Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT07254403Recruiting
Beef vs. plant protein for muscle health in older adults
This study compares how well beef protein and plant protein help build muscle in older adults who may be starting to feel weak or lose muscle. You'll eat test meals and have your muscle response measured using a safe, stable isotope technique.
College Station, TexasAges 65–95 - NCT06973239Recruiting
Safety and performance of a new bone filler injection
This trial tests Neocement® Inject P, a paste that hardens to fill bone gaps. It might help if you have a bone defect from surgery or injury that does not need structural support.
BarcelosAges 18 years+ - NCT06464770Recruiting
Improving infection prevention before shoulder surgery
This study compares different ways to clean the skin before shoulder surgery to prevent infection. It might help if you are going to have shoulder surgery and want safer, more effective infection prevention.
Seattle, WashingtonAges 18–89 - NCT06707363Recruiting
Psychological factors and pain after orthopedic surgery
This study looks at how your thoughts and feelings affect your pain after orthopedic surgery. Researchers want to understand these factors to improve care for future patients.
Krakow, MalopolskaAges 18–65 - NCT07689045Recruiting
Comparing two nerve blocks for shoulder surgery pain
This trial compares two types of nerve blocks for pain control during and after Bankart or Latarjet shoulder surgery. The goal is to see which block provides better pain relief and preserves arm strength.
Cairo, Cairo GovernorateAges 18–65 - NCT07686809Recruiting
Leg therapy for children with one-sided weakness
This study tests a new leg exercise program to help children with hemiplegia walk better. The therapy may improve balance and movement in the affected leg.
CairoAges 6–8 - NCT06703671Recruiting
Acupuncture for disc-related low back pain
This trial tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can help people with low back pain caused by a damaged disc. If you have had back pain for at least a month and have not had certain other treatments recently, you may be eligible.
Beijing, Beijing MunicipalityAges 18–70 - NCT07183475Recruiting
Returning to sports after knee replacement
This study looks at how well people can get back to sports after having a knee replacement. If you have had a knee replacement and are active in sports, you may be able to join to help researchers learn more about recovery.
Munich, BavariaAges 18–85 - NCT07528092Recruiting
Pinning methods for broken metatarsal bones in the foot
This trial compares two surgical techniques for fixing broken bones in the middle of the foot (metatarsals). If your fracture couldn't stay in place with a cast alone, this study tests which pinning method works better for healing and foot function.
SohagAges 18–65 - NCT07677722Recruiting
Comparing two types of partial knee replacements
This trial compares two designs of partial knee replacements (fixed bearing vs mobile bearing) to see which offers better results and fewer problems for people with arthritis in the inner part of the knee. If you meet the criteria, this study might help you and your doctor choose the best option.
Ieper, Oost-VlaanderenAges 50–80 - NCT06995690Recruiting
Ketamine to prevent low blood pressure during orthopedic surgery
This study tests if a low dose of ketamine (a pain medicine) given before spinal anesthesia can prevent dangerously low blood pressure during orthopedic surgery. It might help keep your blood pressure steady, making the procedure safer.
CairoAges 18 years+ - NCT06468904Recruiting
Neck exercises for hand strength in chronic neck pain
This trial tests whether special neck exercises can improve hand grip strength in people with long-term neck pain caused by muscle knots. If you have chronic neck pain and hand weakness, this study may help you get stronger while reducing pain.
GizaAges 20–45 - NCT05701046Recruiting
Front vs back surgery for a slipped lower-back vertebra
This trial compares two surgical approaches—operating from the front/side versus from the back—for a specific type of lower-back slip called lumbar isthmic spondylolisthesis. You may be eligible if you need surgery at a single level and have not had prior spine surgery, and if your back condition matches their exact limits.
Vancouver, British ColumbiaAges 18 years+ - NCT06767280Recruiting
Testing calf muscle in chronic nerve pain patients
This study looks at how a muscle in your calf (gastrocnemius) responds to a gentle electrical test in people with long-term nerve pain from the lower back. It aims to learn more about how the condition affects muscle function, which could help improve future treatments.
Sixth of October, Giza GovernorateAges 18–55 - NCT05994833Recruiting
Virtual physical therapy for injured runners
This study tests whether virtual physical therapy sessions can help runners with long-lasting injuries like runner's knee or Achilles tendinitis. You would join online therapy for a month instead of in-person visits, and they will check how you improve.
Gainesville, FloridaAges 18–65 - NCT06973746Recruiting
Sitting up in a chair in the ICU for patients on breathing machines
This study tests whether getting patients who are on a breathing machine to sit in a chair helps them recover better. It looks at whether this simple activity can improve how well they get back to normal function.
Orléans, Centre-Val de LoireAges 18 years+ - NCT06681311Recruiting
Core and shoulder exercises for master swimmers
This study tests whether adding core and shoulder stabilization exercises to swimming training can improve athletic performance and lower injury risk in master swimmers. It may help you swim stronger and stay injury-free.
Istanbul, MaltepeAges 25–50 - NCT06391957Recruiting
Spirulina for recovery after hard exercise
This trial tests if taking a spirulina supplement helps your muscles recover faster after a tough workout. You might join if you are healthy, exercise regularly, and don't do formal weightlifting.
ExeterAges 18–40 - NCT06686706Recruiting
Treating Plantar Fasciitis with Special Taping and Massage
This study tests two treatments for heel pain caused by plantar fasciitis: a special scraping technique (IASTM) and kinesio taping. It may help if you stand for long hours and have morning heel pain that gets better then worse with activity.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT06472349Recruiting
Upper trapezius muscle and chronic shoulder pain study
This study looks at how the upper trapezius muscle works and how it may be linked to long-term shoulder pain. Researchers will measure muscle shape, activity, and how you move your shoulder to understand pain better.
TaipeiAges 18–50 - NCT07664904Recruiting
Periostin protein levels and quality of life in back pain patients
This study looks at how a protein called periostin relates to back function and quality of life in people with disc herniations or spinal stenosis. You'll fill out two questionnaires and have your periostin measured from a blood draw or MRI.
Daegu, DaeguAges 20–80 - NCT07529093Recruiting
Mobilization and Movement Training for Sacroiliac Joint Pain
This trial tests whether a combination of hands-on joint mobilization techniques and specific movement control exercises can reduce pain and improve function in people with sacroiliac joint dysfunction (pain in the lower back/buttock area where the spine connects to the pelvis). You would receive these treatments over several weeks and be measured on pain relief, movement, walking, and daily activities.
Lahore, Punjab ProvinceAges 45–64 - NCT05795647RecruitingPhase 2
Testing pentoxifylline and vitamin E for jaw bone damage
This trial tests a combination of medicines (pentoxifylline and tocopherol, a form of vitamin E) to treat damage to the jaw bone caused by bone-strengthening drugs. If you have Stage 2 MRONJ and meet other criteria, this treatment may help heal the bone.
LimogesAges 18 years+ - NCT06188767Recruiting
Testosterone and muscle memory study
This study looks at whether taking testosterone can help muscles 'remember' past strength training. You may be able to join if you are healthy, don't smoke, and have not been lifting weights regularly in the last year.
CopenhagenAges 18–40
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.