Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,742
- Phase 2782
- Phase 1577
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3123
Top conditions
- Stroke843
- Parkinson Disease429
- Alzheimer Disease342
- Multiple Sclerosis342
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries153
- Insomnia152
- Sarcopenia150
- Traumatic Brain Injury150
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California680
- Massachusetts299
- New York292
- Florida274
- Texas267
- Maryland246
- Arizona213
- Alabama209
- Illinois189
- Pennsylvania177
Recruiting studies12,405 total
- NCT05698147RecruitingPhase 1/Phase 2
Selinexor plus methotrexate and rituximab for recurrent brain lymphoma
This trial tests selinexor given together with methotrexate and rituximab to treat lymphoma that has returned or not responded in the brain. It may help by attacking cancer cells in the central nervous system (brain/spinal fluid) after prior treatment.
Hefei, AnhuiAges 18–75 - NCT05656105RecruitingEarly Phase 1
PET scan study of brain inflammation after COVID
This early-phase study uses a special PET scan to look for signs of brain inflammation in people with ongoing (long-term) nervous system symptoms after COVID-19. It may help researchers understand what is driving symptoms and whether this imaging approach can detect inflammation.
Birmingham, AlabamaAges 18–65 - NCT05411523Recruiting
Spinal cord stimulation study for long-term chemotherapy nerve pain
This trial tests whether spinal cord stimulation can reduce pain and improve quality of life in people with long-lasting nerve pain from chemotherapy (CIPN). You must already have tried at least two nerve-pain medicines and still have significant pain, and you must have had a successful spinal cord stimulator test before joining.
Rochester, MinnesotaAges 18 years+ - NCT05754372Recruiting
Dialysis-focused treatment study for newborn high ammonia
This trial looks at how to best treat newborns with very high ammonia in the blood when urgent dialysis is needed. It may help doctors choose the most effective way to rapidly lower ammonia and improve outcomes in babies with certain inherited metabolic conditions.
GhentAges Up to 1 year - NCT05764772Recruiting
Testing features of plaque in symptomatic carotid narrowing
This study looks at the makeup of plaque in the carotid artery (the neck blood vessel to the brain) in people who recently had a stroke caused by that narrowing. Researchers will use MRI and planned surgery to see which plaque components may matter for stroke risk and outcomes.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05547152Recruiting
Virtual Reality for Facial Paralysis Recovery
This trial tests whether a virtual reality self-rehabilitation program can help people recover movement and reduce unwanted muscle contractions after recent facial paralysis. You would practice facial exercises using VR technology at home to retrain your facial muscles.
Amiens, PicardieAges 18 years+ - NCT05745623RecruitingPhase 1/Phase 2
Testing an NTRK-fusion drug for advanced tumors
This Phase 1/2 study tests ICP-723, a medicine designed to treat cancers that have an NTRK gene fusion. It may help shrink tumors in people whose cancer test shows this specific genetic change and who haven’t taken an NTRK inhibitor before.
Guangzhou, GuangdongAges 2 years+ - NCT05642611RecruitingPhase 3
Cooling and compression for nerve protection during chemotherapy
This study tests whether using cooling and/or compression on the arms or legs can prevent nerve damage that can happen from certain chemotherapy drugs. If you get eligible chemo soon, this may help lower the chance of painful numbness or tingling during treatment.
Birmingham, AlabamaAges 18 years+ - NCT05572671Recruiting
Study brain scans to predict near-term smoking relapse risk
This study uses MRI brain scans and smoking measurements to understand what may predict when someone is about to smoke again. If you qualify, you’ll be asked to avoid nicotine for 12 hours before a lab visit and complete MRI safety screening.
University Park, PennsylvaniaAges 21–65 - NCT05489393Recruiting
Global registry for people with DRPLA
This study is a global patient registry that collects information from people with DRPLA to better understand the condition over time. It may help researchers learn what to expect and how to support future treatments, and participation mainly involves giving consent and sharing your history.
New York, New YorkAges birth–100 years - NCT05436600Recruiting
Exercise program for people with narrowed neck arteries
This trial studies whether a supervised exercise program can improve mobility and balance in people who have narrowed carotid arteries in the neck but no stroke symptoms. If you fit the criteria, the goal is to see whether exercise helps your movement and safety without increasing risks.
Baltimore, MarylandAges 18–89 - NCT05558566Recruiting
Neurofeedback training for Tourette-related tics in teens
This study tests whether brain training using “neurofeedback” can reduce Tourette syndrome tics in children ages 10–16. It compares an active neurofeedback condition to a control condition while measuring brain activity with an MRI.
New Haven, ConnecticutAges 10–16 - NCT05582785Recruiting
MRI scan evaluation for children without added sedation
This study checks how well a special MRI machine setting (low-field MRI) works for outpatients who are children. It may help your child get an MRI without extra sedation added for the study.
Kansas City, MissouriAges birth–22 years - NCT05327387Recruiting
Brain stimulation study using implanted electrodes
This study tests a model-based way of using electrical brain stimulation in people who are having surgery for drug-resistant epilepsy or brain tumors. It uses implanted electrodes to measure brain activity and may help improve how stimulation is planned during surgical care.
Los Angeles, CaliforniaAges 18 years+ - NCT05272202RecruitingEarly Phase 1
Study brain signals after median nerve stimulation during anesthesia
This early-stage study checks how brain activity changes when the median nerve is gently stimulated while you’re under general anesthesia with propofol. It may help researchers better understand brain–nerve connections and improve how these signals are measured.
BrusselsAges 18–81 - NCT05331937RecruitingPhase 3
TMS plus exposure therapy for severe OCD that won’t improve
This trial studies whether TMS (a brain stimulation treatment) can help people with severe OCD who have not responded well to exposure therapy. It combines brain stimulation with intensive exposure therapy to reduce obsessions and compulsions.
Amsterdam, North HollandAges 18 years+ - NCT05635812Recruiting
Brain and eye tests of facial emotion recognition in autism
This study uses brain and eye measurements to understand how people recognize facial expressions, including in autism and related conditions. It may help researchers find markers that better explain autism-related symptoms and differences in processing emotions.
DijonAges 7–50 - NCT05487131Recruiting
Brain stimulation study for fatigue in healthy adults
This study tests a form of brain/nerve stimulation to see how it affects fatigue. It is looking for healthy adults, which helps researchers understand the effects without other illnesses.
Norman, OklahomaAges 18–50 - NCT05452122Recruiting
Studying how sleep and wakefulness shape memory in epilepsy
This study looks at how your brain makes and keeps memories across waking and sleeping periods. If you have epilepsy and are having depth electrodes placed as part of your care, your team will also use this information to better understand memory and how it may be influenced.
Los Angeles, CaliforniaAges 18–65 - NCT05426681RecruitingPhase 1
Glyburide to protect the spinal cord after injury
This Phase 1 trial tests whether glyburide, a drug used for blood sugar, can help protect nerve tissue after an acute spinal cord injury. It’s mainly focused on safety and early signs that the treatment might be beneficial for people with certain levels of spinal cord damage.
Lexington, KentuckyAges 18–80 - NCT05538286Recruiting
Ultrasound treatment after brain bleed surgery
This trial studies whether a special form of ultrasound through the skull can improve recovery after a spontaneous brain bleed that requires minimally invasive surgery. It may help by targeting the damaged brain tissue after evacuation, and the study will follow participants for up to a year.
New York, New YorkAges 18 years+ - NCT05467813Recruiting
Mirror and augmented reality training for stroke arm recovery
This study tests whether doing therapy with mirror training plus augmented reality (computer-generated prompts you see through a device) improves arm movement after a first stroke. You may be eligible if you had a stroke on one side and can safely follow instructions and do walking and standing tasks.
New Taipei CityAges 20–80 - NCT05433129Recruiting
Test of brain blood-flow control using near-infrared light
This study uses a non-invasive light test on the forehead to measure how your brain regulates its blood flow. It’s meant to help researchers understand brain circulation control in healthy people.
Winnipeg, ManitobaAges 18 years+ - NCT05323149RecruitingPhase 3
Tranexamic acid for non-penetrating brain injury after trauma
This Phase 3 study tests whether tranexamic acid can improve outcomes after traumatic brain injury. It may help by reducing bleeding and related damage soon after the injury in adults with mild to moderate cases.
Asyut, AssuitAges 18–65
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,276 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.