Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,740
- Phase 2781
- Phase 1578
- Phase 3536
- Phase 4343
- Phase 1/Phase 2306
- Phase 2/Phase 3123
Top conditions
- Stroke841
- Parkinson Disease429
- Multiple Sclerosis345
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke201
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries154
- Insomnia152
- Traumatic Brain Injury150
- Sarcopenia149
- Acute Ischemic Stroke137
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California681
- Massachusetts299
- New York292
- Florida273
- Texas268
- Maryland246
- Arizona214
- Alabama210
- Illinois189
- Pennsylvania175
Recruiting studies12,405 total
- NCT07315334Recruiting
Understanding nerve damage from chemotherapy
This study looks at how chemotherapy-related nerve damage affects daily activities like walking and standing. It includes people who currently have or have had nerve-damaging chemotherapy and are experiencing nerve pain or weakness.
SalzburgAges 18 years+ - NCT07008469Enrolling by invitationPhase 3
Long-term safety study of del-desiran for DM1
This study tests whether the drug del-desiran continues to be safe and effective for people with DM1 (myotonic dystrophy type 1) after they complete an earlier study. You'll receive the drug and have regular check-ups to see how you're doing.
Los Angeles, CaliforniaAges 16 years+ - NCT06523296Recruiting
Antibodies and thinking problems in myasthenia or Alzheimer's
This study looks at whether certain antibodies are linked to memory and thinking problems in people with myasthenia gravis or Alzheimer's disease. It involves a one-time use of leftover spinal fluid from a previous diagnostic test.
Nice, Alpes MaritimesAges 18 years+ - NCT07405775Recruiting
SleepFix for Youth: app-based insomnia therapy with psychologist support
This study tests a smartphone app that helps young people with insomnia develop better sleep habits, with guidance from an e-psychologist. It may help you sleep better without needing in-person therapy.
Sydney, New South WalesAges 16–24 - NCT06996652RecruitingPhase 2
Study of adalimumab to delay Parkinson's symptoms in sleep disorder
This trial tests whether adalimumab, an immune system drug, helps people with REM sleep behavior disorder (a condition that may warn of Parkinson's disease) stay healthy longer. Participants will receive injections of the drug or a placebo to see if it prevents Parkinson's-related brain problems.
Los Angeles, CaliforniaAges 50–80 - NCT07215884RecruitingPhase 1
Dopamine and movement in people who stutter
This study looks at how dopamine affects speech and movement in adults who stutter. It may help us understand why stuttering happens.
San Francisco, CaliforniaAges 18–65 - NCT05277025Recruiting
Brain pain testing in long-term joint pain and fibromyalgia
This study looks at how the brain processes pain in people with long-term pain conditions like fibromyalgia and rheumatoid arthritis. You may be asked to undergo pain-related tasks to help researchers understand differences between inflammatory and non-inflammatory chronic pain.
Gainesville, FloridaAges 18–70 - NCT06465810Recruiting
Observational study for ATTR amyloidosis patients
This study follows patients with ATTR amyloidosis over time to understand how the disease affects them. It does not test a new treatment—instead, it asks you to fill out questionnaires about your health and symptoms to help doctors learn more about the condition.
La Jolla, CaliforniaAges 18–130 - NCT05527652Recruiting
Breathing tube device to help blocked upper airways in children
This study tests a self-supporting breathing tube placed through the nose during sleep to reduce upper airway blockage and improve breathing in children. It may help children who have sleep apnea symptoms, especially after tonsil/adenoid treatment or when tonsil removal isn’t possible.
Ann Arbor, MichiganAges 3–21 - NCT04047264Recruiting
Monitoring brain chemistry during brain surgery
This study tests whether a tiny probe can safely measure brain chemistry during and after brain surgery. It may help doctors better understand and treat brain conditions like tumors or epilepsy.
Rochester, MinnesotaAges 18 years+ - NCT07770191Recruiting
Distraction methods for easing pain and fear during blood draws in children
This study tests different distraction techniques, like chewing gum or other activities, to help reduce pain and fear when children aged 5 to 10 get blood drawn. The goal is to make the experience more comfortable and less stressful.
TekirdağAges 5–10 - NCT07498140Recruiting
Epidural steroid injection for leg and back pain
This study is testing a treatment that involves an injection to reduce nerve-related leg and back pain. It looks at how much information about the procedure affects a patient's outlook and pain relief.
Chicago, IllinoisAges Any age - NCT07771335Recruiting
Erlangen stroke registry: tracking strokes over time
This study collects health information from people in Erlangen, Germany who have had a stroke. It helps researchers understand stroke causes and outcomes to improve future care.
ErlangenAges 18 years+ - NCT03260400Recruiting
Muscle and nerve implants to improve bionic arm control
This study tests a new approach that uses small nerve and muscle grafts along with temporary electrodes to help people with an above-wrist arm amputation get better control of a bionic arm. If it works, it could make prosthetics feel more natural and easier to use.
Ann Arbor, MichiganAges 22–75 - NCT05541276RecruitingPhase 3
Melatonin to prevent waking confusion in young children after surgery
This study tests whether giving melatonin before surgery can help prevent agitation and confusion in young children after they wake up from anesthesia. Participation may help your child have a smoother recovery after their procedure.
Copenhagen, Capital RegionAges 1–6 - NCT06666673RecruitingEarly Phase 1
Effects of a muscle relaxant on arm movement after stroke
This study looks at how the brain controls arm movements after a stroke. It tests whether a medication called tizanidine, which relaxes muscles, can improve arm function when combined with physical therapy.
Chicago, IllinoisAges 18–80 - NCT07104032RecruitingPhase 3
Tirabrutinib vs standard therapy for relapsed PCNSL
This study tests a new oral targeted drug called tirabrutinib against a standard treatment combination (rituximab plus temozolomide) for people whose primary central nervous system lymphoma has come back or not responded to prior therapy.
Phoenix, ArizonaAges 18 years+ - NCT07524036Recruiting
Nursing education to help stroke patients follow care plans
This study tests whether a special nursing education session helps stroke patients stick to their recovery plan after going home. The goal is to see if personalized teaching improves how well patients take medications and follow doctor's advice.
BayonneAges 18 years+ - NCT06621329RecruitingPhase 2/Phase 3
Numbing shot for headache after brain bleed
This trial tests a numbing injection inside the nose to quickly relieve severe headaches caused by a brain bleed (subarachnoid hemorrhage). It may help reduce pain without strong medicines.
Sacramento, CaliforniaAges 18–100 - NCT07225491Recruiting
Spine cancer treatment study
This study collects information about people with spine cancer who have surgery to relieve pressure on the spine, followed by radiation therapy. The goal is to learn more about how well these treatments work together.
Indianapolis, IndianaAges 18 years+ - NCT07726875Enrolling by invitation
Orexin and confusion after surgery in older adults
This study looks at a brain chemical called orexin (which helps control wakefulness) in older adults after surgery. The goal is to see if orexin levels are linked to confusion or agitation that can happen when waking up from anesthesia. If you take part, your blood will be tested before and after surgery.
Shanghai, Shanghai MunicipalityAges 60 years+ - NCT07696312Recruiting
Straight leg raise test accuracy for leg pain
This study checks how well the straight leg raise test can find the exact nerve causing your leg pain by comparing it with a targeted nerve block injection. It may help if you have leg pain from a pinched nerve in your lower back.
Istanbul, PENDİKAges 18–65 - NCT04789746Enrolling by invitation
Physical fitness program for children with mobility challenges
This study tests a physical fitness program designed for children who have mobility challenges due to conditions like cerebral palsy. The program aims to improve fitness and overall well-being in a safe and supportive environment.
Chicago Heights, IllinoisAges 6–18 - NCT07770035Enrolling by invitation
School-age outcomes after newborn brain injury
This study looks at how children who had a brain injury around birth (called hypoxic-ischaemic encephalopathy, or HIE) are doing in school and daily life, compared to children without that history. It aims to understand the long-term effects and support needs.
Cork, CorkAges 5–12
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,231 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.