Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT06654882RecruitingPhase 3
Switching medications after first treatment fails in juvenile arthritis
This study tests different medication sequences for children and teens with polyarticular juvenile idiopathic arthritis (JIA) who still have moderate or high disease activity after at least 3 months on their first tumor necrosis factor inhibitor (TNFi) therapy. The goal is to find the best next step to control symptoms and improve quality of life.
San Francisco, CaliforniaAges 2–17 - NCT07286058RecruitingPhase 3
Long-term study of zasocitinib for psoriatic arthritis
This study is for people with psoriatic arthritis who have already completed a year-long treatment with zasocitinib or a similar medicine in a previous study. It tests whether continuing to take zasocitinib remains safe and helpful over a longer time.
Fountain Valley, CaliforniaAges 18 years+ - NCT07319091Recruiting
Cystinosis and Mitochondrial Energy Study
This study looks at how cystinosis affects the energy centers (mitochondria) in your cells. It may help doctors understand how cysteamine treatment works in patients with kidney cystinosis.
BronAges 2 years+ - NCT06916403Enrolling by invitation
Ketamine infusions for fibromyalgia pain
This study looks at whether ketamine given through an IV can help reduce fibromyalgia pain. It reviews past treatments and also plans new treatments to see how well they work and how safe they are.
Thornhill, OntarioAges 18 years+ - NCT05296889Recruiting
Safety follow-up for Ennovate cervical device
This study checks how safely and effectively a cervical device (Ennovate® Cervical) works after it’s been used in routine care. It may help by monitoring real-world safety and performance over time.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT07321873RecruitingPhase 2
Study of JNJ-88545223 for Active Psoriatic Arthritis
This study tests an experimental drug called JNJ-88545223 to see if it can reduce joint pain, swelling, and skin plaques in people with active psoriatic arthritis. It may help if you have both joint symptoms and psoriasis.
Searcy, ArkansasAges 18 years+ - NCT06982105RecruitingPhase 4
Comparing two antibiotics for children with MRSA bone or head infections
This study compares two oral antibiotics, TMP-SMX and clindamycin, to see which works better for children with MRSA infections in bones, joints, or head/neck areas. It aims to find the best treatment after initial IV therapy.
Indianapolis, IndianaAges 2 months–18 years - NCT06663332RecruitingPhase 3
Long-term study of guselkumab in children who previously took it
This study is a long-term follow-up for children who have already finished an earlier study of guselkumab, a medicine for skin conditions like psoriasis. It looks at whether staying on the medicine continues to be safe and helpful over time.
Atlanta, GeorgiaAges 3 years+ - NCT07587684RecruitingPhase 1
Testing IN026 for Hard-to-Treat Gout
This study tests a new drug called IN026 for people with refractory gout—gout that doesn't respond well to current treatments and causes severe symptoms. The goal is to see if IN026 can lower uric acid levels and reduce gout attacks.
WuhanAges 18–75 - NCT07403929Recruiting
Fermented grape juice for fibromyalgia symptoms
This trial tests whether drinking fermented grape juice can help relieve fibromyalgia symptoms like pain and cramping. If you are a woman between 20 and 40 with mild excess weight and fibromyalgia, you may be eligible.
Istanbul, IstanbulAges 20–40 - NCT06791044Recruiting
Vitamin D and bone health in neurological patients
This trial looks at how vitamin D levels relate to bone strength and daily function in people with neurological disorders. If you have a neurological condition or are healthy, you may join to help understand how vitamin D affects bone health.
Nea Liosia, AthensAges 20–85 - NCT07739628Enrolling by invitation
Testing a computer tool for osteoporosis screening from CT scans
This study checks if a new computer program can find people at risk for osteoporosis more easily, using CT scans you already had. If you are found to be high risk, you'll get a free bone density test (DXA) to confirm, and help improve this tool.
Wuhan, HubeiAges 18 years+ - NCT07141004RecruitingPhase 4
Study of guselkumab for psoriatic arthritis in Indian patients
This trial tests if guselkumab, a drug given as an injection under the skin, can help people with psoriatic arthritis (PsA) who haven't had enough relief from standard treatments. It aims to find a new option for managing joint pain and swelling.
AhmedabadAges 18 years+ - NCT06969820Recruiting
Low-dose radiation for heel pain with plantar fasciitis
This study tests whether low-dose radiation therapy (LDRT) can help people with long-term heel pain from plantar fasciitis and a heel spur. It uses imaging and checkups to measure how well the treatment works.
Erlangen, BavariaAges 40 years+ - NCT07085104RecruitingPhase 1
Study of ALLO-329 for lupus, myositis, or scleroderma
This trial tests a new one-time cell therapy (ALLO-329) made from donor cells to target and calm overactive immune cells in people with lupus, myositis, or scleroderma that hasn't improved with usual medications. It aims to see if this treatment is safe and can help reduce disease activity.
Phoenix, ArizonaAges 18–74 - NCT06100744RecruitingPhase 3
Comparing two drugs for children with psoriatic arthritis
This study tests two drugs—risankizumab and adalimumab—to see which is safer and works better for children with active psoriatic arthritis. It's for kids who have not been helped enough by standard disease-modifying drugs.
Little Rock, ArkansasAges 5–17 - NCT07736144Recruiting
Herbal formula study for fibromyalgia pain relief
This study tests a Chinese herbal formula called Yangyin Roujin (which nourishes yin and softens the muscles) to see if it helps reduce pain and other symptoms of fibromyalgia. If you have fibromyalgia and a pain level of 4 or more, you may be able to join.
Beijing, Beijing MunicipalityAges 18–75 - NCT07118501Recruiting
Study of the Incompass total ankle system
This study is testing a new ankle replacement device called Incompass. It aims to see how well the device works and how safe it is for people who need ankle replacement surgery.
Morton Grove, IllinoisAges 21 years+ - NCT07089875RecruitingPhase 3
Testing dotinurad vs allopurinol for people with gout
This study compares a new gout medicine called dotinurad to the common medicine allopurinol. It is for people who have had gout for at least a year, have had at least 2 gout attacks in the last year, and are already taking a stable dose of allopurinol but still have high uric acid levels.
Birmingham, AlabamaAges 18–75 - NCT07535034RecruitingPhase 2
Testing Dotinurad for Gout in People Who Can't Take Other Medications
This trial tests a new drug called dotinurad for gout patients whose standard medications either don't work or cause side effects. Dotinurad works differently by helping your body get rid of uric acid (the substance that causes gout attacks), and the study will see if it safely lowers uric acid levels.
Granada Hills, CaliforniaAges 18–75 - NCT06082531Recruiting
Platelet-rich plasma injection for knee osteoarthritis
This study tests whether injecting platelet-rich plasma (PRP) from your own blood can help knee pain caused by osteoarthritis or injuries to the cartilage and meniscus. It may be an option if you are between 20 and 60 years old and have not had recent steroid shots or certain health problems.
Xi'an, ShannxiAges 20–60 - NCT06011551Recruiting
Gel injection for painful lumbar discs
This trial tests a gel (HYDRAFIL-D) injected into painful discs in your lower back to see if it relieves pain. It's for people whose back pain hasn't improved with other treatments.
Birmingham, AlabamaAges 22–85 - NCT06712628Recruiting
Comparing how long people stay on upadacitinib vs TNF inhibitors for RA
This study compares how well people with rheumatoid arthritis stay on two types of medicines: upadacitinib (Rinvoq) and TNF inhibitors. It looks at real-world experiences in Germany to see if one medicine is more likely to be continued over time.
Freiburg im Breisgau, Baden-WurttembergAges 18 years+ - NCT03704766Recruiting
Testing fluid markers to detect pediatric joint infections
This study checks special lab markers in joint fluid to tell septic (infected) arthritis apart from other inflammatory causes in children. It may help clinicians detect infection more accurately and quickly so kids can get the right treatment.
Atlanta, GeorgiaAges Up to 17 years
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.