Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT07465484Recruiting
Total knee replacement for bow-leg deformity
This study looks at how well total knee replacement works for people who have severe knee arthritis and a bow-leg (varus) deformity. It may help you if you have a lot of knee pain and are considering surgery.
MoscowAges 18 years+ - NCT07470021Recruiting
Numbing injection for pain relief after ankle surgery
This study tests whether a numbing injection around the ankle nerves before surgery can reduce pain and help you recover faster after ankle arthroscopy. It is for people having this keyhole surgery and staying in the hospital for a short time.
Hangzhou, ZhejiangAges 18–65 - NCT07464665Recruiting
Comparing two hip socket implants for first-time hip replacement
This trial compares two types of hip socket implants (dual-mobility cups vs. standard cups) during first-time hip replacement through the front of the hip. It aims to see which type may reduce the risk of dislocation after surgery.
BrugesAges 18 years+ - NCT07467187Recruiting
Home Ventilation with Tracheostomy in Denmark (2016–2025)
This study looks at people in Denmark who need a home ventilator through a tracheostomy. It aims to understand their care and outcomes over several years.
CopenhagenAges Any age - NCT07464821Recruiting
Lipid profile study in Noonan syndrome and related disorders
This study looks at cholesterol and fat levels in people with Noonan syndrome or related conditions. It aims to understand how these levels change with age, gender, and genetic cause.
AlessandriaAges 2–35 - NCT07463937Recruiting
Study of Methotrexate Injections in Rheumatoid Arthritis
This study looks at how well methotrexate injections work in people with rheumatoid arthritis. It is designed for patients who are starting or changing to this type of methotrexate treatment.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07468734Recruiting
Shock wave vs. physical therapy for knee arthritis
This study compares two treatments for chronic knee osteoarthritis: shock wave therapy and traditional physical therapy. The goal is to see which one helps reduce pain and improve function better.
CairoAges 40 years+ - NCT07464639Enrolling by invitation
Comparing two ways to help shoulder pain with movement feedback
This study compares using ultrasound images (dynamic visual feedback) versus manual guidance to help activate shoulder blade muscles and improve space in the shoulder joint for people with shoulder pain when lifting their arm.
Long Beach, CaliforniaAges 18–70 - NCT07469345Enrolling by invitation
Teeth Grinding and Pelvic Pain in Young Men
This study looks at how teeth grinding (bruxism) is linked to pelvic pain, erectile function, and anxiety in young adult men. It aims to understand if these issues are connected, which could help develop better treatments.
KonyaAges 18–30 - NCT07470307Recruiting
Exercise for chronic low back pain: Pilates vs. strength training
This trial compares dynamic lumbar strengthening exercises to Pilates, both combined with myofascial release, for people with ongoing low back pain. It aims to find which approach works better for reducing pain and improving function.
Lahore, Punjab ProvinceAges 25–35 - NCT07466823Recruiting
Spasticity Patterns and Quality of Life in MS
This study looks at patterns of muscle stiffness (spasticity) in people with multiple sclerosis and how these patterns affect daily life and well-being. It aims to better understand the link between spasticity and quality of life.
IstanbulAges 18 years+ - NCT07465991Recruiting
Online insomnia therapy for fibromyalgia and activity
This study tests if an online therapy program for insomnia (using cognitive behavioral therapy, or CBT) can help people with fibromyalgia sleep better and be more physically active. If you have fibromyalgia and trouble sleeping, this treatment may improve your pain and daily function.
OxfordAges 18 years+ - NCT07464080Recruiting
Brain imaging study for knee replacement patients
This study uses advanced brain scans to understand how pain and recovery change after knee replacement surgery. It may help researchers develop better ways to manage pain after surgery.
Ottawa, OntarioAges 18 years+ - NCT07468461Recruiting
Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome study
This study looks at children with CACP syndrome, a rare genetic condition, to learn more about how the condition affects the body over time.
BariAges Up to 18 years - NCT07465159Recruiting
Prehabilitation for frail patients before hip or knee replacement
This study tests whether a 'prehabilitation' program (tailored exercise and nutrition support before surgery) helps older patients who are frail recover better after hip or knee replacement. Participants will be randomly assigned to either the prehabilitation group or the usual care group.
ReykjavikAges 70 years+ - NCT07469787Recruiting
Transition from pediatric to adult rheumatology care study
This study looks at how to improve the shift from pediatric to adult rheumatology care for young people with chronic inflammatory rheumatic diseases. It aims to understand how healthcare services can better support this transition.
Le Kremlin-BicêtreAges 18 years+ - NCT06792305Recruiting
Surgery order for severe pelvic fractures
This study tests the best order of steps during surgery to fix a severe pelvic fracture (Tile C1.2 or C1.3). It may help determine if stabilizing the back or the front of the pelvis first leads to better outcomes.
CairoAges 18–60 - NCT06791226Recruiting
Testing FAPI PET/CT for eye socket tumors
This study tests whether a new type of PET/CT scan (FAPI) can provide better images of tumors in the eye socket than the standard FDG scan. If you have a suspected or newly diagnosed orbital tumor, joining could help doctors see your tumor more clearly.
Beijing, Beijing MunicipalityAges 3–80 - NCT01848028Recruiting
German registry collecting data on new systemic psoriasis treatments
This study is a psoriasis registry that records real-world information about people starting a systemic (whole-body) treatment for the first time. It helps doctors understand how these treatments work in everyday care and may improve future treatment decisions.
HamburgAges 18 years+ - NCT06788860Recruiting
Needle knife release for trigger finger
This trial tests if using a needle knife guided by ultrasound can help release a locked or painful trigger finger. It's for people who have had symptoms for at least 3 months and haven't gotten better with other treatments like splinting or exercises.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT06485206Recruiting
Hybrid disc replacement and fusion for two-level neck disease
This study tests a combination of a disc replacement (Mobi-C) and a spinal fusion (ACDF) for people with degenerative disc disease at two levels in the neck. The goal is to see if this approach is safe and effective for relieving pain and nerve symptoms.
Sacramento, CaliforniaAges 22–69 - NCT06788847Recruiting
Ultrasound-guided needle knife for Dupuytren's contracture
This trial tests a less invasive procedure using a needle-knife guided by ultrasound to treat Dupuytren's contracture, which causes fingers to curl. It may be an option if you haven't had prior treatment on the same hand and are in otherwise good health.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT06794632Recruiting
Hand osteoarthritis self-management program
This trial tests a group program to help people with hand osteoarthritis manage daily activities better. It focuses on peer learning and support to improve your ability to do everyday tasks.
Copenhagen, Capital RegionAges 18 years+ - NCT07459400Recruiting
Mud therapy for young adults with scoliosis back pain
This study tests whether adding mud therapy (peloidotherapy) to standard scoliosis exercises helps reduce pain and improve function in young adults with mild to moderate scoliosis. It may be a good fit if you have idiopathic scoliosis and ongoing back pain.
Istanbul, GaziosmanpasaAges 20–40
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.