Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT07454356Recruiting
Device to help knee bending after replacement
This study tests a non-surgical device called Knee Flexionater to help people who have limited knee bending after total knee replacement. The goal is to improve knee motion and avoid a second surgery.
Houston, TexasAges 40 years+ - NCT07455578RecruitingPhase 1
Study of S-4321 for people with autoimmune or immune diseases
This trial tests a new medicine, S-4321, for people with various autoimmune conditions like rheumatoid arthritis, psoriasis, eczema, or lupus. It aims to see if the drug is safe and can help control the overactive immune system.
Charlestown, New South WalesAges 18–75 - NCT02103361Recruiting
Pregnancy registry for Stelara or Tremfya exposure
This study is a pregnancy exposure registry. It collects information to better understand pregnancy outcomes after exposure to Stelara or Tremfya (medicines used for autoimmune diseases).
La Jolla, CaliforniaAges Any age - NCT07460076Recruiting
Immediate tooth implant with bone graft from the upper jaw
This trial tests placing a dental implant right after removing a tooth, using a small piece of bone from the back of your upper jaw to rebuild the gum area. It may help people who need a front tooth replaced and have a bone defect that requires this type of graft.
Ho Chi Minh City, Ho Chi MinhAges 18 years+ - NCT07461636Recruiting
Robotic-assisted screw placement in spine surgery
This trial studies how well a robotic system helps surgeons place screws in the spine. It may help make the surgery more precise and safer.
GothenburgAges Any age - NCT07461701Recruiting
Comparing two squat intensities for strength in young women
This study compares two ways of doing bodyweight squats (stopping when you lose 15% vs 30% of your speed) to see which is better for building leg strength and endurance in young women who are not very active. It may help find a simple, safe way to improve fitness at home.
Lahore, Punjab ProvinceAges 18–25 - NCT07456657Recruiting
Lavender massage for pain and wrist mobility in rheumatoid arthritis
This trial tests whether lavender aromatherapy massage can reduce pain and improve wrist movement in people with rheumatoid arthritis. If you have stable RA and positive rheumatoid factor, you may be able to join.
Hillah, Babil GovernorateAges 20–60 - NCT07458360Recruiting
Front block for better recovery after hip replacement
This study tests if a special nerve block called the front block (pericapsular nerve group block) improves recovery after hip replacement surgery. You may be eligible if you are having hip replacement under spinal anesthesia and do not have certain health issues.
KonyaAges 18 years+ - NCT07456787Recruiting
Cold therapy after knee replacement surgery
This trial tests a cold therapy approach (cryopressotherapy) to improve recovery after total knee replacement. It may help reduce pain and swelling so you can move better sooner.
Milan, ItalyAges 18–80 - NCT07454252Recruiting
Study on biomarkers for bone, muscle, and energy health
This study looks at blood samples already collected from patients to find markers related to bone, muscle, and energy metabolism. It may help doctors better understand these processes and identify potential health issues.
Milan, ItalyAges 18 years+ - NCT07458971Recruiting
AI-assisted assessment for thumb arthritis
This study tests a new way to assess thumb arthritis using an AI tool that looks at your overall health. It aims to predict your health profile and may help personalize your care.
AnkaraAges 25–74 - NCT07456137Enrolling by invitation
Studying MRI vs. X-ray for spine pain
This trial compares two types of CT scans (upright vs. lying down) to see which gives better images of the lower back. It may help doctors choose the best scan for spine problems.
Kansas City, KansasAges 18 years+ - NCT06280352Recruiting
Robotic vs custom knee replacement trial
This study compares two modern ways of doing knee replacement: robot-assisted surgery versus a custom-made implant tailored to your knee shape. It aims to see which approach leads to better recovery and function for people with osteoarthritis.
Graz, StyriaAges 40–90 - NCT06796881Recruiting
Comparison of two therapies for long-term low back pain
This study compares two hands-on treatments for people with chronic low back pain. One uses special tools to massage tight muscles, while the other uses gentle pressure on muscle knots. Both aim to help you move better and feel less pain.
CairoAges 25–45 - NCT06797414Recruiting
Pilates with or without vibration for upper cross syndrome
This study compares Pilates exercises with and without whole-body vibration (a platform that gently shakes your body) to see which better improves posture and pain in people with upper cross syndrome (a common pattern of rounded shoulders and forward head). It aims to find a more effective way to strengthen muscles and reduce discomfort.
Lahore, Punjab ProvinceAges 20–40 - NCT06796218Recruiting
Arabic mobility test after abdominal surgery
This study tests how well a new Arabic version of a mobility scale works for people recovering from abdominal surgery. If you are between 40 and 60 years old and can read Arabic, you may be able to help.
Al MansurahAges 40–60 - NCT06795932Recruiting
Testing a new nerve stimulation device for frozen shoulder
This study tests if a non-invasive device that stimulates nerves can help treat frozen shoulder (adhesive capsulitis). If you are an adult with frozen shoulder and are in generally good health, you may be able to join to see if this device works.
Saguenay, QuebecAges 18 years+ - NCT04452721Recruiting
Predicting outcomes for a chest brace in pectus carinatum
This study looks at what factors help predict how well a dynamic compression brace works for people with pectus carinatum (a chest wall that sticks out). It uses past patients’ records and later patients to see which early details relate to better or worse results.
Saint-EtienneAges 6–40 - NCT06148818Recruiting
Neck exercises for jaw pain relief
This study tests whether special neck exercises can help reduce jaw pain in people who have both jaw (TMJ) problems and neck pain. If you have had jaw pain for at least 3 months and also have achy neck pain, you may be able to join.
TrabzonAges 18–55 - NCT05966064RecruitingPhase 4
Denosumab for adult fibrous bone lesions with ongoing pain
This trial studies denosumab to reduce pain and active bone disease in adults with fibrous dysplasia / McCune-Albright syndrome. You may be eligible if your FD/MAS is causing persistent pain and has signs of active bone turnover, despite adequate pain treatment.
LeidenAges 18 years+ - NCT06799091Recruiting
Nerve stimulation for fibromyalgia relief
This trial tests whether a nerve stimulation technique can help reduce fibromyalgia symptoms. It is open to women with a confirmed diagnosis of fibromyalgia who have had symptoms for at least three months.
GizaAges 20–45 - NCT07451600Recruiting
TMS for spasticity and balance in multiple sclerosis
This study tests if transcranial magnetic stimulation (TMS) can help reduce muscle stiffness (spasticity) and improve balance in people with multiple sclerosis. TMS uses magnetic pulses to stimulate parts of the brain.
Ankara, YenimahalleAges 18–60 - NCT06550596Recruiting
Amnion membrane for diabetic foot ulcers
This trial tests a wound covering made from donated amniotic tissue (dehydrated human amnion membrane) placed on a diabetic foot ulcer that isn't healing. It aims to see if adding this membrane to standard wound care helps the ulcer close faster.
Thousand Oaks, CaliforniaAges 18 years+ - NCT07449442Recruiting
Pain relief study after knee replacement surgery
This trial tests a special injection around the knee to improve pain control after knee replacement surgery. It may help reduce the need for strong pain medicines.
PoznanAges 65–100
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.