Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07269223Recruiting
Oral vitamin D3 for inflammation in ulcerative colitis
This study tests whether taking vitamin D3 by mouth can reduce inflammation in people with moderate ulcerative colitis and low vitamin D levels. It may help if you have a confirmed diagnosis and are between 20–40 years old.
Lahore, Punjab ProvinceAges 20–40 - NCT07276932Recruiting
Acupoint paste for constipation after chemo
This study tests whether applying a special paste to acupoints (specific points on your body) can help relieve constipation and boost energy (qi) in people with colorectal cancer who've had chemotherapy. It's for patients who feel weak and have trouble with constipation after treatment.
Hangzhou, ZhejiangAges 18 years+ - NCT07275554Recruiting
Gene patterns and risk prediction in hepatitis B liver failure
This study looks at how gene changes (methylation) in people with hepatitis B-related liver failure may predict how well they will do. It aims to create a risk score to guide treatment.
Jinan, ShandongAges 18 years+ - NCT07272187Recruiting
Heat therapy for small pancreatic and adrenal tumors
This trial tests a new treatment that uses an endoscope (a thin, flexible tube with a camera) to deliver heat energy directly to certain small tumors in the pancreas or adrenal gland. It may be an option for people who cannot have surgery or whose tumors are growing slowly.
Herlev, Capital RegionAges 18 years+ - NCT07271576Recruiting
Phycocyanin study for liver fibrosis and cirrhosis
This trial tests if phycocyanin (a natural blue pigment from spirulina) can help protect the liver and slow damage from fibrosis or cirrhosis. It may be an option if you have stable liver disease and are looking for supportive therapy.
HangzhouAges 18–75 - NCT07272928Recruiting
Comparing surgery order for liver spread from colon cancer
This trial looks at whether removing the colon tumor or the liver tumors first affects recovery in patients having both removed at the same time. It helps doctors decide the best surgical approach.
Alessandria, PiedmontAges 18 years+ - NCT07272200Recruiting
Genes and alcohol in liver cancer: a study
This study looks at how your genes and alcohol use together affect the risk of liver cancer. It may help find ways to prevent cancer in people with fatty liver disease or moderate alcohol intake.
Milan, MilanoAges 45–75 - NCT07277439RecruitingPhase 2
Immunotherapy and chemoradiation before surgery for stomach cancer
This study tests combining an immunotherapy drug (PD-1 inhibitor) and a medication to boost your immune system (thymalfasin) with standard chemotherapy and radiation before surgery for stage III cancer where the stomach meets the esophagus. The goal is to see if this approach can shrink the tumor and improve outcomes.
Nanjing, JiangsuAges 18–75 - NCT07269626RecruitingPhase 2
PULSAR therapy for pancreatic cancer
This trial tests whether adding a special type of radiation therapy (PULSAR) to standard chemotherapy can help control pancreatic cancer that has not spread far. It is for people who have already completed a few rounds of chemo without their cancer growing.
Seoul, Select Province/StateAges 19 years+ - NCT07270809Recruiting
Chronic liver disease with organ failure: early outcomes study
This study follows patients with chronic liver disease who are hospitalized non-electively for organ failure, to understand the course of illness and outcomes over six months. It may help doctors improve care for similar patients.
New Delhi, National Capital Territory of DelhiAges 18–70 - NCT07275866Recruiting
Probiotic study for people with constipation
This study tests whether a multi-strain probiotic can help relieve constipation. You would stop other constipation treatments and track your symptoms with a daily diary.
LondonAges 18–70 - NCT07270237Recruiting
New ultrasound imaging for pancreas and thyroid
This study tests new ultrasound methods to better see the pancreas and thyroid. It includes people at high risk for pancreatic cancer, those with pancreatic cancer, those with a thyroid nodule, and healthy volunteers.
Basking Ridge, New JerseyAges 18 years+ - NCT07273643Recruiting
Studying tiny particles in cord blood of very premature babies
This study looks at microscopic particles called extracellular vesicles in the umbilical cord blood of babies born before 28 weeks. Researchers want to see if these particles can help predict severe health problems or death, and eventually improve care for extremely premature newborns.
MontpellierAges birth–3 months - NCT07273071RecruitingPhase 4
N-acetylcysteine for severe infections
This trial tests if N-acetylcysteine, a medicine that helps the liver and fights inflammation, can improve outcomes for adults with a severe infection and liver stress.
CopenhagenAges 18 years+ - NCT07273188RecruitingEarly Phase 1
PET scan to measure gut scarring in Crohn's disease
This study tests a new PET scan with a tracer called 68Ga-FAPI-46 to see how well it can find and measure scarring (fibrosis) in the small bowel caused by Crohn's disease. It may help doctors better understand and manage bowel damage.
Rochester, MinnesotaAges 18 years+ - NCT07277907RecruitingPhase 3
Lubiprostone for slow-transit constipation in adults
This study tests whether lubiprostone (Amitiza) can help people with slow-transit constipation. If you have few bowel movements and tests show that stool moves slowly through your colon, this treatment may help you go more regularly.
Bishan, Chongqing MunicipalityAges 18 years+ - NCT07276035Recruiting
Brain-stomach circuits in chronic nausea
This study looks at how the brain and stomach communicate in people with chronic nausea. It uses a noninvasive brain stimulation method called TMS to understand brain activity. You may qualify if you have chronic nausea or are a healthy volunteer.
Pittsburgh, PennsylvaniaAges 21–60 - NCT07269249Recruiting
Dostarlimab before surgery for advanced rectal cancer
This study looks at how well the immunotherapy drug dostarlimab works before surgery in patients with a specific type of advanced rectal cancer that has DNA repair problems (called dMMR/MSI-H). The goal is to see if it is safe and effective in the real world.
NaplesAges 18 years+ - NCT07277322RecruitingPhase 1/Phase 2
Two immunotherapy drugs before surgery for MSS colorectal cancer with liver spots
This trial tests a combination of two immunotherapy drugs (Dupilumab and Toripalimab) before surgery for people with MSS colorectal cancer that has spread to the liver. The goal is to see if this treatment can shrink the liver tumors and help the body's immune system fight the cancer.
New York, New YorkAges 18 years+ - NCT07275905RecruitingPhase 1
Phage therapy for chronic achromobacter lung infection in cystic fibrosis
This study tests whether giving you a mixture of viruses (called phages) that specifically target the bacteria Achromobacter can help treat your chronic lung infection. You would breathe in the phages, and the study will check if this is safe and helps improve your breathing.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07272382Recruiting
Omega-3 supplements with immunotherapy for advanced esophageal cancer
This trial tests whether adding omega-3 fatty acid supplements to a PD-1 inhibitor (a type of immunotherapy) can help control advanced esophageal cancer. It is for people whose cancer has spread or returned, and who have not already failed a similar immunotherapy.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07276568Enrolling by invitationEarly Phase 1
Hepatocyte-like cell injection for small liver syndrome
This early-phase trial tests an injection of lab-grown liver cells into the stomach muscle to prevent or treat small-for-size syndrome, a condition where a partial liver graft is too small. It may also help people with acute or chronic liver failure.
Beijing, ProvinceAges Any age - NCT07271355RecruitingPhase 3
Pressurized chemo spray for appendix or colorectal cancer spread in abdomen
This trial tests a new way to deliver chemotherapy directly into the abdomen as a pressurized spray, using a drug called mitomycin. It is for people with appendix or colorectal cancer that has spread to the lining of the abdomen and cannot be removed by surgery.
Goodyear, ArizonaAges 18 years+ - NCT07273448Enrolling by invitation
ABO-mismatched living donor liver transplant study
This study looks at the results of liver transplants from living donors with a different blood type than the recipient. It aims to understand how well patients do after this type of transplant.
Ages Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.