Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT07536399RecruitingPhase 3
Bone Marrow Treatment for Jaw Joint Pain Relief
This study tests whether injecting your own bone marrow cells into your jaw joint during a minimally invasive procedure can reduce pain and improve jaw function better than arthroscopy alone. It's for people with significant jaw pain that hasn't improved with conservative treatments like NSAIDs, physical therapy, and bite splints.
New York, New YorkAges 18–75 - NCT06738160RecruitingPhase 2
Combination therapy for bone metastases from advanced lung cancer
This trial tests adding a new drug (narlumosbart) and targeted radiation to standard chemotherapy and immunotherapy for people with advanced non-small cell lung cancer that has spread to the bones. The goal is to see if this combination works better than standard treatment alone.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06737770Recruiting
Bone-anchored leg implant study
This study tests a bone-anchored implant (directly attached to the thighbone) for people with a single leg amputation above the knee. It aims to see if this implant helps with pain, movement, and skin issues caused by a traditional socket prosthetic.
BolognaAges 18–65 - NCT07538037Recruiting
Blood Flow Restriction Training for Taekwondo Athletes
This study tests whether a special training method—using gentle pressure to reduce blood flow during light exercise—can help taekwondo athletes build strength and improve their kicks. You'd train under supervision and complete fitness tests over several weeks.
Shanghai, Shanghai MunicipalityAges 16–25 - NCT06003296Recruiting
Surgery for foot fusion: plate or screw?
This trial compares two ways to join two small bones in the foot during a bigger fusion surgery. It will help find out which method works better and causes fewer problems.
AsyutAges 18–60 - NCT07683650Recruiting
Hyaluronic acid and platelet gel for jaw joint disc pain
This study tests a mixture of hyaluronic acid (a natural lubricant) and platelet-rich fibrin (from your own blood) injected into the jaw joint to see if it helps people with a misaligned jaw disc and pain. It may improve jaw movement and reduce discomfort.
Al MansurahAges 18–45 - NCT07538830Recruiting
Probiotic supplement for muscle strength in older adults
This study tests whether a specific probiotic (a beneficial bacteria called Lactiplantibacillus plantarum) can help improve muscle strength and physical function in adults aged 50–84. The probiotic may work by improving gut health, which could support muscle health.
BusanAges 50–85 - NCT05980793Recruiting
Nerve Treatment for Finger Joint Osteoarthritis
This study tests if a procedure that quiets the nerves around a painful finger joint (PIP joint denervation) can reduce pain and improve hand function for people with osteoarthritis. It offers a possible alternative before considering more invasive surgery.
StockholmAges 18 years+ - NCT07219654RecruitingPhase 2
Study of TPX-115 for partial rotator cuff tear
This study tests an experimental treatment called TPX-115 for people with a partial-thickness rotator cuff tear. It aims to see if the treatment can reduce pain and improve function compared to standard care.
La Mesa, CaliforniaAges 18 years+ - NCT07578051Recruiting
Two approaches to gait training for above-knee amputees
This study compares two methods of physical therapy for people with above-knee (thighbone) amputations: one focuses on improving specific movements, the other on practicing everyday walking tasks. Researchers want to see which approach helps patients walk better with a prosthetic leg.
Islamabad, Punjab ProvinceAges 18–40 - NCT05830825Recruiting
Follow-up study for The Tether to treat scoliosis
This study tracks how well The Tether™ (a growth-friendly spine treatment) works and how people do after surgery in the UK. It is for teens with progressive scoliosis who couldn’t stick with bracing and where their doctor has already decided The Tether is appropriate.
LondonAges birth–30 years - NCT07613138Recruiting
Tart Cherry Tablet for High Uric Acid Without Gout Symptoms
This trial tests whether a tart cherry effervescent tablet can help lower uric acid levels in people who have high uric acid but have never had a gout attack. High uric acid can lead to gout and other health problems, so finding a safe way to lower it might help prevent these complications.
Xiamen, FujianAges 18–65 - NCT07204119Recruiting
Comparing two therapies for knee stiffness after fracture surgery
This trial tests two physical therapy techniques to help people regain knee movement after surgery for a broken leg bone. It may help if you are still having trouble bending or straightening your knee a few weeks after your operation.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT06009978Recruiting
Added muscle stimulation after Achilles tendon rupture
This trial tests whether adding neuromuscular electrical stimulation (NMES) to standard care helps people recover better after an Achilles tendon rupture. It might improve strength and function in the leg.
Mölndal, VGregionAges 18–65 - NCT06214442Recruiting
Menstrual cycle and calf muscle properties in women
This study looks at how the menstrual cycle affects the calf muscles in women. It compares women with natural cycles and those taking birth control pills, both active and sedentary.
Porto AlegreAges 18–30 - NCT06258538Recruiting
Robot-assisted arm therapy and exercise after stroke
This study tests if combining arm exercises with two types of robot-assisted therapy helps people who have had a stroke improve their arm movement, daily activities, and quality of life. It is designed for individuals with moderate arm weakness.
Taoyuan, TaoyuanAges 20–75 - NCT06966544Recruiting
Imagery training for children with brachial plexus injury
This study tests whether graded motor imagery training — a type of mental practice involving imagining movements — can help children aged 7–18 with a brachial plexus injury that happened at birth. It could offer a new way to improve movement without needing hands-on therapy.
Izmir, MenemenAges 7–18 - NCT07339475Recruiting
Using vein size to predict blood pressure drops in older adults during hip or leg surgery
This study uses an ultrasound to measure the size of a vein in your leg before surgery to see if it can predict a drop in blood pressure during the procedure. If you are over 60 and having planned lower-limb surgery with spinal anesthesia, this non-invasive test might help your doctors prepare for your care.
CairoAges 60 years+ - NCT05876143Recruiting
Study of a knee implant with patient follow-up surveys
This trial follows people who already have (or are receiving) a specific partial knee implant to see how they do over time using questionnaires after surgery. It may help improve care for future patients with knee arthritis who get this type of implant.
Pierre-BéniteAges 18 years+ - NCT07550647Recruiting
Early Rehab Program After Hip Replacement Surgery
This study tests a rehabilitation program that starts soon after hip replacement surgery for arthritis or hip developmental issues. The program uses telehealth (video calls) to help you recover strength and mobility at home.
Niğde, MerkezAges 50–75 - NCT07170930Enrolling by invitation
Training program for soccer players in preseason
This trial tests a training program for soccer players during their preseason. It looks at how fitness, blood markers, and body function change. It may help soccer players improve performance and prepare for the season.
Athens, DaphniAges 18–35 - NCT07714031Recruiting
Wrist Release Therapy for Overuse Syndrome
This study tests a special hands-on therapy technique for people with wrist pain from overuse, like computer workers. It may help improve movement and reduce pain without surgery.
Faisalabad, Punjab ProvinceAges 20–50 - NCT07190456Recruiting
Study on fear of movement after ACL surgery
This study looks at different types of fear people might feel after ACL surgery, especially when doing jumping tasks. It aims to help understand these fears better so rehab can be improved.
Caparica, AlmadaAges 18–35 - NCT07551245Recruiting
High-intensity laser vs traditional treatment for knee osteoarthritis
This study tests whether high-intensity laser therapy works better than traditional physical therapy methods for knee osteoarthritis pain and function. You'll be randomly assigned to receive either laser treatments or standard rehabilitation exercises.
Erbil, Erbil GovernorateAges 30–60
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.