Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT05028972Recruiting
Improving how the emergency room supports people with hearing loss
This study looks at strategies to help people with hearing difficulties in VA emergency departments and measure how well those strategies work. You may be asked about your communication needs and then followed for outcomes during your emergency visit.
Aurora, ColoradoAges 60 years+ - NCT05052216Recruiting
Wearable monitor study for kids’ sleep apnea
This study tests a wearable device that can help monitor breathing and sleep in children. It compares children with sleep apnea to children without sleep apnea using a simple nighttime monitoring approach.
Bethesda, MarylandAges 3–12 - NCT04976036RecruitingPhase 2
Nintedanib to reduce nosebleeds in adults with HHT
This trial tests whether nintedanib can reduce how often and how severe nosebleeds are in adults with hereditary hemorrhagic telangiectasia (HHT). It may help by calming blood-vessel problems that cause bleeding.
BronAges 18 years+ - NCT04971954Recruiting
Nicotine test to improve age-related hearing processing
This study tests whether nicotine can improve how your brain processes sounds, which can get worse with age. It’s designed for non-smokers without significant hearing or medical/medication issues.
Irvine, CaliforniaAges 18–85 - NCT04944914RecruitingPhase 3
Camrelizumab with targeted radiation for limited nasopharyngeal cancer spread
This trial tests whether combining camrelizumab (an immune medicine) with stereotactic body radiotherapy (high-precision radiation) works better than camrelizumab alone. It’s for people whose nasopharyngeal cancer has spread to a small number of spots in the body and may help control those metastases longer.
Guangzhou, GuangdongAges 18–70 - NCT04988074RecruitingPhase 2
Test cemiplimab for HPV-positive throat cancer using tumor biomarkers
This Phase 2 trial studies whether cemiplimab (with or without chemotherapy first) can improve treatment for HPV-positive oropharynx throat cancer. It also uses lab “biomarkers” to help guide which treatment you get next.
Baltimore, MarylandAges 18 years+ - NCT04966481RecruitingPhase 3
Palbociclib plus cetuximab versus cetuximab alone
This trial studies whether adding palbociclib to cetuximab works better than cetuximab by itself for head and neck cancer that is growing again after an anti–PD-1/PD-L1 treatment. It is for people whose tumor has a specific gene change (CDKN2A loss) and who have not had too many prior treatments.
Worthington, MinnesotaAges 18 years+ - NCT03215719RecruitingPhase 2
De-escalating treatment for HPV-positive throat cancer with low-risk signals
This Phase 2 trial tests whether people with HPV-positive oropharyngeal (throat) cancer who look “lower risk” can safely receive less intensive treatment. It uses HPV blood test results and cancer staging scans to guide whether treatment can be de-escalated.
New York, New YorkAges 18 years+ - NCT04915183RecruitingPhase 2
Atorvastatin to help prevent cisplatin-related hearing loss
This Phase 2 trial tests whether a cholesterol medicine called atorvastatin can protect hearing in people with head and neck cancer receiving cisplatin plus radiation. If it works, it may reduce the chance or severity of treatment-related hearing damage.
Atlanta, GeorgiaAges 18–100 - NCT04900623RecruitingPhase 2
Using HPV blood test to guide treatment for HPV throat cancer
This Phase 2 study tests a “risk-adapted” treatment plan for HPV-related throat cancer, using an HPV DNA blood test to help decide how treatment is done. If your baseline blood test shows detectable HPV DNA, the study may help tailor therapy to your risk and potentially improve outcomes while limiting unnecessary treatment.
Boston, MassachusettsAges 22 years+ - NCT04923087Recruiting
Sound and eating pleasure study for older adults
This trial tests if listening to sounds while eating can make the experience more enjoyable for older adults in hospitals or nursing homes. If you are 65 or older and can safely eat cookies, you may be eligible.
NiceAges 65 years+ - NCT04859335Recruiting
Tracking balance and inner-ear function after Gamma Knife for schwannoma
This study looks at how balance and inner-ear (vestibular) function change after Gamma Knife radiosurgery for vestibular schwannoma. It may help doctors understand what to expect during recovery and how well these functions improve.
ToulouseAges 18–65 - NCT04901234RecruitingPhase 2
Adaptive radiation for advanced throat cancer
This study tests an approach called “adaptive radiotherapy,” where the radiation plan may be adjusted based on how your tumor and anatomy look during treatment. It is for adults with biopsy-proven oropharyngeal (throat) squamous cell carcinoma who are planning curative radiation, with or without chemotherapy.
MelbourneAges 18 years+ - NCT04899037Recruiting
Long-term follow-up for people using an implanted hearing device
This study checks how well long-term care works for people who may use an osseointegrated hearing device (an implanted option that connects to bone). It may help by improving long-term support and outcomes for hearing and day-to-day functioning over about three years.
Tampa, FloridaAges 18–85 - NCT04806282Recruiting
Study to track hearing instability and find helpful targets
This study follows adults with hearing instability to better understand what causes it, measure it in new ways, and look for potential treatment targets. If you qualify, you may get hearing and balance-related testing (including scans) over a period of time.
Bethesda, MarylandAges 18–80 - NCT03109171Recruiting
Test accuracy using a scope-based feeling test for sleep apnea
This study checks how accurately a special camera/scope test can measure throat sensation in people being evaluated for obstructive sleep apnea (OSA). If the test works well, it may help improve how clinicians understand and assess OSA-related changes.
Bogotá, Bogota D.C.Ages 18 years+ - NCT04791748Recruiting
Virtual reality balance training for kids with inner-ear problems
This study uses virtual reality tasks to understand and compare balance and movement in children with long-term inner-ear (vestibular) problems versus those without. It may help doctors learn what supports best balance and safety during daily activities.
ParisAges 7 years+ - NCT04812093Recruiting
Tests a way to evaluate middle ear infection
This study looks at a test method to check middle ear infections in people who are planning surgery. It may help clinicians better evaluate the infection before or during treatment.
Orange, CaliforniaAges Up to 21 years - NCT04807660Recruiting
Testing germs in children with ear drainage
This study checks what germs are causing ear drainage (“otorrhea”) in children. The results may help doctors choose the right treatment.
CréteilAges 3 months–15 years - NCT04782284Recruiting
Swallowing therapy for people with MSA and swallowing trouble
This study tests a comprehensive swallowing rehabilitation program for people with MSA (a nervous system condition) who have trouble swallowing. If you qualify, you may get structured swallowing therapy aimed at improving how safely you swallow.
SeoulAges 19 years+ - NCT04798950Recruiting
Bronchial Dilation Study in Polynesian Patients
This is a retrospective study (looking back at medical records) examining bronchial dilation—a condition where airways in the lungs become abnormally enlarged—in Polynesian patients. Researchers want to understand this condition better by reviewing past medical records from 2010–2020.
PapeeteAges 18 years+ - NCT04743609Recruiting
Studying RSV illness impact in babies with ear or lung symptoms
This study looks at how RSV (a common virus that can affect breathing) leads to illness in young children who come to the doctor with ear infections and/or breathing symptoms. It may help doctors better understand the “burden” RSV causes in both home/outpatient and hospital settings.
CréteilAges 1 day–2 years - NCT04755855Recruiting
Study of treatment outcomes in sinonasal cancer patients
This study follows people who have sinonasal cancer and are being treated at Mayo Clinic. It looks at how patients do over time, which may help improve care for future patients.
Rochester, MinnesotaAges 4 weeks–99 years - NCT04695600RecruitingPhase 2/Phase 3
Botox for swallowing problems after brain injury
This trial tests if Botox injections in the throat can help people who have trouble swallowing due to a brain condition like stroke. It aims to improve safety and ease of eating and drinking.
New Delhi, National Capital Territory of DelhiAges 14 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.