Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07526350RecruitingEarly Phase 1
MTS109 for Hard-to-Treat Autoimmune Diseases
This early-stage trial tests a new treatment called MTS109 for autoimmune diseases (like lupus, muscle inflammation, scleroderma, vasculitis, or Sjögren's syndrome) that haven't responded well to standard medications. The goal is to see if MTS109 can help control disease that keeps flaring or getting worse despite current treatments.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07526337Recruiting
Digital Planning for Sinus Lift Dental Implants
This study examines how computer planning improves dental implant surgery when bone needs to be built up in the upper back jaw. Researchers will assess whether digital planning helps predict better outcomes for patients getting sinus lift procedures.
Beirut, BeirutAges 18 years+ - NCT07526493RecruitingPhase 1
QH103 Cell Therapy for Resistant Autoimmune Nerve and Brain Diseases
This Phase 1 trial tests whether QH103 cell injections can help patients with serious autoimmune diseases affecting nerves and the brain (like MS, NMOSD, myasthenia gravis, and others) that haven't responded well to standard treatments. The goal is to evaluate safety and whether the treatment helps reduce symptoms.
Wuhan, HubeiAges 18–75 - NCT07528300Recruiting
Acupuncture for pain relief in muscle injury patients
This study tests whether a type of acupuncture called "battlefield acupuncture" can help reduce pain in people hospitalized with rhabdomyolysis—a serious muscle injury that causes muscle breakdown and pain. Researchers want to see if this treatment helps patients feel better while they're in the hospital.
TAMC, HawaiiAges 18–99 - NCT07528807Recruiting
Exercise, Pain Beliefs, and Activity in Musculoskeletal Pain
This study explores how exercise, your beliefs about pain, and your daily activity patterns affect musculoskeletal pain (pain in muscles, joints, or bones). Researchers want to understand these connections better to potentially improve pain management and help people stay active.
IstanbulAges 18–65 - NCT07529197Recruiting
Study of Immunoadsorption Treatment for Post-Infectious ME/CFS
This study observes how a blood-cleaning treatment called immunoadsorption works in patients with ME/CFS (severe fatigue condition) who have specific immune markers. Researchers will track whether this treatment helps reduce symptoms and improve daily functioning.
Berlin, State of BerlinAges 18–65 - NCT07532070Recruiting
Exercise and Therapy for Chronic Pain and Sleep Problems
This study tests whether exercise, talk therapy for sleep problems, or both together can help people with long-term back, hip, or knee pain who also struggle with sleep. You'll attend video appointments and try one of these approaches for several weeks.
San Antonio, NevadaAges 18 years+ - NCT07532226Recruiting
Tracking how long patients stay on guselkumab for psoriatic arthritis
This study follows people with psoriatic arthritis (joint pain and swelling linked to psoriasis) who are starting a newer medication called guselkumab. Researchers want to learn how long patients continue taking this medicine and how well it works for them.
LilleAges 18 years+ - NCT07533188Recruiting
Robotic Knee Replacement Surgery Alignment Techniques Study
This study compares two different ways surgeons can align and position a robotic knee replacement to see which gives better results. You'll be randomly assigned to one approach and tracked over time to measure pain, function, and satisfaction.
SingaporeAges 18 years+ - NCT07536529Recruiting
Oxidative Stress in Autoimmune Joint Diseases
This study looks at a type of cellular damage called oxidative stress in people with autoimmune joint diseases like rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis. Researchers want to understand how this damage relates to your disease and may help develop better treatments.
Larissa, ThessalyAges 18 years+ - NCT07538141Recruiting
Hyalex implant for big toe joint arthritis
This trial tests a special implant designed to repair damage and arthritis in the big toe joint. If you have moderate-to-severe big toe pain and aren't helped by other treatments, this surgery may reduce pain and improve movement.
LodzAges 21–75 - NCT07538323Recruiting
Wrist Strengthening Exercise Program After Fracture
This trial compares a structured wrist strengthening exercise program (WISE) to standard care advice for people recovering from a broken wrist (distal radius fracture). The goal is to see if guided exercises help reduce pain and improve how well your wrist works.
Aarhus NAges 50 years+ - NCT07543016Recruiting
Amino Acids and Exercise for FSHD Muscle Weakness
This study tests whether amino acid supplements combined with exercise can help people with FSHD (a genetic muscle disease) build strength and reduce fatigue. Researchers will compare participants who receive amino acids plus exercise training to a control group.
Voghera, PaviaAges 18–50 - NCT07543484Recruiting
Tennis Serve Movement Study for Shoulder Pain
This research study examines how your shoulder muscles and joints move during a tennis serve, comparing players with shoulder pain to those without. The goal is to better understand shoulder injuries in tennis and help prevent or treat them.
TaipeiAges 18–40 - NCT07544394Recruiting
Understanding Fatigue in Sjögren's Syndrome
This study explores why people with Sjögren's syndrome experience fatigue and what factors predict it. Researchers will follow you for 3 months to better understand your fatigue patterns and potentially improve treatment.
KahramanmaraşAges 18 years+ - NCT07544823Recruiting
Study of Early Markers for Osteoarthritis
This study looks for early signs of osteoarthritis (joint wear and tear) in your blood or other samples. Understanding these markers may help doctors detect and treat osteoarthritis sooner.
Xinxiang, HenanAges 40–70 - NCT07545616Recruiting
Finding biomarkers for femoral head bone death
This study looks for biological signs (biomarkers) that can help identify and understand osteonecrosis of the femoral head—a condition where bone in the hip dies. Researchers hope these signs will improve how doctors diagnose and treat the condition.
Xinxiang, HenanAges 18–70 - NCT07546084Recruiting
Exercise Program for Rotator Cuff Shoulder Pain
This study tests whether a special exercise program that trains you to focus your attention in different ways can reduce shoulder pain and improve function. You'll do exercises designed to help your rotator cuff (the muscles that stabilize your shoulder) while learning to shift your mental focus during movement.
IstanbulAges 18–65 - NCT07546240Recruiting
Radiation therapy for persistent heel pain
This trial tests whether targeted radiation can relieve long-lasting heel pain (plantar fasciitis) that hasn't improved with other treatments. If your heel pain has lasted months and other options haven't worked, radiation might help reduce pain and improve walking.
GliwiceAges 40 years+ - NCT07546539Recruiting
Light Therapy for Chronic Fatigue Syndrome
This study tests whether a special type of light therapy (called photobiomodulation) can reduce severe tiredness in people with chronic fatigue syndrome. The light is applied to the skin and may help boost energy levels and improve daily function.
Larkana, SindhAges 18–60 - NCT07546552Recruiting
Egg Development Study: Testing a New Hormone Signal
This research study looks at how a specific hormone signal affects egg development in the ovary. Researchers are trying to understand if changing this signal might improve egg quality or fertility outcomes.
Skive, Midt JyllandAges 18 years+ - NCT07547566Recruiting
TECAR Therapy vs. Cycling for Athletic Recovery
This study compares two recovery methods—TECAR therapy (a heating treatment) and cycling—to see which helps young athletes recover better after jumping exercises. The goal is to understand which approach reduces fatigue and helps athletes bounce back faster.
Córdoba, CórdobaAges 18 years+ - NCT07547605RecruitingPhase 4
Comparing PRP, Steroid, and Combined Injections for Neck and Shoulder Pain
This study tests three different injection treatments for upper trapezius myofascial pain (a specific type of muscle knot in your neck/shoulder area). Researchers will compare platelet-rich plasma (PRP, made from your own blood), a steroid injection, and a combination of both to see which works best for pain relief.
Kyrenia, KeryneiaAges 18–65 - NCT07547735RecruitingPhase 2
Stem Cell Treatment for Knee Osteoarthritis
This study tests whether special stem cells (called UC-MSCs, derived from umbilical cord tissue) can reduce pain and improve function in people with moderate knee osteoarthritis. Researchers will inject these cells into your knee to see if they help repair damaged cartilage and reduce inflammation.
WuhanAges 40–70
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.