Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06962306RecruitingPhase 4
Pain relief study for children having cleft palate surgery
This trial tests different ways to manage pain after cleft palate repair in young children. The goal is to find which approach works best to lower pain and improve recovery.
Durham, North CarolinaAges 6 months–4 years - NCT06963450Recruiting
Screening jaundice in newborns with a smartphone app
This trial tests a smartphone app that checks for jaundice in newborns. The goal is to see if the app works well for on-the-spot screening, which could help parents and doctors detect jaundice early.
LondonAges Up to 4 weeks - NCT06966167Recruiting
Laser vs. standard cataract surgery in Fuchs' dystrophy
This study compares two types of cataract surgery in people with Fuchs' dystrophy: one using a laser and the standard method. It looks at which approach gives better results for the cornea and vision.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT06966375Recruiting
Worldwide yearly screening for repaired hypospadias
This study will test a yearly screening program for males who have had surgery to fix hypospadias (a birth defect where the urine opening is on the underside of the penis). It aims to understand how screening can help monitor long-term health.
Madison, WisconsinAges 5–65 - NCT06966635RecruitingPhase 4
Potassium citrate for gout treatment
This study tests whether a potassium citrate tablet can help people with gout lower uric acid and prevent flares. It is for adults on stable gout medication who are not having a current flare.
ShanghaiAges 18–70 - NCT06967831Recruiting
Testing existing drugs for mitochondrial disorders
This trial looks at whether drugs already approved for other conditions might help people with Leigh syndrome, a rare mitochondrial disorder. Researchers will study cells made from your skin to see how these drugs work.
Düsseldorf, North Rhine-WestphaliaAges Any age - NCT06969209Recruiting
Brain aging in adults with PKU
This study looks at how the brain ages in adults with PKU. It uses an MRI scan to compare brain changes between people with PKU and healthy volunteers.
BernAges 18 years+ - NCT06969924Recruiting
How CRT works for adults with congenital heart disease
This study looks at how well cardiac resynchronization therapy (CRT) works for adults who were born with a heart defect. Researchers will review medical records to see if the therapy helps improve heart function.
Leiden, South HollandAges 18 years+ - NCT06970028Recruiting
Sensation study in ADPKD patients
This study looks at how people with ADPKD (a kidney condition that causes cysts) sense touch and temperature on their skin. It will compare their results with those of healthy volunteers to better understand the condition and help future treatments.
LeuvenAges 12 years+ - NCT06970158Recruiting
Smart scan for babies with one-sided cleft lip and palate
This study tests using a smart camera (artificial intelligence) to help plan surgery for newborns with a single-sided cleft lip and palate. Your baby will have a quick and painless 3D scan of their mouth to guide their doctors, and you'll be closely supported throughout.
ChennaiAges 1 day–6 months - NCT06971146Recruiting
Nurse-led telehealth for gout management
This trial tests whether nurse-led telehealth visits can help people with gout maintain healthy urate levels. If you have gout and are already on medication like allopurinol, this study may offer a convenient way to manage your condition from home.
AarhusAges 18 years+ - NCT06974877RecruitingPhase 1
PET/CT Imaging for Amyloid in CAPS on Anakinra
This trial uses a special PET/CT scan to see if a radioactive tracer can measure changes in amyloid buildup in people with CAPS who have developed a skin reaction to anakinra. It may help doctors understand how the disease is affecting your organs.
Bethesda, MarylandAges 18–120 - NCT06974890Recruiting
Balance training for children with mild cognitive impairment
This study tests if special balance exercises can help improve walking, balance, and posture control in children with mild cognitive impairment. It may help your child move more confidently and safely.
Lahore, Punjab ProvinceAges 6–12 - NCT06975189RecruitingPhase 2
Reducing radiation in preterm baby lung scans
This trial tests whether using ultrasound instead of X-rays for lung imaging can safely reduce radiation exposure in very premature babies. If your baby needs lung imaging, they may be able to join.
Melbourne, VictoriaAges Up to 1 day - NCT06975865RecruitingPhase 3
Rilzabrutinib for sickle-cell disease pain episodes
This study tests an oral medicine called rilzabrutinib to see if it can reduce painful episodes in people with sickle-cell disease. It may be an option if you have regular pain crises and are looking for a new treatment.
Birmingham, AlabamaAges 10–65 - NCT06975982Recruiting
Lung function and frailty in children with esophageal atresia
This study compares breathing, muscle strength, and frailty in children who had esophageal atresia repair with healthy children. It aims to understand how this condition affects lungs and everyday physical abilities.
Ankara, AnkaraAges 6–18 - NCT06976606Recruiting
A study of adults with PKP2-linked arrhythmogenic cardiomyopathy
This study follows people with a confirmed PKP2 genetic mutation and arrhythmogenic cardiomyopathy (ACM) to understand how their condition changes over time. It may help doctors learn more about the disease and plan future treatments.
Redwood City, CaliforniaAges 18–65 - NCT06977672Recruiting
Yoga for writing skills in children with Down syndrome
This study tests whether a simple yoga pose (Downward Dog) can help children with Down syndrome improve the fine motor skills they need for writing. It is designed for children ages 4 to 8 who can stand and walk on their own.
Lahore, Punjab ProvinceAges 4–8 - NCT06979492RecruitingPhase 4
Blood transfusions for pregnant women with sickle cell disease
This study tests whether giving regular blood transfusions during early pregnancy can help prevent complications for women with sickle cell disease. If you are between 6 and 20 weeks pregnant, you may join to see if this treatment improves outcomes.
Atlanta, GeorgiaAges 18 years+ - NCT06982352RecruitingPhase 1
Testing safety of LPX-TI641 for eczema and psoriasis
This study tests a new drug called LPX-TI641 to see if it's safe and how it works in people with atopic dermatitis (eczema) or psoriasis. If you have moderate-to-severe symptoms that haven't been helped by standard creams, you might be able to join.
Fargo, North DakotaAges 18 years+ - NCT06982417Recruiting
RP2 Genetic Condition Registry
This registry study collects information from people who have a genetic change in the RP2 gene (a cause of inherited eye disease) and their families. It helps researchers learn more about the condition and how it affects daily life.
Göttingen, Lower SaxonyAges Any age - NCT06984445Recruiting
Cord Blood Protein in Anemia Transfusion Study
This study measures a protein (S100B) in cord blood from babies who had or did not need a blood transfusion in the womb for hemolytic disease. It looks for possible markers of brain health.
WarsawAges 18 years+ - NCT06984679Recruiting
Physical function study for kids with cystic fibrosis
This trial compares physical abilities between children with cystic fibrosis and healthy children. It aims to find differences that could lead to better care and therapies.
IzmirAges 6–18 - NCT06988189Recruiting
Finding hidden heart rhythm problems in adults
This study looks for hidden heart rhythm problems in adults. It involves simple tests to find conditions that might otherwise go unnoticed.
LondonAges 18–100
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.