Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05408065Recruiting
Compare pain relief from two shoulder injections for arthritis
This study compares how well two different shoulder injections reduce pain from moderate-to-severe shoulder osteoarthritis. You would receive injections in only one shoulder and answer questionnaires about pain and function.
Montreal, QuebecAges 20 years+ - NCT05408715Recruiting
Natural history study of growth in children with type II collagen disorders
This study follows children with certain inherited “type II collagen” conditions that cause short height, to better understand how growth changes over time. It does not test a new treatment; it mainly tracks health and growth so doctors can learn what to expect.
ParisAges Up to 12 years - NCT05413759Recruiting
Helping rheumatoid arthritis patients take medicines on schedule
This study looks at how well people with rheumatoid arthritis (RA) take their RA medicines—especially medicines like methotrexate and other targeted or biologic treatments. It may help improve medication adherence (taking doses correctly) and supports safer, more consistent treatment at home.
Pierre-Bénite, LyonAges 18 years+ - NCT05418218Recruiting
International headache registry for people with headache diagnoses
This study collects information from people who have headaches to better understand different headache types. You may help researchers by keeping headache records and allowing follow-up over time.
Hangzhou, ZhejiangAges 4–99 - NCT05419518RecruitingPhase 2
Higher-dose radiation to ease pain from metastatic tumors
This Phase 2 study tests whether a stronger (higher-dose) radiation plan can better reduce pain from tumors that have spread to bone or other areas. It’s meant to help people live more comfortably by targeting painful spots while avoiding certain high-risk situations.
Hamilton, New JerseyAges 18 years+ - NCT05419960Recruiting
Hearing and balance testing for teens with osteogenesis imperfecta
This study checks how well the inner ear and balance system work in children and young adults with osteogenesis imperfecta (OI). The goal is to better understand hearing and balance issues that can affect daily life.
ParisAges 12–20 - NCT05423587Recruiting
Knee artery procedure for long-lasting knee arthritis pain
This study looks at whether blocking small blood vessels in the knee (genicular artery embolisation) can reduce pain from knee osteoarthritis when other non-surgical treatments haven't helped. It also checks safety and whether people can tolerate the imaging tests needed for the procedure.
ReadingAges 45 years+ - NCT05428488RecruitingPhase 3
Step-by-step treatment for rheumatoid arthritis with TNF medicine
This trial tests a step-by-step plan for treating rheumatoid arthritis when current medicines aren’t controlling the disease. It compares how well a targeted approach works by adjusting treatment for people who need a TNF inhibitor.
Montpellier, FranceAges 18 years+ - NCT05435781RecruitingPhase 4
Hydrocortisone added during stress in people on low-dose prednisolone
This study tests whether adding supplemental hydrocortisone during stressful events can prevent problems in people who develop adrenal insufficiency from long-term prednisolone. It is meant to see if “stress dosing” is safer and helps the body respond to stress.
AarhusAges 50 years+ - NCT05439850RecruitingPhase 4
Bioinductive patch for severe torn shoulder tendons
This trial studies a special patch placed during minimally invasive shoulder surgery to help heal full-thickness rotator cuff tears. It may help people whose tears are large or massive and who already tried non-surgical treatment without enough improvement.
Detroit, MichiganAges 18 years+ - NCT05440240RecruitingPhase 4
Needling and possibly steroid shot for Dupuytren’s hand tightness
This trial tests a minimally invasive procedure that uses a needle to release tight tissue in the hand, and may include a steroid injection. It aims to improve hand finger straightening for people with Dupuytren’s contracture.
SilkeborgAges 45–99 - NCT05443100Recruiting
Testing whole-body cold therapy for metabolic, neurologic, or fibromyalgia pain
This trial studies whether a whole-body cold therapy called “WBC” can help people with certain metabolic conditions, neurologic conditions, or fibromyalgia. You may be able to join if you meet age and weight requirements and don’t have certain medical or safety risks.
Oggebbio, Verbano-Cusio-OssolaAges 18–65 - NCT05450510Recruiting
Testing slow vs faster rehab for severe shoulder tears
This study compares two physical therapy rehab plans to see which helps people recover better after a severe, irreparable rotator cuff tear. It may help you find the pace of rehab that works best for your shoulder and daily function.
KırşehirAges 18–65 - NCT05454527Recruiting
Biobank study follow-up for adults with inflammatory muscle disease
This study follows adults who have (or are being evaluated for) inflammatory muscle conditions to collect health data and genetic test information. It may help researchers better understand these diseases and improve future care.
ParisAges 18 years+ - NCT05459948Recruiting
Follow-up study for a primary knee replacement
This study tracks outcomes after a standard (first-time) total knee replacement using the GMK SpheriKA implant. It mainly looks at how well the knee works in everyday life, including activity and self-checks over time.
MérignacAges 18–80 - NCT05461326Recruiting
Compare two tendon grafts for ACL surgery recovery
This study compares two ways to rebuild the ACL using different tendon grafts (quadriceps tendon vs patellar tendon) taken from your own body. It aims to learn which option leads to better recovery after ACL reconstruction, including strength and function.
Birmingham, AlabamaAges 14–65 - NCT05463757Recruiting
Oral drugs for advanced or multiple basal cell skin cancer
This study registers people in the Netherlands who have certain types of basal cell skin cancer and take an oral hedgehog-blocking medicine. It may help doctors understand how well these tablets work and how patients do in real life.
Nijmegen, GelderlandAges Any age - NCT05464498Recruiting
Collagen device plus physiotherapy for Achilles tendon pain
This trial tests a collagen-based medical device used along with physical therapy to see if it helps people with Achilles tendon pain heal and improve function. You may be a good candidate if your symptoms are recent and the tendon problem is confirmed by ultrasound.
Roma, ROAges 18–70 - NCT05471752Recruiting
Study of special cells taken during orthopedic surgery
This study collects small cell samples from certain body tissues during planned orthopedic surgeries. The researchers will study these cells to understand their potential use in future treatments and to see if using them is safe and helpful.
MilanAges 18 years+ - NCT05473689Recruiting
Sleep study in early spinal cord injury
This study looks at how sleep quality affects movement problems after a new spinal cord injury. Researchers hope to identify sleep targets that could improve motor function during recovery.
Toronto, OntarioAges 18 years+ - NCT05479448Recruiting
Tracking what predicts response in new PMR or GCA
This study looks at people newly diagnosed with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA) and uses their health and treatment information to learn what predicts how well treatment works. It may help your care in the future by improving which patients respond best and how.
BaselAges 18 years+ - NCT05481879RecruitingPhase 1/Phase 2
Study medicine for DM1 to improve muscle function
This early-stage study tests DYNE-101 to see how safe it is and whether it can improve measurable muscle function in people with myotonic dystrophy type 1 (DM1). You may be asked to do several walking and strength tests and undergo heart and breathing screening measurements.
Stanford, CaliforniaAges 18–65 - NCT05484089Recruiting
CapFlex implant trial for finger joint replacement
This trial studies a new implant (the CapFlex) to replace a damaged finger joint (the PIP joint) when conservative treatments are not enough. It may help reduce pain and improve stability for the right type of joint problem.
Zoetermeer, South HollandAges 18 years+ - NCT05484557Recruiting
Apixaban vs enoxaparin to prevent blood clots after spinal cord injury
This trial studies whether apixaban works as well as enoxaparin to prevent dangerous blood clots after spinal cord injury. If you qualify, you would take one of these medicines to lower clot risk during the recovery period.
RaananaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.