Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,497 recruiting studies in this area right now.
By phase
- Not applicable9,839
- Phase 2787
- Phase 1573
- Phase 3531
- Phase 4344
- Phase 1/Phase 2304
- Phase 2/Phase 3119
Top conditions
- Stroke856
- Parkinson Disease424
- Alzheimer Disease341
- Multiple Sclerosis341
- Dementia228
- Ischemic Stroke201
- Epilepsy196
- Insomnia156
- Obstructive Sleep Apnea155
- Traumatic Brain Injury154
- Spinal Cord Injuries151
- Sarcopenia149
- Acute Ischemic Stroke141
- Cerebral Palsy129
- Mild Cognitive Impairment128
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis107
Leading sponsors
- Beijing Tiantan Hospital135
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University71
- National Taiwan University Hospital69
- University of Minnesota63
Where studies are running
- California675
- Massachusetts305
- New York294
- Florida277
- Texas270
- Maryland245
- Alabama213
- Arizona211
- Illinois193
- Pennsylvania177
Recruiting studies12,495 total
- NCT07000526RecruitingPhase 4
Inhaled sedation for critically ill patients on breathing machines
This trial compares inhaled isoflurane sedation to standard propofol sedation in deeply sedated patients on ventilators. It aims to see if inhaled sedation improves outcomes.
Orihuela, AlicanteAges 18–80 - NCT07325487Recruiting
Brain stimulation for walking and balance in SCA6 ataxia
This study tests a new kind of deep brain stimulation that adjusts automatically to improve balance and coordination in adults with SCA6, a genetic form of ataxia. It may help patients who can still walk but have moderate to severe symptoms.
Gainesville, FloridaAges 21–89 - NCT07673809RecruitingPhase 1/Phase 2
Gene therapy trial for Duchenne muscular dystrophy in young boys
This trial tests a gene therapy called GNR-097 for boys with Duchenne muscular dystrophy (DMD). The therapy aims to help improve muscle function, and the study will check how safe and effective it is.
MinskAges 4–9 - NCT06600438Recruiting
Slow walking study for loss of smell
This study tests if a slow walking program can help prevent Parkinson's disease in people with a reduced sense of smell. You will be randomly assigned to a walking group or a control group and followed for 18 months.
LondonAges 40–100 - NCT05197946Recruiting
Imaging study comparing brain changes in cerebral palsy and typical people
This study uses surveys and brain imaging (MRI) to look for patterns that match chronic pain in people with cerebral palsy, and compares them with people without cerebral palsy. It may help researchers better understand what brain features relate to chronic pain.
Baltimore, MarylandAges 8 years+ - NCT06617377Recruiting
Can MRI predict brain recovery after cardiac arrest?
This study uses brain scans (MRI) to try to predict whether people who are still unconscious after a cardiac arrest will recover. It is looking for adults who are in a coma and have not woken up after being taken off sedation medicines for at least three days.
ToulouseAges 18 years+ - NCT07553923Recruiting
High-intensity walking rehabilitation for spinal cord injury
This study tests whether intensive walking training helps people with incomplete spinal cord injuries regain walking ability. You would work with physical therapists on challenging walking exercises to improve strength and independence.
Edmonton, AlbertaAges 18 years+ - NCT06671600Recruiting
Osteopathic treatment for sleep in Parkinson's disease
This study tests if gentle hands-on treatments (osteopathic manipulative medicine) can improve sleep quality for people with Parkinson's disease. You will wear a Fitbit and a ring to track your sleep, and receive the treatments over several sessions.
Old Westbury, New YorkAges Any age - NCT06998134Recruiting
Exoskeleton walking training for children and young adults
This trial tests whether a robotic leg exoskeleton can help improve walking in children and young adults with certain conditions (like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury) or those with no walking issues. The goal is to find out if the exoskeleton is safe and effective for everyday use, especially in younger people who might lose the ability to walk as they get older.
Bethesda, MarylandAges 5–25 - NCT07674329Recruiting
Virtual reality rehab for arm strength after stroke
This trial tests if using virtual reality (VR) exercises early after an ischemic stroke can help improve arm muscle strength, thinking skills, and mood. It is for people who have had a stroke within the last 10 days.
TaipeiAges 18–85 - NCT07672756RecruitingPhase 1
Testing PL54 injection for adults with PKU
This study tests a new injection called PL54 to see if it is safe and tolerable for adults with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine. It is designed for people with high blood phenylalanine levels and may offer a new treatment option.
Hefei, AnhuiAges 18–55 - NCT03419260Recruiting
Continuous EEG monitoring in critically ill children
This study looks at whether continuous brain-wave monitoring can guide seizure care in sick children in the pediatric intensive care unit. It also studies how this approach may affect children’s thinking and behavior later.
Philadelphia, PennsylvaniaAges 1 month–18 years - NCT06216717Recruiting
Study of electrode location for brain stimulation in chronic pain
This study looks at where electrodes are placed in the brain for people who have a device that stimulates the motor cortex to treat chronic nerve pain. The goal is to help improve how these devices are positioned for better pain relief.
Nice, Alpes MaritimesAges 18 years+ - NCT07430345RecruitingPhase 1/Phase 2
Buprenorphine for pain in older adults with broken bones
This trial tests a low-dose pain medicine called buprenorphine for people 65 and older who come to the emergency room with a broken bone. It aims to find a safe way to manage pain in older adults.
Camden, New JerseyAges 65 years+ - NCT03510208RecruitingPhase 1/Phase 2
Uses a dye drug during brain or nerve tumor surgery
This trial tests whether a medicine with a fluorescent dye (panitumumab-IRDye800) helps doctors better see certain tumors during surgery. It may help safer, more complete tumor removal for people with glioblastoma or vestibular schwannoma.
Palo Alto, CaliforniaAges 18 years+ - NCT06734611Recruiting
Folic acid salt study in Zambia
This trial tests whether adding folic acid to salt can help prevent birth defects. It is for women who are not pregnant, not planning pregnancy, and not breastfeeding.
Birmingham, AlabamaAges 18–45 - NCT05501236Recruiting
Nerve stimulation for sleep apnea using neck nerve signals
This study tests a device that stimulates nerves in the neck to help keep your airway open during sleep for obstructive sleep apnea. If you fit the safety and sleep-study requirements, it may offer an alternative approach to improving breathing at night.
Nashville, TennesseeAges 18 years+ - NCT03893643Recruiting
Skin and mouth symptoms of NF2 in children under 15
This study looks at skin and mouth problems that children with NF2 may have. It helps doctors learn more about NF2 symptoms in kids, which may lead to better care.
NiceAges birth–15 years - NCT06285643RecruitingPhase 2
Gene therapy for moderate Parkinson's disease
This trial tests a gene therapy (AAV2-GDNF) to see if it can slow or improve symptoms of Parkinson's disease. It is for people who have had moderate Parkinson's for 4 to 10 years and still respond to levodopa therapy.
Phoenix, ArizonaAges 45–75 - NCT07596823Recruiting
Blood counts and nerve pain relief after a nerve block
This study looks at how blood cell counts change when you receive a nerve-blocking injection for neuropathic pain (nerve damage pain). Researchers want to understand if these blood changes can predict how well the injection will help your pain.
Ankara, CankayaAges 18 years+ - NCT07571109RecruitingPhase 3
Weight Loss Medicine for Sleep Apnea on CPAP
This study tests a new injectable medicine (NNC0487-0111) to help people lose weight and improve obstructive sleep apnea (a breathing condition during sleep). You must already be using a CPAP machine (positive airway pressure device) for your sleep apnea.
Gilbert, ArizonaAges 18 years+ - NCT07633301RecruitingPhase 2
TAK-360 Study for Adults With Narcolepsy Type 1
This study tests a new medication called TAK-360 to help adults with narcolepsy type 1 (a condition that causes extreme daytime sleepiness and sudden muscle weakness called cataplexy) feel more alert during the day. The goal is to see if this treatment is safe and effective for managing narcolepsy symptoms.
Redwood City, CaliforniaAges 18–70 - NCT07643922Recruiting
Endovascular Treatment for Brain Blood Vessel Spasm After Aneurysm Rupture
This trial tests an endovascular procedure (a minimally invasive catheter-based treatment delivered through blood vessels) combined with a heart medication called milrinone to treat cerebral vasospasm—dangerous blood vessel narrowing that can occur after a ruptured brain aneurysm. The goal is to improve neurological recovery and prevent stroke.
Beijing, Beijing MunicipalityAges 18–80 - NCT07673354Enrolling by invitation
Spinal cord stimulation at home for hand and arm function in MS
This trial tests if gentle electrical stimulation can help improve hand and arm function in people with multiple sclerosis. You will use a small device at home with support from a caregiver.
Seattle, WashingtonAges 18–70
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,497 recruiting neurology studies from the U.S. registry right now, out of 19,911 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.