Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,859 recruiting studies in this area right now.
By phase
- Not applicable2,773
- Phase 2283
- Phase 1236
- Phase 3215
- Phase 1/Phase 2203
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease142
- Atopic Dermatitis128
- Congenital Heart Disease85
- Cystic Fibrosis78
- Down Syndrome55
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California341
- Maryland161
- Alabama131
- Massachusetts116
- New York84
- Arizona78
- Texas72
- Minnesota67
- Pennsylvania66
- Ohio57
Recruiting studies3,859 total
- NCT03764748RecruitingPhase 1
Washed stool transplant for Tourette syndrome in kids
This Phase 1 study tests whether a “washed” stool microbiota transplant can reduce Tourette syndrome tics in children. It aims to see if changing gut bacteria is safe and may improve tic severity.
Nanjing, JiangsuAges 6–17 - NCT03773159Recruiting
Testing a blood clot test using whole blood flow
This trial tests a new lab device that measures how well your body forms primary blood clots while blood is kept in flowing conditions. It may help doctors better assess bleeding or clotting tendencies and guide future care.
BesançonAges 18 years+ - NCT03775954Recruiting
Fetal heart testing in high-risk pregnancies after baby loss
This study checks unborn babies’ heart signals using special scans during pregnancy and then checks the baby’s heart shortly after birth. It may help researchers understand why certain high-risk pregnancies can lead to fetal demise and improve care.
Madison, WisconsinAges 18 years+ - NCT03786549Recruiting
Sickle cell care transition program for teens and families
This study tests a structured program to help teens with sickle cell disease smoothly transition from pediatric care to adult care, with support for parents or legal guardians. It may help families coordinate care sooner and more confidently during this change.
Fort-de-France-La Martinique, La MartiniqueAges 16–17 - NCT03788122Recruiting
Learn how parents view fetal surgery
This study asks parents about their feelings, concerns, and understanding of two types of fetal (baby before birth) surgery. Your answers may help improve how future fetal surgeries are explained and supported.
LeuvenAges 18–65 - NCT03789721Recruiting
ALD registry study for patients and families in the U.S.
This study builds a national registry to better understand adrenoleukodystrophy (ALD) in patients and families. You may help researchers learn how ALD affects people over time and improve future care.
Minneapolis, MinnesotaAges Any age - NCT03793348Recruiting
Micro-coring device to improve moderate to severe facial wrinkles
This study tests a device that removes tiny skin cores (“micro-coring”) to improve moderate to severe wrinkles on the face, especially the cheeks. It mainly checks safety and whether skin texture looks better after treatment.
Sacramento, CaliforniaAges 40–70 - NCT03797183Recruiting
Check heart and lung function using a painless chest scan
This study uses a noninvasive scan that measures electrical signals across the chest to better understand breathing and heart-related circulation problems. It may help doctors learn what to monitor and how conditions like lung/airway pressure and vessel narrowing progress.
Aurora, ColoradoAges 2 weeks–40 years - NCT03805919Recruiting
Study for men with high inherited risk of prostate cancer
This study is for men who have a known inherited gene change that raises their prostate cancer risk. It aims to help prevent or detect prostate cancer earlier, and you may be asked to undergo MRI and other study steps.
Bethesda, MarylandAges 30–75 - NCT03810651RecruitingEarly Phase 1
Radiation planning for kidney tumors in children and teens
This early study tests a type of radiation delivery (“pencil beam scanning”) for certain kidney cancers in children and teens. It may help doctors better target the tumor while reducing radiation to nearby healthy tissue.
Philadelphia, PennsylvaniaAges birth–30 years - NCT03821129Recruiting
Reduce recurrent stroke with a PFO closure device and antiplatelet pills
This study looks at whether closing a heart opening called a patent foramen ovale (PFO) with a special septal occluder, along with antiplatelet medications, can lower the risk of another stroke. It is for people who recently had a stroke thought to be caused by a clot that traveled from the heart but without another clear source.
Tucson, ArizonaAges 18–70 - NCT03821051Recruiting
Registry for heartbeat rhythm problems from structural heart disease
This is a registry that collects information about people with certain dangerous heartbeat rhythm problems caused by structural (anatomical) heart diseases. It may help researchers understand patterns and risks, and improve how these conditions are studied and managed.
Beijing, Beijing MunicipalityAges Any age - NCT03835767RecruitingPhase 2
Predicting food allergy from blood IgE levels in eczema patients
This study looks for blood test patterns that may predict whether a child with eczema (atopic dermatitis) is likely to have a food allergy. If you join, you may do supervised oral food challenges with a placebo and the suspected foods to see what triggers symptoms.
Bethesda, MarylandAges 3–21 - NCT03836521Recruiting
Registry for valve replacement in bicuspid aortic stenosis patients
This registry collects information about adults with severe narrowing of the aortic valve caused by a bicuspid (two-leaflet) valve shape, especially if symptoms are present. It may help doctors better understand who benefits from a catheter-based valve replacement (TAVR).
Los Angeles, CaliforniaAges 19–129 - NCT03841981Recruiting
Body fat and female hormone function study
This study looks at how body fat and exercise relate to how your ovaries work and how your hormones function. It may help explain why some women have irregular ovulation or hormone problems, and how lifestyle factors affect them.
Madrid, MadridAges 18–40 - NCT03848923Recruiting
Study bleeding and inflammation in low-platelet newborns
This study looks at how very low platelet levels (and platelet transfusions, if needed) affect bleeding and inflammation in newborns. It may help doctors better understand which newborns are at higher risk and how to manage low platelets.
Boston, MassachusettsAges birth–6 months - NCT03851484Recruiting
Study sensory symptoms in people with Tourette-related tics
This study looks at sensory symptoms in adults who have Tourette syndrome or similar long-term tic disorders. Your answers to questionnaires may help researchers understand these symptoms and how they relate to the condition.
Nashville, TennesseeAges 18 years+ - NCT03856034Recruiting
Open vs minimally invasive surgery for spina bifida baby
This study compares two ways to correct spina bifida while the baby is still in the womb: an open operation (laparotomy) versus a minimally invasive endoscopic approach (percutaneous endoscopic). The goal is to see which approach leads to better outcomes for the baby and pregnancy.
Los Angeles, CaliforniaAges 18 years+ - NCT03866213Recruiting
Test a jaundice device for newborns in low-resource settings
This trial checks whether a new device can accurately detect and track yellowing of the skin (newborn jaundice) in hospitals with limited resources. It may help clinicians monitor jaundice and decide on treatments like blue light therapy more reliably.
Houston, TexasAges birth–4 weeks - NCT03880708Recruiting
Registry for inherited dangerous heart rhythm conditions
This study is a heart rhythm registry for people with inherited conditions that can cause abnormal heart beats. By collecting health and testing information, researchers hope to better understand these conditions and improve care.
Beijing, Beijing MunicipalityAges 1 hour–90 years - NCT03882827Recruiting
Natural history study of Duchenne muscular dystrophy in young boys
This study follows boys with Duchenne muscular dystrophy over time to better understand how the condition changes and how standard treatments affect health and function. It does not appear to test a new medicine, but it may help doctors plan better future care and studies.
BrusselsAges 4–9 - NCT03891160Recruiting
Using heart scans to plan a support pump in children
This trial is testing a way to help doctors assess babies and children with congenital heart disease and heart failure before placing a temporary heart support pump. It may help improve planning by using heart scans to decide who needs support and how to prepare.
Gainesville, FloridaAges Any age - NCT03900286Recruiting
Testing a low-calorie diet for partial fat loss diabetes
This trial studies whether a low-calorie (low energy) diet can improve diabetes control in adults with familial partial lipodystrophy. It likely helps by changing how your body handles blood sugar and fat use, but you must meet specific safety and eligibility checks.
CambridgeAges 18–99 - NCT03920774Recruiting
Study of Familial Dysautonomia in People With IKBKAP Changes
This study looks at how familial dysautonomia (FD) progresses over time in people who have a confirmed IKBKAP genetic change. It may help doctors better understand the condition and plan future treatments.
New York, New YorkAges 4 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,859 recruiting medical genetics studies from the U.S. registry right now, out of 5,745 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.