Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06943508Recruiting
Nordic walking for balance in children with Down syndrome
This study tests whether a special walking program (Nordic walking with poles) can help children with Down syndrome improve their balance and leg strength. It may be a good fit for children who can walk but have balance difficulties.
Lahore, Punjab ProvinceAges 8–13 - NCT06944067Recruiting
Genetic risk of immune response after blood transfusions in sickle cell disease
This study looks at whether certain genes make people with sickle cell disease more likely to develop an immune reaction to blood transfusions. It aims to help doctors predict transfusion risks and improve care.
Bethesda, MarylandAges 2–99 - NCT06945081Recruiting
Measuring skin elasticity in Wilson's disease patients on D-Penicillamine
This study checks if D-Penicillamine, a treatment for Wilson's disease, causes skin damage by measuring skin elasticity on the forearm and cheek. It compares results between patients taking the drug and healthy volunteers matched by age and sex.
BronAges 12 years+ - NCT06946017Recruiting
Dairy protein and fiber supplement for gut health
This trial tests if a fermented dairy protein drink with added fiber can improve gut symptoms. It is for active people living in Phoenix who may have mild lactose issues.
Phoenix, ArizonaAges 18–50 - NCT06946563Recruiting
Fetoscopic surgery for spina bifida before birth
This trial tests a special fetal surgery (fetoscopic repair) to fix spina bifida before birth. It might help reduce spine and brain damage in babies with this condition.
Portland, OregonAges 18 years+ - NCT06946641RecruitingPhase 1
Testing QLS12010 safety in healthy adults and people with eczema
This trial tests a new drug, QLS12010, to see if it is safe and how it works in healthy volunteers and in people with moderate to severe atopic dermatitis (eczema). It may offer a new treatment option for those whose eczema has not improved with topical creams.
BeijingAges 18–75 - NCT06947980RecruitingPhase 2
Study of CM512 for moderate-to-severe atopic dermatitis
This trial tests a new treatment called CM512 for people with moderate-to-severe eczema (atopic dermatitis). It aims to see if the drug can improve skin symptoms like itching and rash.
BeijingAges 18–75 - NCT06950385RecruitingPhase 3
Testing eRapa medicine for FAP
This trial tests a new medicine called eRapa for people with Familial Adenomatous Polyposis (FAP), a condition that causes many polyps in the colon and raises the risk of cancer. The goal is to see if eRapa can help reduce polyps and improve outcomes.
Arcadia, CaliforniaAges 18 years+ - NCT06951516Recruiting
Can simple language help young kids with Down syndrome learn?
This study looks at whether using simpler language helps children with Down syndrome understand and learn better. It is for children ages 2 to 7 who speak English as their main language.
East Lansing, MichiganAges 2–7 - NCT06952777Recruiting
Testing sensors to monitor babies in the womb
This study tests new sensors to check on a baby's wellbeing during the third trimester of pregnancy, as an alternative to standard monitors. You would wear a sensor on your belly to track your baby's heartbeat and movements without wires or needles.
ManchesterAges 16–50 - NCT06952842RecruitingPhase 1/Phase 2
Gene therapy trial for retinitis pigmentosa with RHO mutation
This trial tests a new gene therapy called ZVS203e for people with retinitis pigmentosa caused by a specific RHO gene mutation. It aims to see if the treatment is safe and can help improve vision.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06952933Recruiting
Trauma and resilience in adults with congenital heart disease
This study surveys adults with congenital heart disease to understand how psychological trauma and resilience affect their health. You would complete online questionnaires about your experiences and coping.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06953505Recruiting
At-home ammonia monitoring for inherited metabolic disorders
This trial tests a device for measuring ammonia levels at home in people with rare metabolic conditions that cause high ammonia. It aims to make monitoring easier and more convenient for patients.
Portland, OregonAges 12 years+ - NCT06953622Recruiting
Migraine and PFO: A Follow-up Study
This study is for people who have migraines and a small hole in their heart called a patent foramen ovale (PFO). It will track your health over time to learn more about how these conditions are related.
BeijingAges Any age - NCT06953583RecruitingPhase 3
Testing omaveloxolone for children and teens with Friedreich's Ataxia
This study tests a drug called omaveloxolone (BIIB141) for children and teens with Friedreich’s Ataxia. It looks at how well the drug works and how safe it is over a longer time.
Los Angeles, CaliforniaAges 2–15 - NCT06954142Recruiting
Fluid levels to prevent lung disease in preterm babies
This trial compares giving less fluid versus the usual amount to very early preterm babies to see if it helps prevent bronchopulmonary dysplasia, a chronic lung condition. The goal is to find the safest way to manage fluids and protect their developing lungs.
AarauAges 1 week+ - NCT06954272Recruiting
Study of skin structure in eczema and healthy skin
This study uses special imaging to look at the structure of skin, comparing people with eczema (who have used steroid creams) to healthy volunteers. Researchers want to understand how the skin changes with eczema and its treatment.
Sheffield, South YorkshireAges 6 months+ - NCT06955052Recruiting
Maze activity for balance and walking in Down syndrome
This study tests a fun activity program called 'Minds In Motion The Maze' to see if it helps improve balance and walking in children with Down syndrome.
Lahore, Punjab ProvinceAges 8–12 - NCT06958978Recruiting
Quantum probe for skin tightening in liposculpture patients
This trial tests a new device called the QUANTUM Probe, which is used during liposculpture to tighten skin and improve results. It may help people who are already planning body contouring procedures.
Bogotá, DCAges 18–60 - NCT06959251Recruiting
Glycine and magnesium with thiamine for primary ciliary dyskinesia
This trial tests whether a combination of glycine, magnesium, and thiamine can help people with primary ciliary dyskinesia (a condition that affects the tiny hairs in your lungs). It aims to see if these supplements improve breathing and reduce lung problems.
Mexico CityAges 5 years+ - NCT06960213RecruitingPhase 3
Study of ADX-324 for preventing HAE attacks
This study tests a new medicine called ADX-324 to see if it can prevent HAE attacks in adults with type I or II HAE. If you've had attacks recently and are willing to pause your current prevention medication, this trial may be an option.
Litchfield Park, ArizonaAges 18 years+ - NCT06960902Recruiting
Study of Heart Artery Plaque in Familial Hypercholesterolemia
This study uses a heart CT scan to look for plaque buildup in the arteries of people with familial hypercholesterolemia (a genetic high-cholesterol condition). It aims to understand why some people with FH develop heart disease while others don't.
DijonAges 40 years+ - NCT06961565RecruitingPhase 1
Study of PAS-004 for adults with NF1 and plexiform neurofibromas
This trial tests an oral medication called PAS-004 for adults with Neurofibromatosis Type 1 who have at least one symptomatic plexiform neurofibroma that cannot be surgically removed. The goal is to see if the drug can shrink these tumors or improve symptoms, and to understand side effects.
Birmingham, AlabamaAges 18 years+ - NCT06961591Recruiting
Cooking skills for long-term weight loss in young adults with ID
This program teaches cooking skills to help young adults with intellectual disabilities lose weight and keep it off for 2 years. You’ll learn to prepare healthier meals with support from a family member or caregiver.
Kansas City, KansasAges 18–35
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.