Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05093673Recruiting
Brain stimulation for language recovery after stroke
This study tests whether stimulating the cerebellum can improve word-finding and language skills in people with aphasia after a left-sided stroke. It’s meant for people who are months past their stroke and still have naming difficulties.
Baltimore, MarylandAges 18–99 - NCT05094362Recruiting
Training to reduce stiff leg reflexes after spinal cord injury
This study tests a special training approach designed to calm overactive leg reflexes (spasticity) after spinal cord injury. If you qualify, you may do structured walking/reflex training to see whether your leg reflexes and movement improve.
Charleston, South CarolinaAges 18 years+ - NCT05095571Recruiting
Extension study of vitamin supplements for ALS
This study looks at continuing a nicotinamide/pterostilbene supplement in people with ALS who already finished an earlier related NO-ALS study. It may help researchers learn whether the supplement can be continued safely and potentially benefit longer-term outcomes.
BergenAges 35 years+ - NCT05095857RecruitingPhase 4
Ketamine to improve care in severe acute brain injury
This Phase 4 trial tests whether giving ketamine during anesthesia is safe and helpful for adults with severe sudden brain injuries after surgery. It may improve how patients are sedated and cared for while they are on a breathing machine.
CopenhagenAges 18 years+ - NCT05097001Recruiting
Personalized brain-stimulation program for dystonia using imaging
This study tests whether using brain imaging to guide stimulation settings can improve symptoms in people with long-term deep brain stimulation for dystonia. It will compare different stimulation approaches in a blinded, step-by-step crossover design to see which one helps more.
Würzburg, BavariaAges 18 years+ - NCT05097261RecruitingPhase 4
Ketamine for adults with severe brain injury in the ICU
This trial studies whether ketamine can improve outcomes for adults with severe traumatic brain injury when they are in the ICU and need sedation. It focuses on patients who have pressure monitoring inside the brain soon after admission.
BonheidenAges 18 years+ - NCT05098665Recruiting
Home monitoring to help prevent hospital stays for ATTR heart disease
This trial tests whether using home weight/health tracking can help people with ATTR cardiomyopathy avoid going to the hospital. It may help by catching fluid build-up or worsening earlier so treatment can be adjusted sooner.
London, LondonAges 18 years+ - NCT05098340Recruiting
Blood RNA test study for new stroke patients
This trial looks at certain molecules in the blood (called circRNA) in people who have a new ischemic stroke (a blockage in a blood vessel). It may help researchers understand what these blood signals mean soon after stroke, which could guide future treatments or monitoring.
Xuzhou, JiangsuAges 18 years+ - NCT05100771Recruiting
MRI study for kids with focal epilepsy
This trial studies how to make MRI images better for children with epilepsy that starts in one area of the brain. It may help doctors use brain MRI more effectively when evaluating where seizures begin.
AngersAges 1–18 - NCT05102747Recruiting
Surgery-like brain radiation for up to 5 metastases
This trial compares two ways of giving focused radiation to the brain for people with a limited number of brain metastases. It aims to see which schedule works best (and is likely best for costs and quality of life).
BordeauxAges 18 years+ - NCT05101304Recruiting
European registry for people with amyloidosis
This study collects health information from people who may have amyloidosis or who already have a confirmed diagnosis. It aims to better understand amyloidosis in real-world care across European centers, which can help future patients and treatments.
CréteilAges Any age - NCT05101161Recruiting
Neurofeedback delivered through implanted brain stimulation
This study tests a brain “feedback” approach using electrodes already placed as part of standard medical care. It aims to see whether this method is safe and helpful for people undergoing deep brain stimulation after surgery.
Zurich, Canton of ZurichAges 18 years+ - NCT05103566Recruiting
Noninvasive vagus nerve stimulation for ruptured brain aneurysm bleed
This trial studies whether a noninvasive device that stimulates the vagus nerve can be safely given soon after a ruptured aneurysm bleed to improve outcomes. It may help calm the brain’s stress response after this type of stroke-like emergency.
Boston, MassachusettsAges 18–85 - NCT05104983RecruitingPhase 2
Sirolimus to prevent first seizures in babies with TSC
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
Birmingham, AlabamaAges 1 day–6 months - NCT05104736RecruitingPhase 2
PT-112 for thymus gland tumors after prior chemotherapy
This trial studies PT-112, a new treatment, in people with thymoma or thymic carcinoma that has grown despite at least one prior platinum chemotherapy treatment. It may help shrink tumors or slow disease progression, especially when surgery is not possible.
Bethesda, MarylandAges 18–120 - NCT05105633RecruitingPhase 2/Phase 3
Tenecteplase for basilar stroke within an extended time window
This trial tests whether giving a clot-busting medicine (tenecteplase) can help people with a specific type of stroke caused by a basilar artery blockage, even if treatment starts later than usual. It aims to improve brain recovery and function by reopening the blocked artery.
Bankstown, New South WalesAges 18 years+ - NCT05106140Recruiting
Robots help measure arm learning after a new stroke
This study uses robotic devices to understand how your arm learns movement after a recent stroke. It may help researchers improve stroke rehabilitation by figuring out what kinds of practice work best.
Calgary, AlbertaAges 18 years+ - NCT05106296RecruitingPhase 1
Chemo-immunotherapy with ibrutinib and indoximod for pediatric brain tumors
This Phase 1 study tests a combination treatment (ibrutinib plus indoximod along with chemotherapy) for children with brain tumors that have come back or are hard to treat. It may help shrink active tumor or control the disease when standard treatments can’t cure it.
Augusta, GeorgiaAges 3–25 - NCT05106725Recruiting
Wearable health tracking study for cancer and brain conditions
This study tests wearable devices and related health measurements (“biomarkers”) in people who have cancer-related nerve problems, a brain/neurological condition, or who are healthy for comparison. It may help researchers better understand health signals over time in these groups.
San Diego, CaliforniaAges 18 years+ - NCT05107466Recruiting
Tests brain responses in adults with hearing loss
This study measures how your brain reacts to sounds and visual information. It may help researchers better understand brain function changes that can happen with hearing loss and how to assess them.
Lebanon, New HampshireAges 18 years+ - NCT05111093Recruiting
Epidural electrical stimulation for steadier blood pressure after spinal injury
This study tests a treatment that delivers electrical stimulation through an epidural device to help stabilize blood pressure and improve trunk control in people with a spinal cord injury. It may help reduce episodes of dizziness or drops in blood pressure when standing and support better body control during activity.
Lausanne, Canton of VaudAges 18 years+ - NCT05112549RecruitingPhase 1
PD-1 antibody placed into brain fluid for metastatic cancer
This early-phase study tests a PD-1 antibody delivered directly into the brain fluid (intrathecal space) to treat metastatic solid tumors that have spread to the lining around the brain/spinal cord (leptomeningeal disease). It aims to see whether this approach can better control cancer in that area and whether it’s safe.
BonnAges 18 years+ - NCT05113043Recruiting
Study links gut changes with stroke in younger adults
This study looks at whether differences in gut bacteria (microecology) are linked to stroke in adults ages 18–45. You may be asked to provide stool (fecal) samples soon after admission to help researchers understand possible connections.
ShanghaiAges 18–45 - NCT05114876Recruiting
Tested a new plan to support older adults after surgery
This study looks at a redesigned surgical care plan to better support older adults who may have memory or thinking changes after major planned surgery. If you qualify, you would be assessed before surgery and followed after to see whether this approach helps.
Toronto, OntarioAges 60 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.