Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease84
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California325
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York85
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT04218318Recruiting
Stopping light therapy early in newborns with blood breakdown
This study looks for a safe threshold to stop the “light therapy” (phototherapy) in newborns who have jaundice caused by blood cell breakdown (hemolytic disease). It may help some babies avoid unnecessary extra days of treatment while still staying safe.
MadinahAges 1 hour–2 weeks - NCT07520656Recruiting
Heart Valve Surgery and Sleep Breathing Problems
This study looks at whether fixing heart valve problems with minimally invasive procedures (TAVI or MTEER) can improve sleep-related breathing issues. Researchers will monitor your sleep patterns before and after your scheduled heart valve procedure.
Athens, AtticaAges 18 years+ - NCT07519876Recruiting
Blood Clots in the Lungs and Heart Shunts Study
This study looks at whether people with blood clots in their lungs have hidden holes in their hearts that let blood bypass normal circulation. Researchers will use imaging tests to understand this connection and see if it affects how patients do.
Boston, MassachusettsAges 18 years+ - NCT07516496Recruiting
Understanding Body Chemistry in Vascular Ehlers-Danlos Syndrome
This study looks at how bodies with vascular Ehlers-Danlos syndrome (vEDS) process nutrients and energy differently. By comparing people with vEDS to healthy volunteers, researchers hope to find new ways to manage the condition better.
CambridgeAges 18–85 - NCT07519915Recruiting
Understanding Nerve Stimulation for Bowel Problems in Children
This research study looks at using sacral neuromodulation—a treatment that uses mild electrical stimulation of nerves in the lower spine—to help children with bowel movement problems. Researchers want to understand how well this treatment works and what improvements matter most to patients and families.
ErlangenAges 3–18 - NCT07523399Recruiting
Joint Health and Balance in Adults with Hemophilia A
This study looks at how hemophilia A affects joint health, balance, and quality of life in adults. Researchers will assess your joints and balance to understand the relationship between joint damage and everyday function.
VanAges 18–65 - NCT07521930Recruiting
Brain implant to restore communication and movement control
This trial tests a surgically implanted brain device designed to help people with severe paralysis or movement disorders regain the ability to communicate and control their limbs. The device reads signals from your brain and translates them into commands that could help you interact with computers or assistive technology.
Baltimore, MarylandAges 18–80 - NCT07516288RecruitingPhase 1
Second CAR-DC Cell Infusion for Advanced Heart Failure
This trial tests a second dose of specialized immune cells (called CAR-DC) in patients with severe dilated cardiomyopathy (a weakened heart muscle) who received one dose before but saw their heart function decline back to baseline. The goal is to see if a second dose is safe and can improve heart function when the first treatment's benefits wore off.
Hangzhou, Zhejiang / 浙江Ages 18–75 - NCT06657911Recruiting
Studying a new sizing method for bicuspid aortic valves
This trial looks back at people with a specific type of bicuspid aortic valve (a valve with two flaps instead of three) who had a transcatheter aortic valve replacement. Researchers want to see how well a special sizing method called LIRA worked for choosing the right valve size.
Brescia, ItalyAges 18 years+ - NCT06732713Recruiting
Swiss ball vs. Frenkel exercises for Down syndrome
This trial compares using a Swiss ball versus Frenkel exercises to improve balance and coordination in children with Down syndrome. It may help children who can stand and walk on their own.
Lahore, Punjab ProvinceAges 8–13 - NCT06757829Recruiting
Lung function in sickle cell: testing Acu-TENS therapy
This study tests if a gentle electrical nerve stimulation treatment (called Acu-TENS) can help improve your lung function. It's for people with sickle cell disease who are not currently in pain or have other major health issues.
Dokki, Giza GovernorateAges 20–50 - NCT06756633Recruiting
Breathing and movement study for neuromuscular disease
This study looks at breathing, chest and belly movement, and exercise ability in people with Duchenne Muscular Dystrophy or Spinal Muscular Atrophy, as well as healthy people. The goal is to compare these functions to help understand how these diseases affect the body.
Ankara, ÇankayaAges 5–15 - NCT06488274Recruiting
Study of a new infant formula for digestive issues in babies
This trial is testing a new infant formula to see if it helps with common digestive problems like spitting up, colic, or constipation in babies up to 4 months old. It aims to improve symptoms and comfort for infants who are formula-fed.
NiceAges Up to 4 months - NCT06759103Recruiting
Study of patients with aortic coarctation
This study collects information from people diagnosed with aortic coarctation before or shortly after birth, to better understand the condition and improve care. It may be a fit if you or your child were diagnosed before or within one month of birth.
BolognaAges Any age - NCT06758648Recruiting
Eye blood vessels in Fabry disease
This study looks at the tiny blood vessels in the eyes of people with Fabry disease using a special camera. It may help doctors understand how the disease affects the eyes over time.
München, BavariaAges 18 years+ - NCT06759142Recruiting
Study of people with ADPKD
This study looks at people with autosomal dominant polycystic kidney disease to learn more about the condition. It is an observational study, meaning no new treatments are tested—just gathering information from your medical history and tests.
BolognaAges 18 years+ - NCT07514481Recruiting
Lung ultrasound comparison of two surfactant delivery methods in preterm babies
This study compares two ways of giving surfactant (a lung-coating medicine) to newborns with breathing trouble: LISA (a gentler, less invasive method) versus traditional breathing tube delivery. Researchers will use ultrasound to see how the medicine spreads in each baby's lungs to find the best approach.
DohaAges 6 months–10 months - NCT07509229Enrolling by invitationPhase 1/Phase 2
Algae Extract for Retinitis Pigmentosa
This study tests an extract from a type of algae that is rich in a special form of vitamin A. It may help improve vision for people with retinitis pigmentosa caused by certain gene mutations that affect how the eye processes vitamin A.
Tel LitwinskyAges 18 years+ - NCT07513844Recruiting
Ultrasound Treatment for Huntington's Disease Movement Symptoms
This trial tests a new focused ultrasound technique aimed at reducing involuntary movements (chorea) in people with Huntington's disease. The treatment targets a specific brain region and may help improve movement control and quality of life.
Fuzhou, FujianAges 18–75 - NCT07511660Enrolling by invitation
Ovarian cell injection for perimenopause symptom relief
This trial tests injecting special cells called Muse cells into the ovaries to help relieve perimenopause symptoms and possibly restore ovarian function. It may help women experiencing irregular periods, hot flashes, sleep problems, mood changes, or trouble thinking clearly.
Monterrey, Nuevo LeónAges 28–70 - NCT07512934Recruiting
Pancreatic Function Study in Early Type 2 Diabetes
This study examines how the pancreas works in people newly diagnosed with type 2 diabetes. Researchers will assess pancreatic function to better understand early diabetes and potentially improve treatment.
Aktobe, AktobeAges 18–74 - NCT07515235Recruiting
DMD Gene Variants and Heart Function in Young Males
This study examines how different genetic changes in the DMD gene affect heart function in boys with dystrophinopathy (a muscle-weakening condition). Understanding this connection may help doctors better monitor and treat heart problems in affected boys.
ThessalonikiAges 2–24 - NCT07508904Recruiting
Exercise effects in children with cystic fibrosis
This study tests whether a specific exercise program can improve muscle strength, breathing, and fitness in children with cystic fibrosis who are stable and able to exercise.
LahoreAges 6–18 - NCT07513038RecruitingPhase 1/Phase 2
Using dye imaging to diagnose bile duct blockage in infants
This trial tests whether a special fluorescent dye called indocyanine green (ICG) can help doctors better diagnose biliary atresia—a rare condition where a baby's bile ducts don't form properly. The dye is used during an imaging scan to light up the bile system so doctors can see it more clearly.
Boston, MassachusettsAges birth–3 months
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,456 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.