Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07317609RecruitingPhase 1
Immunotherapy plus chemo before endoscopic resection for esophageal cancer
This trial tests a treatment plan that combines immunotherapy with chemotherapy before possible endoscopic surgery. It is for people with a specific type of esophageal cancer that has not been treated before and is either potentially removable or not suitable for standard surgery.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05489289RecruitingPhase 3
AK104 to prevent HCC coming back after surgery
This trial tests whether AK104, taken after liver cancer surgery, can lower the chance that the cancer returns. It is for people with high risk of recurrence but no remaining cancer after surgery.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04510129Recruiting
Cancer biospecimen collection study for immunotherapy patients
This study collects samples (like tissue biopsies and imaging information) from people with certain cancers who are starting anti–PD-1/PD-L1 immunotherapy. It helps researchers gather material to study how these treatments work.
San Francisco, CaliforniaAges 18 years+ - NCT06541431Recruiting
Testing a new fluid monitoring platform after surgery
This trial tests a new platform that looks at fluid from drains after abdominal or pelvic surgery to see if it can help detect complications early. It may help doctors monitor your recovery more closely.
Hamilton, OntarioAges Any age - NCT04653324Recruiting
Registry for people with diagnosed food allergies
This registry aims to collect information from people who already have a diagnosed food allergy. Joining may help researchers better understand food allergy patterns and needs.
McLean, VirginiaAges Any age - NCT06595719Recruiting
Probiotics plus standard care for mild to moderate UC
This trial tests whether adding a multi-strain probiotic supplement to your usual care can help manage mild to moderate ulcerative colitis (UC). It lasts 12 weeks and requires you to stay on your current medications without changes.
Cheras, Kuala LumpurAges 18–90 - NCT06371157RecruitingPhase 3
Testing AK104 and Lenvatinib with TACE for liver cancer
This trial tests if adding a new combination of drugs (AK104 and lenvatinib) to a standard liver cancer procedure called TACE is more effective than TACE alone. It is for people whose liver cancer has not spread and cannot be removed by surgery, but who are well enough to receive these treatments.
Zhengzhou, HenanAges 18–75 - NCT06864221Recruiting
How fat molecules in blood affect liver cancer radiotherapy
This study looks at whether certain fats in your blood can help predict how well radiotherapy works for liver cancer. If you are getting radiation for liver cancer, your blood samples may help doctors learn more about your treatment response.
Guangzhou, GuangdongAges 18–80 - NCT06858384Recruiting
Optimizing PPI use through education and intervention
This trial tests whether educating doctors can reduce unnecessary prescriptions of proton pump inhibitors (PPIs, a type of acid-reducing medicine). If you are an adult patient who has been prescribed a PPI that might not be needed, your doctor may join this study to improve your care.
Ras al-KhaimahAges 18 years+ - NCT06873165Recruiting
Gut bacteria treatment for fatty liver disease
This study tests whether a specially designed gut bacteria treatment can help people with fatty liver disease and related health issues like high blood sugar, high cholesterol, or high blood pressure. It aims to see if the treatment is safe and improves liver health.
TaipeiAges 18–70 - NCT06873269Recruiting
Holmium-166 radiation therapy for liver cancer
This trial tests a radiation treatment for liver cancer that cannot be removed with surgery or ablation. Tiny beads containing Holmium-166 are injected into the liver's blood supply to target the tumor directly.
BrusselsAges 18 years+ - NCT06871605Recruiting
Nerve blocks for chronic groin pain after hernia surgery
This study compares two types of nerve blocks (injections near the nerves) to treat chronic groin pain after hernia surgery. The goal is to find which block provides better pain relief.
AnkaraAges 18 years+ - NCT06250803Recruiting
Early pancreatic stent for PEP prevention
This trial tests placing a small plastic tube (stent) in your pancreatic duct early during ERCP to try to prevent pancreatitis (inflammation of the pancreas). It’s for people having their first ERCP to get into their bile duct.
Hefei, AnhuiAges 18 years+ - NCT06179498Recruiting
Partner navigation for hepatitis C treatment in young people who inject drugs
This trial offers a partner navigation program to help young people who inject drugs and their main injecting partner work together to get treatment for hepatitis C (a liver infection).
San Francisco, CaliforniaAges 18 years+ - NCT04807868Recruiting
Liver fat registry for adults with or at risk for fatty liver
This study builds a research registry (and optional test results follow-up) for adults who either need a routine liver biopsy or may have fatty liver risk based on body weight and other health history. It helps researchers learn more about non-alcoholic fatty liver disease (fatty liver not caused by alcohol) and how it may progress.
Orlando, FloridaAges 18 years+ - NCT04701853Recruiting
Exercise training after permanent stoma surgery
This trial looks at a specific exercise program after planned surgery to create a permanent stoma (an opening for stool). The goal is to see whether the training helps people recover and function better after surgery.
GothenburgAges Any age - NCT05346757Recruiting
Test stool DNA changes to screen or find colorectal cancer
This study checks whether a stool test that looks for tiny genetic signals can help detect colorectal cancer (or find it again after prior findings). You may be asked to provide a stool sample around the time you get a colonoscopy.
BarcelonaAges 18–80 - NCT07308548RecruitingPhase 2
Testing HP515 for fatty liver disease (NASH/MASH)
This trial tests a new drug called HP515 for people with non-alcoholic fatty liver disease, including NASH or MASH. It aims to see if the drug can help reduce liver fat and improve liver health.
Beijing, Beijing MunicipalityAges 18–65 - NCT07310173RecruitingPhase 2
Study of AST-3424 for advanced liver cancer with high AKR1C3
This trial tests a new drug called AST-3424 in people with advanced liver cancer that has gotten worse after prior treatment. It is for those whose tumor cells have high levels of a protein called AKR1C3, which the drug targets.
Nanjing, JiangsuAges 18–75 - NCT07310095RecruitingPhase 4
Study of ustekinumab for Crohn's disease with loss of response
This study tests a new treatment for people with Crohn's disease who have lost response to ustekinumab (Stelara). It aims to see if a different dosing or additional treatment can help regain control of symptoms.
GuangzhouAges 18 years+ - NCT07314294RecruitingPhase 2
Study of EMB-01 for advanced left-sided colorectal cancer
This trial tests a new drug, EMB-01, in people with advanced left-sided colorectal cancer that has spread or cannot be removed. It may help if standard treatments have stopped working or caused side effects.
BeijingAges 18 years+ - NCT07310446Recruiting
Blood test study for colorectal cancer detection
This study is collecting blood samples to improve a test that looks for signs of colorectal cancer in the blood. It may help find cancer earlier or better understand how to detect it.
Lake Barrington, IllinoisAges 45–84 - NCT06698757RecruitingPhase 2
Testing different cycles of sintilimab before surgery for colorectal cancer
This trial tests how many cycles of the immunotherapy drug sintilimab given before surgery help treat colorectal cancer that is mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H). It is for locally advanced cancer that has not spread to other parts of the body.
Zheng'zhou, HenanAges 18–75 - NCT06874036Recruiting
Bowel prep and colonoscopy safety in heart, kidney, or liver disease
This study tests how well people with chronic heart, kidney, or liver disease tolerate bowel preparation and colonoscopy. It aims to ensure the procedure is safe and effective for you.
Hyderabad, TelanganaAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.