic nerve is using ultrasound while you do gentle leg movements. It compares people with sciatica to healthy volunteers to understand nerve changes.
GizaAges 25–40 - NCT07137715Recruiting
Wellness and recovery for veterans with chronic back or neck pain
This study tests a psychological program to help veterans manage chronic back or neck pain. It aims to improve your wellbeing and daily function through counseling or coaching sessions.
Aurora, ColoradoAges 18 years+ - NCT07137065Recruiting
A new approach to managing low back pain in primary care
This study tests a program designed to help people with low back pain get better care from their general practitioner. If you have low back pain (with or without leg pain) and haven't seen your doctor for this same problem in the last 3 months, you may be able to join.
Geneva, Canton of GenevaAges 18 years+ - NCT07139483Recruiting
Preventing chronic phantom limb pain with mirror therapy and brain stimulation
This study tests whether combining mirror therapy (looking at a reflection of your healthy limb) with a gentle brain stimulation technique called tDCS can prevent phantom limb pain from becoming long-lasting. It is for people who recently had a limb amputated and are already starting to feel phantom pain.
Raanana, IsraelAges 18 years+ - NCT07140432Recruiting
Bone scan for neck fusion problems
This study uses a special bone scan to check if the neck bones did not fuse properly after your surgery. It may help find the cause of ongoing neck pain and guide further treatment.
Bourg-en-BresseAges 21–99 - NCT07141108Recruiting
Using a digital tool to track chronic pain and improve quality of life
This trial tests a digital tool that helps you track your pain and activity level. The goal is to see if using the tool can improve your quality of life. You would use a smartphone or tablet app and share updates with your primary care team.
Malmö, Skåne CountyAges 18 years+ - NCT06693479Recruiting
Using a feedback device to help manage shoulder pain at work
This study tests whether a feedback device can help people with work-related shoulder pain manage their symptoms. You may qualify if you have shoulder pain from rotator cuff issues, arthritis, or rheumatoid arthritis and work full-time.
Québec, QuebecAges 18 years+ - NCT06962046Recruiting
Can virtual reality improve knee replacement surgery results?
This trial tests if using virtual reality (VR) during knee replacement surgery can help improve your recovery. You wear a VR headset during the procedure to relax and distract you, which may lead to better outcomes.
BelfastAges 18–100 - NCT06344169RecruitingPhase 2/Phase 3
Pain relief after C-section with Naldebain
This trial tests a long-acting painkiller, Naldebain, for women having a planned C-section. It aims to see if it provides better pain control after the surgery.
Dalin, Chai-YiAges 20 years+ - NCT07132736Recruiting
Underwater vs. regular exercise for quality of life and muscle power
This trial compares exercising underwater to doing regular aerobic exercise on land. It aims to see which type of exercise better improves muscle strength, energy levels, and overall quality of life in people with excess weight.
AmmanAges 18–50 - NCT07134660Recruiting
Comparing two numbing medicines for lung surgery pain
This study compares two types of numbing medicine (liposomal vs. hydrochloride bupivacaine) injected near the ribs during lung surgery. The goal is to see which one provides better pain relief after the operation.
ShanghaiAges 18–80 - NCT07130747Recruiting
Comparing massage techniques for c-section scar recovery
This study compares two types of gentle manual therapy (myofascial release and deep friction massage) to see which works better for reducing pain, helping the belly recover, and improving a C-section scar. It may be a good option if you're between 30–45, had a C-section over 6 months ago, and still have scar or pelvic pain.
AlexandriaAges 30–45 - NCT07133139Recruiting
Dry needling for chronic low back pain
This study tests whether a treatment called dry needling (using thin needles on muscle knots) helps people with long-term low back pain tied to muscle tightness. It is for those who have not tried this treatment before and whose main pain is in the lower back.
Pittsburgh, PennsylvaniaAges 20–70 - NCT07132762Recruiting
Shock wave therapy for chronic low back pain
This study tests whether adding a special sound wave therapy (called ESWT) to standard care (like exercise and education) can reduce pain and improve daily function in people with long-term low back pain. It is designed for people whose back pain does not have a specific known cause.
DenizliAges 18–65 - NCT07128030Recruiting
Moderate exercise for pain in breast cancer survivors
This study tests whether moderate exercise (like brisk walking) can help reduce pain and sensitivity in breast cancer survivors. It's designed for women who have finished their main treatments and still have discomfort in their arm or shoulder on the side where they had surgery.
MadridAges Any age - NCT07133724Recruiting
Digital health study for lumbar spine wear and tear
This study uses digital tools to measure how lumbar degeneration affects walking. It aims to find early signs of spine problems in people without current back pain.
TaipeiAges 50–80 - NCT07130084Recruiting
Virtual reality for first-time planned cesarean births
This trial tests if using virtual reality (VR) during a planned cesarean section can help reduce anxiety and improve the birth experience. It is for women having their first planned cesarean and who own a compatible smartphone or tablet.
BathAges 18 years+ - NCT07130760Recruiting
Testing two numbing methods for tooth pain in a back molar
This trial compares two ways to numb a painful lower back molar. If you have a tooth infection that needs a root canal, you may receive one of two injection techniques to see which works better.
Ferrol, A coruñaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.