Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,273 recruiting studies in this area right now.
By phase
- Not applicable891
- Phase 2156
- Phase 3103
- Phase 148
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma74
- Dysphagia67
- Hearing Loss61
- Tinnitus29
- Head and Neck Cancer24
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,273 total
- NCT04318717RecruitingPhase 2
Pembrolizumab plus radiation for resected mucosal melanoma
This trial studies whether giving pembrolizumab (an immunotherapy) together with a targeted form of radiation can help after surgery for mucosal melanoma. It aims to lower the chance of the cancer coming back and improve outcomes in people whose tumor was removed.
St Louis, MissouriAges 16 years+ - NCT04290130Enrolling by invitation
Study brain signals during audiovisual speech in neurosurgery patients
This study measures brain activity to understand how your brain combines what you see and hear during speech. It may help scientists build better ways to understand and treat problems with speech processing.
Philadelphia, PennsylvaniaAges 21–65 - NCT04194216Enrolling by invitationPhase 3
Antibiotic prevention during rhinoplasty surgery
This trial studies whether giving antibiotics before and around rhinoplasty (nose reshaping) can lower the risk of infection. If you qualify, you may be randomized to receive antibiotic prevention or another approach to prevention.
Stanford, CaliforniaAges 18 years+ - NCT04178174RecruitingPhase 3
Boost radiation for HPV throat cancer with shorter treatment
This trial studies whether adding a precise “extra boost” to radiation can work as well as (or better than) standard radiation for HPV-related oropharynx cancer, while keeping the overall treatment shorter. It may help improve tumor control while aiming for manageable side effects.
London, OntarioAges 18 years+ - NCT04190953Recruiting
Braces and expanders in kids to improve airflow space
This study looks at how jaw and palate treatments affect airflow through the upper airway in children with a specific bite and jaw shape. It may help researchers understand which treatments improve space for breathing and related pressure changes.
Edmonton, AlbertaAges 8–14 - NCT04185974Recruiting
Carbon ion re-irradiation for returning head and neck cancer
This trial tests a type of radiation called carbon-ion re-irradiation for people whose head and neck cancer has come back or grown again after earlier radiation. It may help control the cancer after certain surgeries, but it also requires specific safety conditions about timing, prior treatment areas, and overall health.
HeidelbergAges 18 years+ - NCT04198909Recruiting
Testing a new way to measure hearing nerve health
This study uses a painless, non-invasive method to test how well the hearing nerve works in people with normal hearing. It may help doctors better understand hearing loss in the future.
Clermont-FerrandAges 18–55 - NCT04240561Recruiting
Study of hearing aid results in people with Alzheimer’s dementia
This study looks at how much hearing aid outcomes vary in older adults who have Alzheimer’s dementia or mild memory problems. It may help researchers understand what hearing aids work best and for whom.
Chicago, IllinoisAges 50–90 - NCT04151082RecruitingPhase 1/Phase 2
Steroid therapy for late nerve damage after throat cancer radiation
This trial tests whether high-dose steroids (prednisone or methylprednisolone) can improve symptoms of nerve damage that may occur years after radiation treatment for oropharyngeal cancer. It includes a registry for tracking similar nerve issues in head and neck cancer survivors.
Houston, TexasAges 18 years+ - NCT04152551RecruitingPhase 4
Bisphosphonate use and hearing loss in type 1 osteogenesis imperfecta
This study looks at whether bisphosphonate treatment affects hearing loss in people with type 1 osteogenesis imperfecta. If you qualify, it may help researchers understand if treatment can protect hearing over time.
New York, New YorkAges 6–100 - NCT04198766RecruitingPhase 1/Phase 2
New OX40 immunotherapy for advanced solid tumors
This trial tests a new immunotherapy drug (INBRX-106) alone or with Keytruda (pembrolizumab) for adults with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can help the immune system fight cancer.
Duarte, CaliforniaAges 18 years+ - NCT04066348RecruitingPhase 2
TNF medication trial for blast-related tinnitus
This Phase 2 study tests whether a TNF-α medicine can reduce tinnitus symptoms after blast or loud noise exposure, sometimes with traumatic brain injury. You may be a candidate if your tinnitus is at least moderately severe and stable over time, and if you meet other health and medication rules.
Celebration, FloridaAges 18 years+ - NCT04074356Enrolling by invitation
Tests for esophagus function using noninvasive body measurements
This study looks for noninvasive ways to measure how well your esophagus is moving. It may help doctors better evaluate swallowing and esophagus movement without relying only on invasive testing.
Nashville, TennesseeAges 18 years+ - NCT04104126Recruiting
Blood flow restriction therapy for an Achilles injury
This trial looks at whether “blood flow restriction” during exercise can improve healing for people with an Achilles injury. You may be asked to also do standard physical therapy, but the study focuses on the added blood-flow-restriction approach.
New York, New YorkAges 18–65 - NCT04085900Recruiting
Screening test for nasopharyngeal cancer blood markers
This study screens people in certain cities to see whether signs in the blood related to a virus (EBV) can help find nasopharyngeal cancer earlier. It may help identify higher-risk people so they can be checked sooner.
Zhongshan, GuangdongAges 30–69 - NCT04142697Recruiting
Study of how you feel motion with sight and balance
This study looks at how people with normal health—and people with balance (vestibular) loss—perceive motion using their eyes and inner ear. You may help researchers understand how vision and balance systems work together.
Rochester, New YorkAges 18–80 - NCT03882229Recruiting
MED-EL hearing implant registry study
This study collects real-world information from people who have, or will have, a MED-EL cochlear implant. The goal is to build a registry so researchers and the company can better understand outcomes over time.
CairoAges Any age - NCT03980275Recruiting
Nerve-sparing surgery for both vocal cords that won’t move
This trial studies a surgical technique to improve breathing and voice in people whose both vocal cords do not move. It’s meant for cases that have not improved on their own for at least 6 months, and it may help restore better movement and function.
New York, New YorkAges 18–70 - NCT03907826RecruitingPhase 3
PD-1 therapy plus chemoradiation for recurrent nasopharyngeal cancer
This trial studies whether adding a PD-1 antibody (an immunotherapy) to standard chemoradiation can better control recurrent nasopharyngeal cancer that can’t be removed with surgery. If you qualify, you’d receive the study treatment and be closely monitored for side effects and cancer response.
Guangzhou, GuangdongAges 18–70 - NCT03893643Recruiting
Skin and mouth symptoms of NF2 in children under 15
This study looks at skin and mouth problems that children with NF2 may have. It helps doctors learn more about NF2 symptoms in kids, which may lead to better care.
NiceAges birth–15 years - NCT03727399Enrolling by invitation
Testing blood for grass or birch allergy antibodies
This study looks at your blood to find allergy-related antibodies if you have pollen allergies to grass or birch. It may help researchers better understand what in the immune system drives allergy symptoms.
Zurich, Canton of ZurichAges 18 years+ - NCT03725956Recruiting
Sleep study before and after nasal polyp surgery
This study uses a sleep test to look at breathing and sleep patterns in people with nasal polyps who need surgery because medicine didn’t help. It may help doctors understand how nasal polyps affect sleep and how surgery changes those sleep measurements.
LilleAges 18 years+ - NCT03829033Recruiting
Photon vs proton radiation for early tonsil cancer
This trial compares two types of radiation—photon therapy and proton therapy—for early-stage tonsil cancer. The goal is to see which approach works well for cure while affecting surrounding tissues differently.
GävleAges 18 years+ - NCT03704207Recruiting
Testing a diagnostic workup to guide care for PCD
This study checks whether using “PCD diagnostics” helps clinicians make better care decisions for people being evaluated for PCD. You might be able to join if you’re referred for PCD diagnosis and can complete the study steps.
Nashville, TennesseeAges 1 year+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,273 recruiting otolaryngology studies from the U.S. registry right now, out of 2,079 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.