Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07651215Enrolling by invitation
Short-Stem Shoulder Replacement Surgery Outcomes Study
This study looks at how well a newer type of shoulder replacement surgery works. Researchers are checking X-rays and patient function for people who had this specific short-stem surgery at least 2 years ago.
LinzAges 18 years+ - NCT07653828Recruiting
Self-rehab after foot surgery via app
This trial tests if using a connected app to do self-guided rehab at home helps people recover better after bunion (hallux valgus) surgery. It may offer a convenient way to follow your exercises and track progress.
Saint-JeanAges 18–85 - NCT07653841Recruiting
Balance vs. strength training for knee osteoarthritis
This study compares two types of exercise programs (a balance-focused training and a progressive strengthening program) added to usual physical therapy. The goal is to see which works better for reducing knee pain and improving daily function in people with knee osteoarthritis.
Islamabad, ICTAges 40–70 - NCT07653009Recruiting
Nerve stimulation for psoriatic arthritis pain
This trial tests whether a gentle electrical stimulation of a nerve in the ear can reduce pain and inflammation in people with psoriatic arthritis. If you have moderate to high disease activity despite stable treatment, you may be able to join.
IstanbulAges 18–65 - NCT07652437Recruiting
Wearable device study for knee osteoarthritis walking
This study tests whether a wearable device can help people with knee osteoarthritis walk more easily and for longer periods. If you have knee pain or stiffness on most days and find walking difficult, this might help you improve your mobility.
Cambridge, MassachusettsAges 21–100 - NCT07646262Recruiting
Gluten-Free vs Mediterranean Diet for Rheumatoid Arthritis
This study compares two eating patterns—a gluten-free diet and a Mediterranean diet—to see which might help reduce inflammation and improve symptoms in people with rheumatoid arthritis. You would follow one diet for the study period while your doctors monitor how you feel.
Gaziantep, ŞehitkamilAges 19–65 - NCT07651462Recruiting
Fasting Before Hip Surgery and Gut Health
This study tests whether fasting for 20 days before hip replacement surgery changes your gut bacteria in ways that might help your recovery. Researchers want to understand if this dietary approach affects how well you heal after the operation.
Berlin, State of BerlinAges 18–75 - NCT06686719Recruiting
Stretching and relaxation for kids with spastic cerebral palsy
This trial compares three gentle stretching and muscle relaxation techniques to see which one best helps children with spastic cerebral palsy move more easily and feel less stiff. The goal is to find a safe, non-invasive way to improve daily function.
RawalpindiAges 8–18 - NCT06686706Recruiting
Treating Plantar Fasciitis with Special Taping and Massage
This study tests two treatments for heel pain caused by plantar fasciitis: a special scraping technique (IASTM) and kinesio taping. It may help if you stand for long hours and have morning heel pain that gets better then worse with activity.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT06686732Recruiting
Multimodal rehab for tennis elbow
This study tests a combination of treatments (multimodal rehabilitation) for people with tennis elbow (lateral epicondylitis) that has lasted at least 2 months. It aims to see if this approach helps reduce pain and improve function.
Wāh, Punjab ProvinceAges 18–45 - NCT06686277Recruiting
Comparing two hand-on treatments for frozen shoulder
This study compares two gentle hand-on techniques (Gong’s and Mulligan mobilization) to see which one works better for people with frozen shoulder. If you are 40–50 years old and your shoulder is in the stiff, hard-to-move phase, this trial may be able to help you improve movement and reduce pain.
Lahore, Punjab ProvinceAges 40–50 - NCT06009978Recruiting
Added muscle stimulation after Achilles tendon rupture
This trial tests whether adding neuromuscular electrical stimulation (NMES) to standard care helps people recover better after an Achilles tendon rupture. It might improve strength and function in the leg.
Mölndal, VGregionAges 18–65 - NCT06658249Recruiting
Core exercises vs foot-ankle strength for knee arthritis
This study compares core strengthening exercises with foot-ankle exercises to see which helps more with knee osteoarthritis symptoms like pain and walking difficulty. It might help you move better and climb stairs more easily.
Lahore, Punjab ProvinceAges 40–65 - NCT07642583Enrolling by invitation
Dry Needling and Exercise for Achilles Tendon Pain
This study tests whether a combination of dry needling (a technique using thin needles) plus exercise can relieve pain in the Achilles tendon (the cord at the back of your heel). If you have ongoing Achilles pain, this trial might help you find relief and return to activities like running or walking.
Fort Sam Houston, TexasAges 18–64 - NCT07641179RecruitingPhase 2
Testing MAR002 for Acromegaly (a Pituitary Tumor Condition)
This study tests a new drug called MAR002 to treat acromegaly, a hormone disorder caused by a pituitary tumor that makes too much growth hormone. The drug is designed to help lower hormone levels and improve symptoms.
Phoenix, ArizonaAges 18–75 - NCT07645989Recruiting
Registry tracking long-term outcomes after MuseCell treatment
This registry follows patients who have received Dezawa MuseCells (a type of cell therapy) to understand how well the treatment works over 5 years. You'll complete online surveys about your health and progress periodically.
North Palm Beach, FloridaAges Up to 89 years - NCT07639944Recruiting
REN Device Study for Jaw Pain and Headaches
This study tests whether a treatment called REN can help reduce headaches and jaw pain caused by temporomandibular disorders (TMD). You would use the REN device at home on your smartphone or tablet over several months.
Newark, DelawareAges 12 years+ - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Birmingham, AlabamaAges 40 years+ - NCT07639424RecruitingPhase 4
New cartilage regeneration treatment for knee repair
This study tests a new platform to help repair damaged knee cartilage. If your knee has a specific type of cartilage damage, this treatment might help restore function and reduce pain.
Daegu, DaeguAges 19–64 - NCT07640425RecruitingPhase 1/Phase 2
Testing a new collagenase injection for Dupuytren's contracture
This study tests whether a new injectable enzyme called CNT201 can safely and effectively treat Dupuytren's contracture—a condition where fingers curl and can't straighten. The injection aims to break down the thick tissue cords causing the problem, without surgery.
Kippa-Ring, QueenslandAges 18–75 - NCT03984461RecruitingPhase 2
Platelet-rich treatment with joint fluid or bone cells for arthritis
This trial tests a joint treatment made from your own platelets (platelet-rich plasma, or PRP) combined with other biologic material (from fat tissue and/or bone marrow) to help osteoarthritis symptoms. It may be an option if you have early-to-moderate osteoarthritis in a major joint and meet safety requirements.
Kelowna, British ColumbiaAges 19–79 - NCT05035693Recruiting
Follow-up study after a neck disc replacement surgery
This study tracks people after they get the MOVE-C artificial disc in the neck. It checks how well the device works over time and monitors safety and recovery.
ViennaAges 18 years+ - NCT06308965Recruiting
Does blood vessel-sparing hip replacement improve recovery?
This study compares two different surgical techniques for total hip replacement using an anterior approach. The goal is to see if saving the small blood vessels around the hip during surgery leads to a better recovery for patients.
Genk, LimburgAges 18 years+ - NCT06617806Recruiting
Preventing falls in very old, active adults
This trial tests if advanced practice nurses can help prevent falls in robust adults aged 80 and older. It may help you stay independent and avoid injuries.
Nantes, Loire-AtlantiqueAges 80 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.