Ophthalmology
Eyes & vision clinical trials
Eye disease and conditions that affect sight. We’re tracking 1,819 recruiting studies in this area right now.
By phase
- Not applicable1,253
- Phase 3132
- Phase 2121
- Phase 1120
- Phase 492
- Phase 1/Phase 285
- Phase 2/Phase 316
Top conditions
- Glaucoma108
- Cataract89
- Myopia89
- Diabetic Retinopathy52
- Dry Eye42
- Keratoconus34
- Age-Related Macular Degeneration33
- Retinitis Pigmentosa31
- Sjogren's Syndrome29
- Diabetic Macular Edema26
- Eye Diseases26
- Graves Disease26
- Amblyopia24
- Astigmatism23
- Dry Eye Disease (DED)23
- Multiple Sclerosis23
- Retinal Disease23
- Ocular Hypertension22
Leading sponsors
- Zhongshan Ophthalmic Center, Sun Yat-sen University28
- Second Affiliated Hospital, School of Medicine, Zhejiang University23
- Medical University of Vienna19
- Fondation Ophtalmologique Adolphe de Rothschild18
- National Taiwan University Hospital17
- Assistance Publique - Hôpitaux de Paris16
- Eye & ENT Hospital of Fudan University15
- National Eye Institute (NEI)15
- Shanghai Eye Disease Prevention and Treatment Center15
- Duke University13
Where studies are running
- California141
- Arizona66
- Texas41
- Maryland39
- Massachusetts34
- New York34
- Florida32
- Alabama27
- North Carolina21
- Pennsylvania20
Recruiting studies1,819 total
- NCT04440280RecruitingPhase 2
NAC drops to improve cornea disease during cataract surgery
This Phase 2 study tests whether eye drops containing a medicine called N-acetylcysteine (NAC) can reduce damaging “reactive oxygen” in people with advanced Fuchs’ endothelial corneal dystrophy (FECD). It involves people who need a special cornea transplant (DMEK) at the same time as cataract surgery, aiming to improve cornea healing and vision.
Boston, MassachusettsAges 21 years+ - NCT04461444Recruiting
Cohort study for Bardet-Biedl and Alström syndromes
This study follows people with Bardet-Biedl syndrome (BBS) or Alström syndrome (ALMS) to spot early vision, metabolic (body chemistry/energy), and kidney problems. You may be asked to have clinical checks over time to help researchers better understand how these complications develop.
StrasbourgAges 4 months+ - NCT04463316Recruiting
Clinic study for people with rare genetic conditions
This study is for people who have a rare syndrome or rare congenital condition and are seen at a rare-disease clinic. It aims to better understand these conditions and how care works in a team setting, which may help guide future treatment decisions.
Rotterdam, South HollandAges 18 years+ - NCT04468932Recruiting
TMS brain stimulation for progressive supranuclear palsy
This trial tests whether repeated non-invasive magnetic brain stimulation (TMS) can improve symptoms in people with progressive supranuclear palsy (PSP). It may help by targeting brain circuits involved in movement and balance.
Portland, OregonAges 40–85 - NCT04504123RecruitingPhase 2
Doxycycline eye treatment for persistent wet macular degeneration fluid
This trial tests whether an “MMP-9 inhibitor” medicine given as doxycycline (a tetracycline-type antibiotic) can reduce persistent leaking and fluid in wet age-related macular degeneration. It may help people whose wet AMD is not fully controlled even after several anti-VEGF injections.
Iowa City, IowaAges 50–99 - NCT04505618Recruiting
Eye scan study using special imaging for blood-vessel disease
This study uses a detailed eye scan (optical coherence tomography angiography) to look at how blood vessels in the retina are affected. It may help researchers better understand retinal vascular diseases, though some people will be excluded for safety or image-quality reasons.
Baltimore, MarylandAges 18–99 - NCT04519619Recruiting
Safety study of aflibercept eye injections in Japanese glaucoma patients
This trial checks how safe aflibercept (eye injection) is for Japanese people with neovascular glaucoma. You may be able to join if you already received aflibercept treatment under the approved Japanese instructions and have the correct diagnosis.
Multiple LocationsAges Any age - NCT04528355Recruiting
Study of hospital data after stem cell transplant for non-cancer illness
This study collects medical information from people with certain non-cancer conditions who receive a stem cell transplant. It may help doctors better understand transplant outcomes and care, since the study focuses on data collection rather than adding new treatment.
Pittsburgh, PennsylvaniaAges 2 months–60 years - NCT04528082RecruitingPhase 3
Apremilast for children with frequent mouth ulcers from Behçet’s disease
This study tests apremilast to help reduce active, recurring mouth (oral) ulcers in children with Behçet’s disease. It may help if your child has had repeated mouth ulcers despite at least one non-biologic treatment.
BronAges 2–17 - NCT04547439RecruitingPhase 2
Melatonin for diabetic eye disease and better sleep
This Phase 2 study tests whether melatonin can improve sleep and possibly outcomes related to diabetic retinopathy (damage to the retina from diabetes). It also checks whether it affects related symptoms while keeping people safe.
Chicago, IllinoisAges 40–65 - NCT04561557RecruitingEarly Phase 1
Cell therapy for relapsing nervous system autoimmune diseases
This early-phase trial tests CT103A “CAR-T” cell therapy to treat certain relapsing or treatment-resistant autoimmune diseases that affect the nervous system. It aims to see whether the cells are safe and may help reduce disease activity when standard treatments haven’t controlled symptoms.
Wuhan, HubeiAges 18–75 - NCT04570020Recruiting
Check how well wide-view scans guide scleral lens fitting
This study tests whether a special wide-area eye scan (OCT) can help fit scleral contact lenses more accurately. It may help people who need scleral lenses because of certain cornea shape problems or after past eye surgeries.
Portland, OregonAges 18 years+ - NCT04603222Recruiting
Testing a medicated eyelid brush for blepharitis
This trial tests the SUMMIT BRUSH to see if it helps treat blepharitis, an eyelid problem that can be linked to bacteria or tiny mites. It checks whether using the brush improves eyelid signs and symptoms in people who have specific visible findings on exam.
Boulder, ColoradoAges 18 years+ - NCT04634383Recruiting
Testing a brain-connected implant to help some blind people see
This early safety study tests an implanted device placed in the brain to help people with very limited sight (no or minimal light). It focuses on whether the implant can be safely used and whether it may support vision-related signals over time.
Chicago, IllinoisAges 19–70 - NCT04635020Recruiting
iStent versus laser for exfoliation glaucoma with cataract
This trial compares two treatment options for people with exfoliation glaucoma who also have cataracts: a tiny implant placed during cataract surgery (iStent) versus laser treatment. It aims to see which approach better controls eye pressure over 12 months and improves outcomes.
HelsinkiAges 50–100 - NCT04648462Recruiting
Proton therapy planning for certain brain tumors
This study builds and tests how proton therapy planning could better protect the brain compared with standard radiation (photon therapy) for adults with certain brain tumors. It may help reduce radiation to sensitive areas like the hippocampus, with the goal of better long-term brain function.
Maastricht, LimburgAges 18 years+ - NCT04651530Recruiting
Endoscopic laser treatment for normal-pressure glaucoma
This study tests an endoscopic laser procedure to lower eye pressure and slow damage in people with normal-tension glaucoma. It may help protect the optic nerve, especially if your glaucoma is stable on drops and you also have a cataract.
HelsinkiAges 55–100 - NCT04658238Recruiting
Dry eye study of the eye microbiome and immune system
This trial looks at how changes in the eye’s normal germs (microbiome) and the immune response may relate to dry eye. It may help researchers better understand what drives symptoms and how to improve care.
BernAges 18 years+ - NCT04663750RecruitingPhase 3
Surgery to treat bleeding under the retina in wet macular degeneration
This trial tests whether a specific eye surgery plus targeted clot-busting medicine and gas can improve vision after bleeding under the retina from “wet” age-related macular degeneration. It aims to reduce how long the bleeding lasts and help protect the central vision.
BonnAges 50–120 - NCT04665726Recruiting
Natural history study of Usher syndrome hearing and vision changes
This study follows people with Usher syndrome over time to better understand how hearing and vision symptoms change. It may help researchers measure disease progression and support future treatments.
ParisAges Any age - NCT04673643RecruitingPhase 2
Nerve stimulation for dry eye symptoms
This Phase 2 study tests a device that delivers gentle stimulation to a nerve near the ear to help improve dry eye disease. It may help reduce dryness and discomfort, if you meet the study’s health and safety requirements.
BeijingAges 18–65 - NCT04681417RecruitingPhase 2/Phase 3
Eye-sparing treatment options for children with retinoblastoma
This trial studies whether newer “save-the-eye” treatment plans can control retinoblastoma (eye cancer) while keeping vision as good as possible. It compares different conservative treatment strategies depending on how the tumor looks and where it is.
Saint-Denis, La RéunionAges 6 months–6 years - NCT04697095Recruiting
Testing immune cells from specific AMD eye types
This study collects immune cells (from a blood sample) from people with certain types of age-related macular degeneration (AMD) and compares how long they live. It may help researchers understand how immune-related changes relate to AMD outcomes.
LyonAges 15 years+ - NCT04706234Recruiting
Check swallowing and voice function in neurodegenerative diseases
This study looks at how well the throat and voice-related functions work in people with certain long-term brain or nerve conditions. It uses a specific throat exam during FEES to better understand swallowing and laryngopharyngeal (throat-area) function.
Innsbruck, TyrolAges 18 years+
Common questions
- How many eyes & vision clinical trials are recruiting?
- Clin2 is tracking 1,819 recruiting ophthalmology studies from the U.S. registry right now, out of 2,909 we cover in this area in total.
- What does “Eyes & vision” cover here?
- Eye disease and conditions that affect sight. We group each study into eyes & vision based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a eyes & vision trial near me?
- Use the search to filter eyes & vision studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
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- Pain
- Injuries & trauma
- Mouth & dental
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.